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7. Investigating the Role of PPARβ/δ in Retinal Vascular Remodeling Using Pparβ / δ -Deficient Mice.

Author

Ho SY, Kwan YP, Qiu B, Tan A, Murray HL, Barathi VA, Tan NS, Cheung CMG, Wong TY, Wahli W, and Wang X

Subjects
Animals, Cells, Cultured, Disease Models, Animal, Haploinsufficiency, Humans, Lasers adverse effects, Mice, Retinal Vessels cytology, Retinal Vessels metabolism, Choroidal Neovascularization genetics, Receptors, Cytoplasmic and Nuclear deficiency, Vascular Remodeling genetics
Abstract

Peroxisome proliferator-activated receptor (PPAR)β/δ is a member of the nuclear receptor superfamily of transcription factors, which plays fundamental roles in cell proliferation and differentiation, inflammation, adipogenesis, and energy homeostasis. Previous studies demonstrated a reduced choroidal neovascularization (CNV) in Pparβ / δ -deficient mice. However, PPARβ/δ's role in physiological blood vessel formation and vessel remodeling in the retina has yet to be established. Our study showed that PPARβ/δ is specifically required for disordered blood vessel formation in the retina. We further demonstrated an increased arteriovenous crossover and wider venous caliber in Pparβ / δ -haplodeficient mice. In summary, these results indicated a critical role of PPARβ/δ in pathological angiogenesis and blood vessel remodeling in the retina.

Published
2020
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