35 results on '"Ho Cheol Song"'
Search Results
2. Renal Outcome of IgM Nephropathy: A Comparative Prospective Cohort Study
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Young Soo Kim, Eun Sil Koh, Hyung Wook Kim, Yura Chae, Cheol Whee Park, Sungjin Chung, Ho Cheol Song, Bum Soon Choi, Young Ok Kim, Hye Eun Yoon, and Yoon Kyung Chang
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medicine.medical_specialty ,IgM nephropathy ,kidney biopsy ,Urology ,urologic and male genital diseases ,Article ,Focal segmental glomerulosclerosis ,Biopsy ,medicine ,Minimal change disease ,renal outcome ,Prospective cohort study ,Kidney ,Proteinuria ,medicine.diagnostic_test ,business.industry ,urogenital system ,Glomerulonephritis ,General Medicine ,medicine.disease ,medicine.anatomical_structure ,Medicine ,Mesangial proliferative glomerulonephritis ,prognosis ,medicine.symptom ,business ,glomerulonephritis - Abstract
Immunoglobulin M nephropathy (IgMN) is an idiopathic glomerulonephritis characterized by diffuse deposits of IgM in the glomerular mesangium. However, its renal prognosis remains unknown. We compared renal outcomes of IgMN patients with those of patients with minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), or mesangial proliferative glomerulonephritis (MsPGN) from a prospective observational cohort, with 1791 patients undergoing native kidney biopsy in eight hospitals affiliated with The Catholic University of Korea between December 2014 and October 2020. IgMN had more mesangial proliferation and matrix expansion than MsPGN and more tubular atrophy and interstitial fibrosis than MCD. IgMN patients had decreased eGFR than MCD patients in the earlier follow-up. However, there was no significant difference in urine protein or eGFR among all patients at the last follow-up. When IgMN was divided into three subtypes, patients with FSGS-like IgMN tended to have lower eGFR than those with MCD-like or MsPGN-like IgMN but higher proteinuria than MsPGN-like IgMN without showing a significant difference. The presence of hypertension at the time of kidney biopsy predicted ≥20% decline of eGFR over two years in IgMN patients. Our data indicate that IgMN would have a clinical course and renal prognosis similar to MCD, FSGS, and MsPGN.
- Published
- 2021
3. Spontaneous Renal Artery Dissection Resulting in Renal Infarction: A Case Report and Review of the Literature
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Ho Cheol Song, Yoorim Seo, Ji Won Min, Myung Ah Ha, and Yong Kyun Kim
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medicine.medical_specialty ,Right flank ,Kidney ,Flank pain ,business.industry ,Renal infarction ,Infarction ,General Medicine ,Dissection (medical) ,030204 cardiovascular system & hematology ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,Internal Medicine ,medicine ,030211 gastroenterology & hepatology ,Radiology ,business ,Renal artery dissection ,Rare disease - Abstract
Spontaneous renal artery dissection is a rare disease and an uncommon cause of renal infarction. The patient was a man who presented to the emergency room with sudden-onset right flank pain. Computed tomography revealed right renal infarction; thus, anticoagulation was initiated. Renal angiography revealed luminal narrowing of the segmental artery to the superior pole of right kidney without a dissection flap or false lumen. We stopped anticoagulation due to a lack of evidence of thrombi or luminal narrowing of the dissected vessels. When patients present with acute flank pain, it is important to suspect renal infarction and to perform a correct diagnostic workup, even when the patient shows normal urinalysis results and a normal LDH value.
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- 2019
4. Overhydration Negatively Affects Quality of Life in Peritoneal Dialysis Patients: Evidence from a Prospective Observational Study
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Byoung Geun Han, Hye Eun Yoon, Tae Won Lee, Yong-Soo Kim, Ki Ryang Na, Jong Tae Cho, Hyung Wook Kim, Jin Kuk Kim, Jong Hoon Chung, Kitae Bang, Young Rim Song, Seong Suk Kim, Yang Wook Kim, Young Joo Kwon, Ho Cheol Song, Jong Hyeok Jeong, Kyoung Hyoub Moon, Byung Soo Kim, Kwang Young Lee, Young Ok Kim, Sung Ro Yun, Yoon Kyung Chang, Chang Hwa Lee, Seok Joon Shin, and Eun Ah Hwang
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Adult ,Male ,medicine.medical_specialty ,Pediatrics ,medicine.medical_treatment ,030232 urology & nephrology ,030204 cardiovascular system & hematology ,Gastroenterology ,Peritoneal dialysis ,03 medical and health sciences ,0302 clinical medicine ,Vascular Stiffness ,Quality of life ,Bioimpedance spectroscopy ,Internal medicine ,bioimpedance ,Medicine ,Humans ,quality of life ,fluid overload ,Hydration status ,Aged ,Heart Failure ,Dehydration ,business.industry ,overhydration ,General Medicine ,Middle Aged ,medicine.disease ,humanities ,Quartile ,peritoneal dialysis ,Heart failure ,Dielectric Spectroscopy ,Quality of Life ,Observational study ,Female ,Kidney Diseases ,business ,Kidney disease ,Research Paper - Abstract
Backgound: This study evaluated whether the hydration status affected health-related quality of life (HRQOL) during 12 months in peritoneal dialysis (PD) patients. Methods: The hydration status and the HRQOL were examined at baseline and after 12 months using a bioimpedance spectroscopy and Kidney Disease Quality of Life-Short Form, respectively in PD patients. Four hundred eighty-one patients were included and divided according to the baseline overhydration (OH) value; normohydration group (NH group, -2L≤ OH ≤+2L, n=266) and overhydration group (OH group, OH >+2L, n=215). Baseline HRQOL scores were compared between the two groups. The subjects were re-stratified into quartiles according to the OH difference (OH value at baseline - OH value at 12 months
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- 2016
5. The Natural Course of Biopsy-Proven Isolated Microscopic Hematuria: a Single Center Experience of 350 Patients
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Kyungsoo Lee, Euy Jin Choi, Ho Cheol Song, Hae Min Lee, Ji Won Min, Ji In Hyun, and Yong Kyun Kim
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Adult ,Male ,medicine.medical_specialty ,Pathology ,genetic structures ,Adolescent ,Biopsy ,030232 urology & nephrology ,Renal function ,urologic and male genital diseases ,Kidney ,Gastroenterology ,Asymptomatic ,Nephropathy ,End stage renal disease ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,030212 general & internal medicine ,Hematuria ,Retrospective Studies ,Proteinuria ,medicine.diagnostic_test ,business.industry ,Glomerulonephritis, IGA ,General Medicine ,Middle Aged ,medicine.disease ,Prognosis ,Nephrology ,Kidney Failure, Chronic ,Original Article ,Female ,Renal biopsy ,medicine.symptom ,business ,Kidney disease ,Glomerular Filtration Rate - Abstract
The increasing interest in healthcare and health screening events is revealing additional cases of asymptomatic isolated microscopic hematuria (IMH). However, a consensus of the evaluation and explanation of the IMH prognosis is controversial among physicians. Here, we present the natural course of IMH together with the pathological diagnosis and features to provide supportive data when approaching patients with IMH. We retrospectively evaluated 350 patients with IMH who underwent a renal biopsy between 2002 and 2011, and the pathological diagnosis and chronic histopathological features (glomerulosclerosis, interstitial fibrosis, and tubular atrophy) were reviewed. Deterioration of renal function was examined during follow up. The patients with IMH were evaluated for a mean of 86 months. IgA nephropathy was the most common diagnosis in 164 patients (46.9%). Chronic histopathological changes were observed in 166 (47.4%) but was not correlated with proteinuria or a decline in renal function. Ten patients developed proteinuria, and all of them had IgA nephropathy. Three patients progressed to chronic kidney disease with an estimated glomerular filtration rate < 60 mL/min/1.73 m(2) but none progressed to end stage renal disease. In conclusion, IMH had a generally benign course during 7-years of observation, although IgA nephropathy should be monitored if it progresses to proteinuria. Future prospective randomized studies may help conclude the long-term prognosis and lead to a consensus for managing IMH.
- Published
- 2016
6. Minimal change nephrotic syndrome showing complete remission after resection of a neurofibroma in a type I neurofibromatosis patient
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Yong Kyun Kim, Ji Won Min, Ho Cheol Song, Hye Min Lee, Eu Jin Choi, and Ji In Hyun
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0301 basic medicine ,medicine.medical_specialty ,Neurofibromatosis 1 ,medicine.diagnostic_test ,business.industry ,Nephrosis ,030232 urology & nephrology ,Complete remission ,Nephrotic syndrome ,medicine.disease ,Resection ,Surgery ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Neurofibroma, plexiform ,Biopsy ,Minimal change nephrotic syndrome ,Medicine ,Neurofibroma ,Neurofibromatosis ,business ,Letter to the Editor - Published
- 2016
7. The role of autophagy in unilateral ureteral obstruction rat model
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Jun Sung Ko, Jin Kim, Yong Kyun Kim, Ho Cheol Song, Hong Lim Kim, Sang Hee Park, Wan-Young Kim, Euy Jin Choi, Sun Ah Nam, and Yong Soo Kim
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medicine.medical_specialty ,Programmed cell death ,Kidney ,urogenital system ,business.industry ,Autophagy ,Kidney metabolism ,General Medicine ,urologic and male genital diseases ,medicine.disease ,female genital diseases and pregnancy complications ,Endocrinology ,medicine.anatomical_structure ,Nephrology ,Fibrosis ,Internal medicine ,medicine ,Tubulointerstitial fibrosis ,Renal fibrosis ,Cancer research ,business ,PI3K/AKT/mTOR pathway - Abstract
Aim: Autophagy is a cellular process of degradation of damaged cytoplasmic components and regulates cell death or proliferation. Unilateral ureteral obstruction (UUO) is a model of progressive renal fibrosis in the obstructed kidney. And UUO is followed by compensatory cellular proliferation in the contralateral kidney. We investigate the role of autophagy in the obstructed kidney and contralateral kidney after UUO. Methods: To obtain the evidence and the patterns of autophagy during UUO, the rats were sacrificed 3, 7 and 14 days after UUO. To examine the efficacy of the autophagy inhibitors, 3-methyladenine (3-MA), the rats were treated daily with intraperitoneal injection of 3-MA (30 mg/kg per day) for 7 days. Results: After UUO, autophagy was induced in the obstructed kidney in a time-dependent manner. Inhibition of autophagy by 3-MA enhanced tubular cell apoptosis and tubulointerstitial fibrosis in the obstructed kidney after UUO. In the contralateral kidney, autophagy was also induced and prolonged during UUO. Inhibition of autophagy by 3-MA increased the protein expression of proliferating cell nuclear antigen significantly in the contralateral kidney after UUO. The Akt-mammalian target of rapamycin (mTOR) signalling pathway was involved in the induction of autophagy after UUO in both kidneys. Conclusion: Our present results support that autophagy induced by UUO has a renoprotective role in the obstructed kidney and regulatory role of compensatory cellular proliferation in the contralateral kidney through Akt-mTOR signalling pathway.
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- 2012
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8. Relationship between erythropoietin resistance index and left ventricular mass and function and cardiovascular events in patients on chronic hemodialysis
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Yong-Soo Kim, Euy Jin Choi, Sungjin Chung, Ho Cheol Song, Chul Woo Yang, Yong Kyun Kim, Sang-Hyun Ihm, Hee-Yeol Kim, Seok Joon Shin, and Chan Seok Park
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medicine.medical_specialty ,Ejection fraction ,business.industry ,medicine.medical_treatment ,Hematology ,Left ventricular hypertrophy ,medicine.disease ,Surgery ,Muscle hypertrophy ,Nephrology ,Erythropoietin ,Internal medicine ,Cardiology ,Medicine ,In patient ,Chronic hemodialysis ,Hemodialysis ,business ,Prospective cohort study ,medicine.drug - Abstract
The response to erythropoietin (EPO) treatment varies considerably in individual patients on chronic hemodialysis. The EPO resistance index (ERI) has been considered useful to assess the EPO resistance and can be easily calculated in the clinic. The aim of this study was to investigate the association between ERI and left ventricular mass (LVM) and function and to determine whether ERI was associated with cardiovascular events in patients on hemodialysis. This study was designed prospectively. Clinical, laboratory, and echocardiographic variables were assessed in 72 patients on hemodialysis. The ERI was determined as the weekly weight-adjusted dose of EPO (U/kg/week) divided by hemoglobin concentration (g/dL). Patients were divided into three groups by tertiles of ERI. Patients with higher tertiles of ERI had a higher LVM index and lower LV ejection fraction compared with those with lower tertiles of ERI (P = 0.019 and P = 0.030, respectively). The median follow-up period was 53 months. The Kaplan-Meier plot showed increased frequency of cardiovascular events in patients with higher tertiles of ERI, compared with those with lower tertiles of ERI (P = 0.011, log-rank test). The multivariate Cox proportional hazard models showed that the ERI was the significant independent predictor of cardiovascular events (HR 3.00, 95% CI, 1.04-8.62, P = 0.042). Our data show that ERI was related with LVM index, LV systolic function and cardiovascular events in patients with hemodialysis. By monitoring of ERI, early identification of the EPO resistance may be helpful to predict the cardiovascular risk in hemodialysis patients.
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- 2011
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9. SP166THE NATURAL COURSE OF IgA NEPHROPATHY PRESENTING WITH ISOLATED HEMATURIA AT THE TIME OF DIAGNOSIS
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Euy Jin Choi, Seok Joon Shin, Ho Cheol Song, and Ji Won Min
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Transplantation ,Natural course ,medicine.medical_specialty ,Nephrology ,business.industry ,medicine ,business ,medicine.disease ,Dermatology ,Nephropathy - Published
- 2018
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10. Physical Solubility and Diffusivity of N2O and CO2 in Aqueous Sodium Glycinate Solutions
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Sanjeev Maken, and Ho-Cheol Song, Ho Jun Song, Seungmoon Lee, Ho-Chul Shin, and Jinwon Park
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Sodium glycinate ,Aqueous solution ,Chemistry ,General Chemical Engineering ,Inorganic chemistry ,Amine gas treating ,General Chemistry ,Solubility ,equipment and supplies ,Thermal diffusivity ,Mass fraction ,Chemical reaction - Abstract
Physical solubility and diffusivity of N2O and CO2 in pure water and of N2O in aqueous sodium glycinate solutions of mass fraction (0.1 to 0.5) were measured at T = (303.15 to 323.15) K. Since it was not possible to measure these properties for CO2 due to the chemical reaction between CO2 and the amine group of sodium glycinate, these were estimated using the well-known N2O analogy. While the physical solubility increases with a decrease in temperature and with a decrease in mass fraction, diffusivity decreases with a decrease in temperature as well as an increase in mass fraction except for concentrated solution (mass fraction 0.4 and 0.5) where it increases with a decrease in temperature.
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- 2006
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11. Effects of Korean red ginseng and its mixed prescription on the high molecular weight dextran-induced blood stasis in rats and human platelet aggregation
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Sung-Ryong Ko, Young-Doo Park, Shi-Yong Ryu, Sung-Hoon Kim, Kyoo-Seok Ahn, Ho-Cheol Song, Jae-Ho Do, Yeo-Pyo Yun, and Jung-Hyo Kim
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Male ,Platelet Aggregation ,Panax ,Pharmacology ,Biology ,Fibrinogen ,Rats, Sprague-Dawley ,chemistry.chemical_compound ,Ginseng ,Thrombin ,Drug Discovery ,Blood plasma ,medicine ,Animals ,Humans ,Platelet ,Blood Coagulation ,Chromatography, High Pressure Liquid ,Korea ,Plant Extracts ,Anticoagulants ,Dextrans ,Rats ,Dextran ,Coagulation ,Biochemistry ,chemistry ,Hemostasis ,medicine.drug - Abstract
This study was undertaken to evaluate the antithrombotic effects of Korean Red Ginseng (KRG) and its new prescription (KRGP) consisting of five herbs such as Korean red ginseng, Ganoderma, Cinnamomi Cortex, Glycyrrhizae Radix and Laminaria. In rats with blood stasis induced by high molecular weight dextran, KRG and KRGP significantly restored not only the number of platelets and fibrinogen, but also suppressed the fibrin degradation products (FDP) to normal range. In platelet aggregation assay with human platelet rich plasma (PRP), KRG and KRGP significantly inhibited thrombin and collagen-induced platelet aggregation. The IC(50) values of KRG and KRGP were >2 and 0.23+/-0.01 mg/ml for thrombin, 0.32+/-0.01 and 0.17+/-0.02 mg/ml for collagen and 0.72+/-0.25 and >2 mg/ml for ADP, respectively. In coagulation assay, KRG and KRGP significantly prolonged activated partial prothrombin time (APPT) and prothrombin time (PT) as compared with control data. KRGP was found to be more effective than KRG alone on antithrombotic activity. These results suggest that KRGP may exert its antithrombotic activity due to inhibition of platelet aggregation and coagulation activity more than KRG.
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- 2001
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12. Intestinal protein loss in patients with haemorrhagic fever with renal syndrome
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Ho Cheol Song, Byung Kee Bang, Young Ok Kim, Yoon Sik Chang, Yong-Soo Kim, Chul Woo Yang, Euy Jin Choi, Suk Young Kim, and Sun Ae Yoon
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Adult ,Male ,Pathology ,medicine.medical_specialty ,Serum albumin ,Alpha (ethology) ,Vascular permeability ,Disease ,Scintigraphy ,Gastroenterology ,Feces ,Reference Values ,Internal medicine ,medicine ,Humans ,Intestinal Mucosa ,Radionuclide Imaging ,Technetium Tc 99m Aggregated Albumin ,Serum Albumin ,Transplantation ,biology ,medicine.diagnostic_test ,business.industry ,Middle Aged ,Blood proteins ,Pathophysiology ,Nephrology ,Hemorrhagic Fever with Renal Syndrome ,alpha 1-Antitrypsin ,biology.protein ,Female ,Viral disease ,Radiopharmaceuticals ,business - Abstract
Background. In haemorrhagic fever with renal syndrome (HFRS) vascular dysfunction has been observed in various organs, but the involvement of the intestine has not yet been reported. This study was performed to evaluate the association of intestinal protein loss in this disease with other clinical parameters reflecting vascular permeability or disease severity. Methods. Twenty patients with HFRS were included in this study. Intestinal protein loss was measured by 99m Tc-human serum albumin ( 99m Tc-HSA) scintigraphy in the acute stage, and quantitative analysis of protein loss was measured by the faecal clearance of alpha 1-antitrypsin (C AT ) in the acute and the recovery stages. C AT was then compared with clinical parameters reflecting disease activity and vascular permeability. Results. 99m Tc-HSA scintigraphy was positive in 13 (65%) patients, and C AT in the acute stage was significantly increased as compared with C AT in the recovery stage (40.5 ± 24.1 vs 9.2 ± 4.2 ml/day, P < 0.001). C AT was associated with serum albumin levels, frequency of hypotensive episodes, severity of acute renal failure, and degree of thrombocytopenia. Conclusions. Our data suggest that the increased vascular permeability of HFRS is associated with the increased intestinal loss of plasma proteins, which might represent one of the parameters of disease severity in HFRS.
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- 2000
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13. Predictors for diabetic retinopathy in normoalbuminuric people with type 2 diabetes mellitus
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Woo Ho Ban, Sung Rae Kim, Yong-Soo Kim, Soon Jib Yoo, Ho Ra, Euy Jin Choi, Ji Han Yoo, Ho Cheol Song, Seong Su Lee, and Yong Kyun Kim
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medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,Excretion ,Albuminuria ,Risk factor ,Diabetic retinopathy ,Type 2 diabetesmellitus ,Hemoglobin ,Internal medicine ,Diabetes mellitus ,Type 2 diabetes mellitus ,Internal Medicine ,medicine ,Clinical significance ,lcsh:RC620-627 ,business.industry ,Research ,Type 2 Diabetes Mellitus ,medicine.disease ,lcsh:Nutritional diseases. Deficiency diseases ,Endocrinology ,Microalbuminuria ,medicine.symptom ,business - Abstract
Background Previous studies have reported that microalbuminuria is an independent risk factor for the prevalence of diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (DM). For this reason, the clinical significance of DR in normoalbuminuric type 2 DM patients may be overlooked. The aim of this study was to investigate the prevalence of DR and predictors for DR in normoalbuminuric patients with type 2 DM. Methods A total 310 patients with type 2 DM and normoalbuminuria, who were referred to the Department of Ophthalmology for screening of DR were included in this study. DR was clinically graded according to the International Clinical Diabetic Retinopathy guidelines. The urinary albumin excretion rate (UAER) was assessed via 24-hour urine collection and measured by immunoturbidimetric assay. Normoalbuminuria was defined as a UAER Results DR of any grade was present in 64/310 (20.7 %) patients. Mild non-proliferative diabetic retinopathy (NPDR) was most prevalent in patients with DR of any grade (36/64, 56 %). The duration of diabetes (OR 1.01, 95 % CI, 1.01 – 1.02, p Conclusions Our findings suggest that patients with normoalbuminuric type 2 DM also require close monitoring for the early detection of DR, especially if they have a higher UAER, longer duration of diabetes, or lower hemoglobin levels.
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- 2012
14. Relationship between erythropoietin resistance index and left ventricular mass and function and cardiovascular events in patients on chronic hemodialysis
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Sungjin, Chung, Ho Cheol, Song, Seok Joon, Shin, Sang-Hyun, Ihm, Chan Seok, Park, Hee-Yeol, Kim, Chul Woo, Yang, Yong-Soo, Kim, Euy Jin, Choi, and Yong Kyun, Kim
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Male ,Echocardiography ,Renal Dialysis ,Drug Resistance ,Humans ,Kidney Failure, Chronic ,Female ,Hypertrophy, Left Ventricular ,Prospective Studies ,Middle Aged ,Erythropoietin - Abstract
The response to erythropoietin (EPO) treatment varies considerably in individual patients on chronic hemodialysis. The EPO resistance index (ERI) has been considered useful to assess the EPO resistance and can be easily calculated in the clinic. The aim of this study was to investigate the association between ERI and left ventricular mass (LVM) and function and to determine whether ERI was associated with cardiovascular events in patients on hemodialysis. This study was designed prospectively. Clinical, laboratory, and echocardiographic variables were assessed in 72 patients on hemodialysis. The ERI was determined as the weekly weight-adjusted dose of EPO (U/kg/week) divided by hemoglobin concentration (g/dL). Patients were divided into three groups by tertiles of ERI. Patients with higher tertiles of ERI had a higher LVM index and lower LV ejection fraction compared with those with lower tertiles of ERI (P = 0.019 and P = 0.030, respectively). The median follow-up period was 53 months. The Kaplan-Meier plot showed increased frequency of cardiovascular events in patients with higher tertiles of ERI, compared with those with lower tertiles of ERI (P = 0.011, log-rank test). The multivariate Cox proportional hazard models showed that the ERI was the significant independent predictor of cardiovascular events (HR 3.00, 95% CI, 1.04-8.62, P = 0.042). Our data show that ERI was related with LVM index, LV systolic function and cardiovascular events in patients with hemodialysis. By monitoring of ERI, early identification of the EPO resistance may be helpful to predict the cardiovascular risk in hemodialysis patients.
- Published
- 2011
15. The role of autophagy in unilateral ureteral obstruction rat model
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Wan-Young, Kim, Sun Ah, Nam, Ho Cheol, Song, Jun Sung, Ko, Sang Hee, Park, Hong Lim, Kim, Euy Jin, Choi, Yong-Soo, Kim, Jin, Kim, and Yong Kyun, Kim
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Male ,Time Factors ,Adenine ,TOR Serine-Threonine Kinases ,Apoptosis ,Kidney ,Fibrosis ,Rats ,Rats, Sprague-Dawley ,Disease Models, Animal ,Kidney Tubules ,Cytoprotection ,Proliferating Cell Nuclear Antigen ,Autophagy ,Animals ,Proto-Oncogene Proteins c-akt ,Injections, Intraperitoneal ,Cell Proliferation ,Signal Transduction ,Ureteral Obstruction - Abstract
Autophagy is a cellular process of degradation of damaged cytoplasmic components and regulates cell death or proliferation. Unilateral ureteral obstruction (UUO) is a model of progressive renal fibrosis in the obstructed kidney. And UUO is followed by compensatory cellular proliferation in the contralateral kidney. We investigate the role of autophagy in the obstructed kidney and contralateral kidney after UUO.To obtain the evidence and the patterns of autophagy during UUO, the rats were sacrificed 3, 7 and 14 days after UUO. To examine the efficacy of the autophagy inhibitors, 3-methyladenine (3-MA), the rats were treated daily with intraperitoneal injection of 3-MA (30 mg/kg per day) for 7 days.After UUO, autophagy was induced in the obstructed kidney in a time-dependent manner. Inhibition of autophagy by 3-MA enhanced tubular cell apoptosis and tubulointerstitial fibrosis in the obstructed kidney after UUO. In the contralateral kidney, autophagy was also induced and prolonged during UUO. Inhibition of autophagy by 3-MA increased the protein expression of proliferating cell nuclear antigen significantly in the contralateral kidney after UUO. The Akt-mammalian target of rapamycin (mTOR) signalling pathway was involved in the induction of autophagy after UUO in both kidneys.Our present results support that autophagy induced by UUO has a renoprotective role in the obstructed kidney and regulatory role of compensatory cellular proliferation in the contralateral kidney through Akt-mTOR signalling pathway.
- Published
- 2011
16. Relationship of visceral and subcutaneous adiposity with renal function in people with type 2 diabetes mellitus
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Young-Du Kim, Yong Soo Kim, Hyung Wook Kim, Ji Han Yoo, Yeon Soo Lim, Soon Jib Yoo, Seong Su Lee, Yong Kyun Kim, Euy Jin Choi, Chul Woo Yang, Ho Cheol Song, and Sung Rae Kim
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Male ,medicine.medical_specialty ,Cross-sectional study ,Subcutaneous Fat ,Renal function ,Overweight ,Intra-Abdominal Fat ,urologic and male genital diseases ,Kidney Function Tests ,Gastroenterology ,Body Mass Index ,Risk Factors ,Diabetes mellitus ,Internal medicine ,medicine ,Humans ,Obesity ,reproductive and urinary physiology ,Adiposity ,Transplantation ,business.industry ,nutritional and metabolic diseases ,Type 2 Diabetes Mellitus ,Middle Aged ,medicine.disease ,Prognosis ,female genital diseases and pregnancy complications ,Endocrinology ,Cross-Sectional Studies ,Diabetes Mellitus, Type 2 ,Nephrology ,Creatinine ,Female ,Kidney Diseases ,medicine.symptom ,business ,Tomography, X-Ray Computed ,Body mass index ,Kidney disease ,Follow-Up Studies ,Glomerular Filtration Rate - Abstract
Background Obesity and diabetes mellitus (DM) are established risk factors for the development of chronic kidney disease. Visceral adiposity (VAT) and subcutaneous adiposity (SAT) may be associated with the differential metabolic risk. Our study was performed to determine whether VAT or SAT was associated with the decrease of renal function in people with type 2 DM. Methods Nine hundred and twenty-nine people with type 2 DM and who had undergone abdominal computed tomography assessment of the SAT and VAT areas were included. The estimated glomerular filtration rate (eGFR) was calculated using the Cockcroft-Gault equation and the Modification of Diet in Renal Disease (MDRD) four-variable equation at the time of the assessment of the SAT and VAT areas. Results VAT was negatively associated with eGFR using the MDRD equation after adjustment for the clinical variables (β-coefficient = - 0.075, P = 0.034), while SAT was not significantly associated with eGFR. There was no significant association between the abdominal adiposity measurements and the eGFR using the Cockcroft-Gault formula. When stratifying the individuals by the body mass index groups, VAT was negatively associated with eGFR by the MDRD equation and the Cockcroft-Gault formula in the overweight and obese subjects after adjustment for the clinical variables, while there was no significant association between the VAT and the eGFR in the normal weight subjects. SAT was not significantly associated with eGFR in the normal weight, overweight and obese subjects. Conclusions Our data suggest that VAT may be an additional prognostic factor for the decrease of renal function especially in the overweight or obese subjects with type 2 DM.
- Published
- 2010
17. Fibrillary glomerulonephritis in rheumatoid arthritis
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Jun-Ki Min, Ho Cheol Song, Kyungji Lee, Yong Soo Kim, Yu-Seon Yun, Yong Kyun Kim, and Euy Jin Choi
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medicine.medical_specialty ,Nephrotic Syndrome ,Biopsy ,Treatment outcome ,MEDLINE ,Arthritis ,Kidney ,Arthritis, Rheumatoid ,Glomerulonephritis ,Recurrence ,medicine ,Humans ,medicine.diagnostic_test ,business.industry ,Fibrillary Glomerulonephritis ,Kidney pathology ,General Medicine ,Middle Aged ,medicine.disease ,Dermatology ,Treatment Outcome ,Nephrology ,Rheumatoid arthritis ,Immunology ,Female ,business ,Immunosuppressive Agents - Published
- 2010
18. Association between N-terminal pro-brain natriuretic peptide and acute ischemic stroke in patients on chronic hemodialysis
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Sang-Hyun Ihm, Hee-Yeol Kim, Ho Cheol Song, Euy Jin Choi, Chul Woo Yang, Dong Suk Shim, Seok Joon Shin, Yong Kyun Kim, Chan Seok Park, Yong-Soo Kim, and Young-Du Kim
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Nephrology ,Male ,medicine.medical_specialty ,medicine.drug_class ,Urology ,medicine.medical_treatment ,Population ,Brain Ischemia ,Predictive Value of Tests ,Renal Dialysis ,Risk Factors ,Internal medicine ,Diabetes mellitus ,Natriuretic Peptide, Brain ,medicine ,Natriuretic peptide ,Humans ,In patient ,cardiovascular diseases ,Prospective Studies ,education ,Stroke ,education.field_of_study ,business.industry ,Middle Aged ,medicine.disease ,Peptide Fragments ,Mean blood pressure ,Acute Disease ,Cardiology ,Female ,Hemodialysis ,business ,hormones, hormone substitutes, and hormone antagonists - Abstract
Plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) has been reported as a predictor for ischemic stroke in general population. However, predictive value of plasma NT-proBNP for acute ischemic stroke in patients on chronic hemodialysis has not been well established. The aim of this study was to determine whether NT-proBNP could predict acute ischemic stroke in patients on chronic hemodialysis. This study was designed prospectively. Clinical, laboratory, and echocardiographic variables were assessed in 72 patients on chronic hemodialysis. The plasma levels of NT-proBNP were measured by immunoassay. During the follow-up period of 45 months, 11 patients had an acute ischemic stroke. The Kaplan–Meier plot showed an increased frequency of acute ischemic stroke in patients with plasma levels of NT-proBNP above the median values compared to patients with lower concentrations (P = 0.028). The multivariate Cox proportional hazard models showed that the NT-proBNP was a significant independent predictor of acute ischemic stroke after adjustment for age, sex, mean blood pressure, diabetes, serum cholesterol levels, left ventricular mass index, and left ventricular fractional shortening (HR 6.66, 95% CI, 1.22–36.48, P = 0.029). Our data suggest that plasma NT-proBNP levels predict the risk of acute ischemic stroke in patients on chronic hemodialysis.
- Published
- 2009
19. Acquired gitelman syndrome
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Yong Kyun Kim, Euy Jin Choi, Yong-Soo Kim, and Ho Cheol Song
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medicine.medical_specialty ,Physiology ,business.industry ,Hypokalemic metabolic alkalosis ,Disease ,Review Article ,Gitelman syndrome ,medicine.disease ,Gastroenterology ,Hypocalciuria ,Hypomagnesemia ,Endocrinology ,Renal tubular dysfunction ,Prednisone ,Internal medicine ,Internal Medicine ,medicine ,Sjögren's syndrome ,medicine.symptom ,Differential diagnosis ,Cardiology and Cardiovascular Medicine ,business ,thiazide-sensitive NaCl cotransporter ,medicine.drug - Abstract
Acquired renal tubular disorder can be observed in various disease processes, especially autoimmune diseases. Gitelman syndrome is an autosomal recessive disease characterized by hypokalemic metabolic alkalosis, hypomagnesemia, and hypocalciuria. This disorder is caused by mutation in the SLC12A3 gene, which encodes the thiazide-sensitive NaCl cotransporter (NCCT). Acquired Gitelman syndrome has been reported and the majority has been associated with Sjogren's syndrome. The presence of circulating auto-antibodies to NCCT was suggested as a mechanism of acquired Gitelman syndrome. Treatment of acquired Gitelman syndrome was done with supplements of potassium and magnesium and prednisone was effective in some cases. Acquired Gitelman syndrome should be included in the differential diagnosis of renal involvement in patients with autoimmune diseases, especially Sjogren's syndrome.
- Published
- 2009
20. Natural history and renal pathology in patients with isolated microscopic hematuria
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Young Shin Shin, Ho Cheol Song, Yong Kyun Kim, Byung Soo Kim, Yong Soo Kim, Euy Jin Choi, and Young Ok Kim
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Adult ,Male ,medicine.medical_specialty ,Pathology ,genetic structures ,Natural history ,urologic and male genital diseases ,Kidney ,Gastroenterology ,Nephropathy ,Internal medicine ,medicine ,Humans ,Microscopic hematuria ,Hematuria ,Proportional Hazards Models ,Retrospective Studies ,Proteinuria ,medicine.diagnostic_test ,business.industry ,Middle Aged ,medicine.disease ,Prognosis ,Renal pathology ,Chronic Disease ,Mesangial proliferative glomerulonephritis ,Female ,Kidney Diseases ,Original Article ,Renal biopsy ,medicine.symptom ,business ,Kidney disease - Abstract
Background/Aims: No definite conclusions have been reached about the natural history of patients with isolated microscopic hematuria (IMH). In this study, we observed the natural history of patients with IMH and examined factors related to a pathologic diagnosis and subsequent prognosis. Methods: We retrospectively evaluated 156 subjects with IMH who had a renal biopsy performed. Of the 156 subjects, 33.3% were diagnosed with IgA nephropathy, 23.7% with mesangial proliferative glomerulonephritis, 15.4% with glomerular minor lesion, and 12.8% with thin basement membrane nephropathy; 6.4% had normal biopsies. Results: We followed up with 100 subjects for about 31 months. During this follow-up period, two subjects who had received a pathologic diagnosis of IgA nephropathy developed chronic kidney disease. During the course of the study, one of these subjects presented with proteinuria and hypertension and the other with proteinuria. The overall incidences of proteinuria and hypertension were 6% and 5% respectively. Conclusions: The prognosis for patients with IMH was relatively favorable, but patients developing proteinuria and/or hypertension require careful observation and management during the follow-up period. (Korean J Intern Med 2009;24:356-361)
- Published
- 2009
21. The impact of the aortic pulse wave velocity on the cardiovascular outcomes of hemodialysis patients
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Sungjin Chung, Sang-Hyun Ihm, Hyun Wha Chung, Young Ok Kim, Yong-Soo Kim, Yong Kyun Kim, Cheol Whee Park, Eui-Jin Choi, Seok Joon Shin, and Ho Cheol Song
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Adult ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,Cardiovascular Outcomes ,Left ventricular hypertrophy ,Heart Rate ,Renal Dialysis ,Internal medicine ,Diabetes mellitus ,medicine.artery ,Albumins ,Aortic Stiffness ,Heart rate ,medicine ,Aortic Pulse Wave Velocity ,Humans ,Pulse ,Pulse wave velocity ,Aorta ,Aged ,biology ,business.industry ,C-reactive protein ,General Medicine ,Middle Aged ,medicine.disease ,Pulse pressure ,C-Reactive Protein ,Echocardiography ,biology.protein ,Cardiology ,Kidney Failure, Chronic ,Female ,Original Article ,Hemodialysis ,Hydroxymethylglutaryl-CoA Reductase Inhibitors ,business - Abstract
The aims of our study were to identify the risk factors for an increased aortic pulse wave velocity (AoPWV) and to assess the impact of the AoPWV on the cerebro-cardiovascular (CV) outcomes of hemodialysis (HD) patients. Seventy two HD patients were included, and the AoPWV, the echocardiography and the biochemical parameters were measured. After dividing the patients into tertiles according to the AoPWV values, we defined the low, the middle and the high AoPWV groups. The patients in the high AoPWV group showed a significantly higher age and high-sensitivity C-reactive protein level, a greater prevalence of diabetes and statin use, left ventricular hypertrophy, average pulse pressure (PP), AoPWV and left ventricular mass index and a lower serum albumin level than those in the low AoPWV group (p
- Published
- 2008
22. Status of initiating pattern of hemodialysis: a multi-center study
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Sungjin Chung, Young Soo Kim, Hyung Wook Kim, Suk Young Kim, Chul Woo Yang, Young Ok Kim, Yoon Sik Chang, Sang Ju Lee, Ho Cheol Song, Yong-Soo Kim, Hye Eun Yoon, Hyun Wha Chung, Mi Jung Shin, Euy Jin Choi, and Dong Chan Jin
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,medicine.medical_treatment ,Treatment outcome ,Arteriovenous fistula ,Catheterization ,Renal Dialysis ,medicine ,Humans ,Intensive care medicine ,Referral and Consultation ,Aged ,Retrospective Studies ,High rate ,Aged, 80 and over ,business.industry ,Retrospective cohort study ,General Medicine ,Middle Aged ,medicine.disease ,University hospital ,Treatment Outcome ,Nephrology ,Multi center study ,Emergency medicine ,Arteriovenous Fistula ,Multivariate Analysis ,Kidney Failure, Chronic ,Female ,Original Article ,Hemodialysis ,business ,Glomerular Filtration Rate - Abstract
This study was to evaluate the status of initiating pattern of hemodialysis (HD). Five hundred-three patients in 8 University Hospitals were included. Presentation mode (planned vs. unplanned), and access type (central venous catheters [CVC] vs. permanent access) at initiation of HD were evaluated, and the influence of predialysis care on determining the mode of HD and access type was also assessed. Most patients started unplanned HD (81.9%) and the most common initial access type was CVC (86.3%). The main reason for unplanned HD and high rate of CVC use was patient-related factors such as refusal of permanent access creation and failure to attend scheduled clinic appointments. Predialysis care was performed in 57.9% of patients and only 24.1% of these patients started planned HD and 18.9% used permanent accesses initially. Only a minority of patients initiated planned HD with permanent accesses in spite of predialysis care. To overcome this, efforts to improve the quality of predialysis care are needed.
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- 2008
23. A synonymous genetic alteration of LMX1B in a family with nail-patella syndrome
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Hye Young Sung, Ho Cheol Song, Jin Soo Choi, Sung Min Park, Joong-Seok Kim, Seok Joon Shin, Joo Ho Ham, Kyu Re Joo, Yeong Jin Choi, and Eui Jin Choi
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Genetics ,Homeodomain Proteins ,Mutation ,Adolescent ,LIM-Homeodomain Proteins ,Chromosome ,Single-nucleotide polymorphism ,Case Report ,Biology ,medicine.disease ,medicine.disease_cause ,Genetic analysis ,Nephropathy ,Genetic alteration ,Exon ,Nail-Patella Syndrome ,medicine ,Humans ,Female ,Family history ,Gene ,LMX1B ,Nail patella syndrome ,Transcription Factors - Abstract
The gene responsible for nail-patella syndrome, LMX1B, has recently been identified on chromosome 9q. Here we present a patient with nail-patella syndrome and an autosomal dominant pattern of inheritance. A 17-year-old girl visited our clinic for the evaluation and treatment of proteinuria. She had dystrophic nails, palpable iliac horns, and hypoplastic patellae. Electron microscopy of a renal biopsy showed irregular thickening of the glomerular basement membrane. A family history over three generations revealed five affected family members. Genetic analysis found a change of TCG to TCC, resulting in a synonymous alteration at codon 219 in exon 4 of the LMX1B gene in two affected family members. The same alteration was not detected in an unaffected family member. This is the first report of familial nail-patella syndrome associated with an LMX1B in Korea mutation, However, we can not completely rule out the possibility that the G-to-C change may be a single nucleotide polymorphism as this genetic mutation cause no alteration in amino acid sequence of LMX1B.
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- 2007
24. Acquired Gitelman syndrome in a patient with primary Sjögren syndrome
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Chang-Seok Ki, Byung Kee Bang, Yong Kyun Kim, Yeong Jin Choi, Wan-Young Kim, Chul Woo Yang, Hye Eun Yoon, Yong-Soo Kim, Cheol-Whee Park, Ho Cheol Song, Eui Jin Choi, and Jin Kim
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Nephrology ,medicine.medical_specialty ,Pathology ,Systemic disease ,business.industry ,Anatomical pathology ,Gitelman syndrome ,Middle Aged ,medicine.disease ,Hypocalciuria ,Hypomagnesemia ,Sjogren's Syndrome ,Tubulopathy ,Internal medicine ,Medicine ,Humans ,Female ,medicine.symptom ,business ,Gitelman Syndrome ,Kidney disease ,Autoantibodies - Abstract
Acquired Gitelman syndrome (GS) associated with Sjogren syndrome (SS) is rare, and the test to determine the pathophysiological state of acquired GS in patients with primary SS has not been reported previously. A 47-year-old woman with sicca complex presented to our clinic with intermittent muscle cramping and weakness involving both lower extremities over several months. Laboratory findings showed hypokalemic metabolic alkalosis, hypomagnesemia, and hypocalciuria, which met the criteria for GS. Diagnostic evaluation identified primary SS as the cause of the acquired GS. Light microscopic examination of renal tissue from the patient showed mild tubulointerstitial nephritis. Immunohistochemical staining of renal tissue showed the absence of the sodium-chloride cotransporter (NCCT) in the distal convoluted tubules. Incubation of the patient's serum with normal mouse kidney tissue showed a pattern of NCCT in the distal convoluted tubules similar to that of incubation of normal mouse kidney with the rabbit polyclonal anti-NCCT antibody. This is a rare case of acquired GS associated with primary SS, and our findings suggest the presence of circulating autoantibodies to NCCT.
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- 2007
25. The impact of intima-media thickness of radial artery on early failure of radiocephalic arteriovenous fistula in hemodialysis patients
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Ji Il Kim, Young Soo Kim, Ho Cheol Song, Byung Kee Bang, Yeong Jin Choi, Chul Whee Park, Young Ok Kim, Yoon Sik Chang, Sun Ae Yoon, and Byung Soo Kim
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Adult ,Male ,medicine.medical_specialty ,Time Factors ,medicine.medical_treatment ,Arteriovenous fistula ,Arteriovenous Shunt, Surgical ,Renal Dialysis ,Risk Factors ,medicine.artery ,Diabetes mellitus ,medicine ,Humans ,cardiovascular diseases ,Treatment Failure ,Radial artery ,Risk factor ,Early failure ,Aged ,Uremia ,Hyperplasia ,business.industry ,General Medicine ,Middle Aged ,medicine.disease ,Atherosclerosis ,Surgery ,Intima-media thickness ,Radial Artery ,Arteriovenous Fistula ,Female ,Original Article ,Hemodialysis ,business - Abstract
This study was performed to investigate the impact of intima-media thickness (IMT) of radial artery on early failure of radiocephalic arteriovenous fistula (AVF) in hemodialysis (HD) patients. Ninety uremic patients undergoing radiocephalic AVF operation were included in this study. During the operation, 10-mm long partial arterial walls were removed with elliptical form for microscopic analysis. Specimens were stained with trichrome and examined by a pathologist blinded to the clinical data. And then AVF patency was followed up for 1 yr after the operation. Of the total 90 patients, 31 patients (34%) had AVF failure within 1 yr after the operation. Mean IMT was thicker in failed group (n=31) than in patent group (n=59) (486+/-130 micrometer vs. 398+/-130 micrometer, p=0.004). The AVF patency rate within 1 yr after the operation was lower in patients with IMT > or = 500 micrometer (n=26) than in patients with IMT
- Published
- 2006
26. Persistent elevation of C-reactive protein may predict cardiac hypertrophy and dysfunction in patients maintained on hemodialysis
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Suk Young Kim, Yoon Sik Chang, Byung Soo Kim, Ho Cheol Song, Seunghun Lee, Euy Jin Choi, Young Ok Kim, Doo Soo Jeon, Byung Kee Bang, and Mi Jung Shin
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Nephrology ,Adult ,Male ,medicine.medical_specialty ,Heart Diseases ,medicine.medical_treatment ,Inflammation ,Cardiomegaly ,Muscle hypertrophy ,Troponin T ,Predictive Value of Tests ,Renal Dialysis ,Internal medicine ,medicine ,Heart Septum ,Humans ,biology ,business.industry ,C-reactive protein ,Acute-phase protein ,Fibrinogen ,Stroke Volume ,Stroke volume ,Middle Aged ,Heart septum ,Endocrinology ,C-Reactive Protein ,Echocardiography ,biology.protein ,Cardiology ,Kidney Failure, Chronic ,Female ,Hypertrophy, Left Ventricular ,Hemodialysis ,medicine.symptom ,business - Abstract
Background: C-reactive protein (CRP), which reflects chronic inflammation, is a strong predictor of cardiovascular mortality in hemodialysis patients. We investigated whether persistent elevation of CRP is associatedwith cardiac function and morphology in patients maintained on hemodialysis. Methods: Predialysis high-sensitivity CRP (hs-CRP) was measured twice at an interval of 3 weeks in 52 stable hemodialysis patients, and echocardiographic studies were performed. Results: 25 patients showed persistent elevation of predialysis hs-CRP (>3 mg/l, high CRP group). Patients in the high CRP group had a lower dialysis dose (p < 0.01), higher troponin T (p < 0.01), and higher fibrinogen (p < 0.01). Echocardiographic studies showed that left atrial diameter (LA, p < 0.05), interventricular septal thickness (IVST, p < 0.05), left ventricular end-diastolic volume (LVEDV, p < 0.05), and left ventricular mass index (LVMI, p < 0.05) were higher in the high CRP group. However the ejection fraction (EF) was lower in the high CRP group (p < 0.05), which also contained more patients with low EF (Conclusions: Persistent elevation of CRP, which is an independent risk factor for EF, LVMI and IVST, may predict cardiac hypertrophy and dysfunction in patients maintained on hemodialysis.
- Published
- 2004
27. Preexisting intimal hyperplasia of radial artery is associated with early failure of radiocephalic arteriovenous fistula in hemodialysis patients
- Author
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Yeong Jin Choi, Wan Young Kim, Chul Woo Yang, Young Ok Kim, Byung Kee Bang, Ho Cheol Song, Sun Ae Yoon, Yoon Sik Chang, Eun-Jung Lee, and Nam Il Kim
- Subjects
Adult ,Male ,medicine.medical_specialty ,Intimal hyperplasia ,medicine.medical_treatment ,Fistula ,Arteriovenous fistula ,Arteriovenous Shunt, Surgical ,Renal Dialysis ,Risk Factors ,medicine.artery ,Diabetes mellitus ,medicine ,Humans ,Prospective Studies ,Radial artery ,Risk factor ,Aged ,Uremia ,Hyperplasia ,business.industry ,Middle Aged ,medicine.disease ,Surgery ,Nephrology ,Regional Blood Flow ,Arteriovenous Fistula ,Radial Artery ,Female ,Hemodialysis ,business ,Tunica Intima ,Kidney disease ,Follow-Up Studies - Abstract
The radiocephalic arteriovenous fistula (AVF), which provides the best vascular access for hemodialysis, continues to have a high incidence of early failure. Intimal hyperplasia (IH) of the radial artery is observed commonly in uremic patients before hemodialysis, but the impact of this preexisting IH on the early failure of radiocephalic AVFs has not been reported yet. Therefore, we designed this study to: (1) investigate clinical risk factors for IH, and (2) determine whether preexisting IH of the radial artery is associated with early failure of a radiocephalic AVF.Specimens from the radial artery were obtained during the radiocephalic AVF operation. IH was measured with trichrome staining, and AVF patency was prospectively followed up for 12 months after the operation.Of the 59 patients, 45 patients had evidence of IH in their radial artery (76.2%). Patients with IH (n = 45) were older than those without IH (n = 14; 58 +/- 12 versus 44 +/- 17 years; P = 0.003). The incidence of diabetes mellitus in patients with IH was greater than that in patients without IH (60.0% versus 28.6%; P = 0.004). Of the 57 patients, except for 2 patients who died before the end point of the study with patent AVFs, fistula failure was observed only in patients with IH (22 of 44 patients; 50% versus 0%; P0.001). The intima was thicker in the failed-AVF group than the patent-AVF group (93.1 +/- 37.5 versus 45.6 +/- 17.4 micrometer P0.001).This study suggests that early failure of radiocephalic AVFs in hemodialysis patients is closely associated with preexisting IH of the radial artery.
- Published
- 2003
28. Efficacy of Hemocontrol Biofeedback System in Intradialytic Hypotension-Prone Hemodialysis Patients
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So Young Lee, Kitae Bang, Ho Cheol Song, Young Joo Kwon, Young Ok Kim, Jin Kuk Kim, Byoung Geun Han, Hyo-Wook Gil, and Yong-Soo Kim
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,medicine.medical_treatment ,Blood Pressure ,Blood volume ,Young Adult ,Renal Dialysis ,Prone Position ,medicine ,Humans ,Prospective Studies ,Prospective cohort study ,Fatigue ,Dialysis ,Aged ,Blood Volume ,Cross-Over Studies ,business.industry ,Body Weight ,Biofeedback, Psychology ,General Medicine ,Middle Aged ,Clinical Trial ,Crossover study ,Surgery ,Dialysis Volume ,Prone position ,Blood pressure ,Tolerability ,Nephrology ,Anesthesia ,Kidney Failure, Chronic ,Original Article ,Female ,Hemodialysis ,Hypotension ,business - Abstract
We conducted a study to determine whether the hemocontrol biofeedback system (HBS) can improve intradialytic hypotension (IDH) in hypotension-prone hemodialysis (HD) patients compared with conventional HD. In this multicenter prospective crossover study, 60 hypotension-prone patients were serially treated by conventional HD for 8 weeks (period A), by HD with hemoscan blood volume monitoring for 2 weeks (period B0), and by HBS HD for 8 weeks (period B1). The number of sessions complicated by symptomatic IDH during 24 HD sessions (14.9±5.8 sessions, 62.1% in period A vs 9.2±7.2 sessions, 38.4% in period B1, P
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- 2014
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29. Vascular access - 1
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Utz Settmacher, Wu-Chang Yang, Michael Heise, A.R. Zarate, Luc Turmel-Rodrigues, Young Soo Kim, Daniele Ciurlino, Antonius Rabsch, R. Martínez-Cercós, Hidetoshi Kanai, Ramazan Kaya, O. Ibrik, Machiko Okamoto, Silvia Furiani, B. Rossi, Anna Bednarek-Skublewska, Cornelia Zierold, Samir S. Patel, Deven Juneja, Vincenzo La Milia, Suk Young Kim, Roland Kaufmann, Pierre Bourquelot, Serge Cournoyer, Tanja Roche, Sehmus Ozmen, Georgina Bailey, Hossam El-Shazly, George Stavgianoudakis, Nicole Daniel, Michele Roy, Margarita Villa, Alexander Koch, Petra Kirschner, George Soltys, Paraskevi Tseke, Lara Traversi, Mi Jung Shin, Zuhat Urzakci, Mayoor V. Prabhu, Lisa Savoie, Heather Duncan, M. Feriani, Violaine Begin, Michiya Shinozaki, Nestor Thereska, Nektaria Giapraka, Giorgia Bagiatudi, Elena Bruschetta, Francesco Locatelli, Sabina Libardi, Cheuk-Chun Szeto, Wojciech Załuska, Mohan Sathyanarayanan, Lambros Papatzikos, John Paul Killen, Sun Ae Yoon, Andrzej Ksiazek, R. Roca-Tey, Erjola Likaj, Yong Soo Kim, Mahmoud El-Khatib, F. Antonucci, Ahmet Duraku, Tokuya Nakahara, A. Rivas, Stephan Lotze, Christos Andriopoulos, Claudia Foltys, Visweswar Reddy Pachipala, Sridhar Gandhe, Ireen Töpfer, K.S. Nayak, Giuseppe Pontoriero, M. Nordio, Kai Ming Chow, J. Viladoms, Elisavet Stamataki, Ivano Baragetti, Tiziana Mazzullo, Chih-Ching Lin, Sreepada Subhramanyam, Myftar Barbullushi, N. Tessitore, Davut Akin, Giovanni Regine, Giuseppe Bacchini, Murty Mantha, Myeong A. Cheong, Philip Kam-Tao Li, Saimir Seferi, Silvio Bertoli, J.C. Romero, Sandra Dennler, Claudio Musetti, Young Ok Kim, I. Giménez, Julien Gaudric, Kenichi Oguchi, Marek Iłżecki, Prabir Roy-Chaudhury, E. Camerin, Mikiko Ayada, Charlotte Giroux, Konstantinos Salpiggidis, Stanisław Przywara, Palepu B Gopal, Sindy König, Yuet Ling Poon, Kenji Harada, Richard Baer, Manabu Asano, Ahsan Ullah, Evangelos Sarris, Ho Cheol Song, R. Samon, Enzo Corghi, Timmy Lee, G. Piccoli, Jan Tawakol, Claudio Pozzi, Elena Alberghini, Antono Carnabuci, Danai Stavrianaki, M. Raghavendran, Laura Buzzi, Elpida Kalyveza, Merita Rroji, Cristina Sarcina, Guyette Vallee, and Veronica Terraneo
- Subjects
Transplantation ,medicine.medical_specialty ,Nephrology ,business.industry ,medicine ,Vascular access ,Intensive care medicine ,business - Published
- 2009
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30. Cardiovascular complications - 1
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Yasuharu Tohara, Noriaki Kurita, Xiaohong Fan, Mislav Radic, Ionut Nistor, Teresa Adragão, Eiji Yamauchi, Seung-Jung Kim, Mototsugu Tanaka, Koji Okino, Masaaki Inaba, Palaniappan Saravanan, Guangli Ge, Rodoljub Markovic, Fani Dogramatzi, Minoru Furuta, Hye Eun Yoon, Mohit Lathar, Veselinka Djurkovic, Ibrahim Ozdogru, W.V. Kuijk, Rajan K. Patel, Eberhard Ritz, Shahrzad Ossareh, Tadao Akizawa, Toshiko Tokoro, Byung Soo Kim, Friedo W. Dekker, Shinsuke Yamada, Georgios Eftratiadis, Abdel-Bassit El-Shaarawy, Jeong-Min Lee, Erzsebet Fodor, Xiaoyun Wang, Takahiro Kuragano, Kiyoshi Matsuoka, Naobumi Mise, Bruce L. Riser, Yang Sun, Masato Nishimura, Patricia Branco, Marina Toutouza, Elena Banfi, Diana Yonova, Tamás Szabó, Aikaterini Papagianni, Noriyuki Kato, Ping Jiang, Birsel Unal, Jianming Hu, Xiaoyong Yu, Tokuichiro Sugimoto, Apostolos Tsiandoulas, Alan G. Jardine, Daisuke Sanada, Hideyuki Yasuno, Aritoshi Kida, Jyotsana Sen, Ana Pires, Steva Pljesa, Yuri Tanaka, Kyu Bok Choi, Mari Nakamura, Nobuhiko Joki, Meng Zhang, Georgios Niavis, Sehnaz A. Ertekin, M. Aquarius, Masaya Nishida, Mustafa Duran, András Tislér, P.M. Ghezzi, Ljiljana Komadina, Aytül Noyan, Ho Cheol Song, Zsófia K. Németh, Chie Shiraki, Maria Luisa Biondi, Anna-Maria Belechri, Paul Gusbeth-Tatomir, Goce Spasovski, Aikaterini Petrohilou, Maria Protopappa, Hiroaki Ogata, Austin G. Stack, Veselka Stojnova, Kutay Taşdemir, Joaquim Bordalo, Shunli Tian, Limeng Chen, Maurizio Gallieni, Takao Uchida, Loubna Benamar, Hiroyuki Kobayashi, Milenka Sain, Rui Castro, Gavin Freeman, Antoinette Nealon, Luminita Voroneanu, Masayoshi Nanami, Hiroyasu Ishikawa, Mikos Szathmari, Xuemei Li, Jun Qian, Hiroki Niikura, Shinji Tanaka, Hiroki Hase, Alexander G. Logan, Young Ok Kim, Hong Xu, Christoph Wanner, Dimitrios Memmos, Bin Sun, Dimitrios Petras, Vili Amitov, Kiyoshi Maekawa, Aristeidis Stavroulopoulos, György Deák, Takeshi Nakanishi, Tetsuya Hashimoto, Yukiko Hasuike, Aicha Radoui, Aysun Karabay Bayazit, Hiroshi Nonoguchi, Mihai Onofriescu, Karl Winkler, Simeon Antonov, Eiji Ishimura, Aleksandar Sikole, Takahiro Nishi, Satoru Yamazaki, Alan Jardine, Yasuo Imanishi, A. Luik, Phani Markou, Oktay Oymak, Naima Ouzeddoun, Jozsef Egresits, Gulinuer Muteliefu, Li-Tao Cheng, Ming Zeng, Yoshinaga Otaki, Yoshihiko Imamura, Ashraf El-Saeed, Simona Hogas, Claudiu Cusai, Ivo Jelicic, Yasushi Shimonaka, Mehman Aghayev, Vera Krane, Jia Liu, Mike Venning, Gulsah Seydaoglu, Takeshi Miyairi, Sumio Miura, Cengiz Utas, Mario Cozzolino, Saskia le Cessie, Liangying Gan, Aygul Karabayeva, Maria Nedevska, Xuewang Li, Kyun Il Yoon, Catherine Wall, Dong Ryeol Ryu, Intissar Haddiya, Ali Anarat, Kaori Sato, Toshimitsu Niwa, Soeren D. Ladefoged, Kenji Arizono, Ana Oliveira, Ioannis T. Papadakis, Aysa Nimgirova, Ningning Wang, Georgios Efstratiadis, Dimitrios Kirmizis, Atsushi Enomoto, Diego Brancaccio, Kyriaki Stamatellou, Nicola Johnston, A. Serra, Jianling Tao, L. Corazza, Ljiljana Lambic, Saso Gelev, Ryo Imai, Hirotaka Suzuki, Yoshiki Nishizawa, Ivan Kayukov, Rabia Bayahia, Joakim Cordtz, Nozomu Hosaka, Michael Timofeyev, Slavco Tosev, Changying Xing, Henry J. Dargie, Dragan Ljutic, Taha El Hadj Othmane, Pascal Meier, István Kiss, Murat Hayri Sipahioglu, Daryoush Saedi, Yoshio Matsushita, Hyeon Hwa Jeong, Katsukiyo Ito, Hoang Nguyen, Keiko Sai, Athanasia Tsiriga, Noriyuki Iwamoto, Najoua Zbiti, Adrian Covic, Vedran Kovacic, Hari Krishan Aggarwal, Xiangbao Yu, Anoosha Alaee, Serban Ardeleanu, Neil Davidson, Senji Okuno, Yasunori Takahashi, Rie Kitamura, Sijun Li, Duk Hee Kang, Maria Pangalou, Ehsan Hajiaboli, Jinghua Yang, Zijuan Zhou, Ashot Essaian, Yong Zeng, Christiane Drechsler, Ikutaro Kigawa, Masahide Mizobuchi, Aydin Unal, Euy Jin Choi, Ioannis Kakavas, Patrick B. Mark, Mi Jung Shin, Konstantinos Barboutis, Tao Wang, P.G. Bolasco, Toshihiko Ono, B. Fekete, J. Swaanenburg, Mei Wang, Josipa Radic, Bulent Tokgoz, Aphroditi Valtopoulou, Eriko Kinugasa, Zohra Tumur, Raluca Caliniuc, Winfried März, Yong Kyun Kim, Hakima Rhou, Evangelia Koutoupa, Efstathios Alexopoulos, Carmen Volovat, Alexandr Yenkun, Janos Nemcsik, and Xiufen Zhao
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Transplantation ,medicine.medical_specialty ,Nephrology ,business.industry ,medicine ,Intensive care medicine ,business - Published
- 2009
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31. THE STUDY ON DENITRIFICATION WITH NAOH AS ADDITIVE AND TEMPERATURE IN THE NOxOUT SNCR PROCESS.
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SEUNGMOON LEE, KWINAM PARK, HO-CHEOL SONG, HO-CHUL SHIN, EUIHYUN CHUNG, and JINWON PARK
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DENITRIFICATION ,NITRIC oxide ,NITROGEN compounds ,CATALYTIC reduction ,CHEMICAL reduction - Published
- 2004
32. The relationship between the regional abdominal adipose tissue distribution and the serum uric acid levels in people with type 2 diabetes mellitus.
- Author
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Tae Ho Kim, Seong Su Lee, Ji Han Yoo, Sung Rae Kim, Soon Jib Yoo, Ho Cheol Song, Yong-Soo Kim, Euy Jin Choi, and Yong Kyun Kim
- Subjects
ADIPOSE tissues ,SERUM ,PEOPLE with diabetes ,OBESITY ,TOMOGRAPHY - Abstract
Background: Hyperuricemia is associated with obesity. The visceral adiposity and subcutaneous adiposity may be associated with the differential metabolic risk, and the distribution of abdominal adipose tissue was significantly altered in people with type 2 diabetes mellitus (DM) compared to healthy people. Our study was performed to determine to the association between the regional abdominal adipose tissue distribution and serum uric acid levels in people with type 2 DM. Methods: A total of 699 people with type 2 DM and who had undergone abdominal computed tomography assessment of the visceral fat area and subcutaneous fat area were included. The serum uric acid levels were measured by the uricase method. Hyperuricemia was defined by cut-off value of > 7 mg/dl for men and > 6 mg/ dl for women. Results: The visceral fat area was positively associated with the serum uric acid levels after adjustment for age, sex, systolic blood pressure, diastolic blood pressure, serum creatinine, hemoglobin, serum albumin, serum high-density lipoprotein, serum triglyceride and hemoglobin A1c (β-coefficient = 0.117, p < 0.001). The logistic regression analysis showed that the visceral fat area was the significant independent predictor of hyperuricemia (OR 2.33, 95% CI, 1.21-4.50, p = 0.012). But there was no significant association between the subcutaneous fat area and the serum uric acid levels (β-coefficient = 0.061, p = 0.255). Conclusions: our data shows that the visceral fat area was positively associated with the serum uric acid levels, but the subcutaneous fat area was not in people with type 2 DM. [ABSTRACT FROM AUTHOR]
- Published
- 2012
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33. Persistent Elevation of C-Reactive Protein May Predict Cardiac Hypertrophy and Dysfunction in Patients Maintained on Hemodialysis.
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Byung-Soo Kim, Doo Soo Jeon, Mi Jung Shin, Young Ok Kim, Ho Cheol Song, Seung Hun Lee, Suk Young Kim, Euy Jin Choi, Yoon Sik Chang, and Byung Kee Bang
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C-reactive protein ,CARDIAC hypertrophy ,HEMODIALYSIS patients ,PROGNOSIS ,MORTALITY ,CARDIOLOGY - Abstract
Background: C-reactive protein (CRP), which reflects chronic inflammation, is a strong predictor of cardiovascular mortality in hemodialysis patients. We investigated whether persistent elevation of CRP is associatedwith cardiac function and morphology in patients maintained on hemodialysis. Methods: Predialysis high-sensitivity CRP (hs-CRP) was measured twice at an interval of 3 weeks in 52 stable hemodialysis patients, and echocardiographic studies were performed. Results: 25 patients showed persistent elevation of predialysis hs-CRP (>3 mg/l, high CRP group). Patients in the high CRP group had a lower dialysis dose (p < 0.01), higher troponin T (p < 0.01), and higher fibrinogen (p < 0.01). Echocardiographic studies showed that left atrial diameter (LA, p < 0.05), interventricular septal thickness (IVST, p < 0.05), left ventricular end-diastolic volume (LVEDV, p < 0.05), and left ventricular mass index (LVMI, p < 0.05) were higher in the high CRP group. However the ejection fraction (EF) was lower in the high CRP group (p < 0.05), which also contained more patients with low EF (<40%) (p < 0.01). There was no difference in diabetes mellitus, acute infection and type of vascular access between the groups. hs-CRP level was positively correlated with troponin T (r = 0.416, p < 0.01) and fibrinogen (r = 0.560, p < 0.001), and IVST with hs-CRP level (r = 0.291, p < 0.05), whereas the EF was negatively correlated with hs-CRP(r = –0.301, p < 0.05). In addition, the high CRP group correlated positively with IVST (r = 0.281, p < 0.05), LVEDV (r = 0.322, p < 0.05), and LVMI (r = 0.312, p < 0.05) and negatively with EF (r = –0.311, p < 0.05). On multivariate analysis, the high CRP group (β = –0.312, β = 0.238, and β = 0.318, respectively) was a significant predictor of EF (R = 0.62, p = 0.025), LVMI (R = 0.928, p = 0.02) and IVST (R = 0.64, p = 0.01). Conclusions: Persistent elevation of CRP, which is an independent risk factor for EF, LVMI and IVST, may predict cardiac hypertrophy and dysfunction in patients maintained on hemodialysis. Copyright © 2005 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
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- 2005
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34. The relationship between the regional abdominal adipose tissue distribution and the serum uric acid levels in people with type 2 diabetes mellitus
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Tae Ho Kim, Seong Su Lee, Soon Jib Yoo, Yong-Soo Kim, Ho Cheol Song, Sung Rae Kim, Euy Jin Choi, Yong Kyun Kim, and Ji Han Yoo
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medicine.medical_specialty ,obesity ,Endocrinology, Diabetes and Metabolism ,Serum albumin ,Adipose tissue ,chemistry.chemical_compound ,uric acid ,Diabetes mellitus ,Internal medicine ,medicine ,Internal Medicine ,Hyperuricemia ,lcsh:RC620-627 ,adiposity ,biology ,Triglyceride ,business.industry ,Research ,Type 2 Diabetes Mellitus ,computed tomography ,diabetes mellitus ,medicine.disease ,Obesity ,lcsh:Nutritional diseases. Deficiency diseases ,Endocrinology ,chemistry ,biology.protein ,Uric acid ,business - Abstract
Background Hyperuricemia is associated with obesity. The visceral adiposity and subcutaneous adiposity may be associated with the differential metabolic risk, and the distribution of abdominal adipose tissue was significantly altered in people with type 2 diabetes mellitus (DM) compared to healthy people. Our study was performed to determine to the association between the regional abdominal adipose tissue distribution and serum uric acid levels in people with type 2 DM. Methods A total of 699 people with type 2 DM and who had undergone abdominal computed tomography assessment of the visceral fat area and subcutaneous fat area were included. The serum uric acid levels were measured by the uricase method. Hyperuricemia was defined by cut-off value of > 7 mg/dl for men and > 6 mg/dl for women. Results The visceral fat area was positively associated with the serum uric acid levels after adjustment for age, sex, systolic blood pressure, diastolic blood pressure, serum creatinine, hemoglobin, serum albumin, serum high-density lipoprotein, serum triglyceride and hemoglobin A1c (β-coefficient = 0.117, p < 0.001). The logistic regression analysis showed that the visceral fat area was the significant independent predictor of hyperuricemia (OR 2.33, 95% CI, 1.21-4.50, p = 0.012). But there was no significant association between the subcutaneous fat area and the serum uric acid levels (β-coefficient = 0.061, p = 0.255). Conclusions our data shows that the visceral fat area was positively associated with the serum uric acid levels, but the subcutaneous fat area was not in people with type 2 DM.
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35. FIBRILLARY GLOMERULONEPHRITIS IN RHEUMATOID ARTHRITIS.
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Yu-Seon Yun, Ho Cheol Song, Kyungji Lee, Euy Jin Choi, Yong-Soo Kim, Jun-Ki Min, and Yong Kyun Kim
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KIDNEY disease treatments , *HEPATITIS B treatment , *HYPERTENSION , *DIAGNOSIS of edema , *ACE inhibitors , *ANGIOTENSINS , *CASE studies , *PHYSIOLOGY - Abstract
The article presents a case study of a 57-year-old woman who had proteinuria and microscopic haematuria, with a 3 year history of hypertension. She was found to have a pitting oedema in the lower extremities based on the result on physical examination results. She was then diagnosed with hepatitis b-related membranous nephropathy (MN). Moreover, the patient was treated entecavir at o.5 milligrams per day without angiotensin-converting enzyme inhibitor or angiotensin receptor blocker.
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- 2010
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