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Introduction The evidence linking tobacco product advertising to adolescent smoking initiation and resulting long-term addiction, premature death, and disability is well established. Each link in the causal chain has been [...], Recent amendments to federal law and a burgeoning body of research have intensified public health officials' interest in reducing youth initiation of tobacco use, including by regulating the time, place, or manner of tobacco product advertising at the point of sale. This article analyzes legal obstacles to various strategies for reducing youth initiation.