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28 results on '"Hoiseth, Susan K."'

1. Sequence Diversity of the Factor H Binding Protein Vaccine Candidate in Epidemiologically Relevant Strains of Serogroup B Neisseria meningitidis

Author

Murphy, Ellen, Andrew, Lubomira, Lee, Kwok-Leung, Dilts, Deborah A., Nunez, Lorna, Fink, Pamela S., Ambrose, Karita, Borrow, Ray, Findlow, Jamie, Taha, Muhamed-Kheir, Deghmane, Ala-Eddine, Kriz, Paula, Musilek, Martin, Kalmusova, Jitka, Caugant, Dominique A., Alvestad, Torill, Mayer, Leonard W., Sacchi, Claudio T., Wang, Xin, Martin, Diana, von Gottberg, Anne, du Plessis, Mignon, Klugman, Keith P., Anderson, Annaliesa S., Jansen, Kathrin U., Zlotnick, Gary W., and Hoiseth, Susan K.

Published
2009
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2. The Genus Haemophilus

Author

Hoiseth, Susan K., Balows, Albert, editor, Trüper, Hans G., editor, Dworkin, Martin, editor, Harder, Wim, editor, and Schleifer, Karl-Heinz, editor

Published
1992
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10. A Multi-country Evaluation of Neisseria meningitidis Serogroup B Factor H–Binding Proteins and Implications for Vaccine Coverage in Different Age Groups

Author

Hoiseth, Susan K., primary, Murphy, Ellen, additional, Andrew, Lubomira, additional, Vogel, Ulrich, additional, Frosch, Matthias, additional, Hellenbrand, Wiebke, additional, Abad, Raquel, additional, Vazquez, Julio A., additional, Borrow, Ray, additional, Findlow, Jamie, additional, Taha, Muhamed-Kheir, additional, Deghmane, Ala-Eddine, additional, Caugant, Dominique A., additional, Kriz, Paula, additional, Musilek, Martin, additional, Mayer, Leonard W., additional, Wang, Xin, additional, MacNeil, Jessica R., additional, York, Laura, additional, Tan, Charles Y., additional, Jansen, Kathrin U., additional, and Anderson, Annaliesa S., additional

Published
2013
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12. Prevalence and genetic diversity of candidate vaccine antigens among invasive Neisseria meningitidis isolates in the United States

Author

Wang, Xin, primary, Cohn, Amanda, additional, Comanducci, Maurizio, additional, Andrew, Lubomira, additional, Zhao, Xin, additional, MacNeil, Jessica R., additional, Schmink, Susanna, additional, Muzzi, Alessandro, additional, Bambini, Stefania, additional, Rappuoli, Rino, additional, Pizza, Mariagrazia, additional, Murphy, Ellen, additional, Hoiseth, Susan K., additional, Jansen, Kathrin U., additional, Anderson, Annaliesa S., additional, Harrison, Lee H., additional, Clark, Thomas A., additional, Messonnier, Nancy E., additional, and Mayer, Leonard W., additional

Published
2011
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15. Human antibody responses to the meningococcal factor H binding protein (LP2086) during invasive disease, colonization and carriage

Author

Ala’Aldeen, Dlawer A.A., primary, Flint, Mike, additional, Oldfield, Neil J., additional, Omer, Sherko A., additional, McNeil, Lisa K., additional, Jiang, Qin, additional, Murphy, Ellen, additional, Giardina, Peter C., additional, Novikova, Elena G., additional, Dodge-Scully, Ingrid L., additional, Bayliss, Christopher D., additional, Turner, David P.J., additional, Neal, Keith R., additional, Hoiseth, Susan K., additional, Jansen, Kathrin U., additional, and Anderson, Annaliesa S., additional

Published
2010
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16. Broad vaccine coverage predicted for a bivalent recombinant factor H binding protein based vaccine to prevent serogroup B meningococcal disease

Author

Jiang, Han-Qing, primary, Hoiseth, Susan K., additional, Harris, Shannon L., additional, McNeil, Lisa K., additional, Zhu, Duzhang, additional, Tan, Cuiwen, additional, Scott, Adrienne A., additional, Alexander, Kristin, additional, Mason, Kathryn, additional, Miller, Lynn, additional, DaSilva, Ida, additional, Mack, Michelle, additional, Zhao, Xiao-Juan, additional, Pride, Michael W., additional, Andrew, Lubomira, additional, Murphy, Ellen, additional, Hagen, Michael, additional, French, Roger, additional, Arora, Ashoni, additional, Jones, Thomas R., additional, Jansen, Kathrin U., additional, Zlotnick, Gary W., additional, and Anderson, Annaliesa S., additional

Published
2010
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17. NMR dynamics and antibody recognition of the meningococcal lipidated outer membrane protein LP2086 in micellar solution

Author

Mascioni, Alessandro, primary, Moy, Franklin J., additional, McNeil, Lisa K., additional, Murphy, Ellen, additional, Bentley, Breagh E., additional, Camarda, Rosaria, additional, Dilts, Deborah A., additional, Fink, Pamela S., additional, Gusarova, Viktoria, additional, Hoiseth, Susan K., additional, Malakian, Karl, additional, Mininni, Terri, additional, Novikova, Elena, additional, Lin, Shuo, additional, Sigethy, Scott, additional, Zlotnick, Gary W., additional, and Tsao, Désirée H.H., additional

Published
2010
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18. Sequence Diversity of the Factor H Binding Protein Vaccine Candidate in Epidemiologically Relevant Strains of Serogroup BNeisseria meningitidis

Author

Murphy, Ellen, primary, Andrew, Lubomira, additional, Lee, Kwok‐Leung, additional, Dilts, Deborah A., additional, Nunez, Lorna, additional, Fink, Pamela S., additional, Ambrose, Karita, additional, Borrow, Ray, additional, Findlow, Jamie, additional, Taha, Muhamed‐Kheir, additional, Deghmane, Ala‐Eddine, additional, Kriz, Paula, additional, Musilek, Martin, additional, Kalmusova, Jitka, additional, Caugant, Dominique A., additional, Alvestad, Torill, additional, Mayer, Leonard W., additional, Sacchi, Claudio T., additional, Wang, Xin, additional, Martin, Diana, additional, von Gottberg, Anne, additional, du Plessis, Mignon, additional, Klugman, Keith P., additional, Anderson, Annaliesa S., additional, Jansen, Kathrin U., additional, Zlotnick, Gary W., additional, and Hoiseth, Susan K., additional

Published
2009
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19. Structural Basis for the Immunogenic Properties of the Meningococcal Vaccine Candidate LP2086

Author

Mascioni, Alessandro, primary, Bentley, Breagh E., additional, Camarda, Rosaria, additional, Dilts, Deborah A., additional, Fink, Pamela, additional, Gusarova, Viktoria, additional, Hoiseth, Susan K., additional, Jacob, Jaison, additional, Lin, Shuo L., additional, Malakian, Karl, additional, McNeil, Lisa K., additional, Mininni, Terri, additional, Moy, Franklin, additional, Murphy, Ellen, additional, Novikova, Elena, additional, Sigethy, Scott, additional, Wen, Yingxia, additional, Zlotnick, Gary W., additional, and Tsao, Désirée H.H., additional

Published
2009
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21. A Multi-country Evaluation of Neisseria meningitidisSerogroup B Factor H–Binding Proteins and Implications for Vaccine Coverage in Different Age Groups

Author

Hoiseth, Susan K., Murphy, Ellen, Andrew, Lubomira, Vogel, Ulrich, Frosch, Matthias, Hellenbrand, Wiebke, Abad, Raquel, Vazquez, Julio A., Borrow, Ray, Findlow, Jamie, Taha, Muhamed-Kheir, Deghmane, Ala-Eddine, Caugant, Dominique A., Kriz, Paula, Musilek, Martin, Mayer, Leonard W., Wang, Xin, MacNeil, Jessica R., York, Laura, Tan, Charles Y., Jansen, Kathrin U., and Anderson, Annaliesa S.

Abstract

Recombinant vaccines containing factor H–binding protein (fHBP) have been developed for the purpose of protection from invasive meningococcal serogroup B disease. Neisseria meningitidisfHBP sequences can be divided into 2 genetically and immunologically distinct subfamilies (A and B); thus, cross protection is conferred within but not between subfamilies. A comprehensive understanding of fHBP epidemiology is required to accurately assess the potential vaccine impact when considering different vaccination implementation strategies.

Published
2013
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22. Challenges for the evaluation of Staphylococcus aureusprotein based vaccines: Monitoring antigenic diversity

Author

Murphy, Ellen, Lin, Shuo L., Nunez, Lorna, Andrew, Lubomira, Fink, Pamela S., Dilts, Deborah A., Hoiseth, Susan K., Jansen, Kathrin U., and Anderson, Annaliesa S.

Abstract

Clumping factors A (ClfA) and B (ClfB) are Staphylococcus aureusvirulence proteins that are displayed on the cell surface of the organism and have potential as vaccine antigens for the prevention of S. aureusdisease. Here we evaluate the phylogeny of S. aureusin the context of antigenic variation of these two surface proteins. ClfA and ClfB gene sequences, along with epidemiological markers (MLST, spa and capsule genotype) were obtained for 224 S. aureusisolates including both historical strains and a collection representative of current MRSA isolates from the United States. Variation within ClfA and ClfB was consistent with the established population biology of S. aureus, namely, that S. aureusstrains belong to a relatively small number of clonal lineages, with evolution proceeding mainly by mutation and with little to no recombination between clades. Thus most variation in ClfA and ClfB occurs between but not within lineages, and particular groups of ClfA and ClfB variants are closely linked. This has important implications for vaccine development and assessment as it suggests that a relatively small survey of strains will be representative of the total population variation, whereas for species that evolve mainly by recombination, such as Neisseria meningitidis, analysis of a much larger number of strains is needed to accomplish the same purpose. Our study also revealed evidence for the de-evolution of ClfB and therefore its reduced suitability as a target for vaccine development compared to ClfA.

Published
2011
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27. Detection of LP2086 on the cell surface of Neisseria meningitidis and its accessibility in the presence of serogroup B capsular polysaccharide

Author

McNeil, Lisa K., Murphy, Ellen, Zhao, Xiao-Juan, Guttmann, Stephen, Harris, Shannon L., Scott, Adrienne A., Tan, Cuiwen, Mack, Michelle, DaSilva, Ida, Alexander, Kristin, Mason, Kathryn, Jiang, Han-Qing, Zhu, Duzhang, Mininni, Terri L., Zlotnick, Gary W., Hoiseth, Susan K., Jones, Thomas R., Pride, Michael W., Jansen, Kathrin U., and Anderson, Annaliesa S.

Subjects
*CARRIER proteins, *CELL membranes, *NEISSERIA meningitidis, *CLINICAL trials, *POLYSACCHARIDES, *VIRAL vaccines, *IMMUNOGLOBULINS, *FLOW cytometry, *MEMBRANE proteins
Abstract

Abstract: The outer membrane protein LP2086, a human factor H binding protein, is undergoing clinical trials as a vaccine against invasive serogroup B meningococcal (MnB) disease. As LP2086 is a surface protein, expression of capsular polysaccharide could potentially limit accessibility of anti-LP2086 antibodies to LP2086 expressed on the surface of bacteria. To determine whether variability in expression levels of the serogroup B capsule (Cap B) might interfere with accessibility of anti-LP2086 antibody binding to LP2086, we evaluated the ability of anti-Cap B and anti-LP2086 antibodies to bind to the surface of 1263 invasive clinical MnB strains by flow cytometry. One of the anti-LP2086 monoclonal antibodies used recognizes virtually all LP2086 sequence variants. Our results show no correlation between the amount of Cap B expressed and the binding of anti-LP2086 antibodies. Furthermore, the susceptibility of MnB bacteria to lysis by anti-LP2086 immune sera was independent of the level of Cap B expressed. The data presented in this paper demonstrates that Cap B does not interfere with the binding of antibodies to LP2086 expressed on the outer membrane of MnB clinical isolates. [Copyright &y& Elsevier]

Published
2009
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28. Human antibody responses to the meningococcal factor H binding protein (LP2086) during invasive disease, colonization and carriage.

Author

Ala'aldeen DA, Flint M, Oldfield NJ, Omer SA, McNeil LK, Jiang Q, Murphy E, Giardina PC, Novikova EG, Dodge-Scully IL, Bayliss CD, Turner DP, Neal KR, Hoiseth SK, Jansen KU, and Anderson AS

Subjects
Adolescent, Adult, Animals, Antibodies, Bacterial blood, Antibody Specificity, Carrier State microbiology, Female, Humans, Immunoglobulin G blood, Longitudinal Studies, Meningococcal Infections prevention & control, Middle Aged, Neisseria meningitidis, Serogroup B immunology, Rabbits, Young Adult, Antibody Formation, Antigens, Bacterial immunology, Bacterial Proteins immunology, Carrier State immunology, Meningococcal Infections immunology
Abstract

Recombinant forms of Neisseria meningitidis factor H binding protein (fHBP) are undergoing clinical trials in candidate vaccines against serogroup B meningococcal disease. Little is known, however, about the host response to fHBP during natural carriage and disease. Here we report a longitudinal study of the antibody response to fHBP in healthy meningococcal carriers and non-carriers, and in patients with invasive meningococcal disease. Using a highly sensitive quantitative immunoassay, anti-fHBP antibodies were detected in sera from all healthy carriers and non-carriers. Carriers had significantly higher anti-fHBP antibody concentrations than non-carriers. Antibody responses similar to those seen in non-carrier subjects were detected in the sera of patients with invasive disease upon their admission to the hospital. The serum anti-fHBP antibody concentrations in these patients generally rose to reach levels similar to those seen in carriers. No correlation between levels of surface fHBP expressed in vitro by the infecting N. meningitidis strain and the magnitude of antibody responses was observed. These data suggest that fHBP is expressed in vivo during both carriage and invasive disease at levels high enough to elicit a robust antibody response., (Copyright © 2010 Elsevier Ltd. All rights reserved.)

Published
2010
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