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2. Impulsivity across severe mental disorders: a cross-sectional study of immune markers and psychopharmacotherapy

Author

Hjell, Gabriela, Rokicki, Jaroslav, Szabo, Attila, Holst, René, Tesli, Natalia, Bell, Christina, Fischer-Vieler, Thomas, Werner, Maren Caroline Frogner, Lunding, Synve Hoffart, Ormerod, Monica Bettina Elkjær Greenwood, Johansen, Ingrid Torp, Djurovic, Srdjan, Ueland, Thor, Andreassen, Ole Andreas, Melle, Ingrid, Lagerberg, Trine Vik, Mørch-Johnsen, Lynn, Steen, Nils Eiel, and Haukvik, Unn Kristin

Published
2023
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4. Toxoplasma gondii infection associated with inflammasome activation and neuronal injury

Author

Andreou, Dimitrios, Steen, Nils Eiel, Mørch-Johnsen, Lynn, Jørgensen, Kjetil Nordbø, Wortinger, Laura A., Barth, Claudia, Szabo, Attila, O’Connell, Kevin S., Lekva, Tove, Hjell, Gabriela, Johansen, Ingrid Torp, Ormerod, Monica B. E. G., Haukvik, Unn K., Aukrust, Pål, Djurovic, Srdjan, Yolken, Robert H., Andreassen, Ole A., Ueland, Thor, and Agartz, Ingrid

Published
2024
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5. Tobacco smoking related to childhood trauma mediated by cognitive control and impulsiveness in severe mental disorders

Author

Lunding, Synve Hoffart, Ueland, Torill, Aas, Monica, Høegh, Margrethe Collier, Werner, Maren Caroline Frogner, Rødevand, Linn, Johansen, Ingrid Torp, Hjell, Gabriela, Ormerod, Monica Bettina Elkjær Greenwood, Ringen, Petter Andreas, Ottesen, Akiah, Lagerberg, Trine Vik, Melle, Ingrid, Andreassen, Ole A., Simonsen, Carmen, and Steen, Nils Eiel

Published
2023
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9. Interleukin-18 signaling system links to agitation in severe mental disorders

Author

Hjell, Gabriela, Szabo, Attila, Mørch-Johnsen, Lynn, Holst, René, Tesli, Natalia, Bell, Christina, Fischer-Vieler, Thomas, Werner, Maren Caroline Frogner, Lunding, Synve Hoffart, Ormerod, Monica Bettina Elkjær Greenwood, Johansen, Ingrid Torp, Dieset, Ingrid, Djurovic, Srdjan, Melle, Ingrid, Ueland, Thor, Andreassen, Ole Andreas, Steen, Nils Eiel, and Haukvik, Unn Kristin

Published
2022
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13. Sex differences in autonomic adverse effects related to antipsychotic treatment and associated hormone profiles

Author

Johansen, Ingrid T., primary, Steen, Nils Eiel, additional, Rødevand, Linn, additional, Lunding, Synve H., additional, Hjell, Gabriela, additional, Ormerod, Monica B. E. G., additional, Agartz, Ingrid, additional, Melle, Ingrid, additional, Lagerberg, Trine V., additional, Nerhus, Mari, additional, and Andreassen, Ole A., additional

Published
2024
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14. Violent Offending in Males With or Without Schizophrenia: A Role for Social Cognition?

Author

Vaskinn, Anja, Rokicki, Jaroslav, Bell, Christina, Tesli, Natalia, Bang, Nina, Hjell, Gabriela, Fischer-Vieler, Thomas, Haukvik, Unn K, and Friestad, Christine

Subjects
CRIME statistics, VIOLENCE, RESEARCH funding, CRIMINALS, KRUSKAL-Wallis Test, SCHIZOPHRENIA, SOCIAL perception, AFFECTIVE disorders, DESCRIPTIVE statistics, AGGRESSION (Psychology), COGNITION disorders, STATISTICS, ANALYSIS of variance, THOUGHT & thinking
Abstract

Background and Hypothesis Reduced social cognition has been reported in individuals who have committed interpersonal violence. It is unclear if individuals with schizophrenia and a history of violence have larger impairments than violent individuals without psychosis and non-violent individuals with schizophrenia. We examined social cognition in two groups with violent offenses, comparing their performance to non-violent individuals with schizophrenia and healthy controls. Study Design Two social cognitive domains were assessed in four groups: men with a schizophrenia spectrum disorder with (SSD-V, n  = 27) or without (SSD-NV, n  = 42) a history of violence, incarcerated men serving preventive detention sentences (V, n  = 22), and healthy male controls (HC, n  = 76). Theory of mind (ToM) was measured with the Movie for the Assessment of Social Cognition (MASC), body emotion perception with Emotion in Biological Motion (EmoBio) test. Study Results Kruskal–Wallis H -tests revealed overall group differences for social cognition. SSD-V had a global and clinically significant social cognitive impairment. V had a specific impairment, for ToM. Binary logistic regressions predicting violence category membership from social cognition and psychosis (SSD status) were conducted. The model with best fit, explaining 18%–25% of the variance, had ToM as the only predictor. Conclusions Social cognitive impairment was present in individuals with a history of violence, with larger and more widespread impairment seen in schizophrenia. ToM predicted violence category membership, psychosis did not. The results suggest a role for social cognition in understanding interpersonal violence. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Individual-level deviations from normative brain morphology in violence, psychosis, and psychopathy

Author

Haukvik, Unn K, primary, Wolfers, Thomas, additional, Tesli, Natalia, additional, Bell, Christina, additional, Hjell, Gabriela, additional, Fischer-Vieler, Thomas, additional, Bang, Nina, additional, Melle, Ingrid, additional, Andreassen, Ole A, additional, Rasmussen, Kirsten, additional, Agartz, Ingrid, additional, Westlye, Lars T, additional, Friestad, Christine, additional, and Rokicki, Jaroslav, additional

Published
2023
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18. Psychopathy subdomains in violent offenders with and without a psychotic disorder

Author

Bell, Christina, Tesli, Natalia, Gurholt, Tiril Pedersen, Rokicki, Jaroslav, Hjell, Gabriela, Fischer-Vieler, Thomas, Melle, Ingrid, Agartz, Ingrid, Andreassen, Ole, Ringen, Petter Andreas, Rasmussen, Kirsten, Dahl, Hilde, Friestad, Christine, and Haukvik, Unn Kristin Hansen

Subjects
Genetics & Heredity, Science & Technology, NECROSIS-FACTOR-ALPHA, VARIANTS, AMYLOID-BETA, RISK LOCI, Psychiatry and Mental health, PREDICTION MODELS, IMPUTATION, GENOME-WIDE ASSOCIATION, Life Sciences & Biomedicine, METAANALYSIS, GENERATION, RESPONSES
Abstract

Background Violence in psychosis has been linked to antisocial behavior and psychopathy traits. Psychopathy comprises aspects of interpersonal, affective, lifestyle, and antisocial traits which may be differently involved in violent offending by persons with psychotic disorders. We explored psychopathy subdomains among violent offenders with and without a psychotic disorder. Methods 46 males, with a history of severe violence, with (n = 26; age 35.85 ± 10.34 years) or without (n = 20; age 39.10 ± 11.63 years) a diagnosis of a psychotic disorder, were assessed with the Psychopathy Checklist-Revised (PCL-R). PCL-R was split into subdomains following the four-facet model. Group differences in total and subdomain scores were analyzed with a general linear model with covariates. Results Total PCL-R scores did not differ between the groups (p = 0.61, Cohen’s d = 0.17). The violent offenders without psychotic disorders had higher facet 2 scores than the patient group with psychotic disorders (p = 0.029, Cohen’s d = 0.77). Facet 1, 3, or 4 scores did not differ between the groups. Controlling for age did not alter the results. Conclusion Patients with a psychotic disorder and a history of severe violence have lower affective psychopathy scores than violent offenders without psychotic disorders. This observation may point toward distinct underlying mechanisms for violence and may provide a target for focused treatment and prevention.

Published
2022

19. 361. Hypothalamic Nuclei Volumes and Relations to Violence and Psychopathy in Offenders With or Without a Psychotic Disorder

Author

Bell, Christina, primary, Rokicki, Jaroslaw, additional, Tesli, Natalia, additional, Gurholt, Tiril P., additional, Hjell, Gabriela, additional, Fischer-Vieler, Thomas, additional, Bang, Nina, additional, Melle, Ingrid, additional, Agartz, Ingrid, additional, Andreassen, Ole, additional, Ringen, Petter Andreas, additional, Rasmussen, Kirsten, additional, Dahl, Hilde, additional, Friestad, Christine, additional, and Haukvik, Unn Kristin, additional

Published
2023
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20. 244. Interindividual Brain Morphology Deviations From Normative Trajectories in Psychopathy, Psychosis, and Violence

Author

Rokicki, Jaroslav, primary, Wolfers, Thomas, additional, Tesli, Natalia, additional, Bell, Christina, additional, Hjell, Gabriela, additional, Fisher-Vieler, Thomas, additional, Melle, Ingrid, additional, Andreassen, Ole, additional, Rasmussen, Kirsten, additional, Agartz, Ingrid, additional, Westlye, Lars T., additional, Friestad, Christine, additional, and Haukvik, Unn, additional

Published
2023
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22. Composite immune marker scores associated with severe mental disorders and illness course

Author

Elkjaer Greenwood Ormerod, Monica Bettina, primary, Ueland, Thor, additional, Frogner Werner, Maren Caroline, additional, Hjell, Gabriela, additional, Rødevand, Linn, additional, Sæther, Linn Sofie, additional, Lunding, Synve Hoffart, additional, Johansen, Ingrid Torp, additional, Ueland, Torill, additional, Lagerberg, Trine Vik, additional, Melle, Ingrid, additional, Djurovic, Srdjan, additional, Andreassen, Ole Andreas, additional, and Steen, Nils Eiel, additional

Published
2022
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23. Psychopathy subdomains in violent offenders with and without a psychotic disorder.

Author

Bell, Christina, Tesli, Natalia, Gurholt, Tiril P., Rokicki, Jaroslav, Hjell, Gabriela, Fischer-Vieler, Thomas, Melle, Ingrid, Agartz, Ingrid, Andreassen, Ole A., Ringen, Petter Andreas, Rasmussen, Kirsten, Dahl, Hilde, Friestad, Christine, and Haukvik, Unn K.

Subjects
PSYCHOSES, VIOLENT criminals, PSYCHOPATHY, DELINQUENT behavior, FORENSIC psychiatry
Abstract

Violence in psychosis has been linked to antisocial behavior and psychopathy traits. Psychopathy comprises aspects of interpersonal, affective, lifestyle, and antisocial traits which may be differently involved in violent offending by persons with psychotic disorders. We explored psychopathy subdomains among violent offenders with and without a psychotic disorder. 46 males, with a history of severe violence, with (n = 26; age 35.85 ± 10.34 years) or without (n = 20; age 39.10 ± 11.63 years) a diagnosis of a psychotic disorder, were assessed with the Psychopathy Checklist-Revised (PCL-R). PCL-R was split into subdomains following the four-facet model. Group differences in total and subdomain scores were analyzed with a general linear model with covariates. Total PCL-R scores did not differ between the groups (p = 0.61, Cohen's d = 0.17). The violent offenders without psychotic disorders had higher facet 2 scores than the patient group with psychotic disorders (p = 0.029, Cohen's d = 0.77). Facet 1, 3, or 4 scores did not differ between the groups. Controlling for age did not alter the results. Patients with a psychotic disorder and a history of severe violence have lower affective psychopathy scores than violent offenders without psychotic disorders. This observation may point toward distinct underlying mechanisms for violence and may provide a target for focused treatment and prevention. [ABSTRACT FROM AUTHOR]

Published
2023
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25. Childhood Trauma Related to Tobacco Smoking Mediated by Cognitive Control and Impulsiveness in Severe Mental Disorders

Author

Hoffart Lunding, Synve, primary, Ueland, Torill, additional, Aas, Monica, additional, Høegh, Margrethe Collier, additional, Werner, Maren Caroline Frogner, additional, Rødevand, Linn, additional, Johansen, Ingrid Torp, additional, Hjell, Gabriela, additional, Ormerod, Monica Bettina Elkjær Greenwo, additional, Ringen, Petter Andreas, additional, Ottesen, Akiah, additional, Lagerberg, Trine V., additional, Melle, Ingrid, additional, Andreassen, Ole A., additional, Simonsen, Carmen, additional, and Steen, Nils Eiel, additional

Published
2022
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26. Interleukin-1 Family Signaling Related to Agitation in Severe Mental Disorders

Author

Hjell, Gabriela, primary, Szabo, Attila, additional, Mørch-Johnsen, Lynn, additional, Holst, René, additional, Tesli, Natalia, additional, Bell, Christina, additional, Fisher-Vieler, Thomas, additional, Frogner Werner, Maren Caroline, additional, Lunding, Synve Hoffart, additional, Ormerod, Monica, additional, Dieset, Ingrid, additional, Djurovic, Srdjan, additional, Melle, Ingrid, additional, Ueland, Thor, additional, Andreassen, Ole Andreas, additional, Steen, Nils Eiel, additional, and Haukvik, Unn Kristin, additional

Published
2021
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27. White Matter Matters: Unraveling Violence in Psychosis and Psychopathy

Author

Tesli, Natalia, primary, Rokicki, Jaroslav, additional, Maximov, Ivan I., additional, Bell, Christina, additional, Hjell, Gabriela, additional, Gurholt, Tiril P., additional, Vieler-Fischer, Thomas, additional, Tesli, Martin, additional, Westlye, Lars T., additional, Andreasen, Ole A., additional, Melle, Ingrid, additional, Agartz, Ingrid, additional, Friestad, Christine, additional, and Haukvik, Unn Kristin, additional

Published
2021
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28. Childhood trauma and cardiometabolic risk in severe mental disorders: The mediating role of cognitive control

Author

Lunding, Synve Hoffart, primary, Simonsen, Carmen, additional, Aas, Monica, additional, Rødevand, Linn, additional, Werner, Maren Caroline Frogner, additional, Laskemoen, Jannicke Fjæra, additional, Hjell, Gabriela, additional, Ringen, Petter Andreas, additional, Lagerberg, Trine Vik, additional, Melle, Ingrid, additional, Andreassen, Ole A., additional, Ueland, Torill, additional, and Steen, Nils Eiel, additional

Published
2021
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29. Disentangling the relationship between cholesterol, aggression, and impulsivity in severe mental disorders

Author

Hjell, Gabriela, primary, Mørch‐Johnsen, Lynn, additional, Holst, René, additional, Tesli, Natalia, additional, Bell, Christina, additional, Lunding, Synve Hoffart, additional, Rødevand, Linn, additional, Werner, Maren Caroline Frogner, additional, Melle, Ingrid, additional, Andreassen, Ole Andreas, additional, Lagerberg, Trine Vik, additional, Steen, Nils Eiel, additional, and Haukvik, Unn Kristin, additional

Published
2020
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30. Disentangling Violence: Amygdala Nuclei Volumes in Psychotic and Non-Psychotic Violent Offenders

Author

Bell, Christina, primary, Tesli, Natalia, additional, Gurholt, Tiril P., additional, Rokicki, Jaroslaw, additional, Hjell, Gabriela, additional, Fischer-Vieler, Thomas, additional, Melle, Ingrid, additional, Agartz, Ingrid, additional, Andreassen, Ole A., additional, Rasmussen, Kirsten, additional, Johansen, Ragnhild, additional, Friestad, Christine, additional, and Haukvik, Unn Kristin, additional

Published
2020
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31. Hippocampal Subfield and Amygdala Nuclei Volumes in Schizophrenia Patients With a History of Violence

Author

Tesli, Natalia, primary, van der Meer, Dennis, additional, Rokicki, Jaroslav, additional, Storvestre, Guttorm, additional, Røsæg, Cato, additional, Jensen, Arvid, additional, Hjell, Gabriela, additional, Bell, Christina, additional, Fisher-Vieler, Thomas, additional, Tesli, Martin, additional, Andreassen, Ole, additional, Melle, Ingrid, additional, Agartz, Ingrid, additional, and Haukvik, Unn, additional

Published
2020
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32. Polygenic Risk Score Associated With Treatment-Resistance in a Naturalistic Sample of Patients With Schizophrenia Spectrum Disorders

Author

Frogner Werner, Maren Caroline, primary, Wirgenes, Katrine Verena, additional, Haram, Marit, additional, Bettella, Francesco, additional, Lunding, Synve Hoffart, additional, Rødevand, Linn, additional, Hjell, Gabriela, additional, Agartz, Ingrid, additional, Djurovic, Srdjan, additional, Melle, Ingrid, additional, Andreassen, Ole A., additional, and Steen, Nils Eiel, additional

Published
2020
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33. White Matter Matters: Unraveling Violence in Psychosis and Psychopathy.

Author

Tesli, Natalia, Rokicki, Jaroslav, Maximov, Ivan I., Bell, Christina, Hjell, Gabriela, Gurholt, Tiril, Fischer-Vieler, Thomas, Bang, Nina, Tesli, Martin, Westlye, Lars T., Andreassen, Ole A., Melle, Ingrid, Agartz, Ingrid, Rasmussen, Kirsten, Johansen, Ragnhild, Friestad, Christine, and Haukvik, Unn K.

Subjects
AGGRESSION (Psychology), FORENSIC psychiatry, DELINQUENT behavior, SCHIZOPHRENIA, FORENSIC neurology
Abstract

Individuals with psychotic disorders have an increased risk of committing acts of violence. Neurobiological support for the extent to which violence in psychosis is driven by psychotic symptoms and/or antisocial traits could have clinical and legal implications. Neuroimaging studies have reported white matter (WM) abnormalities in individuals with psychosis and in those with antisocial traits. However, it is unknown whether WM abnormalities in psychosis patients with a history of violence (violent-PSY) resemble those found in nonviolent psychosis patients (nonviolent PSY), violent nonpsychotic individuals (violent non-PSY), or both. Diffusion tensor imaging scans from 301 males including violent-PSY (n = 28), violent non-PSY (n = 20), nonviolent PSY (n = 58), and healthy controls (HC, n = 195) were analyzed with tract-based spatial statistics. Fractional anisotropy (FA), mean, axial and radial (RD) diffusivity were compared between groups. Psychopathic traits in the violent groups were measured with Psychopathy Checklist-revisited (PCL-R). Violent-PSY had globally lower FA and higher RD, compared with nonviolent PSY. Both psychosis groups and violent non-PSY group had widespread disruptions in WM compared with HC. There were no significant WM differences between violent-PSY and violent non-PSY. PCL-R scores did not differ between the violence groups and were associated with higher RD in corpus callosum. Here we demonstrate a widespread pattern of reduced WM integrity in violent-PSY compared with nonviolent PSY. The lack of significant WM and PCL-R differences between the violence groups, together with the positive association between PCL-R and WM deficits in violent-PSY and violent non-PSY may indicate shared neu-robiological underpinnings of trait violence. [ABSTRACT FROM AUTHOR]

Published
2021
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