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1. Brain and Spinal Tumors Originating from the Germ Line Cells

Author

Wong, Tai-Tong, Tsai, Min-Lan, Chang, Hsi, Hsieh, Kevin Li-Chun, Ho, Donald Ming-Tak, Lin, Shih-Chieh, Yen, Hsiu-Ju, Chen, Yi-Wei, Lee, Hsin-Lun, Yang, Tsui-Fen, Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Steinlein, Ortrud, Series Editor, Xiao, Junjie, Series Editor, and Hanaei, Sara, editor

Published
2023
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3. Upregulation of Protein Synthesis and Proteasome Degradation Confers Sensitivity to Proteasome Inhibitor Bortezomib in Myc-Atypical Teratoid/Rhabdoid Tumors.

Author

Tran, Huy Minh, Wu, Kuo-Sheng, Sung, Shian-Ying, Changou, Chun Austin, Hsieh, Tsung-Han, Liu, Yun-Ru, Liu, Yen-Lin, Tsai, Min-Lan, Lee, Hsin-Lun, Hsieh, Kevin Li-Chun, Huang, Wen-Chang, Liang, Muh-Lii, Chen, Hsin-Hung, Lee, Yi-Yen, Lin, Shih-Chieh, Ho, Donald Ming-Tak, Chang, Feng-Chi, Chao, Meng-En, Chen, Wan, Chu, Shing-Shung, Yu, Alice L, Yen, Yun, Chang, Che-Chang, and Wong, Tai-Tong

Subjects
Myc-ATRTs, bortezomib, p53, proteasome degradation, protein synthesis, Oncology and Carcinogenesis
Abstract

Atypical teratoid rhabdoid tumors (ATRTs) are among the most malignant brain tumors in early childhood and remain incurable. Myc-ATRT is driven by the Myc oncogene, which directly controls the intracellular protein synthesis rate. Proteasome inhibitor bortezomib (BTZ) was approved by the Food and Drug Administration as a primary treatment for multiple myeloma. This study aimed to determine whether the upregulation of protein synthesis and proteasome degradation in Myc-ATRTs increases tumor cell sensitivity to BTZ. We performed differential gene expression and gene set enrichment analysis on matched primary and recurrent patient-derived xenograft (PDX) samples from an infant with ATRT. Concomitant upregulation of the Myc pathway, protein synthesis and proteasome degradation were identified in recurrent ATRTs. Additionally, we found the proteasome-encoding genes were highly expressed in ATRTs compared with in normal brain tissues, correlated with the malignancy of tumor cells and were essential for tumor cell survival. BTZ inhibited proliferation and induced apoptosis through the accumulation of p53 in three human Myc-ATRT cell lines (PDX-derived tumor cell line Re1-P6, BT-12 and CHLA-266). Furthermore, BTZ inhibited tumor growth and prolonged survival in Myc-ATRT orthotopic xenograft mice. Our findings suggest that BTZ may be a promising targeted therapy for Myc-ATRTs.

Published
2020

4. Molecular-Clinical Correlation in Pediatric Medulloblastoma: A Cohort Series Study of 52 Cases in Taiwan.

Author

Wu, Kuo-Sheng, Ho, Donald Ming-Tak, Jou, Shiann-Tarng, Yu, Alice L, Tran, Huy Minh, Liang, Muh-Lii, Chen, Hsin-Hung, Lee, Yi-Yen, Chen, Yi-Wei, Lin, Shih-Chieh, Chang, Feng-Chi, Tsai, Min-Lan, Liu, Yen-Lin, Lee, Hsin-Lun, Hsieh, Kevin Li-Chun, Huang, Wen-Chang, Sung, Shian-Ying, Chang, Che-Chang, Changou, Chun Austin, Liang, Kung-Hao, Hsieh, Tsung-Han, Liu, Yun-Ru, Chao, Meng-En, Chen, Wan, Chu, Shing-Shung, Cho, Er-Chieh, and Wong, Tai-Tong

Subjects
DNA damage response, RNA-Seq, genetic predisposition, medulloblastoma, molecular–clinical correlation, risk stratification, somatic mutations, molecular-clinical correlation, Oncology and Carcinogenesis
Abstract

In 2016, a project was initiated in Taiwan to adopt molecular diagnosis of childhood medulloblastoma (MB). In this study, we aimed to identify a molecular-clinical correlation and somatic mutation for exploring risk-adapted treatment, drug targets, and potential genetic predisposition. In total, 52 frozen tumor tissues of childhood MBs were collected. RNA sequencing (RNA-Seq) and DNA methylation array data were generated. Molecular subgrouping and clinical correlation analysis were performed. An adjusted Heidelberg risk stratification scheme was defined for updated clinical risk stratification. We selected 51 genes for somatic variant calling using RNA-Seq data. Relevant clinical findings were defined. Potential drug targets and genetic predispositions were explored. Four core molecular subgroups (WNT, SHH, Group 3, and Group 4) were identified. Genetic backgrounds of metastasis at diagnosis and extent of tumor resection were observed. The adjusted Heidelberg scheme showed its applicability. Potential drug targets were detected in the pathways of DNA damage response. Among the 10 patients with SHH MBs analyzed using whole exome sequencing studies, five patients exhibited potential genetic predispositions and four patients had relevant germline mutations. The findings of this study provide valuable information for updated risk adapted treatment and personalized care of childhood MBs in our cohort series and in Taiwan.

Published
2020

7. Supplementary Figure 3 from Frequent Overexpression of HMGA2 in Human Atypical Teratoid/Rhabdoid Tumor and Its Correlation with let-7a3/let-7b miRNA

Author

Zhang, Keqiang, primary, Gao, Hanlin, primary, Wu, Xiwei, primary, Wang, Jinhui, primary, Zhou, Wendi, primary, Sun, Guihua, primary, Wang, Jinghan, primary, Wang, Yafan, primary, Mu, Bing, primary, Kim, Charles, primary, Chu, Peiguo, primary, Ho, Donald M., primary, Ann, David K., primary, Wong, Tai-Tong, primary, and Yen, Yun, primary

Published
2023
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8. Supplementary Table 1 from Frequent Overexpression of HMGA2 in Human Atypical Teratoid/Rhabdoid Tumor and Its Correlation with let-7a3/let-7b miRNA

Author

Zhang, Keqiang, primary, Gao, Hanlin, primary, Wu, Xiwei, primary, Wang, Jinhui, primary, Zhou, Wendi, primary, Sun, Guihua, primary, Wang, Jinghan, primary, Wang, Yafan, primary, Mu, Bing, primary, Kim, Charles, primary, Chu, Peiguo, primary, Ho, Donald M., primary, Ann, David K., primary, Wong, Tai-Tong, primary, and Yen, Yun, primary

Published
2023
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9. Supplementary Figure 4 from Frequent Overexpression of HMGA2 in Human Atypical Teratoid/Rhabdoid Tumor and Its Correlation with let-7a3/let-7b miRNA

Author

Zhang, Keqiang, primary, Gao, Hanlin, primary, Wu, Xiwei, primary, Wang, Jinhui, primary, Zhou, Wendi, primary, Sun, Guihua, primary, Wang, Jinghan, primary, Wang, Yafan, primary, Mu, Bing, primary, Kim, Charles, primary, Chu, Peiguo, primary, Ho, Donald M., primary, Ann, David K., primary, Wong, Tai-Tong, primary, and Yen, Yun, primary

Published
2023
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10. Supplementary Figure 1 from Frequent Overexpression of HMGA2 in Human Atypical Teratoid/Rhabdoid Tumor and Its Correlation with let-7a3/let-7b miRNA

Author

Zhang, Keqiang, primary, Gao, Hanlin, primary, Wu, Xiwei, primary, Wang, Jinhui, primary, Zhou, Wendi, primary, Sun, Guihua, primary, Wang, Jinghan, primary, Wang, Yafan, primary, Mu, Bing, primary, Kim, Charles, primary, Chu, Peiguo, primary, Ho, Donald M., primary, Ann, David K., primary, Wong, Tai-Tong, primary, and Yen, Yun, primary

Published
2023
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11. Supplementary Figure 2 from Frequent Overexpression of HMGA2 in Human Atypical Teratoid/Rhabdoid Tumor and Its Correlation with let-7a3/let-7b miRNA

Author

Zhang, Keqiang, primary, Gao, Hanlin, primary, Wu, Xiwei, primary, Wang, Jinhui, primary, Zhou, Wendi, primary, Sun, Guihua, primary, Wang, Jinghan, primary, Wang, Yafan, primary, Mu, Bing, primary, Kim, Charles, primary, Chu, Peiguo, primary, Ho, Donald M., primary, Ann, David K., primary, Wong, Tai-Tong, primary, and Yen, Yun, primary

Published
2023
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12. MiR-146a encapsulated liposomes reduce vascular inflammatory responses through decrease of ICAM-1 expression, macrophage activation, and foam cell formation

Author

Ho, Donald, primary, Lynd, Tyler O., additional, Jun, Claire, additional, Shin, Juhee, additional, Millican, Reid C., additional, Estep, Benjamin K., additional, Chen, Jun, additional, Zhang, Xixi, additional, Brott, Brigitta C., additional, Kim, Dong Woon, additional, Sherwood, Jennifer A., additional, and Hwang, Patrick T. J., additional

Published
2023
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13. Additional file 1 of A multi-targeting bionanomatrix coating to reduce capsular contracture development on silicone implants

Author

Hwang, Patrick, Shin, Chung Min, Sherwood, Jennifer A., Kim, DongHo, Vijayan, Vineeth M., Josyula, Krishna C., Millican, Reid C., Ho, Donald, Brott, Brigitta C., Thomas, Vinoy, Choi, Chul Hee, Oh, Sang-Ha, Kim, Dong Woon, and Jun, Ho-Wook

Abstract

Additional file 1: Fig. S1. Scanning electron microscopyimage of uncoated silicone surface. Fig. S2. Contact angle measurement ofuncoated,30-layer bionanomatrix coated, and60-layer bionanomatrix coatedsilicone implants.As per journal requirements, every additional file must have a corresponding caption. In this regard, please be informed that the caption was taken from the additional e-file itself. Please advise if the action taken is appropriate and amend if necessary.There is no problem with captions.

Published
2023
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24. Cognitive and epilepsy outcomes after epilepsy surgery caused by focal cortical dysplasia in children: early intervention maybe better

Author

Chen, Hsin-Hung, Chen, Chien, Hung, Sheng-Che, Liang, Sheng-Yuan, Lin, Shih-Chieh, Hsu, Ting-Rong, Yeh, Tzu-Chen, Yu, Hsiang-Yu, Lin, Chun-Fu, Hsu, Sanford P. C., Liang, Muh-Lii, Yang, Tsui-Fen, Chu, Lee-Shing, Lin, Yung-Yang, Chang, Kai-Ping, Kwan, Shang-Yeong, Ho, Donald M., Wong, Tai-Tong, and Shih, Yang-Hsin

Published
2014
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26. Establishment of quantitative indicators for an efficient treatment on masticatory muscle pain.

Author

Sunhee Lee, Hye-Min Ju, Ho, Donald, Byong-Sop Song, Sung-Hee Jeong, Yong-Woo Ahn, Soo-Min Ok, and Kyounga Cheon

Subjects
MASTICATORY muscles, MYALGIA, TEMPORALIS muscle, PERCEIVED Stress Scale, MASSETER muscle
Abstract

Background: Although several studies have investigated effective treatments for masticatory muscle pain (MMP), no unified conclusion has been drawn regarding the effectiveness of these treatments. Objectives: This study aimed to define quantitative indicators for predicting the outcome of MMP treatment. Materials and Methods: In total, patients aged 20-70 years were recruited and divided into the MMP (n = 24) and control (n = 36) groups, based on the presence of MMP according to the Diagnostic Criteria for Temporomandibular Disorders. At pretreatment, the MMP group was assessed using quantitative indicators such as subjective pain levels, pain duration, graded chronic pain scale (GCPS), and perceived stress scale (PSS). Salivary alpha-amylase (sAA) and interleukin-6 (IL-6) levels were analyzed. The masticatory muscle palpation score and the range of mouth opening were measured. At posttreatment, subjective pain levels, mouth opening, and treatment/medication duration were examined. The PSS and sAA levels were assessed in the control group. Results: sAA levels in the MMP group were significantly higher than those in the control group (p < .05). The masseter muscle palpation score (MPS) showed a positive correlation with IL-6 levels (= 0.503, p < .05) and a negative correlation with nonsteroidal anti-inflammatory drug (NSAID) treatment period (= -0.462, p < .05). The temporalis muscle palpation score (TPS) was positively correlated with pain duration and GCPS grade (= 0.483, p < .05, and = 0.445, p < .05, respectively). Conclusions: Treatment with NSAIDs was effective in the MMP group with high MPS and IL-6 levels, but not in the MMP group with high TPS, pain duration, and GCPS grade. [ABSTRACT FROM AUTHOR]

Published
2023
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