514 results on '"Hoft, Daniel F"'
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2. Safety and immunogenicity of a thermostable ID93 + GLA-SE tuberculosis vaccine candidate in healthy adults
- Author
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Sagawa, Zachary K., Goman, Cristina, Frevol, Aude, Blazevic, Azra, Tennant, Janice, Fisher, Bridget, Day, Tracey, Jackson, Stephen, Lemiale, Franck, Toussaint, Leon, Kalisz, Irene, Jiang, Joe, Ondrejcek, Lisa, Mohamath, Raodoh, Vergara, Julie, Lew, Alan, Beckmann, Anna Marie, Casper, Corey, Hoft, Daniel F., and Fox, Christopher B.
- Published
- 2023
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3. Immunomodulators for immunocompromised patients hospitalized for COVID-19: a meta-analysis of randomized controlled trials
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Hermine, Olivier, Mariette, Xavier, Ravaud, Philippe, Bureau, Serge, Dougados, Maxime, Resche-Rigon, Matthieu, Tharaux, Pierre-Louis, Tibi, Annick, Azoulay, Elie, Cadranel, Jacques, Emmerich, Joseph, Fartoukh, Muriel, Guidet, Bertrand, Humbert, Marc, Lacombe, Karine, Mahevas, Matthieu, Pene, Frédéric, Porcher, Raphaël, Pourchet-Martinez, Valerie, Schlemmer, Frédéric, Yazdanpanah, Yazdan, Baron, Gabriel, Perrodeau, Elodie, Vanhoye, Damien, Kedzia, Cécile, Demerville, Lauren, Gysembergh-Houal, Anne, Bourgoin, Alexandre, Raked, Nabil, Mameri, Lakhdar, Montlahuc, Claire, Biard, Lucie, Alary, St.phanie, Hamiria, Samir, Bariz, Thinhinane, Semri, Hala, Hai, Dhiaa Meriem, Benafla, Moustafa, Belloul, Mohamed, Vauboin, Pernelle, Flamand, Saskia, Pacheco, Claire, Walter-Petrich, Anouk, Stan, Emilia, Benarab, Souad, Nyanou, Corine, Charreteur, Robin, Dupre, Céline, Cardet, Kévin, Lehmann, Blandine, Baghli, Kamyl, Madelaine, Claire, D'Ortenzio, Eric, Puéchal, Oriane, Semaille, Caroline, Savale, 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F., Yazdanpanah, Y., Mentre, F., Peiffer-Smadja, N., Lescure, F.X., Poissy, J., Bouadma, L., Timsit, J.F., Lina, B., Morfin-Sherpa, F., Bouscambert, M., Gaymard, A., Peytavin, G., Abel, L., Guedj, J., Andrejak, C., Burdet, C., Laouenan, C., Belhadi, D., Dupont, A., Alfaiate, T., Basli, B., Chair, A., Laribi, S., Level, J., Schneider, M., Tellier, M.C., Dechanet, A., Costagliola, D., Terrier, B., Ohana, M., Couffin-Cadiergues, S., Esperou, H., Delmas, C., Saillard, J., Fougerou, C., Moinot, L., Wittkop, L., Cagnot, C., Le Mestre, S., Lebrasseur-Longuet, D., Petrov-Sanchez, V., Diallo, A., Mercier, N., Icard, V., Leveau, B., Tubiana, S., Hamze, B., Gelley, A., Noret, M., D’Ortenzio, E., Puechal, O., Semaille, C., Welte, T., Paiva, J.A., Halanova, M., Kieny, M.P., Balssa, E., Birkle, C., Gibowski, S., Landry, E., Le Goff, A., Moachon, L., Moins, C., Wadouachi, L., Paul, C., Levier, A., Bougon, D., Djossou, F., Epelboin, L., Dellamonica, J., Marquette, C.H., Robert, C., Gibot, S., Senneville, E., Jean-Michel, V., Zerbib, Y., Chirouze, C., Boyer, A., Cazanave, C., Gruson, D., Malvy, D., Andreu, P., Quenot, J.P., Terzi, N., Faure, K., Chabartier, C., Le Moing, V., Klouche, K., Ferry, T., F, Valour, Gaborit, B., Canet, E., Le Turnier, P., Boutoille, D., Bani-Sadr, F., Benezit, F., Revest, M., Cameli, C., Caro, A., Um Tegue, MJ Ngo, Le Tulzo, Y., Laviolle, B., Laine, F., Thiery, G., Meziani, F., Hansmann, Y., Oulehri, W., Tacquard, C., Vardon-Bounes, F., Riu-Poulenc, B., Murris-Espin, M., Bernard, L., Garot, D., Hinschberger, O., Martinot, M., Bruel, C., Pilmis, B., Bouchaud, O., Loubet, P., Roger, C., Monnet, X., Figueiredo, S., Godard, V., Mira, J.P., Lachatre, M., Kerneis, S., Aboab, J., Sayre, N., Crockett, F., Lebeaux, D., Buffet, A., Diehl, J.L., Fayol, A., Hulot, J.S., Livrozet, M., Dessap, A Mekontso, Ficko, C., Stefan, F., Le Pavec, J., Mayaux, J., Ait-Oufella, H., Molina, J.M., Pialoux, G., Fartoukh, M., Textoris, J., Brossard, M., Essat, A., Netzer, E., Riault, Y., Ghislain, M., Beniguel, L., Genin, M., Gouichiche, L., Betard, C., Belkhir, L., Altdorfer, A., Centro, V Fraipont, Braz, S., Ribeiro, JM Ferreira, Alburqueque, R Roncon, Berna, M., Alexandre, M., Lamprecht, B., Egle, A., Greil, R., Joannidis, M., Patterson, Thomas F., Ponce, Philip O., Taylor, Barbara S., Patterson, Jan E., Bowling, Jason E., Javeri, Heta, Kalil, Andre C., Larson, LuAnn, Hewlett, Angela, Mehta, Aneesh K., Rouphael, Nadine G., Saklawi, Youssef, Scanlon, Nicholas, Traenkner, Jessica J., Trible, Ronald P., Jr., Walter, Emmanuel B., Ivey, Noel, Holland, Thomas L., Ruiz-Palacios, Guillermo M., Ponce de León, Alfredo, Rajme, Sandra, Hsieh, Lanny, Amin, Alpesh N., Watanabe, Miki, Lee, Helen S., Kline, Susan, Billings, Joanne, Noren, Brooke, Kim, Hyun, Bold, Tyler D., Tapson, Victor, Grein, Jonathan, Sutterwala, Fayyaz, Iovine, Nicole, Beattie, Lars K., Wakeman, Rebecca Murray, Shaw, Matthew, Jain, Mamta K., Mocherla, Satish, Meisner, Jessica, Luque, Amneris, Sweeney, Daniel A., Benson, Constance A., Ali, Farhana, Atmar, Robert L., El Sahly, Hana M., Whitaker, Jennifer, Falsey, Ann R., Branche, Angela R., Rozario, Cheryl, Pineda, Justino Regalado, Martinez-Orozco, José Arturo, Lye, David Chien, Ong, Sean WX., Chia, Po Ying, Young, Barnaby E., Sandkovsky, Uriel, Berhe, Mezgebe, Haley, Clinton, Dishner, Emma, Cantos, Valeria D., Kelley, Colleen F., Rebolledo Esteinou, Paulina A., Kandiah, Sheetal, Doernberg, Sarah B., Crouch, Pierre-Cedric B., Jang, Hannah, Luetkemeyer, Anne F., Dwyer, Jay, Cohen, Stuart H., Thompson, George R., 3rd, Nguyen, Hien H., Finberg, Robert W., Wang, Jennifer P., Perez-Velazquez, Juan, Wessolossky, Mireya, Jackson, Patrick E.H., Bell, Taison D., West, Miranda J., Taiwo, Babafemi, Krueger, Karen, Perez, Johnny, Pearson, Triniece, Paules, Catharine I., Julian, Kathleen G., Ahmad, Danish, Hajduczok, Alexander G., Arguinchona, Henry, Arguinchona, Christa, Erdmann, Nathaniel, Goepfert, Paul, Ahuja, Neera, Frank, Maria G., Wyles, David, Young, Heather, Oh, Myoung-don, Park, Wan Beom, Kang, Chang Kyung, Marconi, Vincent, Moanna, Abeer, Cribbs, Sushma, Harrison, Telisha, Kim, Eu Suk, Jung, Jongtak, Song, Kyoung-Ho, Kim, Hong Bin, Tan, Seow Yen, Shafi, Humaira, Chien, Jaime, Fong, Raymond KC., Murray, Daniel D., Lundgren, Jens, Nielsen, Henrik, Jensen, Tomas, Zingman, Barry S., Grossberg, Robert, Riska, Paul F., Yang, Otto O., Ahn, Jenny, Arias, Rubi, Rapaka, Rekha R., Hauser, Naomi, Campbell, James D., Short, William R., Tebas, Pablo, Baron, Jillian T., McLellan, Susan L.F., Blanton, Lucas S., Seashore, Justin B., Creech, C. Buddy, Rice, Todd W., Walker, Shannon, Thomsen, Isaac P., Lopez de Castilla, Diego, Van Winkle, Jason W., Riedo, Francis X., Pada, Surinder Kaur, Wang, Alvin DY., Lin, Li, Harkins, Michelle, Mertz, Gregory, Sosa, Nestor, Ann Chai, Louis Yi, Tambyah, Paul Anantharajah, Tham, Sai Meng, Archuleta, Sophia, Yan, Gabriel, Lindholm, David A., Markelz, Ana Elizabeth, Mende, Katrin, Mularski, Richard, Hohmann, Elizabeth, Torres-Soto, Mariam, Jilg, Nikolaus, Maves, Ryan C., Utz, Gregory C., George, Sarah L., Hoft, Daniel F., Brien, James D., Paredes, Roger, Mateu, Lourdes, Loste, Cora, Kumar, Princy, Thornton, Sarah, Mohanraj, Sharmila, Hynes, Noreen A., Sauer, Lauren M., Colombo, Christopher J., Schofield, Christina, Colombo, Rhonda E., Chambers, Susan E., Novak, Richard M., Wendrow, Andrea, Gupta, Samir K., Lee, Tida, Lalani, Tahaniyat, Holodniy, Mark, Chary, Aarthi, Huprikar, Nikhil, Ganesan, Anuradha, Ohmagari, Norio, Mikami, Ayako, Price, D. Ashley, Duncan, Christopher J.A., Dierberg, Kerry, Neumann, Henry J., Taylor, Stephanie N., Lacour, Alisha, Masri, Najy, Swiatlo, Edwin, Widmer, Kyle, Neaton, James D., Bessesen, Mary, Stephens, David S., Burgess, Timothy H., Uyeki, Timothy M., Walker, Robert, Marks, G. Lynn, Osinusi, Anu, Cao, Huyen, Cardoso, Anabela, de Bono, Stephanie, Schlichting, Douglas E., Chung, Kevin K., Ferreira, Jennifer L., Green, Michelle, Makowski, Mat, Wierzbicki, Michael R., Conrad, Tom M., El-Khorazaty, Jill Ann, Hill, Heather, Bonnett, Tyler, Gettinger, Nikki, Engel, Theresa, Lewis, Teri, Wang, Jing, Beigel, John H., Tomashek, Kay M., Ghazaryan, Varduhi, Beresnev, Tatiana, Nayak, Seema, Dodd, Lori E., Dempsey, Walla, Nomicos, Effie, Lee, Marina, Pikaart-Tautges, Rhonda, Elsafy, Mohamed, Jurao, Robert, Koo, Hyung, Proschan, Michael, Yokum, Tammy, Arega, Janice, Florese, Ruth, Voell, Jocelyn D., Davey, Richard, Serrano, Ruth C., Wiley, Zanthia, Phadke, Varun K., Goepfert, Paul A., Gomez, Carlos A., Sofarelli, Theresa A., Certain, Laura, Imlay, Hannah N., Wolfe, Cameron R., Ko, Emily R., Engemann, John J., Felix, Nora Bautista, Wan, Claire R., Elmor, Sammy T., Bristow, Laurel R., Harkins, Michelle S., Iovine, Nicole M., Elie-Turenne, Marie-Carmelle, Tapson, Victor F., Choe, Pyoeng Gyun, Mularski, Richard A., Rhie, Kevin S., Hussein, Rezhan H., Ince, Dilek, Winokur, Patricia L., Takasaki, Jin, Saito, Sho, McConnell, Kimberly, Wyles, David L., Sarcone, Ellen, Grimes, Kevin A., Perez, Katherine, Janak, Charles, Whitaker, Jennifer A., Rebolledo, Paulina A., Gharbin, John, Lambert, Allison A., Zea, Diego F., Bainbridge, Emma, Hostler, David C., Hostler, Jordanna M., Shahan, Brian T., Ling, Evelyn, Go, Minjoung, Hubbard, Fleesie A., Chakrabarty, Melony, Laguio-Vila, Maryrose, Walsh, Edward E., Guirgis, Faheem, Marconi, Vincent C., Madar, Christian, Borgetti, Scott A., Levine, Corri, Nock, Joy, Candiotti, Keith, Rozman, Julia, Dangond, Fernando, Hyvert, Yann, Seitzinger, Andrea, Cross, Kaitlyn, Pettibone, Stephanie, Nayak, Seema U., Deye, Gregory A., Siempos, Ilias I., Belhadi, Drifa, Veiga, Viviane Cordeiro, Cavalcanti, Alexandre Biasi, Branch-Elliman, Westyn, Papoutsi, Eleni, Gkirgkiris, Konstantinos, Xixi, Nikoleta A., and Kotanidou, Anastasia
- Published
- 2024
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4. Lower risk for COVID-19 hospitalization among patients in the United States with past vaccinations for herpes zoster and tetanus, diphtheria and pertussis
- Author
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Salas, Joanne, Morley, John E., Hoft, Daniel F., and Scherrer, Jeffrey F.
- Published
- 2023
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5. Baricitinib versus dexamethasone for adults hospitalised with COVID-19 (ACTT-4): a randomised, double-blind, double placebo-controlled trial
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Wahid, Lana, Walter, Emmanuel B., Belur, Akhila G., Dreyer, Grace, Patterson, Jan E., Bowling, Jason E., Dixon, Danielle O., Hewlett, Angela, Odrobina, Robert, Pupaibool, Jakrapun, Mocherla, Satish, Lazarte, Suzana, Cayabyab, Meilani, Hussein, Rezhan H., Golamari, Reshma R., Krill, Kaleigh L., Rajme, Sandra, Riska, Paul F., Zingman, Barry S., Mertz, Gregory, Sosa, Nestor, Goepfert, Paul A., Berhe, Mezgebe, Dishner, Emma, Fayed, Mohamed, Hubel, Kinsley, Martinez-Orozco, José Arturo, Bautista Felix, Nora, Elmor, Sammy T., Bechnak, Amer Ryan, Saklawi, Youssef, Van Winkle, Jason W., Zea, Diego F., Laguio-Vila, Maryrose, Walsh, Edward E., Falsey, Ann R., Carvajal, Karen, Hyzy, Robert C., Hanna, Sinan, Olbrich, Norman, Traenkner, Jessica J., Kraft, Colleen S., Tebas, Pablo, Baron, Jillian T, Levine, Corri, Nock, Joy, Billings, Joanne, Kim, Hyun, Elie-Turenne, Marie-Carmelle, Whitaker, Jennifer A., Luetkemeyer, Anne F., Dwyer, Jay, Bainbridge, Emma, Gyun Choe, Pyoeng, Kyung Kang, Chang, Jilg, Nikolaus, Cantos, Valeria D, Bhamidipati, Divya R., Nithin Gopalsamy, Srinivasa, Chary, Aarthi, Jung, Jongtak, Song, Kyoung-Ho, Kim, Hong Bin, Benson, Constance A., McConnell, Kimberly, Wang, Jennifer P., Wessolossky, Mireya, Perez, Katherine, Eubank, Taryn A, Berjohn, Catherine, Utz, Gregory C., Jackson, Patrick E.H., Bell, Taison D., Haughey, Heather M., Moanna, Abeer, Cribbs, Sushma, Harrison, Telisha, Colombo, Christopher J., Schofield, Christina, Colombo, Rhonda E., Tapson, Victor F., Grein, Jonathan, Sutterwala, Fayyaz, Ince, Dilek, Winokur, Patricia L., Fung, Monica, Jang, Hannah, Wyles, David, Frank, Maria G., Sarcone, Ellen, Neumann, Henry, Viswanathan, Anand, Hochman, Sarah, Mulligan, Mark, Eckhardt, Benjamin, Carmody, Ellie, Ahuja, Neera, Nadeau, Kari, Svec, David, Macaraeg, Jeffrey C., Morrow, Lee, Quimby, Dave, Bessesen, Mary, Nicholson, Lindsay, Adams, Jill, Kumar, Princy, Lambert, Allison A., Arguinchona, Henry, Alicic, Radica Z., Saito, Sho, Ohmagari, Norio, Mikami, Ayako, Chien Lye, David, Hong Lee, Tau, Ying Chia, Po, Hsieh, Lanny, Amin, Alpesh N., Watanabe, Miki, Candiotti, Keith A., Castro, Jose G., Antor, Maria A., Lee, Tida, Lalani, Tahaniyat, Novak, Richard M., Wendrow, Andrea, Borgetti, Scott A., George, Sarah L., Hoft, Daniel F., Brien, James D., Cohen, Stuart H., Thompson, George R., 3rd, Chakrabarty, Melony, Guirgis, Faheem, Davey, Richard T., Voell, Jocelyn, Strich, Jeffrey R., Lindholm, David A., Mende, Katrin, Wellington, Trevor R., Rapaka, Rekha R., Husson, Jennifer S., Levine, Andrea R., Yen Tan, Seow, Shafi, Humaira, Chien, Jaime M F, Hostler, David C., Hostler, Jordanna M., Shahan, Brian T., Adams, David H., Osinusi, Anu, Cao, Huyen, Burgess, Timothy H., Rozman, Julia, Chung, Kevin K., Nieuwoudt, Christina, El-Khorazaty, Jill A., Hill, Heather, Pettibone, Stephanie, Gettinger, Nikki, Engel, Theresa, Lewis, Teri, Wang, Jing, Deye, Gregory A., Nomicos, Effie, Pikaart-Tautges, Rhonda, Elsafy, Mohamed, Jurao, Robert, Koo, Hyung, Proschan, Michael, Yokum, Tammy, Arega, Janice, Florese, Ruth, Wolfe, Cameron R, Tomashek, Kay M, Patterson, Thomas F, Gomez, Carlos A, Marconi, Vincent C, Jain, Mamta K, Yang, Otto O, Paules, Catharine I, Palacios, Guillermo M Ruiz, Grossberg, Robert, Harkins, Michelle S, Mularski, Richard A, Erdmann, Nathaniel, Sandkovsky, Uriel, Almasri, Eyad, Pineda, Justino Regalado, Dretler, Alexandra W, de Castilla, Diego Lopez, Branche, Angela R, Park, Pauline K, Mehta, Aneesh K, Short, William R, McLellan, Susan L F, Kline, Susan, Iovine, Nicole M, El Sahly, Hana M, Doernberg, Sarah B, Oh, Myoung-don, Huprikar, Nikhil, Hohmann, Elizabeth, Kelley, Colleen F, Holodniy, Mark, Kim, Eu Suk, Sweeney, Daniel A, Finberg, Robert W, Grimes, Kevin A, Maves, Ryan C, Ko, Emily R, Engemann, John J, Taylor, Barbara S, Ponce, Philip O, Larson, LuAnn, Melendez, Dante Paolo, Seibert, Allan M, Rouphael, Nadine G, Strebe, Joslyn, Clark, Jesse L, Julian, Kathleen G, de Leon, Alfredo Ponce, Cardoso, Anabela, de Bono, Stephanie, Atmar, Robert L, Ganesan, Anuradha, Ferreira, Jennifer L, Green, Michelle, Makowski, Mat, Bonnett, Tyler, Beresnev, Tatiana, Ghazaryan, Varduhi, Dempsey, Walla, Nayak, Seema U, Dodd, Lori E, Beigel, John H, and Kalil, Andre C
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- 2022
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6. Tumor microenvironment metabolites directing T cell differentiation and function
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Liu, Xia, Hoft, Daniel F., and Peng, Guangyong
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- 2022
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7. Tristetraprolin mediates immune evasion of mycobacterial infection in macrophages.
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Wei, Jiawei, Ning, Huan, Ramos‐Espinosa, Octavio, Eickhoff, Christopher S., Hou, Rong, Wang, Qinghong, Fu, Mingui, Liu, Ethan Y., Fan, Daping, Hoft, Daniel F., and Liu, Jianguo
- Subjects
MYCOBACTERIAL diseases ,PROTEIN stability ,MYCOBACTERIUM tuberculosis ,PROTEOLYSIS ,KNOCKOUT mice - Abstract
Immune evasion of Mycobacterium tuberculosis (Mtb) facilitates intracellular bacterial growth. The mechanisms of immune evasion, however, are still not fully understood. In this study, we reveal that tristetraprolin (TTP), one of the best characterized RNA‐binding proteins controlling the stability of targeted mRNAs, mediates innate immune evasion of mycobacteria. We found that TTP knockout mice displayed reduced bacterial burden in the early stage after Mtb aerosol challenge. Macrophages deficient in TTP also showed an inhibition in intracellular mycobacterial growth. Live mycobacteria induced TTP protein expression in macrophages, which was blocked by the mTOR inhibitor rapamycin. Rapamycin and AZD8055 specifically blocked 4EBP1 phosphorylation in infected macrophages and suppressed intracellular BCG growth. Rapamycin promoted TTP protein degradation through the ubiquitination pathway, whereas the proteasome inhibitor MG‐132 blocked rapamycin function and thus stabilized TTP protein. TTP induction suppressed the expression of iNOS/TNF‐α/IL‐12/IL‐23, and weakened protective immune responses in macrophages, whereas rapamycin enhanced the bactericidal effects through TTP inhibition. Moreover, blocking TTP binding increased the expression of TNF‐α and iNOS and suppressed intracellular mycobacterial growth. Overall, our study reveals a novel role for RNA‐binding protein TTP in Mtb immune evasion mechanisms and provides a potential target for host‐directed therapy against tuberculosis (TB). [ABSTRACT FROM AUTHOR]
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- 2024
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8. Efficacy of interferon beta-1a plus remdesivir compared with remdesivir alone in hospitalised adults with COVID-19: a double-blind, randomised, placebo-controlled, phase 3 trial
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Hewlett, Angela, Taylor, Barbara S, Bowling, Jason E, Serrano, Ruth C, Rouphael, Nadine G, Wiley, Zanthia, Phadke, Varun K, Certain, Laura, Imlay, Hannah N, Engemann, John J, Walter, Emmanuel B, Meisner, Jessica, Rajme, Sandra, Billings, Joanne, Kim, Hyun, Martinez-Orozco, Jose A, Bautista Felix, Nora, Elmor, Sammy T, Bristow, Laurel R, Mertz, Gregory, Sosa, Nestor, Bell, Taison D, West, Miranda J, Elie-Turenne, Marie-Carmelle, Grein, Jonathan, Sutterwala, Fayyaz, Gyun Choe, Pyoeng, Kyung Kang, Chang, El Sahly, Hana M, Rhie, Kevin S, Hussein, Rezhan H, Winokur, Patricia L, Mikami, Ayako, Saito, Sho, Benson, Constance A, McConnell, Kimberly, Berhe, Mezgebe, Dishner, Emma, Frank, Maria G, Sarcone, Ellen, Crouch, Pierre-Cedric B, Jang, Hannah, Jilg, Nikolaus, Perez, Katherine, Janak, Charles, Cantos, Valeria D, Rebolledo, Paulina A, Gharbin, John, Zingman, Barry S, Riska, Paul F, Falsey, Ann R, Walsh, Edward E, Branche, Angela R, Arguinchona, Henry, Arguinchona, Christa, Van Winkle, Jason W, Zea, Diego F, Jung, Jongtak, Song, Kyoung-Ho, Kim, Hong Bin, Dwyer, Jay, Bainbridge, Emma, Hostler, David C, Hostler, Jordanna M, Shahan, Brian T, Hsieh, Lanny, Amin, Alpesh N, Watanabe, Miki, Short, William R, Tebas, Pablo, Baron, Jillian T, Ahuja, Neera, Ling, Evelyn, Go, Minjoung, Yang, Otto O, Ahn, Jenny, Arias, Rubi, Rapaka, Rekha R, Hubbard, Fleesie A, Campbell, James D, Cohen, Stuart H, Thompson, George R, 3rd, Chakrabarty, Melony, Taylor, Stephanie N, Masri, Najy, Lacour, Alisha, Lee, Tida, Lalani, Tahaniyat, Lindholm, David A, Markelz, Ana Elizabeth, Mende, Katrin, Colombo, Christopher J, Schofield, Christina, Colombo, Rhonda E, Guirgis, Faheem, Holodniy, Mark, Chary, Aarthi, Bessesen, Mary, Hynes, Noreen A, Sauer, Lauren M, Marconi, Vincent C, Moanna, Abeer, Harrison, Telisha, Lye, David C, Ong, Sean W X, Ying Chia, Po, Huprikar, Nikhil, Ganesan, Anuradha, Madar, Christian, Novak, Richard M, Wendrow, Andrea, Borgetti, Scott A, George, Sarah L, Hoft, Daniel F, Brien, James D, McLellan, Susan L F, Levine, Corri, Nock, Joy, Yen Tan, Seow, Shafi, Humaira, Chien, Jaime M F, Candiotti, Keith, Finberg, Robert W, Wang, Jennifer P, Wessolossky, Mireya, Utz, Gregory C, Chambers, Susan E, Stephens, David S, Burgess, Timothy H, Rozman, Julia, Hyvert, Yann, Seitzinger, Andrea, Osinusi, Anu, Cao, Huyen, Chung, Kevin K, Conrad, Tom M, Cross, Kaitlyn, El-Khorazaty, Jill A, Hill, Heather, Pettibone, Stephanie, Wierzbicki, Michael R, Gettinger, Nikki, Engel, Theresa, Lewis, Teri, Wang, Jing, Deye, Gregory A, Nomicos, Effie, Pikaart-Tautges, Rhonda, Elsafy, Mohamed, Jurao, Robert, Koo, Hyung, Proschan, Michael, Davey, Richard, Yokum, Tammy, Arega, Janice, Florese, Ruth, Kalil, Andre C, Mehta, Aneesh K, Patterson, Thomas F, Erdmann, Nathaniel, Gomez, Carlos A, Jain, Mamta K, Wolfe, Cameron R, Ruiz-Palacios, Guillermo M, Kline, Susan, Regalado Pineda, Justino, Luetkemeyer, Anne F, Harkins, Michelle S, Jackson, Patrick E H, Iovine, Nicole M, Tapson, Victor F, Oh, Myoung-don, Whitaker, Jennifer A, Mularski, Richard A, Paules, Catharine I, Ince, Dilek, Takasaki, Jin, Sweeney, Daniel A, Sandkovsky, Uriel, Wyles, David L, Hohmann, Elizabeth, Grimes, Kevin A, Grossberg, Robert, Laguio-Vila, Maryrose, Lambert, Allison A, Lopez de Castilla, Diego, Kim, EuSuk, Larson, LuAnn, Wan, Claire R, Traenkner, Jessica J, Ponce, Philip O, Patterson, Jan E, Goepfert, Paul A, Sofarelli, Theresa A, Mocherla, Satish, Ko, Emily R, Ponce de Leon, Alfredo, Doernberg, Sarah B, Atmar, Robert L, Maves, Ryan C, Dangond, Fernando, Ferreira, Jennifer, Green, Michelle, Makowski, Mat, Bonnett, Tyler, Beresnev, Tatiana, Ghazaryan, Varduhi, Dempsey, Walla, Nayak, Seema U, Dodd, Lori, Tomashek, Kay M, and Beigel, John H
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- 2021
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9. NK and NKT cells have distinct properties and functions in cancer
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Liu, Xia, Li, Lingyun, Si, Fusheng, Huang, Lan, Zhao, Yangjing, Zhang, Chenchen, Hoft, Daniel F., and Peng, Guangyong
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- 2021
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10. Phase 1 Open-Label Dose Escalation Trial for the Development of a Human Bacillus Calmette-Guérin Challenge Model for Assessment of Tuberculosis Immunity In Vivo
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Blazevic, Azra, primary, Edwards, Rachel L, additional, Xia, Mei, additional, Eickhoff, Christopher S, additional, Hamzabegovic, Fahreta, additional, Meza, Krystal A, additional, Ning, Huan, additional, Tennant, Janice, additional, Mosby, Karla J, additional, Ritchie, James C, additional, Girmay, Tigisty, additional, Lai, Lilin, additional, McCullough, Michele, additional, Beck, Allison, additional, Kelley, Colleen, additional, Edupuganti, Srilatha, additional, Kabbani, Sarah, additional, Buchanan, Wendy, additional, Makhene, Mamodikoe K, additional, Voronca, Delia, additional, Cherikh, Sami, additional, Goll, Johannes B, additional, Rouphael, Nadine G, additional, Mulligan, Mark J, additional, and Hoft, Daniel F, additional
- Published
- 2023
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11. 2395. An Interim Report of the Safety, Reactogenicity, and Immunogenicity of a Self-amplifying mRNA (samRNA) COVID-19 Vaccine GRT-R910 as a Booster in Healthy Adults
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Whitaker, Jennifer, primary, Rebolledo, Paulina, additional, Rouphael, Nadine, additional, Abate, Getahun, additional, Babu, Tara M, additional, Wald, Anna, additional, Sahly, Hana El, additional, Garbes, Pedro, additional, Jooss, Karin, additional, Allen, Andrew, additional, McQuarrie, Lisa, additional, Sitaula, Ranjan, additional, Roberts, Paul C, additional, Makhene, Mamodikoe, additional, Posavad, Christine M, additional, Juliana McElrath, M, additional, De Rosa, Stephen, additional, Coler, Rhea, additional, Montefiori, David, additional, Eaton, Amanda, additional, Koelle, David M, additional, and Hoft, Daniel F, additional
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- 2023
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12. Senescent T cells within suppressive tumor microenvironments: emerging target for tumor immunotherapy
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Liu, Xia, Hoft, Daniel F., and Peng, Guangyong
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Cancer -- Drug therapy ,Immunotherapy ,T cells ,Intelligence gathering ,Tumors ,Health care industry - Abstract
The functional state of the preexisting T cells in the tumor microenvironment is a key determinant for effective antitumor immunity and immunotherapy. Increasing evidence suggests that immunosenescence is an important state of T cell dysfunction that is distinct from exhaustion, a key strategy used by malignant tumors to evade immune surveillance and sustain the suppressive tumor microenvironment. Here, we discuss the phenotypic and functional characteristics of senescent T cells and their role in human cancers. We also explore the possible mechanisms and signaling pathways responsible for induction of T cell senescence by malignant tumors, and then discuss potential strategies to prevent and/or reverse senescence in tumor-specific T cells. A better understanding of these critical issues should provide novel strategies to enhance cancer immunotherapy., Introduction Cell senescence has been well recognized over the past several decades as a biological process with stable cell cycle arrest in diploid cells. This phenomenon was initially described in [...]
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- 2020
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13. TLR8-Mediated Metabolic Control of Human Treg Function: A Mechanistic Target for Cancer Immunotherapy
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Li, Lingyun, Liu, Xia, Sanders, Katherine L., Edwards, James L., Ye, Jian, Si, Fusheng, Gao, Aiqin, Huang, Lan, Hsueh, Eddy C., Ford, David A., Hoft, Daniel F., and Peng, Guangyong
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- 2019
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14. Homodimeric Granzyme A Opsonizes Mycobacterium tuberculosis and Inhibits Its Intracellular Growth in Human Monocytes via Toll-Like Receptor 4 and CD14.
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Rasi, Valerio, Phelps, Kathleen R, Paulson, Keegan R, Eickhoff, Christopher S, Chinnaraj, Mathivanan, Pozzi, Nicola, Gioia, Marco Di, Zanoni, Ivan, Shakya, Shubha, Carlson, Haley L, Ford, David A, Kolar, Grant R, and Hoft, Daniel F
- Abstract
Mycobacterium tuberculosis (Mtb)-specific γ9δ2 T cells secrete granzyme A (GzmA) protective against intracellular Mtb growth. However, GzmA-enzymatic activity is unnecessary for pathogen inhibition, and the mechanisms of GzmA-mediated protection remain unknown. We show that GzmA homodimerization is essential for opsonization of mycobacteria, altered uptake into human monocytes, and subsequent pathogen clearance within the phagolysosome. Although monomeric and homodimeric GzmA bind mycobacteria, only homodimers also bind cluster of differentiation 14 (CD14) and Toll-like receptor 4 (TLR4). Without access to surface-expressed CD14 and TLR4, GzmA fails to inhibit intracellular Mtb. Upregulation of Rab11FIP1 was associated with inhibitory activity. Furthermore, GzmA colocalized with and was regulated by protein disulfide isomerase AI (PDIA1), which cleaves GzmA homodimers into monomers and prevents Mtb inhibitory activity. These studies identify a previously unrecognized role for homodimeric GzmA structure in opsonization, phagocytosis, and elimination of Mtb in human monocytes, and they highlight PDIA1 as a potential host-directed therapy for prevention and treatment of tuberculosis, a major human disease. [ABSTRACT FROM AUTHOR]
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- 2024
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15. Safety and Immunogenicity of a Delayed Heterologous Avian Influenza A(H7N9) Vaccine Boost Following Different Priming Regimens: A Randomized Clinical Trial.
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Sahly, Hana M El, Yildirim, Inci, Frey, Sharon E, Winokur, Patricia, Jackson, Lisa A, Bernstein, David I, Creech, C Buddy, Chen, Wilbur H, Rupp, Richard E, Whitaker, Jennifer A, Phadke, Varun, Hoft, Daniel F, Ince, Dilek, Brady, Rebecca C, Edwards, Kathryn M, Ortiz, Justin R, Berman, Megan A, Weiss, Julia, Wegel, Ashley, and Group, DMID 17-0090 Study
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AVIAN influenza ,CLINICAL trials ,IMMUNE response ,CLINICAL trial registries ,ANTIBODY titer - Abstract
Background Influenza A (H7N9) has caused multiple disease waves with evidence of strain diversification. Optimal influenza A (H7N9) prime-boost vaccine strategies are unknown. Methods We recruited participants who had received monovalent inactivated A/Shanghai/2/2013 (H7N9) vaccine (MIV) approximately 5 years earlier, as follows: MIV with MF59 (MF59 × 2 group), MIV with AS03 (AS03 × 2 group), unadjuvanted MIV (No Adj group), MIV with MF59 or AS03 followed by unadjuvanted MIV (Adjx1 group), and A/H7-naive (unprimed group). Participants were randomized to receive 1 dose of AS03-adjuvanted or unadjuvanted A/Hong Kong/125/2017 (H7N9) MIV and were followed for safety and immunogenicity using hemagglutination inhibition (HAI) and neutralizing antibody assays. Results We enrolled 304 participants: 153 received the adjuvanted boost and 151 received the unadjuvanted boost. At 21 days postvaccination, the proportion of participants with HAI antibody titers against the boosting vaccine strain of ≥40 in the adjuvanted and unadjuvanted arms, respectively, were 88% and 49% in MF59 × 2 group, 89% and 75% in AS03 × 2 group, 59% and 20% in No Adj group, 94% and 55% in Adjx1group, and 9% and 11% in unprimed group. Conclusions Serologic responses to a heterologous A(H7N9) MIV boost were highest in participants primed and boosted with adjuvant-containing regimens. Clinical Trials Registration NCT03738241. [ABSTRACT FROM AUTHOR]
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- 2024
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16. Homodimeric Granzyme A Opsonizes Mycobacterium tuberculosis and Inhibits Its Intracellular Growth in Human Monocytes via Toll-Like Receptor 4 and CD14
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Rasi, Valerio, primary, Phelps, Kathleen R, additional, Paulson, Keegan R, additional, Eickhoff, Christopher S, additional, Chinnaraj, Mathivanan, additional, Pozzi, Nicola, additional, Di Gioia, Marco, additional, Zanoni, Ivan, additional, Shakya, Shubha, additional, Carlson, Haley L, additional, Ford, David A, additional, Kolar, Grant R, additional, and Hoft, Daniel F, additional
- Published
- 2023
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17. Identification of immunodominant T cell epitopes induced by natural Zika virus infection
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Eickhoff, Christopher S., primary, Meza, Krystal A., additional, Terry, Frances E., additional, Colbert, Chase G., additional, Blazevic, Azra, additional, Gutiérrez, Andres H., additional, Stone, E. Taylor, additional, Brien, James D., additional, Pinto, Amelia K., additional, El Sahly, Hana M., additional, Mulligan, Mark J., additional, Rouphael, Nadine, additional, Alcaide, Maria L., additional, Tomashek, Kay M., additional, Focht, Chris, additional, Martin, William D., additional, Moise, Leonard, additional, De Groot, Anne S., additional, and Hoft, Daniel F., additional
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- 2023
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18. Reversed isoniazids: Design, synthesis and evaluation against Mycobacterium tuberculosis
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Kumar, Malkeet, Singh, Kawaljit, Ngwane, Andile H., Hamzabegovic, Fahreta, Abate, Getahun, Baker, Bienyameen, Wiid, Ian, Hoft, Daniel F., Ruminski, Peter, and Chibale, Kelly
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- 2018
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19. Preliminary aggregate safety and immunogenicity results from three trials of a purified inactivated Zika virus vaccine candidate: phase 1, randomised, double-blind, placebo-controlled clinical trials
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Modjarrad, Kayvon, Lin, Leyi, George, Sarah L, Stephenson, Kathryn E, Eckels, Kenneth H, De La Barrera, Rafael A, Jarman, Richard G, Sondergaard, Erica, Tennant, Janice, Ansel, Jessica L, Mills, Kristin, Koren, Michael, Robb, Merlin L, Barrett, Jill, Thompson, Jason, Kosel, Alison E, Dawson, Peter, Hale, Andrew, Tan, C Sabrina, Walsh, Stephen R, Meyer, Keith E, Brien, James, Crowell, Trevor A, Blazevic, Azra, Mosby, Karla, Larocca, Rafael A, Abbink, Peter, Boyd, Michael, Bricault, Christine A, Seaman, Michael S, Basil, Anne, Walsh, Melissa, Tonwe, Veronica, Hoft, Daniel F, Thomas, Stephen J, Barouch, Dan H, and Michael, Nelson L
- Published
- 2018
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20. Interleukin-17A Promotes Parietal Cell Atrophy by Inducing Apoptosis
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Bockerstett, Kevin A., Osaki, Luciana H., Petersen, Christine P., Cai, Catherine W., Wong, Chun Fung, Nguyen, Thanh-Long M., Ford, Eric L., Hoft, Daniel F., Mills, Jason C., Goldenring, James R., and DiPaolo, Richard J.
- Published
- 2018
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21. Priming Vaccination With Influenza Virus H5 Hemagglutinin Antigen Significantly Increases the Duration of T cell Responses Induced by a Heterologous H5 Booster Vaccination
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Hoft, Daniel F., Lottenbach, Kathleen, Goll, Johannes B., Hill, Heather, Winokur, Patricia L., Patel, Shital M., Brady, Rebecca C., Chen, Wilbur H., Edwards, Kathryn, Creech, C. Buddy, Frey, Sharon E., Blevins, Tamara P., Salomon, Rachelle, and Belshe, Robert B.
- Published
- 2016
22. A New Recombinant Bacille Calmette-Guérin Vaccine Safely Induces Significantly Enhanced Tuberculosis-Specific Immunity in Human Volunteers
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Hoft, Daniel F, Blazevic, Azra, Abate, Getahun, Hanekom, Willem A, Kaplan, Gilla, Soler, Jorge H, Weichold, Frank, Geiter, Larry, Sadoff, Jerald C, and Horwitz, Marcus A
- Subjects
HIV/AIDS ,Infectious Diseases ,Immunization ,Tuberculosis ,Tuberculosis Vaccine ,Orphan Drug ,Rare Diseases ,Vaccine Related ,Prevention ,3.4 Vaccines ,Prevention of disease and conditions ,and promotion of well-being ,Infection ,Inflammatory and immune system ,Good Health and Well Being ,Adult ,Antibodies ,Bacterial ,Antigens ,Bacterial ,BCG Vaccine ,Epitopes ,T-Lymphocyte ,Female ,Humans ,Interferon-gamma ,Male ,Mycobacterium tuberculosis ,Recombinant Fusion Proteins ,T-Lymphocytes ,Vaccines ,Synthetic ,Young Adult ,Biological Sciences ,Medical and Health Sciences ,Microbiology - Abstract
BackgroundOne strategy for improving anti-tuberculosis (TB) vaccination involves the use of recombinant bacille Calmette-Guérin (rBCG) overexpressing protective TB antigens. rBCG30, which overexpresses the Mycobacterium tuberculosis secreted antigen Ag85b, was the first rBCG shown to induce significantly greater protection against TB in animals than parental BCG.MethodsWe report here the first double-blind phase 1 trial of rBCG30 in 35 adults randomized to receive either rBCG30 or parental Tice BCG intradermally. Clinical reactogenicity was assessed, and state-of-the-art immunological assays were used to study Ag85b-specific immune responses induced by both vaccines.ResultsSimilar clinical reactogenicity occurred with both vaccines. rBCG30 induced significantly increased Ag85b-specific T cell lymphoproliferation, interferon (IFN)-gamma secretion, IFN-gamma enzyme-linked immunospot responses, and direct ex vivo intracellular IFN-gamma responses. Additional flow cytometry studies measuring carboxyfluorescein succinimidyl ester dilution and intracellular cytokine production demonstrated that rBCG30 significantly enhanced the population of Ag85b-specific CD4(+) and CD8(+) T cells capable of concurrent expansion and effector function. More importantly, rBCG30 significantly increased the number of Ag85b-specific T cells capable of inhibiting intracellular mycobacteria.ConclusionsThese results provide proof of principal that rBCG can safely enhance human TB immunity and support further development of rBCG overexpressing Ag85b for TB vaccination.
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- 2008
23. Pilot studies of a human BCG challenge model
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Blazevic, Azra, Xia, Mei, Turan, Aldin, Tennant, Janice, and Hoft, Daniel F.
- Published
- 2017
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24. Mucosal Bacille Calmette-Guérin Vaccination of Humans Inhibits Delayed-Type Hypersensitivity to Purified Protein Derivative but Induces Mycobacteria-Specific Interferon-γ Responses
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Hoft, Daniel F., Brown, Robin M., and Belshe, Robert B.
- Published
- 2000
25. In vitro Measurement of Protective Mycobacterial Immunity: Antigen-Specific Expansion of T Cells Capable of Inhibiting Intracellular Growth of Bacille Calmette-Guérin
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Hoft, Daniel F.
- Published
- 2000
26. Clinical Reactogenicity of Intradermal Bacille Calmette-Guérin Vaccination
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Hoft, Daniel F. and Kemp, Brian
- Published
- 1999
27. Data from MCPIP1 Selectively Destabilizes Transcripts Associated with an Antiapoptotic Gene Expression Program in Breast Cancer Cells That Can Elicit Complete Tumor Regression
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Lu, Wenbao, primary, Ning, Huan, primary, Gu, Ling, primary, Peng, Hui, primary, Wang, Qinghong, primary, Hou, Rong, primary, Fu, Mingui, primary, Hoft, Daniel F., primary, and Liu, Jianguo, primary
- Published
- 2023
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28. Data from Specific Recruitment of γδ Regulatory T Cells in Human Breast Cancer
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Ye, Jian, primary, Ma, Chunling, primary, Wang, Fang, primary, Hsueh, Eddy C., primary, Toth, Karoly, primary, Huang, Yi, primary, Mo, Wei, primary, Liu, Shuai, primary, Han, Bing, primary, Varvares, Mark A., primary, Hoft, Daniel F., primary, and Peng, Guangyong, primary
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- 2023
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29. Supplementary Figure 2 from Specific Recruitment of γδ Regulatory T Cells in Human Breast Cancer
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Ye, Jian, primary, Ma, Chunling, primary, Wang, Fang, primary, Hsueh, Eddy C., primary, Toth, Karoly, primary, Huang, Yi, primary, Mo, Wei, primary, Liu, Shuai, primary, Han, Bing, primary, Varvares, Mark A., primary, Hoft, Daniel F., primary, and Peng, Guangyong, primary
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- 2023
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30. Supplementary Data from MCPIP1 Selectively Destabilizes Transcripts Associated with an Antiapoptotic Gene Expression Program in Breast Cancer Cells That Can Elicit Complete Tumor Regression
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Lu, Wenbao, primary, Ning, Huan, primary, Gu, Ling, primary, Peng, Hui, primary, Wang, Qinghong, primary, Hou, Rong, primary, Fu, Mingui, primary, Hoft, Daniel F., primary, and Liu, Jianguo, primary
- Published
- 2023
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31. Supplementary Figure 1 from Specific Recruitment of γδ Regulatory T Cells in Human Breast Cancer
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Ye, Jian, primary, Ma, Chunling, primary, Wang, Fang, primary, Hsueh, Eddy C., primary, Toth, Karoly, primary, Huang, Yi, primary, Mo, Wei, primary, Liu, Shuai, primary, Han, Bing, primary, Varvares, Mark A., primary, Hoft, Daniel F., primary, and Peng, Guangyong, primary
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- 2023
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32. Supplementary Figure 3 from Specific Recruitment of γδ Regulatory T Cells in Human Breast Cancer
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Ye, Jian, primary, Ma, Chunling, primary, Wang, Fang, primary, Hsueh, Eddy C., primary, Toth, Karoly, primary, Huang, Yi, primary, Mo, Wei, primary, Liu, Shuai, primary, Han, Bing, primary, Varvares, Mark A., primary, Hoft, Daniel F., primary, and Peng, Guangyong, primary
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- 2023
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33. Supplementary Materials and Methods and Figure Legends from Specific Recruitment of γδ Regulatory T Cells in Human Breast Cancer
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Ye, Jian, primary, Ma, Chunling, primary, Wang, Fang, primary, Hsueh, Eddy C., primary, Toth, Karoly, primary, Huang, Yi, primary, Mo, Wei, primary, Liu, Shuai, primary, Han, Bing, primary, Varvares, Mark A., primary, Hoft, Daniel F., primary, and Peng, Guangyong, primary
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- 2023
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34. Impact of BCG vaccination on the repertoire of human γδ T cell receptors
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Xia, Mei, primary, Blazevic, Azra, additional, Fiore-Gartland, Andrew, additional, and Hoft, Daniel F., additional
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- 2023
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35. Imprinting of Gut-Homing Receptors on Mtb-Specific Th1* Cells Is Associated with Reduced Lung Homing after Gavage BCG Vaccination of Rhesus Macaques
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Hoft, Stella G., primary, Kauffman, Keith D., additional, Sakai, Shunsuke, additional, Lindestam Arlehamn, Cecilia S., additional, Sette, Alessandro, additional, Hoft, Daniel F., additional, Herbert, Richard, additional, and Barber, Daniel L., additional
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- 2023
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36. Corrigendum: The Vacc-SeqQC project: Benchmarking RNA-Seq for clinical vaccine studies
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Goll, Johannes B., primary, Bosinger, Steven E., additional, Jensen, Travis L., additional, Walum, Hasse, additional, Grimes, Tyler, additional, Tharp, Gregory K., additional, Natrajan, Muktha S., additional, Blazevic, Azra, additional, Head, Richard D., additional, Gelber, Casey E., additional, Steenbergen, Kristen J., additional, Patel, Nirav B., additional, Sanz, Patrick, additional, Rouphael, Nadine G., additional, Anderson, Evan J., additional, Mulligan, Mark J., additional, and Hoft, Daniel F., additional
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- 2023
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37. A Multicenter, Controlled Human Infection Study of Influenza A(H1N1)pdm09 in Healthy Adults
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Ortiz, Justin R, primary, Bernstein, David I, additional, Hoft, Daniel F, additional, Woods, Christopher W, additional, McClain, Micah T, additional, Frey, Sharon E, additional, Brady, Rebecca C, additional, Bryant, Christopher, additional, Wegel, Ashley, additional, Frenck, Robert W, additional, Walter, Emmanuel B, additional, Abate, Getahun, additional, Williams, Sarah R, additional, Atmar, Robert L, additional, Keitel, Wendy A, additional, Rouphael, Nadine, additional, Memoli, Mathew J, additional, Makhene, Mamodikoe K, additional, Roberts, Paul C, additional, and Neuzil, Kathleen M, additional
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- 2023
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38. The Vacc-SeqQC project: Benchmarking RNA-Seq for clinical vaccine studies
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Goll, Johannes B., primary, Bosinger, Steven E., additional, Jensen, Travis L., additional, Walum, Hasse, additional, Grimes, Tyler, additional, Tharp, Gregory K., additional, Natrajan, Muktha S., additional, Blazevic, Azra, additional, Head, Richard D., additional, Gelber, Casey E., additional, Steenbergen, Kristen J., additional, Patel, Nirav B., additional, Sanz, Patrick, additional, Rouphael, Nadine G., additional, Anderson, Evan J., additional, Mulligan, Mark J., additional, and Hoft, Daniel F., additional
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- 2023
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39. Use of Leishmania major parasites expressing a recombinant Trypanosoma cruzi antigen as live vaccines against Chagas disease
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Cai, Catherine W., primary, O’Shea, Anne, additional, Eickhoff, Christopher S., additional, Guo, Hongjie, additional, Lewis, Warren G., additional, Beverley, Stephen M., additional, and Hoft, Daniel F., additional
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- 2022
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40. A Multi-Center, Controlled Human Infection Study of Influenza A (H1N1)pdm09 in Healthy Adults
- Author
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Ortiz, Justin R., primary, Bernstein, David I., additional, Hoft, Daniel F., additional, Woods, Christopher W., additional, McClain, Micah T., additional, Frey, Sharon E., additional, Brady, Rebecca C., additional, Bryant, Christopher, additional, Wegel, Ashley, additional, Frenck, Robert W, additional, Walter, Emmanuel B., additional, Abate, Getahun, additional, Williams, Sarah R., additional, Atmar, Robert L., additional, Keitel, Wendy A., additional, Rouphael, Nadine, additional, Memoli, Mathew J., additional, Makhene, Mamodikoe K., additional, Roberts, Paul C., additional, and Neuzil, Kathleen M., additional
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- 2022
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41. Baricitinib versus dexamethasone for adults hospitalised with COVID-19 (ACTT-4): a randomised, double-blind, double placebo-controlled trial
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Wolfe, Cameron R, primary, Tomashek, Kay M, additional, Patterson, Thomas F, additional, Gomez, Carlos A, additional, Marconi, Vincent C, additional, Jain, Mamta K, additional, Yang, Otto O, additional, Paules, Catharine I, additional, Palacios, Guillermo M Ruiz, additional, Grossberg, Robert, additional, Harkins, Michelle S, additional, Mularski, Richard A, additional, Erdmann, Nathaniel, additional, Sandkovsky, Uriel, additional, Almasri, Eyad, additional, Pineda, Justino Regalado, additional, Dretler, Alexandra W, additional, de Castilla, Diego Lopez, additional, Branche, Angela R, additional, Park, Pauline K, additional, Mehta, Aneesh K, additional, Short, William R, additional, McLellan, Susan L F, additional, Kline, Susan, additional, Iovine, Nicole M, additional, El Sahly, Hana M, additional, Doernberg, Sarah B, additional, Oh, Myoung-don, additional, Huprikar, Nikhil, additional, Hohmann, Elizabeth, additional, Kelley, Colleen F, additional, Holodniy, Mark, additional, Kim, Eu Suk, additional, Sweeney, Daniel A, additional, Finberg, Robert W, additional, Grimes, Kevin A, additional, Maves, Ryan C, additional, Ko, Emily R, additional, Engemann, John J, additional, Taylor, Barbara S, additional, Ponce, Philip O, additional, Larson, LuAnn, additional, Melendez, Dante Paolo, additional, Seibert, Allan M, additional, Rouphael, Nadine G, additional, Strebe, Joslyn, additional, Clark, Jesse L, additional, Julian, Kathleen G, additional, de Leon, Alfredo Ponce, additional, Cardoso, Anabela, additional, de Bono, Stephanie, additional, Atmar, Robert L, additional, Ganesan, Anuradha, additional, Ferreira, Jennifer L, additional, Green, Michelle, additional, Makowski, Mat, additional, Bonnett, Tyler, additional, Beresnev, Tatiana, additional, Ghazaryan, Varduhi, additional, Dempsey, Walla, additional, Nayak, Seema U, additional, Dodd, Lori E, additional, Beigel, John H, additional, Kalil, Andre C, additional, Wahid, Lana, additional, Walter, Emmanuel B., additional, Belur, Akhila G., additional, Dreyer, Grace, additional, Patterson, Jan E., additional, Bowling, Jason E., additional, Dixon, Danielle O., additional, Hewlett, Angela, additional, Odrobina, Robert, additional, Pupaibool, Jakrapun, additional, Mocherla, Satish, additional, Lazarte, Suzana, additional, Cayabyab, Meilani, additional, Hussein, Rezhan H., additional, Golamari, Reshma R., additional, Krill, Kaleigh L., additional, Rajme, Sandra, additional, Riska, Paul F., additional, Zingman, Barry S., additional, Mertz, Gregory, additional, Sosa, Nestor, additional, Goepfert, Paul A., additional, Berhe, Mezgebe, additional, Dishner, Emma, additional, Fayed, Mohamed, additional, Hubel, Kinsley, additional, Martinez-Orozco, José Arturo, additional, Bautista Felix, Nora, additional, Elmor, Sammy T., additional, Bechnak, Amer Ryan, additional, Saklawi, Youssef, additional, Van Winkle, Jason W., additional, Zea, Diego F., additional, Laguio-Vila, Maryrose, additional, Walsh, Edward E., additional, Falsey, Ann R., additional, Carvajal, Karen, additional, Hyzy, Robert C., additional, Hanna, Sinan, additional, Olbrich, Norman, additional, Traenkner, Jessica J., additional, Kraft, Colleen S., additional, Tebas, Pablo, additional, Baron, Jillian T, additional, Levine, Corri, additional, Nock, Joy, additional, Billings, Joanne, additional, Kim, Hyun, additional, Elie-Turenne, Marie-Carmelle, additional, Whitaker, Jennifer A., additional, Luetkemeyer, Anne F., additional, Dwyer, Jay, additional, Bainbridge, Emma, additional, Gyun Choe, Pyoeng, additional, Kyung Kang, Chang, additional, Jilg, Nikolaus, additional, Cantos, Valeria D, additional, Bhamidipati, Divya R., additional, Nithin Gopalsamy, Srinivasa, additional, Chary, Aarthi, additional, Jung, Jongtak, additional, Song, Kyoung-Ho, additional, Kim, Hong Bin, additional, Benson, Constance A., additional, McConnell, Kimberly, additional, Wang, Jennifer P., additional, Wessolossky, Mireya, additional, Perez, Katherine, additional, Eubank, Taryn A, additional, Berjohn, Catherine, additional, Utz, Gregory C., additional, Jackson, Patrick E.H., additional, Bell, Taison D., additional, Haughey, Heather M., additional, Moanna, Abeer, additional, Cribbs, Sushma, additional, Harrison, Telisha, additional, Colombo, Christopher J., additional, Schofield, Christina, additional, Colombo, Rhonda E., additional, Tapson, Victor F., additional, Grein, Jonathan, additional, Sutterwala, Fayyaz, additional, Ince, Dilek, additional, Winokur, Patricia L., additional, Fung, Monica, additional, Jang, Hannah, additional, Wyles, David, additional, Frank, Maria G., additional, Sarcone, Ellen, additional, Neumann, Henry, additional, Viswanathan, Anand, additional, Hochman, Sarah, additional, Mulligan, Mark, additional, Eckhardt, Benjamin, additional, Carmody, Ellie, additional, Ahuja, Neera, additional, Nadeau, Kari, additional, Svec, David, additional, Macaraeg, Jeffrey C., additional, Morrow, Lee, additional, Quimby, Dave, additional, Bessesen, Mary, additional, Nicholson, Lindsay, additional, Adams, Jill, additional, Kumar, Princy, additional, Lambert, Allison A., additional, Arguinchona, Henry, additional, Alicic, Radica Z., additional, Saito, Sho, additional, Ohmagari, Norio, additional, Mikami, Ayako, additional, Chien Lye, David, additional, Hong Lee, Tau, additional, Ying Chia, Po, additional, Hsieh, Lanny, additional, Amin, Alpesh N., additional, Watanabe, Miki, additional, Candiotti, Keith A., additional, Castro, Jose G., additional, Antor, Maria A., additional, Lee, Tida, additional, Lalani, Tahaniyat, additional, Novak, Richard M., additional, Wendrow, Andrea, additional, Borgetti, Scott A., additional, George, Sarah L., additional, Hoft, Daniel F., additional, Brien, James D., additional, Cohen, Stuart H., additional, Thompson, George R., additional, Chakrabarty, Melony, additional, Guirgis, Faheem, additional, Davey, Richard T., additional, Voell, Jocelyn, additional, Strich, Jeffrey R., additional, Lindholm, David A., additional, Mende, Katrin, additional, Wellington, Trevor R., additional, Rapaka, Rekha R., additional, Husson, Jennifer S., additional, Levine, Andrea R., additional, Yen Tan, Seow, additional, Shafi, Humaira, additional, Chien, Jaime M F, additional, Hostler, David C., additional, Hostler, Jordanna M., additional, Shahan, Brian T., additional, Adams, David H., additional, Osinusi, Anu, additional, Cao, Huyen, additional, Burgess, Timothy H., additional, Rozman, Julia, additional, Chung, Kevin K., additional, Nieuwoudt, Christina, additional, El-Khorazaty, Jill A., additional, Hill, Heather, additional, Pettibone, Stephanie, additional, Gettinger, Nikki, additional, Engel, Theresa, additional, Lewis, Teri, additional, Wang, Jing, additional, Deye, Gregory A., additional, Nomicos, Effie, additional, Pikaart-Tautges, Rhonda, additional, Elsafy, Mohamed, additional, Jurao, Robert, additional, Koo, Hyung, additional, Proschan, Michael, additional, Yokum, Tammy, additional, Arega, Janice, additional, and Florese, Ruth, additional
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- 2022
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42. Safety and reactogenicity of BCG revaccination with isoniazid pretreatment in TST positive adults
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Hatherill, Mark, Geldenhuys, Hendrik, Pienaar, Bernadette, Suliman, Sara, Chheng, Phalkun, Debanne, Sara M., Hoft, Daniel F., Boom, W. Henry, Hanekom, Willem A., and Johnson, John L.
- Published
- 2014
- Full Text
- View/download PDF
43. The Vacc-SeqQC Project: Benchmarking RNA-Seq for Clinical Vaccine Studies
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Goll, Johannes B., primary, Bosinger, Steven E., additional, Jensen, Travis L., additional, Walum, Hasse, additional, Grimes, Tyler, additional, Tharp, Gregory D., additional, Natrajan, Muktha S, additional, Blazevic, Azra, additional, Heada, Rich, additional, Gelber, Casey E., additional, Patel, Nirav B., additional, Sanz, Patrick, additional, Rouphael, Nadine G., additional, Anderson, Evan J., additional, Mulligan, Mark J., additional, and Hoft, Daniel F., additional
- Published
- 2022
- Full Text
- View/download PDF
44. Plasmalogen Loss in Sepsis and SARS-CoV-2 Infection
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Pike, Daniel P., primary, McGuffee, Reagan M., additional, Geerling, Elizabeth, additional, Albert, Carolyn J., additional, Hoft, Daniel F., additional, Shashaty, Michael G. S., additional, Meyer, Nuala J., additional, Pinto, Amelia K., additional, and Ford, David A., additional
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- 2022
- Full Text
- View/download PDF
45. In response to: JVAC-D-21-02863, detection of a potential error in the results of the manuscript, dementia risk following influenza vaccination in a large veteran cohort, that could call into question the main conclusion
- Author
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Wiemken, Timothy L, primary, Salas, Joanne, additional, Hoft, Daniel F., additional, Jacobs, Christine, additional, Morley, John E., additional, and Scherrer, Jeffrey F., additional
- Published
- 2022
- Full Text
- View/download PDF
46. The fate and function of NK cells in the suppressive tumor microenvironment
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Liu, Xia, primary, Ma, Feiya, additional, Zhang, Yuanqin, additional, Tao, Yan, additional, Hoft, Daniel F, additional, and Peng, Guangyong, additional
- Published
- 2022
- Full Text
- View/download PDF
47. Impact of BCG vaccination on the repertoire of human γδ T cell receptors.
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Mei Xia, Blazevic, Azra, Fiore-Gartland, Andrew, and Hoft, Daniel F.
- Subjects
BCG vaccines ,T cell receptors ,MUCOUS membranes ,MYCOBACTERIAL diseases ,T cells - Abstract
Introduction: Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) infection is a serious threat to human health. Vaccination with BCG prevents the development of the most severe forms of TB disease in infants and was recently shown to prevent Mtb infection in previously uninfected adolescents. γδ T cells play a major role in host defense at mucosal sites and are known to respond robustly to mycobacterial infection. However, our understanding of the effects of BCG vaccination on γδ T cell responses is incomplete.. Methods: In this study we performed γδ T cell receptor (TCR) repertoire sequencing of samples provided pre- and post-BCG vaccination from 10 individuals to identify specific receptors and TCR clones that are induced by BCG.. Results: Overall, there was no change in the diversity of γTCR or δTCR clonotypes in post- vs pre-BCG samples. Furthermore, the frequencies of TCR variable and joining region genes were minimally modulated by BCG vaccination at either the γTCR or δTCR loci. However, the γTCR and δTCR repertoires of individuals were highly dynamic; a median of ~1% of γTCR and ~6% of δTCR in the repertoire were found to significantly expand or contract in post- vs pre-BCG comparisons (FDR-q < 0.05). While many of the clonotypes whose frequency changed after BCG vaccination were not shared among multiple individuals in the cohort, several shared (i.e., "public") clonotypes were identified with a consistent increase or decrease in frequency across more than one individual; the degree of sharing of these clonotypes was significantly greater than the minimal sharing that would be expected among γTCR and δTCR repertoires. An in vitro analysis of Mtb antigen-reactive γδ T cells identified clonotypes that were similar or identical to the single-chain γTCRs and δTCRs that changed consistently after BCG vaccination; pairings of γTCRs and δTCRs that increased after BCG vaccination were significantly over-represented among the Mtb-reactive γδ T cells (p = 1.2e-6).. Discussion: These findings generate hypotheses about specific γδTCR clonotypes that may expand in response to BCG vaccination and may recognize Mtb antigens. Future studies are required to validate and characterize these clonotypes, with an aim to better understand the role of γδ T cells in Mtb immunity. [ABSTRACT FROM AUTHOR]
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- 2023
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48. Human regulatory T cells induce T-lymphocyte senescence
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Ye, Jian, Huang, Xingxu, Hsueh, Eddy C., Zhang, Qunyuan, Ma, Chunling, Zhang, Yanping, Varvares, Mark A., Hoft, Daniel F., and Peng, Guangyong
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- 2012
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49. Improved Purification of Human Granzyme A/B and Granulysin Using a Mammalian Expression System
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Rasi, Valerio, primary, Hameed, Owais Abdul, additional, Matthey, Patricia, additional, Bera, Sibes, additional, Grandgenett, Duane P., additional, Salentinig, Stefan, additional, Walch, Michael, additional, and Hoft, Daniel F., additional
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- 2022
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50. Effects of BCG vaccination on donor unrestricted T cells in two prospective cohort studies
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Gela, Anele, primary, Murphy, Melissa, additional, Rodo, Miguel, additional, Hadley, Kate, additional, Hanekom, Willem A., additional, Boom, W.Henry, additional, Johnson, John L., additional, Hoft, Daniel F., additional, Joosten, Simone A., additional, Ottenhoff, Tom H.M., additional, Suliman, Sara, additional, Moody, D.Branch, additional, Lewinsohn, David M., additional, Hatherill, Mark, additional, Seshadri, Chetan, additional, Nemes, Elisa, additional, Scriba, Thomas J., additional, Briel, Libby, additional, Veldtsman, Hellen, additional, Khomba, Nondumiso, additional, Pienaar, Bernadette, additional, Africa, Hadn, additional, and Steyn, Marcia, additional
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- 2022
- Full Text
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