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208 results on '"Hofland, Ingrid"'

1. Neoadjuvant nivolumab or nivolumab plus ipilimumab in early-stage triple-negative breast cancer: a phase 2 adaptive trial

Author

Nederlof, Iris, Isaeva, Olga I., de Graaf, Manon, Gielen, Robbert C. A. M., Bakker, Noor A. M., Rolfes, Adrianne L., Garner, Hannah, Boeckx, Bram, Traets, Joleen J. H., Mandjes, Ingrid A. M., de Maaker, Michiel, van Brussel, Thomas, Chelushkin, Maksim, Champanhet, Elisa, Lopez-Yurda, Marta, van de Vijver, Koen, van den Berg, José G., Hofland, Ingrid, Klioueva, Natasja, Mann, Ritse M., Loo, Claudette E., van Duijnhoven, Frederieke H., Skinner, Victoria, Luykx, Sylvia, Kerver, Emile, Kalashnikova, Ekaterina, van Dongen, Marloes G. J., Sonke, Gabe S., Linn, Sabine C., Blank, Christian U., de Visser, Karin E., Salgado, Roberto, Wessels, Lodewyk F. A., Drukker, Caroline A., Schumacher, Ton N., Horlings, Hugo M., Lambrechts, Diether, and Kok, Marleen

Published
2024
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3. A pan-cancer analysis of the microbiome in metastatic cancer

Author

Battaglia, Thomas W., Mimpen, Iris L., Traets, Joleen J.H., van Hoeck, Arne, Zeverijn, Laurien J., Geurts, Birgit S., de Wit, Gijs F., Noë, Michaël, Hofland, Ingrid, Vos, Joris L., Cornelissen, Sten, Alkemade, Maartje, Broeks, Annegien, Zuur, Charlotte L., Cuppen, Edwin, Wessels, Lodewyk, van de Haar, Joris, and Voest, Emile

Published
2024
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7. Comprehensive multiplexed immune profiling of the ductal carcinoma in situ immune microenvironment regarding subsequent ipsilateral invasive breast cancer risk

Author

Almekinders, Mathilde M., Bismeijer, Tycho, Kumar, Tapsi, Yang, Fei, Thijssen, Bram, van der Linden, Rianne, van Rooijen, Charlotte, Vonk, Shiva, Sun, Baohua, Parra Cuentas, Edwin R., Wistuba, Ignacio I., Krishnamurthy, Savitri, Visser, Lindy L., Seignette, Iris M., Hofland, Ingrid, Sanders, Joyce, Broeks, Annegien, Love, Jason K., Menegaz, Brian, Wessels, Lodewyk, Thompson, Alastair M., de Visser, Karin E., Hooijberg, Erik, Lips, Esther, Futreal, Andrew, and Wesseling, Jelle

Published
2022
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9. A proof-of-concept study of sequential treatment with the HDAC inhibitor vorinostat following BRAF and MEK inhibitors in BRAFV600mutated melanoma

Author

Embaby, Alaa, primary, Huijberts, Sanne C.F.A., additional, Wang, Liqin, additional, Leite de Oliveira, Rodrigo, additional, Rosing, Hilde, additional, Nuijen, Bastiaan, additional, Sanders, Joyce, additional, Hofland, Ingrid, additional, van Steenis, Charlaine, additional, Kluin, Roelof J.C., additional, Lieftink, Cor, additional, Smith, Christopher G., additional, Blank, Christian U., additional, van Thienen, Johannes V., additional, Haanen, John B.A.G., additional, Steeghs, Neeltje, additional, Opdam, Frans L., additional, Beijnen, Jos H., additional, Huitema, Alwin D.R., additional, Bernards, Rene, additional, Schellens, Jan H.M., additional, and Wilgenhof, Sofie, additional

Published
2024
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10. A pan-cancer analysis of the microbiome in metastatic cancer

Author

CMM, CMM Groep Van Mil, Battaglia, Thomas W., Mimpen, Iris L., Traets, Joleen J.H., van Hoeck, Arne, Zeverijn, Laurien J., Geurts, Birgit S., de Wit, Gijs F., Noë, Michaël, Hofland, Ingrid, Vos, Joris L., Cornelissen, Sten, Alkemade, Maartje, Broeks, Annegien, Zuur, Charlotte L., Cuppen, Edwin, Wessels, Lodewyk, van de Haar, Joris, Voest, Emile, CMM, CMM Groep Van Mil, Battaglia, Thomas W., Mimpen, Iris L., Traets, Joleen J.H., van Hoeck, Arne, Zeverijn, Laurien J., Geurts, Birgit S., de Wit, Gijs F., Noë, Michaël, Hofland, Ingrid, Vos, Joris L., Cornelissen, Sten, Alkemade, Maartje, Broeks, Annegien, Zuur, Charlotte L., Cuppen, Edwin, Wessels, Lodewyk, van de Haar, Joris, and Voest, Emile

Published
2024

11. Propranolol monotherapy in angiosarcoma - A window-of-opportunity study (PropAngio)

Author

Apotheek O&O&O, Cancer, Embaby, Alaa, Heinhuis, Kimberley M, IJzerman, Nikki S, Koenen, Anne Miek, van der Kleij, Stephanie, Hofland, Ingrid, van Boven, Hester, Sanders, Joyce, van der Graaf, Winette T A, Haas, Rick L, Huitema, Alwin D R, van Houdt, Winan J, Steeghs, Neeltje, Apotheek O&O&O, Cancer, Embaby, Alaa, Heinhuis, Kimberley M, IJzerman, Nikki S, Koenen, Anne Miek, van der Kleij, Stephanie, Hofland, Ingrid, van Boven, Hester, Sanders, Joyce, van der Graaf, Winette T A, Haas, Rick L, Huitema, Alwin D R, van Houdt, Winan J, and Steeghs, Neeltje

Published
2024

12. A proof-of-concept study of sequential treatment with the HDAC inhibitor vorinostat following BRAF and MEK inhibitors in BRAFV600mutated melanoma

Author

Apotheek O&O&O, Cancer, Embaby, Alaa, Huijberts, Sanne C F A, Wang, Liqin, Leite de Oliveira, Rodrigo, Rosing, Hilde, Nuijen, Bastiaan, Sanders, Joyce, Hofland, Ingrid, van Steenis, Charlaine, Kluin, Roelof J C, Lieftink, Cor, Smith, Christopher G, Blank, Christian U, van Thienen, Johannes V, Haanen, John B A G, Steeghs, Neeltje, Opdam, Frans L, Beijnen, Jos H, Huitema, Alwin D R, Bernards, Rene, Schellens, Jan H M, Wilgenhof, Sofie, Apotheek O&O&O, Cancer, Embaby, Alaa, Huijberts, Sanne C F A, Wang, Liqin, Leite de Oliveira, Rodrigo, Rosing, Hilde, Nuijen, Bastiaan, Sanders, Joyce, Hofland, Ingrid, van Steenis, Charlaine, Kluin, Roelof J C, Lieftink, Cor, Smith, Christopher G, Blank, Christian U, van Thienen, Johannes V, Haanen, John B A G, Steeghs, Neeltje, Opdam, Frans L, Beijnen, Jos H, Huitema, Alwin D R, Bernards, Rene, Schellens, Jan H M, and Wilgenhof, Sofie

Published
2024

13. Away from definition and back to the clinic – As response to Kumar et al, ‘Evidence is not sufficient to declare the tubal gland conglomerates as salivary’

Author

Pringle, Sarah, primary, Bikker, Floris J., additional, Vogel, Wouter, additional, de Bakker, Bernadette S., additional, Hofland, Ingrid, additional, van der Vegt, Bert, additional, Bootsma, Hendrika, additional, Kroese, Frans G.M., additional, Vissink, Arjan, additional, and Valstar, Matthijs, additional

Published
2024
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14. CMTM6 shapes antitumor T cell response through modulating protein expression of CD58 and PD-L1

Author

Miao, Beiping, primary, Hu, Zhaoqing, additional, Mezzadra, Riccardo, additional, Hoeijmakers, Lotte, additional, Fauster, Astrid, additional, Du, Shangce, additional, Yang, Zhi, additional, Sator-Schmitt, Melanie, additional, Engel, Helena, additional, Li, Xueshen, additional, Broderick, Caroline, additional, Jin, Guangzhi, additional, Gomez-Eerland, Raquel, additional, Rozeman, Lisette, additional, Lei, Xin, additional, Matsuo, Hitoshi, additional, Yang, Chen, additional, Hofland, Ingrid, additional, Peters, Dennis, additional, Broeks, Annegien, additional, Laport, Elke, additional, Fitz, Annika, additional, Zhao, Xiyue, additional, Mahmoud, Mohamed A.A., additional, Ma, Xiujian, additional, Sander, Sandrine, additional, Liu, Hai-kun, additional, Cui, Guoliang, additional, Gan, Yu, additional, Wu, Wei, additional, Xiao, Yanling, additional, Heck, Albert J.R., additional, Guan, Wenxian, additional, Lowe, Scott W., additional, Horlings, Hugo M., additional, Wang, Cun, additional, Brummelkamp, Thijn R., additional, Blank, Christian U., additional, Schumacher, Ton N.M., additional, and Sun, Chong, additional

Published
2023
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15. Androgen receptor signalling in macrophages promotes TREM-1-mediated prostate cancer cell line migration and invasion

Author

Cioni, Bianca, Zaalberg, Anniek, van Beijnum, Judy R., Melis, Monique H. M., van Burgsteden, Johan, Muraro, Mauro J., Hooijberg, Erik, Peters, Dennis, Hofland, Ingrid, Lubeck, Yoni, de Jong, Jeroen, Sanders, Joyce, Vivié, Judith, van der Poel, Henk G., de Boer, Jan Paul, Griffioen, Arjan W., Zwart, Wilbert, and Bergman, Andries M.

Published
2020
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17. CMTM6 shapes antitumor T cell response through modulating protein expression of CD58 and PD-L1

Author

Miao, Beiping, Hu, Zhaoqing, Mezzadra, Riccardo, Hoeijmakers, Lotte, Fauster, Astrid, Du, Shangce, Yang, Zhi, Sator-Schmitt, Melanie, Engel, Helena, Li, Xueshen, Broderick, Caroline, Jin, Guangzhi, Gomez-Eerland, Raquel, Rozeman, Lisette, Lei, Xin, Matsuo, Hitoshi, Yang, Chen, Hofland, Ingrid, Peters, Dennis, Broeks, Annegien, Laport, Elke, Fitz, Annika, Zhao, Xiyue, Mahmoud, Mohamed A A, Ma, Xiujian, Sander, Sandrine, Liu, Hai-Kun, Cui, Guoliang, Gan, Yu, Wu, Wei, Xiao, Yanling, Heck, Albert J R, Guan, Wenxian, Lowe, Scott W, Horlings, Hugo M, Wang, Cun, Brummelkamp, Thijn R, Blank, Christian U, Schumacher, Ton N M, Sun, Chong, Miao, Beiping, Hu, Zhaoqing, Mezzadra, Riccardo, Hoeijmakers, Lotte, Fauster, Astrid, Du, Shangce, Yang, Zhi, Sator-Schmitt, Melanie, Engel, Helena, Li, Xueshen, Broderick, Caroline, Jin, Guangzhi, Gomez-Eerland, Raquel, Rozeman, Lisette, Lei, Xin, Matsuo, Hitoshi, Yang, Chen, Hofland, Ingrid, Peters, Dennis, Broeks, Annegien, Laport, Elke, Fitz, Annika, Zhao, Xiyue, Mahmoud, Mohamed A A, Ma, Xiujian, Sander, Sandrine, Liu, Hai-Kun, Cui, Guoliang, Gan, Yu, Wu, Wei, Xiao, Yanling, Heck, Albert J R, Guan, Wenxian, Lowe, Scott W, Horlings, Hugo M, Wang, Cun, Brummelkamp, Thijn R, Blank, Christian U, Schumacher, Ton N M, and Sun, Chong

Abstract

The dysregulated expression of immune checkpoint molecules enables cancer cells to evade immune destruction. While blockade of inhibitory immune checkpoints like PD-L1 forms the basis of current cancer immunotherapies, a deficiency in costimulatory signals can render these therapies futile. CD58, a costimulatory ligand, plays a crucial role in antitumor immune responses, but the mechanisms controlling its expression remain unclear. Using two systematic approaches, we reveal that CMTM6 positively regulates CD58 expression. Notably, CMTM6 interacts with both CD58 and PD-L1, maintaining the expression of these two immune checkpoint ligands with opposing functions. Functionally, the presence of CMTM6 and CD58 on tumor cells significantly affects T cell-tumor interactions and response to PD-L1-PD-1 blockade. Collectively, these findings provide fundamental insights into CD58 regulation, uncover a shared regulator of stimulatory and inhibitory immune checkpoints, and highlight the importance of tumor-intrinsic CMTM6 and CD58 expression in antitumor immune responses.

Published
2023

18. CMTM6 shapes antitumor T cell response through modulating protein expression of CD58 and PD-L1

Author

Afd Biomol.Mass Spect. and Proteomics, Sub Biomol.Mass Spectrometry & Proteom., Biomolecular Mass Spectrometry and Proteomics, Miao, Beiping, Hu, Zhaoqing, Mezzadra, Riccardo, Hoeijmakers, Lotte, Fauster, Astrid, Du, Shangce, Yang, Zhi, Sator-Schmitt, Melanie, Engel, Helena, Li, Xueshen, Broderick, Caroline, Jin, Guangzhi, Gomez-Eerland, Raquel, Rozeman, Lisette, Lei, Xin, Matsuo, Hitoshi, Yang, Chen, Hofland, Ingrid, Peters, Dennis, Broeks, Annegien, Laport, Elke, Fitz, Annika, Zhao, Xiyue, Mahmoud, Mohamed A A, Ma, Xiujian, Sander, Sandrine, Liu, Hai-Kun, Cui, Guoliang, Gan, Yu, Wu, Wei, Xiao, Yanling, Heck, Albert J R, Guan, Wenxian, Lowe, Scott W, Horlings, Hugo M, Wang, Cun, Brummelkamp, Thijn R, Blank, Christian U, Schumacher, Ton N M, Sun, Chong, Afd Biomol.Mass Spect. and Proteomics, Sub Biomol.Mass Spectrometry & Proteom., Biomolecular Mass Spectrometry and Proteomics, Miao, Beiping, Hu, Zhaoqing, Mezzadra, Riccardo, Hoeijmakers, Lotte, Fauster, Astrid, Du, Shangce, Yang, Zhi, Sator-Schmitt, Melanie, Engel, Helena, Li, Xueshen, Broderick, Caroline, Jin, Guangzhi, Gomez-Eerland, Raquel, Rozeman, Lisette, Lei, Xin, Matsuo, Hitoshi, Yang, Chen, Hofland, Ingrid, Peters, Dennis, Broeks, Annegien, Laport, Elke, Fitz, Annika, Zhao, Xiyue, Mahmoud, Mohamed A A, Ma, Xiujian, Sander, Sandrine, Liu, Hai-Kun, Cui, Guoliang, Gan, Yu, Wu, Wei, Xiao, Yanling, Heck, Albert J R, Guan, Wenxian, Lowe, Scott W, Horlings, Hugo M, Wang, Cun, Brummelkamp, Thijn R, Blank, Christian U, Schumacher, Ton N M, and Sun, Chong

Published
2023

19. WEE1 inhibitor adavosertib in combination with carboplatin in advanced TP53 mutated ovarian cancer: A biomarker-enriched phase II study

Author

CMM Groep De Ridder, Cancer, Apotheek O&O&O, MS Medische Oncologie, Genetica Sectie Research, Child Health, Embaby, Alaa, Kutzera, Joachim, Geenen, Jill J, Pluim, Dick, Hofland, Ingrid, Sanders, Joyce, Lopez-Yurda, Marta, Beijnen, Jos H, Huitema, Alwin D R, Witteveen, Petronella O, Steeghs, Neeltje, van Haaften, Gijs, van Vugt, Marcel A T M, de Ridder, Jeroen, Opdam, Frans L, CMM Groep De Ridder, Cancer, Apotheek O&O&O, MS Medische Oncologie, Genetica Sectie Research, Child Health, Embaby, Alaa, Kutzera, Joachim, Geenen, Jill J, Pluim, Dick, Hofland, Ingrid, Sanders, Joyce, Lopez-Yurda, Marta, Beijnen, Jos H, Huitema, Alwin D R, Witteveen, Petronella O, Steeghs, Neeltje, van Haaften, Gijs, van Vugt, Marcel A T M, de Ridder, Jeroen, and Opdam, Frans L

Published
2023

20. Table S4 from SRC3 Phosphorylation at Serine 543 Is a Positive Independent Prognostic Factor in ER-Positive Breast Cancer

Author

Zwart, Wilbert, primary, Flach, Koen D., primary, Rudraraju, Bharath, primary, Abdel-Fatah, Tarek M.A., primary, Gojis, Ondrej, primary, Canisius, Sander, primary, Moore, David, primary, Nevedomskaya, Ekaterina, primary, Opdam, Mark, primary, Droog, Marjolein, primary, Hofland, Ingrid, primary, Chan, Steve, primary, Shaw, Jacqui, primary, Ellis, Ian O., primary, Coombes, R. Charles, primary, Carroll, Jason S., primary, Ali, Simak, primary, and Palmieri, Carlo, primary

Published
2023
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21. Supplemtary Figures S 1-14 from SRC3 Phosphorylation at Serine 543 Is a Positive Independent Prognostic Factor in ER-Positive Breast Cancer

Author

Zwart, Wilbert, primary, Flach, Koen D., primary, Rudraraju, Bharath, primary, Abdel-Fatah, Tarek M.A., primary, Gojis, Ondrej, primary, Canisius, Sander, primary, Moore, David, primary, Nevedomskaya, Ekaterina, primary, Opdam, Mark, primary, Droog, Marjolein, primary, Hofland, Ingrid, primary, Chan, Steve, primary, Shaw, Jacqui, primary, Ellis, Ian O., primary, Coombes, R. Charles, primary, Carroll, Jason S., primary, Ali, Simak, primary, and Palmieri, Carlo, primary

Published
2023
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23. SERPINB9 is commonly amplified and high expression in cancer cells correlates with poor immune checkpoint blockade response

Author

Ibáñez-Molero, Sofía, primary, van Vliet, Alex, additional, Pozniak, Joanna, additional, Hummelink, Karlijn, additional, Terry, Alexandra M., additional, Monkhorst, Kim, additional, Sanders, Joyce, additional, Hofland, Ingrid, additional, Landeloos, Ewout, additional, Van Herck, Yannick, additional, Bechter, Oliver, additional, Kuilman, Thomas, additional, Zhong, Weiwei, additional, Marine, Jean-Christophe, additional, Wessels, Lodewyk, additional, and Peeper, Daniel S., additional

Published
2022
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24. Tumour-specific proline vulnerability uncovered by differential ribosome codon reading

Author

Loayza-Puch, Fabricio, Rooijers, Koos, Buil, Levi C.M., Zijlstra, Jelle, Vrielink, Joachim F. Oude, Lopes, Rui, Ugalde, Alejandro Pineiro, van breugel, Pieter, Hofland, Ingrid, Wesseling, Jelle, van Tellingen, Olaf, Bex, Axel, and Agami, Reuven

Subjects
Physiological aspects, Genetic aspects, Research, Ribosomes -- Physiological aspects -- Research, Proline -- Physiological aspects -- Genetic aspects -- Research, Protein synthesis -- Physiological aspects -- Genetic aspects -- Research, Codons -- Physiological aspects -- Research, Protein biosynthesis -- Physiological aspects -- Genetic aspects -- Research, Codon -- Physiological aspects -- Research
Abstract

In previous work we used ribosome profiling to map changes in translation of wild-type and disease-triggering mutant mitochondria (8). A mitochondrial disease-promoting tryptophan transfer RNA (tRNA) mutation elicited specific pausing [...], Tumour growth and metabolic adaptation may restrict the availability of certain amino acids for protein synthesis. It has recently been shown that certain types of cancer cells depend on glycine, glutamine, leucine and serine metabolism to proliferate and survive (1-4). In addition, successful therapies using L-asparaginase-induced asparagine deprivation have been developed for acute lymphoblastic leukaemia (5). However, a tailored detection system for measuring restrictive amino acids in each tumour is currently not available. Here we harness ribosome profiling (6) for sensing restrictive amino acids, and develop diricore, a procedure for differential ribosome measurements of codon reading. We first demonstrate the functionality and constraints of diricore using metabolic inhibitors and nutrient deprivation assays. Notably, treatment with L-asparaginase elicited both specific diricore signals at asparagine codons and high levels of asparagine synthetase (ASNS). We then applied diricore to kidney cancer and discover signals indicating restrictive proline. As for asparagine, this observation was linked to high levels of PYCR1, a key enzyme in proline production (7), suggesting a compensatory mechanism allowing tumour expansion. Indeed, PYCR1 is induced by shortage of proline precursors, and its suppression attenuated kidney cancer cell proliferation when proline was limiting. High PYCR1 is frequently observed in invasive breast carcinoma. In an in vivo model system of this tumour, we also uncover signals indicating restrictive proline. We further show that CRISPR-mediated knockout of PYCR1 impedes tumorigenic growth in this system. Thus, diricore has the potential to reveal unknown amino acid deficiencies, vulnerabilities that can be used to target key metabolic pathways for cancer treatment.

Published
2016

25. Identification of CMTM6 and CMTM4 as PD-L1 protein regulators

Author

Mezzadra, Riccardo, Sun, Chong, Jae, Lucas T., Gomez-Eerland, Raquel, de Vries, Evert, Wu, Wei, Logtenberg, Meike E. W., Slagter, Maarten, Rozeman, Elisa A., Hofland, Ingrid, Broeks, Annegien, Horlings, Hugo M., Wessels, Lodewyk F. A., Blank, Christian U., Xiao, Yanling, Heck, Albert J. R., Borst, Jannie, Brummelkamp, Thijn R., and Schumacher, Ton N. M.

Published
2017
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26. Epithelial-to-Mesenchymal Transition Drives Invasiveness of Breast Cancer Brain Metastases

Author

Margarido, Andreia S., primary, Uceda-Castro, Rebeca, additional, Hahn, Kerstin, additional, de Bruijn, Roebi, additional, Kester, Lennart, additional, Hofland, Ingrid, additional, Lohuis, Jeroen, additional, Seinstra, Danielle, additional, Broeks, Annegien, additional, Jonkers, Jos, additional, Broekman, Marike L. D., additional, Wesseling, Pieter, additional, Vennin, Claire, additional, Vizoso, Miguel, additional, and van Rheenen, Jacco, additional

Published
2022
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29. The tubarial glands paper: A starting point. A reply to comments

Author

Valstar, Matthijs H., de Bakker, Bernadette S., Steenbakkers, Roel J.H.M., de Jong, Kees H., Smit, Laura A., Klein Nulent, Thomas J.W., van Es, Robert J.J., Hofland, Ingrid, de Keizer, Bart, Jasperse, Bas, Balm, Alfons J.M., van der Schaaf, Arjen, Langendijk, Johannes A., Smeele, Ludi E., and Vogel, Wouter V.

Published
2021
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30. Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma

Author

Sun, Chong, Wang, Liqin, Huang, Sidong, Heynen, Guus J. J. E., Prahallad, Anirudh, Robert, Caroline, Haanen, John, Blank, Christian, Wesseling, Jelle, Willems, Stefan M., Zecchin, Davide, Hobor, Sebastijan, Bajpe, Prashanth K., Lieftink, Cor, Mateus, Christina, Vagner, Stephan, Grernrum, Wipawadee, Hofland, Ingrid, Schlicker, Andreas, Wessels, Lodewyk F. A., Beijersbergen, Roderick L., Bardelli, Alberto, Di Nicolantonio, Federica, Eggermont, Alexander M. M., and Bernards, Rene

Published
2014
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31. Distinct Patterns of Myeloid Cell Infiltration in Patients With hrHPV-Positive and hrHPV-Negative Penile Squamous Cell Carcinoma: The Importance of Assessing Myeloid Cell Densities Within the Spatial Context of the Tumor

Author

Rafael, Tynisha S., primary, de Vries, Hielke M., additional, Ottenhof, Sarah R., additional, Hofland, Ingrid, additional, Broeks, Annegien, additional, de Jong, Jeroen, additional, Bekers, Elise, additional, Horenblas, Simon, additional, de Menezes, Renée X., additional, Jordanova, Ekaterina S., additional, and Brouwer, Oscar R., additional

Published
2021
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32. The tubarial salivary glands: A potential new organ at risk for radiotherapy

Author

MS Mondziekten/Kaakchirurgie, MS Hoofd-Hals Chirurgische Oncologie, Cancer, MS Radiologie, Valstar, Matthijs H., de Bakker, Bernadette S., Steenbakkers, Roel J.H.M., de Jong, Kees H., Smit, Laura A., Klein Nulent, Thomas J.W., van Es, Robert J.J., Hofland, Ingrid, de Keizer, Bart, Jasperse, Bas, Balm, Alfons J.M., van der Schaaf, Arjen, Langendijk, Johannes A., Smeele, Ludi E., Vogel, Wouter V., MS Mondziekten/Kaakchirurgie, MS Hoofd-Hals Chirurgische Oncologie, Cancer, MS Radiologie, Valstar, Matthijs H., de Bakker, Bernadette S., Steenbakkers, Roel J.H.M., de Jong, Kees H., Smit, Laura A., Klein Nulent, Thomas J.W., van Es, Robert J.J., Hofland, Ingrid, de Keizer, Bart, Jasperse, Bas, Balm, Alfons J.M., van der Schaaf, Arjen, Langendijk, Johannes A., Smeele, Ludi E., and Vogel, Wouter V.

Published
2021

33. The tubarial glands paper: A starting point. A reply to comments

Author

MS Hoofd-Hals Chirurgische Oncologie, Cancer, MS Radiologie, Valstar, Matthijs H, de Bakker, Bernadette S, Steenbakkers, Roel J H M, de Jong, Kees H, Smit, Laura A, Klein Nulent, Thomas J W, van Es, Robert J J, Hofland, Ingrid, de Keizer, Bart, Jasperse, Bas, Balm, Alfons J M, van der Schaaf, Arjen, Langendijk, Johannes A, Smeele, Ludi E, Vogel, Wouter V, MS Hoofd-Hals Chirurgische Oncologie, Cancer, MS Radiologie, Valstar, Matthijs H, de Bakker, Bernadette S, Steenbakkers, Roel J H M, de Jong, Kees H, Smit, Laura A, Klein Nulent, Thomas J W, van Es, Robert J J, Hofland, Ingrid, de Keizer, Bart, Jasperse, Bas, Balm, Alfons J M, van der Schaaf, Arjen, Langendijk, Johannes A, Smeele, Ludi E, and Vogel, Wouter V

Published
2021

34. High CD8 + tumour‐infiltrating lymphocyte density associates with unfavourable prognosis in oesophageal adenocarcinoma following poor response to neoadjuvant chemoradiotherapy

Author

Koemans, Willem J, primary, Dieren, Jolanda M, additional, Berg, Jose G, additional, Meijer, Gerrit A, additional, Snaebjornsson, Petur, additional, Chalabi, Myriam, additional, Lecot, Frederig, additional, Riedl, Robert, additional, Krijgsman, Oscar, additional, Hofland, Ingrid, additional, Broeks, Annegien, additional, Voncken, Francine E M, additional, Peppelenbosch, Maikel P, additional, Sosef, Meindert N, additional, Sandick, Johanna W, additional, and Kodach, Liudmila L, additional

Published
2021
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35. Identification of recurrent FGFR3 fusion genes in lung cancer through kinome-centred RNA sequencing

Author

Majewski, Ian J, Mittempergher, Lorenza, Davidson, Nadia M, Bosma, Astrid, Willems, Stefan M, Horlings, Hugo M, de Rink, Iris, Greger, Liliana, Hooijer, Gerrit KJ, Peters, Dennis, Nederlof, Petra M, Hofland, Ingrid, de Jong, Jeroen, Wesseling, Jelle, Kluin, Roelof JC, Brugman, Wim, Kerkhoven, Ron, Nieboer, Frank, Roepman, Paul, Broeks, Annegien, Muley, Thomas R, Jassem, Jacek, Niklinski, Jacek, van Zandwijk, Nico, Brazma, Alvis, Oshlack, Alicia, van den Heuvel, Michel, and Bernards, René

Published
2013
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37. Androgen receptor signalling in macrophages promotes TREM-1-mediated prostate cancer cell line migration and invasion

Author

Hubrecht Institute with UMC, Cioni, Bianca, Zaalberg, Anniek, van Beijnum, Judy R., Melis, Monique H.M., van Burgsteden, Johan, Muraro, Mauro J., Hooijberg, Erik, Peters, Dennis, Hofland, Ingrid, Lubeck, Yoni, de Jong, Jeroen, Sanders, Joyce, Vivié, Judith, van der Poel, Henk G., de Boer, Jan Paul, Griffioen, Arjan W., Zwart, Wilbert, Bergman, Andries M., Hubrecht Institute with UMC, Cioni, Bianca, Zaalberg, Anniek, van Beijnum, Judy R., Melis, Monique H.M., van Burgsteden, Johan, Muraro, Mauro J., Hooijberg, Erik, Peters, Dennis, Hofland, Ingrid, Lubeck, Yoni, de Jong, Jeroen, Sanders, Joyce, Vivié, Judith, van der Poel, Henk G., de Boer, Jan Paul, Griffioen, Arjan W., Zwart, Wilbert, and Bergman, Andries M.

Published
2020

40. TLE3 loss confers AR inhibitor resistance by facilitating GR-mediated human prostate cancer cell growth

Author

Palit, Sander AL, primary, Vis, Daniel, additional, Stelloo, Suzan, additional, Lieftink, Cor, additional, Prekovic, Stefan, additional, Bekers, Elise, additional, Hofland, Ingrid, additional, Šuštić, Tonći, additional, Wolters, Liesanne, additional, Beijersbergen, Roderick, additional, Bergman, Andries M, additional, Győrffy, Balázs, additional, Wessels, Lodewyk FA, additional, Zwart, Wilbert, additional, and van der Heijden, Michiel S, additional

Published
2019
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41. Author response: TLE3 loss confers AR inhibitor resistance by facilitating GR-mediated human prostate cancer cell growth

Author

Palit, Sander AL, primary, Vis, Daniel, additional, Stelloo, Suzan, additional, Lieftink, Cor, additional, Prekovic, Stefan, additional, Bekers, Elise, additional, Hofland, Ingrid, additional, Šuštić, Tonći, additional, Wolters, Liesanne, additional, Beijersbergen, Roderick, additional, Bergman, Andries M, additional, Győrffy, Balázs, additional, Wessels, Lodewyk FA, additional, Zwart, Wilbert, additional, and van der Heijden, Michiel S, additional

Published
2019
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42. High CD8+ tumour‐infiltrating lymphocyte density associates with unfavourable prognosis in oesophageal adenocarcinoma following poor response to neoadjuvant chemoradiotherapy.

Author

Koemans, Willem J, Dieren, Jolanda M, Berg, Jose G, Meijer, Gerrit A, Snaebjornsson, Petur, Chalabi, Myriam, Lecot, Frederig, Riedl, Robert, Krijgsman, Oscar, Hofland, Ingrid, Broeks, Annegien, Voncken, Francine E M, Peppelenbosch, Maikel P, Sosef, Meindert N, Sandick, Johanna W, and Kodach, Liudmila L

Subjects
PROGRAMMED cell death 1 receptors, PROGNOSIS, TUMOR microenvironment, FORKHEAD transcription factors, CHEMORADIOTHERAPY, BIOMARKERS, PROGRESSION-free survival, BREAST cancer prognosis, TUMOR-infiltrating immune cells
Abstract

Aims: Determining prognosis following poor response to neoadjuvant chemoradiotherapy (nCRT) in oesophageal adenocarcinoma (OAC) remains challenging. An immunosuppressive tumour microenvironment (TME) as well as immune infiltrate density and composition are considered to play a critical role in the immune interaction between host and tumour and can predict therapy response and survival in many cancers, including gastrointestinal malignancies. The aim of this study was to establish the TME characteristics associated with survival following a poor response to nCRT. Methods and results: The prognostic significance of OAC‐associated CD3+, CD4+, CD8+, forkhead box protein 3 (FoxP3+) and programmed cell death ligand 1 (PD‐L1) expression was studied by immunohistochemistry and quantified by automated image analysis in 123 patients who underwent nCRT and curative resection. Results from good and poor responders were contrasted and immune infiltration was related to disease course in both groups. Subsequently a cohort of 57 patients with a moderate response to nCRT was analysed in a similar fashion. Tumour cell percentage positively correlated to immune infiltration markers. In good and moderate responders, none of the immune infiltrate parameters was associated with survival; in poor responders CD8+ was an independent negative predictor of OS in univariate analysis (P = 0.03) and high CD8+ infiltration was associated with worse OS (15 versus 32 months, P = 0.042). Conclusion: A high CD8+ density is an independent biomarker of poor OS in poor responders to nCRT, but not in good and moderate responders. Our results suggest that patients with a poor response to nCRT but concomitant high CD8+ counts in the resection specimen require adjuvant therapy. [ABSTRACT FROM AUTHOR]

Published
2021
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43. Breast adipocyte size associates with ipsilateral invasive breast cancer risk after ductal carcinoma in situ.

Author

Almekinders, Mathilde M. M., Schaapveld, Michael, Thijssen, Bram, Visser, Lindy L., Bismeijer, Tycho, Sanders, Joyce, Isnaldi, Edoardo, Hofland, Ingrid, Mertz, Marjolijn, Wessels, Lodewyk F. A., Broeks, Annegien, Hooijberg, Erik, Zwart, Wilbert, Lips, Esther H., Grand Challenge PRECISION Consortium, Desmedt, Christine, and Wesseling, Jelle

Published
2021
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44. Abstract B188: CMTM6, beyond a regulator of PD-L1 expression

Author

Sun, Chong, primary, Mezzadra, Riccardo, additional, Gomez-Eerland, Raquel, additional, Hofland, Ingrid, additional, Peters, Dennis, additional, Broeks, Annegien, additional, Horlings, Hugo M., additional, Wu, Wei, additional, Heck, Albert J. R., additional, and Schumacher, Ton N.M., additional

Published
2019
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45. The association of diabetes mellitus and insulin treatment with expression of insulin-related proteins in breast tumors

Author

Bronsveld, Heleen K, De Bruin, Marie L, Wesseling, Jelle, Sanders, Joyce, Hofland, Ingrid, Jensen, Vibeke Frøkjær, Bazelier, Marloes T, ter Braak, Bas, de Boer, Anthonius, Vestergaard, Peter, Schmidt, Marjanka K, Bronsveld, Heleen K, De Bruin, Marie L, Wesseling, Jelle, Sanders, Joyce, Hofland, Ingrid, Jensen, Vibeke Frøkjær, Bazelier, Marloes T, ter Braak, Bas, de Boer, Anthonius, Vestergaard, Peter, and Schmidt, Marjanka K

Abstract

BACKGROUND: The insulin receptor (INSR) and the insulin growth factor 1 receptor (IGF1R) play important roles in the etiology of both diabetes mellitus and breast cancer. We aimed to evaluate the expression of hormone and insulin-related proteins within or related to the PI3K and MAPK pathway in breast tumors of women with or without diabetes mellitus, treated with or without insulin (analogues).METHODS: Immunohistochemistry was performed on tumor tissue of 312 women with invasive breast cancer, with or without pre-existing diabetes mellitus, diagnosed in 2000-2010, who were randomly selected from a Danish breast cancer cohort. Women with diabetes were 2:1 frequency matched by year of birth and age at breast cancer diagnosis to those without diabetes. Tumor Microarrays were successfully stained for p-ER, EGFR, p-ERK1/2, p-mTOR, and IGF1R, and scored by a breast pathologist. Associations of expression of these proteins with diabetes, insulin treatment (human insulin and insulin analogues) and other diabetes medication were evaluated by multivariable logistic regression adjusting for menopause and BMI; effect modification by menopausal status, BMI, and ER status was assessed using interactions terms.RESULTS: We found no significant differences in expression of any of the proteins in breast tumors of women with (n = 211) and without diabetes (n = 101). Among women with diabetes, insulin use (n = 53) was significantly associated with higher tumor protein expression of IGF1R (OR = 2.36; 95%CI:1.02-5.52; p = 0.04) and p-mTOR (OR = 2.35; 95%CI:1.13-4.88; p = 0.02), especially among women treated with insulin analogues. Menopause seemed to modified the association between insulin and IGF1R expression (p = 0.07); the difference in IGF1R expression was only observed in tumors of premenopausal women (OR = 5.10; 95%CI:1.36-19.14; p = 0.02). We found no associations between other types of diabetes medication, such as metformin, and protein expression of the five

Published
2018

47. The association of diabetes mellitus and insulin treatment with expression of insulin-related proteins in breast tumors

Author

Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology, Bronsveld, Heleen K, De Bruin, Marie L, Wesseling, Jelle, Sanders, Joyce, Hofland, Ingrid, Jensen, Vibeke Frøkjær, Bazelier, Marloes T, ter Braak, Bas, de Boer, Anthonius, Vestergaard, Peter, Schmidt, Marjanka K, Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology, Bronsveld, Heleen K, De Bruin, Marie L, Wesseling, Jelle, Sanders, Joyce, Hofland, Ingrid, Jensen, Vibeke Frøkjær, Bazelier, Marloes T, ter Braak, Bas, de Boer, Anthonius, Vestergaard, Peter, and Schmidt, Marjanka K

Published
2018

48. Prognostic role of tumour-associated macrophages and regulatory T cells in EBV-positive and EBV-negative nasopharyngeal carcinoma

Author

Pathologie Opleiding, Cancer, MS Hoofd-Hals Chirurgische Oncologie, Pathologie Pathologen staf, Ooft, Marc L., van Ipenburg, Jolique A., Sanders, Maxime E., Kranendonk, Mariette, Hofland, Ingrid, de Bree, Remco, Koljenović, Senada, Willems, Stefan M., Pathologie Opleiding, Cancer, MS Hoofd-Hals Chirurgische Oncologie, Pathologie Pathologen staf, Ooft, Marc L., van Ipenburg, Jolique A., Sanders, Maxime E., Kranendonk, Mariette, Hofland, Ingrid, de Bree, Remco, Koljenović, Senada, and Willems, Stefan M.

Published
2018

49. EpCAM-based flow cytometry in cerebrospinal fluid greatly improves diagnostic accuracy of leptomeningeal metastases from epithelial tumors

Author

Milojkovic Kerklaan, B., Pluim, Dick, Bol, Mijke, Hofland, Ingrid, Westerga, Johan, van Tinteren, Harm, Beijnen, Jos H, Boogerd, Willem, Schellens, Jan H M, Brandsma, Dieta, Sub Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology, Sub Clinical Pharmacology, and Pharmacoepidemiology and Clinical Pharmacology

Subjects
Adult, Male, Cancer Research, Pathology, medicine.medical_specialty, epithelial cell adhesion molecule (EpCAM), Clinical Investigations, cerebrospinal fluid (CSF), leptomeningeal metastases (LM), Flow cytometry, 03 medical and health sciences, chemistry.chemical_compound, Young Adult, carcinomatous meningitis, 0302 clinical medicine, Cerebrospinal fluid, Circulating tumor cell, Cytology, medicine, Meningeal Neoplasms, Humans, Prospective Studies, Prospective cohort study, Whole blood, Aged, Aged, 80 and over, medicine.diagnostic_test, business.industry, Epithelial cell adhesion molecule, Magnetic resonance imaging, Epithelial Cells, Middle Aged, Epithelial Cell Adhesion Molecule, Flow Cytometry, Magnetic Resonance Imaging, carcinomatous meningitis, cerebrospinal fluid (CSF), circulating tumor cells (CTC), epithelial cell adhesion molecule (EpCAM), leptomeningeal metastases (LM), circulating tumor cells (CTC), Oncology, chemistry, 030220 oncology & carcinogenesis, Female, Neurology (clinical), business, 030217 neurology & neurosurgery
Abstract

BACKGROUND: Moderate diagnostic accuracy of MRI and initial cerebrospinal fluid (CSF) cytology analysis results in at least 10%-15% false negative diagnoses of leptomeningeal metastases (LM) of solid tumors, thus postponing start of therapy. The aim of this prospective clinical study was to determine the diagnostic value of epithelial cell adhesion molecule (EpCAM)-based flow cytometry versus cytology in CSF for the diagnosis of LM in patients with epithelial tumors. METHODS: Patients with a clinical suspicion of LM but a negative or inconclusive MRI in whom a diagnostic lumbar puncture has to be performed were included. At least 5 mL of CSF for cytology, 5 mL for flow cytometry, 2 mL for cell count and biochemistry, and 8 mL whole blood samples for circulating tumor cells measurements and biochemistry were drawn. Tumor cells in CSF and whole blood were detected by multiparameter flow cytometry using EpCAM antibody. RESULTS: In total 29 eligible patients were enrolled in the study. Thirteen patients were ultimately diagnosed with LM. The flow cytometry assay showed 100% sensitivity and 100% specificity for diagnosing LM, while sensitivity of CSF cytology was only 61.5%. Cell count or biochemical parameters in CSF were abnormal in 100% of patients with LM. CONCLUSIONS: Our results suggest that the EpCAM-based flow cytometry assay is superior to CSF cytology for the diagnosis of LM in patients with an epithelial tumor, a clinical suspicion of LM, and a nonconclusive MRI. Confirmation of these data is needed in a larger dataset to recommend dual CSF diagnostics for LM. CLINICALTRIALSGOV IDENTIFIER: NCT01713699.

Published
2016

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