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13 results on '"Hoashi, Shu"'

1. Retrospective national cohort study of pregnancy outcomes for women with type 1 and type 2 diabetes mellitus in Republic of Ireland

Author

Newman, Christine, Egan, Aoife M., Ahern, Tomas, Al-Kiyumi, Maisa, Bacon, Siobhan, Bahaeldein, Elgelani, Balan, Gabriela, Brassill, Mary-Jane, Breslin, Emily, Brosnan, Elizabeth, Carmody, Louise, Clarke, Hilda, Coogan Kelly, Caroline, Culliney, Linda, Davern, Recie, Durkan, Maeve, Elhilo, Kalthoom, Cullen, Elizabeth, Fenlon, Mairead, Ferry, Pauline, Gabir, Ahmed, Guinan, Linda, Hanlon, Geraldine, Heffernan, Marie, Higgins, Tom, Hoashi, Shu, Kgosidialwa, Oratile, Khamis, Amjed, Kinsley, Brendan, Kirwan, Breda, James, Anne, Kyithar, Pyeh, Liew, Aaron, Malik, Ihtisham, Matthews, Linda, McGurk, Colm, McHugh, Cathy, Moloney, Yvonne, Murphy, Matt S, Murphy, Paula, Nagodra, Dina, Noctor, Eoin, Nolan, Marie, O'Connor, Aislong, O'Connor, Emily, O'Halloran, Domhnall, O'Mahoney, Linda, O'Shea, Triona, O'Sullivan, Eoin P., Peters, Moby, Roberts, Graham, Rooney, Hannorah, Sharma, Jayant, Smyth, Aoife, Synnott, Maria, Tarachand, Bheesham, Tighe, Marie, Todd, Marie, Towers, Michael, Tuthill, Antoinette, Mahmood, Wan, Yousif, Obada, and Dunne, Fidelma P.

Published
2022
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3. Cytokine Profiling in Type 2 Diabetes

Author

Gupta, Saket, primary, Maratha, Ashwini, additional, Natarajan, Anandan, additional, Siednienko, Jacub, additional, Gajanayake, Thusitha, additional, Hoashi, Shu, additional, and Miggin, Sinead, additional

Published
2011
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11. Breath acetone concentration decreases with blood glucose concentration in type I diabetes mellitus patients during hypoglycaemic clamps

Author

Turner, Claire, Walton, Christopher, Hoashi, Shu, Evans, Mark, Turner, Claire, Walton, Christopher, Hoashi, Shu, and Evans, Mark

Abstract

Conventional wisdom is that breath acetone may be markedly elevated in type 1 diabetes, but that this only occurs during poor blood glucose control and/or intercurrent illness. In contrast, little is known about breath acetone at more representative everyday blood glucose levels in diabetes. We used selected ion flow tube mass spectrometry (SIFT-MS) to monitor the breath of 8 patients with type 1 diabetes mellitus during “insulin clamp” studies in which insulin and glucose were infused into patients to lower blood glucose levels in steps from normal values into the low glucose (hypoglycaemic) range. The concentration of acetone in breath and the blood sugar concentration of the patients were monitored at each blood glucose concentration. The blood glucose level at the start of the study was typically about 6mM/L, whereas the breath acetone concentration at this blood glucose level was unexpectedly variable, ranging from one part-per-million (ppm) to 21 ppm, in contrast to what was previously believed, i.e. that type 1 diabetes mellitus (T1DM) is characterised by high acetone levels. In all 8 patients, the breath acetone declined linearly with blood glucose concentration.

12. Breath acetone concentration decreases with blood glucose concentration in type I diabetes mellitus patients during hypoglycaemic clamps

Author

Turner, Claire, Walton, Christopher, Hoashi, Shu, Evans, Mark, Turner, Claire, Walton, Christopher, Hoashi, Shu, and Evans, Mark

Abstract

Conventional wisdom is that breath acetone may be markedly elevated in type 1 diabetes, but that this only occurs during poor blood glucose control and/or intercurrent illness. In contrast, little is known about breath acetone at more representative everyday blood glucose levels in diabetes. We used selected ion flow tube mass spectrometry (SIFT-MS) to monitor the breath of 8 patients with type 1 diabetes mellitus during “insulin clamp” studies in which insulin and glucose were infused into patients to lower blood glucose levels in steps from normal values into the low glucose (hypoglycaemic) range. The concentration of acetone in breath and the blood sugar concentration of the patients were monitored at each blood glucose concentration. The blood glucose level at the start of the study was typically about 6mM/L, whereas the breath acetone concentration at this blood glucose level was unexpectedly variable, ranging from one part-per-million (ppm) to 21 ppm, in contrast to what was previously believed, i.e. that type 1 diabetes mellitus (T1DM) is characterised by high acetone levels. In all 8 patients, the breath acetone declined linearly with blood glucose concentration.

13. Glucose Stimulated Activation of Hypothalamic Arcuate Neurones and Early Phase Insulin Release Are Reduced by Brain Glucokinase Inhibition: Evidence for Role of Brain Glucokinase in Controlling Insulin Secretion.

Author

Osundiji, Mayowa, Yueh, Chen-Yu, Shaw, Jill, Moore, Stephen, Hoashi, Shu, Heisler, Lora, and Evans, Mark L.

Subjects
GLUCOKINASE, INSULIN, SECRETION, BLOOD sugar, NEURONS, PHOSPHOTRANSFERASES
Abstract

The article discusses the role of brain glucokinase in controlling insulin secretion. Glucose-sensing in the arcuate (ARC) hypothalamic nucleus may rely on the low affinity hexokinase glucokinase (GK) to determine an increase in glucose and facilitate glucose-stimulated insulin secretion (GSIS). The results imply that ARC glucose-sensing neurons are activated by a systemic glucose challenge in a GK-mediated way leading to increased insulin release.

Published
2007

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