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1. DAHEAN: A Danish nationwide study ensuring quality assurance through real-world data for suspected hereditary anemia patients

Author

Glenthøj, Andreas, Rasmussen, Andreas Ørslev, Bendtsen, Selma Kofoed, Hasle, Henrik, Hoffmann, Marianne, Rieneck, Klaus, Dziegiel, Morten Hanefeld, Sjö, Lene Dissing, Frederiksen, Henrik, Hansen, Dennis Lund, Fassi, Daniel El, Rathe, Mathias, Jensen, Peter-Diedrich Matthias, Winther-Larsen, Anne, Nielsen, Christian, Olsen, Marianne, Toft, Nina, Lorenzen, Mads Okkels Birk, Jensen, Lise Heilmann, Gudbrandsdottir, Sif, Helby, Jens, Rossing, Maria, van Wijk, Richard, and Petersen, Jesper

Published
2024
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2. A Rare Case of <italic>De Novo</italic> Beta-Thalassemia Diagnosed by Whole-Genome Sequencing in an Ethnically Danish Newborn.

Author

Ravichandran, Stefni, Hoffmann, Marianne, Petersen, Jesper, Sjø, Lene, Rasmussen, Andreas Ørslev, Eidesgaard, Annetta, and Glenthøj, Andreas

Subjects
*WHOLE genome sequencing, *BETA-Thalassemia, *BONE marrow transplantation, *NEWBORN infants, *PARENTS
Abstract

AbstractIn 2020, a 2-month-old ethnically Danish girl was diagnosed with β-thalassemia after presenting with persistent jaundice. The peripheral blood smear showed significant aniso- and poikilocytosis, increased number of reticulocytes and erythroblastosis. Trio analysis of the index patient and both parents was performed by whole-genome sequencing. Here, both parents were found normal, however the analysis revealed an apparently de novo HBB:c.444A > C variant in the child. The child has recently been discharged three months after a successful bone marrow transplantation with a matched sibling-donor. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Dabigatran etexilate for the treatment of acute venous thromboembolism in children (DIVERSITY): a randomised, controlled, open-label, phase 2b/3, non-inferiority trial

Author

Nurmeev, Ildar, Safina, Asiya, Zapletal, Ondrej, Brandão, Leonardo R, Kuhn, Tomas, Votava, Tomas, Felgenhauer, Judy, Sharathkumar, Anjali, Svirin, Pavel, Amid, Ali, Halton, Jacqueline, Gorbatikov, Kirill, Saracco, Paola, Kiss, Csongor, Halimeh, Susan, Reschke, Madlen, Wulff, Beate, David, Michele, Novak, Zbynek, Trunina, Inna, Albisetti, Manuela, Frisk, Tony, Glosli, Heidi, Groll, Andreas, Lvova, Olga, Sasmaz, Ilgen, Sosothikul, Darintr, Zilinskaite, Virginija, Cockrell, Erin, Digtyar, Valeriy, Hadacova, Ivana, Palmu, Sauli, Pawar, Anjali, Annichino Bizzacchi, Joyce Maria, Caliskan, Umran, Celkan, Tiraje, Dmytriiev, Dmytro, Druzgal, Colleen Harkins, Onelda Elena, Graciela, Kattamis, Antonis, Kavakli, Ramazan Kaan, Male, Christoph, Ozdemir, Nihal, Van Damme, An, Zvereva, Tatiana, Aarli, Aanen, Paredes Aguilera, Rogelio Alejandro, Aytac, Selin, Carneiro, Jorge, Chistolini, Antonio, Mazzucconi, Maria Gabriela, Corrales-Medina, Fernando, Couturaud, Francis, Croteau, Stacey E, Trenor III, Cameron, Damgaard, Michael, Dixon, Natalia, Galustyan, Anna, Hak, Jiri, Hoffmann, Marianne, Kupesiz, Alphan, Labarque, Veerle, van Geet, Christel, Lin, Ming-Chih, Fu, Yun-Ching, Loggetto, Sandra, Mondelaers, Veerle, Odri-Komazec, Irena, Revel-Vilk, Shoshana, Sevilla, Julian, Fuzzato Silva, Luciano, Kerr Saraiva, José, Montes Tapia, Fernando Felix, Woods-Swafford, Wendy, Luciani, Matteo, Bomgaars, Lisa, Chalmers, Elizabeth, Mitchell, Lesley G, Tartakovsky, Igor, Simetzberger, Monika, Huang, Fenglei, Sun, Zhichao, Kreuzer, Jörg, Gropper, Savion, Reilly, Paul, and Brueckmann, Martina

Published
2021
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6. Addition of plasma exchange to red cell exchange improves outcomes of fat embolism syndrome in sickle cell disease

Author

Tsitsikas, Dimitris A., primary, Rowe, Susan, additional, Bosch, Alessandra, additional, Hui, Caitlyn, additional, Sadasivam, Nandini, additional, Palaskas, Nicolaos J., additional, Pancham, Shivan, additional, Rizvi, Syed, additional, Taylor, Joseph, additional, Greaves, Paul, additional, Glenthøj, Andreas, additional, Hoffmann, Marianne, additional, Drasar, Emma, additional, and Eleftheriou, Perla, additional

Published
2023
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7. A survey on thromboprophylaxis and coagulation assessment in children and young adults with acute lymphoblastic leukaemia ( ALL ) in the Nordic and Baltic countries: Different practices of assessment and management

Author

Andersson, Nadine G., primary, Rathe, Mathias, additional, Mølle, Ingolf, additional, Jarvis, Kirsten Brunswig, additional, Hoffmann, Marianne, additional, Huurre, Anu, additional, Joelsson, Joel, additional, Albertsen, Birgitte Klug, additional, Lohi, Olli, additional, Långström, Satu, additional, Overgaard, Ulrik, additional, Saulyte Trakymiene, Sonata, additional, Vepsäläinen, Kaisa, additional, Vogt, Hartmut, additional, and Ranta, Susanna, additional

Published
2022
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8. Intracranial haemorrhage in children and adolescents with severe haemophilia A or B – the impact of prophylactic treatment

Author

Andersson, Nadine G., Auerswald, Günter, Barnes, Chris, Carcao, Manuel, Dunn, Amy L., Fijnvandraat, Karin, Hoffmann, Marianne, Kavakli, Kaan, Kenet, Gili, Kobelt, Rainer, Kurnik, Karin, Liesner, Ri, Mäkipernaa, Anne, Manco‐Johnson, Marilyn J., Mancuso, Maria E., Molinari, Angelo C., Nolan, Beatrice, Perez Garrido, Rosario, Petrini, Pia, Platokouki, Helen E., Shapiro, Amy D., Wu, Runhui, and Ljung, Rolf

Published
2017
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12. Dabigatran etexilate for the treatment of acute venous thromboembolism in children (DIVERSITY): a randomised, controlled, open-label, phase 2b/3, non-inferiority trial

Author

Halton, Jacqueline, primary, Brandão, Leonardo R, additional, Luciani, Matteo, additional, Bomgaars, Lisa, additional, Chalmers, Elizabeth, additional, Mitchell, Lesley G, additional, Nurmeev, Ildar, additional, Sharathkumar, Anjali, additional, Svirin, Pavel, additional, Gorbatikov, Kirill, additional, Tartakovsky, Igor, additional, Simetzberger, Monika, additional, Huang, Fenglei, additional, Sun, Zhichao, additional, Kreuzer, Jörg, additional, Gropper, Savion, additional, Reilly, Paul, additional, Brueckmann, Martina, additional, Albisetti, Manuela, additional, Safina, Asiya, additional, Zapletal, Ondrej, additional, Kuhn, Tomas, additional, Votava, Tomas, additional, Felgenhauer, Judy, additional, Amid, Ali, additional, Halton, Jacqueline, additional, Saracco, Paola, additional, Kiss, Csongor, additional, Halimeh, Susan, additional, Reschke, Madlen, additional, Wulff, Beate, additional, David, Michele, additional, Novak, Zbynek, additional, Trunina, Inna, additional, Frisk, Tony, additional, Glosli, Heidi, additional, Groll, Andreas, additional, Lvova, Olga, additional, Sasmaz, Ilgen, additional, Sosothikul, Darintr, additional, Zilinskaite, Virginija, additional, Cockrell, Erin, additional, Digtyar, Valeriy, additional, Hadacova, Ivana, additional, Palmu, Sauli, additional, Pawar, Anjali, additional, Annichino Bizzacchi, Joyce Maria, additional, Caliskan, Umran, additional, Celkan, Tiraje, additional, Dmytriiev, Dmytro, additional, Druzgal, Colleen Harkins, additional, Onelda Elena, Graciela, additional, Kattamis, Antonis, additional, Kavakli, Ramazan Kaan, additional, Male, Christoph, additional, Ozdemir, Nihal, additional, Van Damme, An, additional, Zvereva, Tatiana, additional, Aarli, Aanen, additional, Paredes Aguilera, Rogelio Alejandro, additional, Aytac, Selin, additional, Carneiro, Jorge, additional, Chistolini, Antonio, additional, Mazzucconi, Maria Gabriela, additional, Corrales-Medina, Fernando, additional, Couturaud, Francis, additional, Croteau, Stacey E, additional, Trenor III, Cameron, additional, Damgaard, Michael, additional, Dixon, Natalia, additional, Galustyan, Anna, additional, Hak, Jiri, additional, Hoffmann, Marianne, additional, Kupesiz, Alphan, additional, Labarque, Veerle, additional, van Geet, Christel, additional, Lin, Ming-Chih, additional, Fu, Yun-Ching, additional, Loggetto, Sandra, additional, Mondelaers, Veerle, additional, Odri-Komazec, Irena, additional, Revel-Vilk, Shoshana, additional, Sevilla, Julian, additional, Fuzzato Silva, Luciano, additional, Kerr Saraiva, José, additional, Montes Tapia, Fernando Felix, additional, and Woods-Swafford, Wendy, additional

Published
2021
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13. Additional file 1 of Interprofessional versus monoprofessional case-based learning in childhood cancer and the effect on healthcare professionals’ knowledge and attitudes: study protocol for a randomised trial

Author

Topperzer, Martha Krogh, Hoffmann, Marianne, Larsen, Hanne Bækgaard, Rosthøj, Susanne, Nersting, Jacob, Roug, Louise Ingerslev, Pontoppidan, Peter, Andrés-Jensen, Liv, Lausen, Birgitte, Schmiegelow, Kjeld, and Sørensen, Jette Led

Subjects
Data_FILES
Abstract

Additional file 1.

Published
2020
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14. Twelve tips for postgraduate interprofessional case-based learning.

Author

Topperzer, Martha Krogh, Roug, Louise Ingerslev, Andrés-Jensen, Liv, Pontoppidan, Peter, Hoffmann, Marianne, Larsen, Hanne Baekgaard, Schmiegelow, Kjeld, and Sørensen, Jette Led

Subjects
PROBLEM-based learning, LEARNING strategies, GRADUATE education, DECISION making, INTERPROFESSIONAL relations, INTERDISCIPLINARY education
Abstract

Based on developing, implementing, and evaluating postgraduate interprofessional case-based learning, we have written these twelve tips for health education planners who wish to apply case-based learning in the clinical setting. Interprofessional case-based learning engages participants in a structured manner towards uncovering decisions processes and patterns of action that resemble the clinical reality in which various healthcare professionals handle multifaceted tasks related to the optimal patient treatment. Postgraduate interprofessional case-based learning has the potential to break down traditional hierarchical structures as interactions generate respectful behaviour. We present two models of case-based learning to assist in standardising, structuring, and systematising postgraduate interprofessional case-based learning. We have created 12 practical tips for the design, implementation, and evaluation of successful postgraduate interprofessional case-based learning integrated into the existing clinical setting. [ABSTRACT FROM AUTHOR]

Published
2022
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16. Flow cytometric analysis of cerebrospinal fluid improves detection of leukaemic blasts in infants with acute lymphoblastic leukaemia.

Author

Thastrup, Maria, Marquart, Hanne Vibeke, Levinsen, Mette, Modvig, Signe, Abrahamsson, Jonas, Albertsen, Birgitte Klug, Frost, Britt‐Marie, Harila‐Saari, Arja, Pesola, Jouni, Ulvmoen, Aina, Wojcik, Dorota Malgorzata, Taskinen, Mervi, Hoffmann, Marianne, Lausen, Birgitte, and Schmiegelow, Kjeld

Subjects
CEREBROSPINAL fluid examination, LYMPHOBLASTIC leukemia, ACUTE leukemia, CENTRAL nervous system, INFANTS
Abstract

Summary: Infants with acute lymphoblastic leukaemia (ALL) have a high frequency of central nervous system (CNS) involvement. Flow cytometric analysis of cerebrospinal fluid (CSF) was recently demonstrated to be a sensitive method for detecting CNS involvement in childhood ALL. In the present study, CSF from 14 infants was collected at routine lumbar punctures and analysed by multicolour flow cytometry. At initial diagnosis, leukaemic blasts were detected in CSF by flow cytometry in 11 patients (78·6%) compared to seven patients (50%) by cytospin. Larger studies are needed to determine if CSF flow cytometry has prognostic value in infant ALL. [ABSTRACT FROM AUTHOR]

Published
2021
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18. Clinical impact of leukemic blast heterogeneity at diagnosis in cytogenetic intermediate-risk acute myeloid leukemia

Author

Hoffmann, Marianne Hutchings, primary, Klausen, Tobias Wirenfeldt, additional, Boegsted, Martin, additional, Larsen, Steffen Falgreen, additional, Schmitz, Alexander, additional, Leinoe, Eva Birgitte, additional, Schmiegelow, Kjeld, additional, Hasle, Henrik, additional, Bergmann, Olav Jonas, additional, Sorensen, Suzette, additional, Nyegaard, Mette, additional, Dybkaer, Karen, additional, and Johnsen, Hans Erik, additional

Published
2012
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19. The Prognostic Impact of Blast Cell Immunophenotyping in Intermediate Risk AML Patients at Diagnosis.

Author

Hoffmann, Marianne H., primary, Leinoe, Eva B., primary, Klausen, Tobias W., primary, Danielsen, Ronnie C., primary, Kjaersgaard, Erik, primary, Schmiegelow, Kjeld, primary, Hasle, Henrik, primary, Hastrup, Nina, primary, Kristensen, Jorgen S., primary, Dufva, Inge H., primary, Hansen, Niels E., primary, Bergmann, Olav J., primary, and Johnsen, Hans E., primary

Published
2004
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20. Interaction of Actin and Myosin in the Absence and Presence of ATP

Author

Dancker, Peter and Hoffmann, Marianne

Abstract

The binding between F-actin and myosin has been studied by analyzing the amount of radio-actively labelled (by means of 14C-NEM) F-actin and myosin in the formed unsoluble actomyosin pellet after centrifugation of the reaction mixture. In the absence of ATP, the amount of actin bound to myosin varies, depending on the amounts of actin and myosin present, between 0.18 mg actin/mg myosin (2 actin units per 1 myosin molecule) and about 2 mg actin/mg myosin (each actin fibril only uncompletely saturated with myosin). In 0.03 ᴍ KCl ATP decreases, if at all, the affinity of actin towards myosin only slightly; but less actin is bound to myosin in the presence of MgATP and in low ionic strength, indicating that myosin is now more densily distributed over fewer actin fibrils leaving the rest of fibrils free. For precipitation of the total amount of myosin (myosin alone is soluble in MgATP) incomplete saturation of myosin with actin suffices; obviously actin promotes filament formation of myosin. The activation of myosin ATPase by actin depends in a similar manner as actin binding does on actin concentration, hence the enzymatic interaction between actin and myosin is accompanied by true actin-myosin binding. An actin-tropomyosin-troponin preparation, whose reduced viscosity is lower than that of F-actin and which consists of about 30% actin, activates myosin ATPase to the same extent as F-actin does. It competes with F-actin for the same binding sites on myosin and can in the presence of MgATP be displaced from myosin by those preparations of F-actin which have a strong tendency to become fully saturated with myosin. The activation of myosin ATPase by actin-tropomyosin-troponin is reduced after tryptic digestion of actin-tropomyosin-troponin, which affects, according to SDS gel electro­ phoresis, mainly two components of troponin with molecular weights of about 32 000 and 25 000, respectively.

Published
1973
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23. Mary Kelly 'A Father and Child'.

Author

Hoffmann, Marianne

Subjects
EXPERIMENTAL films, EXHIBITIONS
Abstract

The article reviews the exhibition "A Father and Child," featuring the works of psychologist Mary Kelly at the Galerie Voss in Düsseldorf, Germany from March 30 to May 5, 2012.

Published
2012

24. [Challenges and advances in paediatric arterial ischaemic stroke].

Author

Bindslev JB, Truelsen T, Gyhrs M, Kondziella D, Hoffmann M, Stensballe J, Hauerberg J, Stavngaard T, Lundstrøm K, Born AP, Larsen VA, Hansen K, and Hoei-Hansen CE

Subjects
Child, Delayed Diagnosis, Humans, Risk Factors, Brain Ischemia diagnosis, Brain Ischemia therapy, Ischemic Stroke, Stroke diagnosis, Stroke drug therapy, Stroke etiology
Abstract

Neurological sequelae occur in more than 50% of children with arterial ischemic stroke. Early recognition and treatment are essential in improving outcome. However, diagnostic delay in paediatric stroke often extends beyond 24 hours, and children rarely access hyperacute recanalisation therapies. This review describes clinical presentations, risk factors and treatment of paediatric ischaemic stroke. Additionally, we share our experience from a systematic paediatric stroke pathway implemented in Eastern Denmark since 2017.

Published
2021

25. Multiplex reverse transcription polymerase chain reaction screening in acute myeloid leukemia detects cytogenetically unrevealed abnormalities of prognostic significance.

Author

Hutchings Hoffmann M, Wirenfeldt Klausen T, Hasle H, Schmiegelow K, Brondum-Nielsen K, and Johnsen HE

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Alternative Splicing, Child, Child, Preschool, Chromosome Aberrations, Female, Humans, Infant, Infant, Newborn, Male, Middle Aged, Oncogene Proteins, Fusion genetics, Prognosis, Cytogenetics methods, Leukemia, Myeloid, Acute diagnosis, Leukemia, Myeloid, Acute genetics, Reverse Transcriptase Polymerase Chain Reaction methods, Translocation, Genetic
Abstract

A commercial multiplex reverse transcription polymerase chain reaction screening assay, covering 28 leukemic fusion transcripts, was applied in 143 samples obtained from patients with acute myeloid leukemia at primary diagnosis. In five patients, a cytogenetically unrevealed fusion gene of prognostic importance was detected, while the assay failed to detect one case of t(15;17).

Published
2005

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