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9. Five‐year EuroQol 5‐Dimension Outcomes After Endoscopic Sinus Surgery.

Author

Tashman, Katherine, Adams, Dara, Vickery, Thad W., Holbrook, Eric H., Gray, Stacey T., Bleier, Benjamin S., Scangas, George, and Metson, Ralph

Abstract

Objective: The EuroQol 5‐Dimension (EQ‐5D) is a general health survey that is quick to administer, widely used, and directly convertible to health utility values (HUV). We aim to describe the five‐year EQ‐5D outcomes among patients who undergo surgical treatment for chronic rhinosinusitis (CRS). Study Design: Prospective observational cohort study. Methods: Patients with CRS completed the EQ‐5D questionnaire preoperatively and annually for five years following endoscopic sinus surgery. Paired t‐tests and McNemar's tests were used to compare preoperative and postoperative scores. Mixed‐effects modeling was used for multivariate analysis. Results: Among 1296 patients enrolled in our study, 812 (74.7%) completed the postoperative survey at one year and 336 (38.9%) completed it at five years. There was a significant and sustained reduction of patients reporting pain/discomfort (74.9% vs. 58.0%, p < 0.001) and anxiety/depression (49.6% vs. 38.1%, p = 0.01) out to five years. Frequency of problems reported in the usual activity domain decreased at one year and was sustained through year four (30.6% vs 19.7%, p = 0.003). After multivariable modeling, female gender (p = 0.02), prior sinus surgery (p = 0.01), tobacco use (p = 0.038), headaches (p = 0.013), allergies (p = 0.001), diabetes (p = 0.022), hypertension (p = 0.036), higher preoperative SNOT‐22 score (p < 0.001), and a lower preoperative Lund‐Mackay score (p < 0.001) were associated with significantly worse EQ‐5D HUV over time. Similarly, a worse EQ‐5D Visual Analog Scale (VAS) over time was associated with allergies (p = 0.03), diabetes (p < 0.001), hypertension (p = 0.04), higher preoperative SNOT‐22 score (p < 0.001), and prior sinus surgery (p < 0.001). Conclusion: Patients with chronic rhinosinusitis experience significant sustained improvements in health‐related quality of life up to five years after ESS as measured by the EQ‐5D instrument. Level of Evidence: Level 2 Laryngoscope, 134:2592–2601, 2024 [ABSTRACT FROM AUTHOR]

Published
2024
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14. Trends of Odontogenic Sinusitis Incidence During the COVID‐19 Pandemic.

Author

Ringel, Barak, Kons, Zachary A., Holbrook, Eric H., and Gray, Stacey T.

Abstract

Objectives: The COVID‐19 pandemic affected the epidemiology of several diseases. This study aims to compare the incidence of surgically treated odontogenic sinusitis (ODS) before and during the COVID‐19 pandemic and identify unique features. Methods: A retrospective chart review of patients who underwent at least maxillary antrostomy at a tertiary referral center was performed. The patients were divided into two cohorts: "pre‐COVID" (March 2018 to February 2020) and "COVID" (March 2020 to February 2022). Data on demographics, comorbidities, and treatment interventions were collected and analyzed. Results: Of the 734 patients who underwent maxillary antrostomy, 370 (50.4%) were operated on during the COVID period, with a mean age of 53.1 ± 15.7 years. ODS was found as the etiology of 22 (6%) and 45 (12.2%) of the pre‐COVID and COVID cases, respectively (p = 0.006). Although no difference was found in the incidence of diabetes (p = 0.9) or obesity (p = 0.7) between groups, a trend toward higher incidence of immunosuppression was found in the pre‐COVID patients (18.2% vs. 0%, p = 0.06). A higher incidence of sphenoid sinus involvement (31.8% vs. 8.9%, p < 0.05) was identified in the pre‐COVID group; however, no differences in ethmoid (86.4% vs. 86.7%, p = 0.999) or frontal sinus involvement (54.5% vs. 37.8%, p = 0.3) were found between the groups. Conclusion: There was an increase in the incidence of ODS during the first 2 years of the COVID‐19 pandemic compared to the 2 years prior. Similar clinical characteristics were found in both groups. Future studies focusing on specific etiologies to explain ODS preponderance may help determine optimal treatment and prevention strategies. Level of Evidence: 3 Laryngoscope, 134:1597–1602, 2024 [ABSTRACT FROM AUTHOR]

Published
2024
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15. Solitary Fibrous Tumor of the Nasal Cavity: A Case Report and Review of the Literature.

Author

Marcus, Kathryn S., Wasserman, Isaac, Xiao, Roy, Ayoub, Noel, Gray, Stacey T., and Holbrook, Eric H.

Subjects
PLEURA, NASAL cavity, NASAL tumors, LITERATURE reviews, INTERNAL carotid artery, MAXILLARY artery
Abstract

This article, published in the Journal of Neurological Surgery, discusses a rare case of a solitary fibrous tumor in the nasal cavity. Solitary fibrous tumors are uncommon neoplasms that can arise in various parts of the body, including the head and neck region. Although these tumors are slow-growing, they can potentially spread and invade nearby structures, leading to life-threatening complications. The article highlights the importance of early identification and surgical resection in managing these tumors. The case presented in the article describes the successful removal of the tumor through endoscopic surgical resection after embolization. The article emphasizes the need for prompt diagnosis and treatment due to the potential risks associated with these tumors. [Extracted from the article]

Published
2024
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17. Olfactory Nomenclature: An Orchestrated Effort to Clarify Terms and Definitions of Dysosmia, Anosmia, Hyposmia, Normosmia, Hyperosmia, Olfactory Intolerance, Parosmia, and Phantosmia/Olfactory Hallucination.

Author

Hernandez, Anna Kristina, Landis, Basile N., Altundag, Aytug, Fjaeldstad, Alexander Wieck, Gane, Simon, Holbrook, Eric H, Huart, Caroline, Konstantinidis, Iordanis, Lechner, Matt, Macchi, Alberto, Portillo Mazal, Patricia, Miwa, Takaki, Philpott, Carl M., Pinto, Jayant M., Poletti, Sophia C, Vodicka, Jan, Welge-Luessen, Antje, Whitcroft, Katherine L., and Hummel, Thomas

Subjects
SMELL disorders, HALLUCINATIONS, DEFINITIONS, RESEARCH personnel, SMELL
Abstract

Background: Definitions are essential for effective communication and discourse, particularly in science. They allow the shared understanding of a thought or idea, generalization of knowledge, and comparison across scientific investigation. The current terms describing olfactory dysfunction are vague and overlapping. Summary: As a group of clinical olfactory researchers, we propose the standardization of the terms "dysosmia," "anosmia," "hyposmia," "normosmia," "hyperosmia," "olfactory intolerance," "parosmia," and "phantosmia" (or "olfactory hallucination") in olfaction-related communication, with specific definitions in this text. Key Messages: The words included in this paper were determined as those which are most frequently used in the context of olfactory function and dysfunction, in both clinical and research settings. Despite widespread use in publications, however, there still exists some disagreement in the literature regarding the definitions of terms related to olfaction. Multiple overlapping and imprecise terms that are currently in use are confusing and hinder clarity and universal understanding of these concepts. There is a pressing need to have a unified agreement on the definitions of these olfactory terms by researchers working in the field of chemosensory sciences. With the increased interest in olfaction, precise use of these terms will improve the ability to integrate and advance knowledge in this field. [ABSTRACT FROM AUTHOR]

Published
2023
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25. International consensus statement on allergy and rhinology: Olfaction.

Author

UCL - (SLuc) Service d'oto-rhino-laryngologie, UCL - SSS/IONS/NEUR - Clinical Neuroscience, Patel, Zara M, Holbrook, Eric H, Turner, Justin H, Adappa, Nithin D, Albers, Mark W, Altundag, Aytug, Appenzeller, Simone, Costanzo, Richard M, Croy, Ilona, Davis, Greg E, Dehgani-Mobaraki, Puya, Doty, Richard L, Duffy, Valerie B, Goldstein, Bradley J, Gudis, David A, Haehner, Antje, Higgins, Thomas S, Hopkins, Claire, Huart, Caroline, Hummel, Thomas, Jitaroon, Kawinyarat, Kern, Robert C, Khanwalkar, Ashoke R, Kobayashi, Masayoshi, Kondo, Kenji, Lane, Andrew P, Lechner, Matt, Leopold, Donald A, Levy, Joshua M, Marmura, Michael J, Mclelland, Lisha, Miwa, Takaki, Moberg, Paul J, Mueller, Christian A, Nigwekar, Sagar U, O'Brien, Erin K, Paunescu, Teodor G, Pellegrino, Robert, Philpott, Carl, Pinto, Jayant M, Reiter, Evan R, Roalf, David R, Rowan, Nicholas R, Schlosser, Rodney J, Schwob, James, Seiden, Allen M, Smith, Timothy L, Soler, Zachary M, Sowerby, Leigh, Tan, Bruce K, Thamboo, Andrew, Wrobel, Bozena, Yan, Carol H, UCL - (SLuc) Service d'oto-rhino-laryngologie, UCL - SSS/IONS/NEUR - Clinical Neuroscience, Patel, Zara M, Holbrook, Eric H, Turner, Justin H, Adappa, Nithin D, Albers, Mark W, Altundag, Aytug, Appenzeller, Simone, Costanzo, Richard M, Croy, Ilona, Davis, Greg E, Dehgani-Mobaraki, Puya, Doty, Richard L, Duffy, Valerie B, Goldstein, Bradley J, Gudis, David A, Haehner, Antje, Higgins, Thomas S, Hopkins, Claire, Huart, Caroline, Hummel, Thomas, Jitaroon, Kawinyarat, Kern, Robert C, Khanwalkar, Ashoke R, Kobayashi, Masayoshi, Kondo, Kenji, Lane, Andrew P, Lechner, Matt, Leopold, Donald A, Levy, Joshua M, Marmura, Michael J, Mclelland, Lisha, Miwa, Takaki, Moberg, Paul J, Mueller, Christian A, Nigwekar, Sagar U, O'Brien, Erin K, Paunescu, Teodor G, Pellegrino, Robert, Philpott, Carl, Pinto, Jayant M, Reiter, Evan R, Roalf, David R, Rowan, Nicholas R, Schlosser, Rodney J, Schwob, James, Seiden, Allen M, Smith, Timothy L, Soler, Zachary M, Sowerby, Leigh, Tan, Bruce K, Thamboo, Andrew, Wrobel, Bozena, and Yan, Carol H

Abstract

The literature regarding clinical olfaction, olfactory loss, and olfactory dysfunction has expanded rapidly over the past two decades, with an exponential rise in the past year. There is substantial variability in the quality of this literature and a need to consolidate and critically review the evidence. It is with that aim that we have gathered experts from around the world to produce this International Consensus on Allergy and Rhinology: Olfaction (ICAR:O). Using previously described methodology, specific topics were developed relating to olfaction. Each topic was assigned a literature review, evidence-based review, or evidence-based review with recommendations format as dictated by available evidence and scope within the ICAR:O document. Following iterative reviews of each topic, the ICAR:O document was integrated and reviewed by all authors for final consensus. The ICAR:O document reviews nearly 100 separate topics within the realm of olfaction, including diagnosis, epidemiology, disease burden, diagnosis, testing, etiology, treatment, and associated pathologies. This critical review of the existing clinical olfaction literature provides much needed insight and clarity into the evaluation, diagnosis, and treatment of patients with olfactory dysfunction, while also clearly delineating gaps in our knowledge and evidence base that we should investigate further.

Published
2022

29. International consensus statement on allergy and rhinology: Olfaction

Author

Patel, Zara M., primary, Holbrook, Eric H., additional, Turner, Justin H., additional, Adappa, Nithin D., additional, Albers, Mark W., additional, Altundag, Aytug, additional, Appenzeller, Simone, additional, Costanzo, Richard M., additional, Croy, Ilona, additional, Davis, Greg E., additional, Dehgani‐Mobaraki, Puya, additional, Doty, Richard L., additional, Duffy, Valerie B., additional, Goldstein, Bradley J., additional, Gudis, David A., additional, Haehner, Antje, additional, Higgins, Thomas S., additional, Hopkins, Claire, additional, Huart, Caroline, additional, Hummel, Thomas, additional, Jitaroon, Kawinyarat, additional, Kern, Robert C., additional, Khanwalkar, Ashoke R., additional, Kobayashi, Masayoshi, additional, Kondo, Kenji, additional, Lane, Andrew P., additional, Lechner, Matt, additional, Leopold, Donald A., additional, Levy, Joshua M., additional, Marmura, Michael J., additional, Mclelland, Lisha, additional, Miwa, Takaki, additional, Moberg, Paul J., additional, Mueller, Christian A., additional, Nigwekar, Sagar U., additional, O'Brien, Erin K., additional, Paunescu, Teodor G., additional, Pellegrino, Robert, additional, Philpott, Carl, additional, Pinto, Jayant M., additional, Reiter, Evan R., additional, Roalf, David R., additional, Rowan, Nicholas R., additional, Schlosser, Rodney J., additional, Schwob, James, additional, Seiden, Allen M., additional, Smith, Timothy L., additional, Soler, Zachary M., additional, Sowerby, Leigh, additional, Tan, Bruce K., additional, Thamboo, Andrew, additional, Wrobel, Bozena, additional, and Yan, Carol H., additional

Published
2022
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33. International Consensus Statement on Rhinology and Allergy: Rhinosinusitis

Author

Orlandi, Richard, Kingdom, Todd T., Smith, Timothy L., Bleier, Benjamin, DeConde, Adam, Luong, Amber, Poetker, David M., Soler, Zachary, Welch, Kevin C., Wise, Sarah K., Adappa, Nithin, Alt, Jeremiah A., Anselmo-Lima, Wilma Terezinha, Bachert, Claus, Baroody, Fuad M., Batra, Pete S., Bernal-Sprekelsen, Manuel, Beswick, Daniel, Bhattacharyya, Neil, Chandra, Rakesh K., Chang, Eugene, Chiu, Alexander, Chowdhury, Naweed, Citardi, Martin J., Cohen, Noam, Conley, David B., DelGaudio, John, Desrosiers, Martin, Douglas, Richard, Anderson Eloy, Jean, Fokkens, Wytske J., Gray, Stacey T., Gudis, David A., Hamilos, Daniel L., Han, Joseph K., Harvey, Richard, Hellings, Peter, Holbrook, Eric H., Hopkins, Claire, Hwang, Peter, Javer, Amin R., Jiang, Rong-San, Kennedy, David, Kern, Robert, Laidlaw, Tanya, Lal, Devyani, Lane, Andrew, Lee, Heung-Man, Lee, Jivianne T., Levy, Joshua M., Lin, Sandra Y., Lund, Valerie, McMains, Kevin C., Metson, Ralph, Mullol, Joaquim, Naclerio, Robert, Oakley, Gretchen, Otori, Nobuyoshi, Palmer, James N., Parikh, Sanjay R., Passali, Desiderio, Patel, Zara, Peters, Anju, Philpott, Carl, Psaltis, Alkis J., Ramakrishnan, Vijay R., Ramanathan, Murugappan, Roh, Hwan-Jung, Rudmik, Luke, Sacks, Raymond, Schlosser, Rodney J., Sedaghat, Ahmad, Senior, Brent, Sindwani, Raj, Smith, Kristine, Snidvongs, Kornkiat, Stewart, Michael, Suh, Jeffrey, Tan, Bruce K., Turner, Justin H., van Drunen, Cornelis M., Voegels, Richard, Wang, De-Yun, Woodworth, Bradford A., Wormald, Peter-John, Wright, Erin D., Yan, Carol, Zhang, Luo, and Zhou, Bing

Abstract

Background: The 5 years since the publication of the first International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR‐RS) has witnessed foundational progress in our understanding and treatment of rhinologic disease. These advances are reflected within the more than 40 new topics covered within the ICAR‐RS‐2021 as well as updates to the original 140 topics. This executive summary consolidates the evidence‐based findings of the document. Methods: ICAR‐RS presents over 180 topics in the forms of evidence‐based reviews with recommendations (EBRRs), evidence‐based reviews, and literature reviews. The highest grade structured recommendations of the EBRR sections are summarized in this executive summary. Results: ICAR‐RS‐2021 covers 22 topics regarding the medical management of RS, which are grade A/B and are presented in the executive summary. Additionally, 4 topics regarding the surgical management of RS are grade A/B and are presented in the executive summary. Finally, a comprehensive evidence‐based management algorithm is provided. Conclusion: This ICAR‐RS‐2021 executive summary provides a compilation of the evidence‐based recommendations for medical and surgical treatment of the most common forms of RS.

Published
2021

34. Clinical Olfactory Working Group consensus statement on the treatment of postinfectious olfactory dysfunction

Author

Addison, Alfred B., primary, Wong, Billy, additional, Ahmed, Tanzime, additional, Macchi, Alberto, additional, Konstantinidis, Iordanis, additional, Huart, Caroline, additional, Frasnelli, Johannes, additional, Fjaeldstad, Alexander W., additional, Ramakrishnan, Vijay R., additional, Rombaux, Philippe, additional, Whitcroft, Katherine L., additional, Holbrook, Eric H., additional, Poletti, Sophia C., additional, Hsieh, Julien W., additional, Landis, Basile N., additional, Boardman, James, additional, Welge-Lüssen, Antje, additional, Maru, Devina, additional, Hummel, Thomas, additional, and Philpott, Carl M., additional

Published
2021
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35. Systemic corticosteroids in coronavirus disease 2019 (COVID-19)-related smell dysfunction: an international view.

Author

UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service d'oto-rhino-laryngologie, Huart, Caroline, Philpott, Carl M, Altundag, Aytug, Fjaeldstad, Alexander W, Frasnelli, Johannes, Gane, Simon, Hsieh, Julien W, Holbrook, Eric H, Konstantinidis, Iordanis, Landis, Basile N, Macchi, Alberto, Mueller, Christian A, Negoias, Simona, Pinto, Jayant M, Poletti, Sophia C, Ramakrishnan, Vijay R, Rombaux, Philippe, Vodicka, Jan, Welge-Lüessen, Antje, Whitcroft, Katherine L, Hummel, Thomas, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service d'oto-rhino-laryngologie, Huart, Caroline, Philpott, Carl M, Altundag, Aytug, Fjaeldstad, Alexander W, Frasnelli, Johannes, Gane, Simon, Hsieh, Julien W, Holbrook, Eric H, Konstantinidis, Iordanis, Landis, Basile N, Macchi, Alberto, Mueller, Christian A, Negoias, Simona, Pinto, Jayant M, Poletti, Sophia C, Ramakrishnan, Vijay R, Rombaux, Philippe, Vodicka, Jan, Welge-Lüessen, Antje, Whitcroft, Katherine L, and Hummel, Thomas

Abstract

The frequent association between coronavirus disease 2019 (COVID-19) and olfactory dysfunction is creating an unprecedented demand for a treatment of the olfactory loss. Systemic corticosteroids have been considered as a therapeutic option. However, based on current literature, we call for caution using these treatments in early COVID-19-related olfactory dysfunction because: (1) evidence supporting their usefulness is weak; (2) the rate of spontaneous recovery of COVID-19-related olfactory dysfunction is high; and (3) corticosteroids have well-known potential adverse effects. We encourage randomized placebo-controlled trials investigating the efficacy of systemic steroids in this indication and strongly emphasize to initially consider smell training, which is supported by a robust evidence base and has no known side effects.

Published
2021

36. Clinical Olfactory Working Group consensus statement on the treatment of postinfectious olfactory dysfunction.

Author

UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service d'oto-rhino-laryngologie, Addison, Alfred B, Wong, Billy, Ahmed, Tanzime, Macchi, Alberto, Konstantinidis, Iordanis, Huart, Caroline, Frasnelli, Johannes, Fjaeldstad, Alexander W, Ramakrishnan, Vijay R, Rombaux, Philippe, Whitcroft, Katherine L, Holbrook, Eric H, Poletti, Sophia C, Hsieh, Julien W, Landis, Basile N, Boardman, James, Welge-Lüssen, Antje, Maru, Devina, Hummel, Thomas, Philpott, Carl M, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service d'oto-rhino-laryngologie, Addison, Alfred B, Wong, Billy, Ahmed, Tanzime, Macchi, Alberto, Konstantinidis, Iordanis, Huart, Caroline, Frasnelli, Johannes, Fjaeldstad, Alexander W, Ramakrishnan, Vijay R, Rombaux, Philippe, Whitcroft, Katherine L, Holbrook, Eric H, Poletti, Sophia C, Hsieh, Julien W, Landis, Basile N, Boardman, James, Welge-Lüssen, Antje, Maru, Devina, Hummel, Thomas, and Philpott, Carl M

Abstract

Respiratory tract viruses are the second most common cause of olfactory dysfunction. As we learn more about the effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with the recognition that olfactory dysfunction is a key symptom of this disease process, there is a greater need than ever for evidence-based management of postinfectious olfactory dysfunction (PIOD). Our aim was to provide an evidence-based practical guide to the management of PIOD (including post-coronavirus 2019 cases) for both primary care practitioners and hospital specialists. A systematic review of the treatment options available for the management of PIOD was performed. The written systematic review was then circulated among the members of the Clinical Olfactory Working Group for their perusal before roundtable expert discussion of the treatment options. The group also undertook a survey to determine their current clinical practice with regard to treatment of PIOD. The search resulted in 467 citations, of which 107 articles were fully reviewed and analyzed for eligibility; 40 citations fulfilled the inclusion criteria, 11 of which were randomized controlled trials. In total, 15 of the articles specifically looked at PIOD whereas the other 25 included other etiologies for olfactory dysfunction. The Clinical Olfactory Working Group members made an overwhelming recommendation for olfactory training; none recommended monocycline antibiotics. The diagnostic role of oral steroids was discussed; some group members were in favor of vitamin A drops. Further research is needed to confirm the place of other therapeutic options.

Published
2021

40. Systemic corticosteroids in coronavirus disease 2019 (COVID‐19)‐related smell dysfunction: an international view

Author

Huart, Caroline, primary, Philpott, Carl M., additional, Altundag, Aytug, additional, Fjaeldstad, Alexander W., additional, Frasnelli, Johannes, additional, Gane, Simon, additional, Hsieh, Julien W., additional, Holbrook, Eric H., additional, Konstantinidis, Iordanis, additional, Landis, Basile N., additional, Macchi, Alberto, additional, Mueller, Christian A., additional, Negoias, Simona, additional, Pinto, Jayant M., additional, Poletti, Sophia C., additional, Ramakrishnan, Vijay R., additional, Rombaux, Philippe, additional, Vodicka, Jan, additional, Welge‐Lüessen, Antje, additional, Whitcroft, Katherine L., additional, and Hummel, Thomas, additional

Published
2021
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41. International consensus statement on allergy and rhinology: rhinosinusitis 2021

Author

Orlandi, Richard R., primary, Kingdom, Todd T., additional, Smith, Timothy L., additional, Bleier, Benjamin, additional, DeConde, Adam, additional, Luong, Amber U., additional, Poetker, David M., additional, Soler, Zachary, additional, Welch, Kevin C., additional, Wise, Sarah K., additional, Adappa, Nithin, additional, Alt, Jeremiah A., additional, Anselmo‐Lima, Wilma Terezinha, additional, Bachert, Claus, additional, Baroody, Fuad M., additional, Batra, Pete S., additional, Bernal‐Sprekelsen, Manuel, additional, Beswick, Daniel, additional, Bhattacharyya, Neil, additional, Chandra, Rakesh K., additional, Chang, Eugene H., additional, Chiu, Alexander, additional, Chowdhury, Naweed, additional, Citardi, Martin J., additional, Cohen, Noam A., additional, Conley, David B., additional, DelGaudio, John, additional, Desrosiers, Martin, additional, Douglas, Richard, additional, Eloy, Jean Anderson, additional, Fokkens, Wytske J., additional, Gray, Stacey T., additional, Gudis, David A., additional, Hamilos, Daniel L., additional, Han, Joseph K., additional, Harvey, Richard, additional, Hellings, Peter, additional, Holbrook, Eric H., additional, Hopkins, Claire, additional, Hwang, Peter, additional, Javer, Amin R., additional, Jiang, Rong‐San, additional, Kennedy, David, additional, Kern, Robert, additional, Laidlaw, Tanya, additional, Lal, Devyani, additional, Lane, Andrew, additional, Lee, Heung‐Man, additional, Lee, Jivianne T., additional, Levy, Joshua M., additional, Lin, Sandra Y., additional, Lund, Valerie, additional, McMains, Kevin C., additional, Metson, Ralph, additional, Mullol, Joaquim, additional, Naclerio, Robert, additional, Oakley, Gretchen, additional, Otori, Nobuyoshi, additional, Palmer, James N., additional, Parikh, Sanjay R., additional, Passali, Desiderio, additional, Patel, Zara, additional, Peters, Anju, additional, Philpott, Carl, additional, Psaltis, Alkis J., additional, Ramakrishnan, Vijay R., additional, Ramanathan, Murugappan, additional, Roh, Hwan‐Jung, additional, Rudmik, Luke, additional, Sacks, Raymond, additional, Schlosser, Rodney J., additional, Sedaghat, Ahmad R., additional, Senior, Brent A., additional, Sindwani, Raj, additional, Smith, Kristine, additional, Snidvongs, Kornkiat, additional, Stewart, Michael, additional, Suh, Jeffrey D., additional, Tan, Bruce K., additional, Turner, Justin H., additional, van Drunen, Cornelis M., additional, Voegels, Richard, additional, Wang, De Yun, additional, Woodworth, Bradford A., additional, Wormald, Peter‐John, additional, Wright, Erin D., additional, Yan, Carol, additional, Zhang, Luo, additional, and Zhou, Bing, additional

Published
2021
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44. Contributors

Author

Abuzeid, Waleed M., primary, Adams, Meredith E., additional, Adamson, Peter A., additional, Adenis, Antoine, additional, Akst, Seth, additional, Albers, Sheri L., additional, Albert, David, additional, Alexander, Ronda E., additional, Archbold, Sue, additional, Armstrong, William B., additional, Arriaga, Moisés A., additional, Arts, H. Alexander, additional, Ashram, Yasmine A., additional, Aviv, Jonathan E., additional, Aygun, Nafi, additional, Backous, Douglas D., additional, Baker, Shan R., additional, Balkany, Thomas J., additional, Baloh, Robert W., additional, Barkmeier-Kraemer, Julie, additional, Baroody, Fuad M., additional, Bartlett, Nancy L., additional, Baskin, Jonathan Z., additional, Bastian, Robert W., additional, Bauer, Carol A., additional, Benninger, Michael S., additional, Bhama, Prabhat K., additional, Bhatti, Nasir Islam, additional, Blitzer, Andrew, additional, Boardman, Simone, additional, Boss, Emily F., additional, Brackmann, Derald E., additional, Bradford, Carol R., additional, Branstetter, Barton F., additional, Braun, Edward B., additional, Briggs, Robert J.S., additional, Brodie, Hilary A., additional, Brown, Carolyn J., additional, Brown, David J., additional, Brown, Kevin D., additional, Browne, J. Dale, additional, Buatti, John M., additional, Buchmann, Luke, additional, Byrne, Patrick J., additional, Galzada, Gabriel G., additional, Carey, John P., additional, Casselbrant, Margaretha L., additional, Castelnuovo, Paolo, additional, Chang, Steven, additional, Chegar, Burke E., additional, Chen, Amy, additional, Chen, Eunice Y., additional, Chen, Theodore, additional, Chepeha, Douglas B., additional, Cheuk, Alice, additional, Chheda, Neil N., additional, Chien, Wade, additional, Choi, Sukgi S., additional, Chole, Richard A., additional, Christian, James M., additional, Chu, Eugene A., additional, Citardi, Martin J., additional, Cohen, Marc A., additional, Collins, Savita, additional, Collop, Nancy A., additional, Contencin, Philippe, additional, Cook, Raymond, additional, Corey, Jacquelynne, additional, Cotton, Robin T., additional, Couch, Marion Everett, additional, Courey, Mark S., additional, Crane, Benjamin T., additional, Crumley, Roger L., additional, Cruz, Oswaldo Laércio M., additional, Culicchia, Frank, additional, Cummings, Charles W., additional, Cunningham, Calhoun D., additional, Davis, Greg E., additional, Davis, Larry E., additional, Day, Terry A., additional, De la Cruz, Antonio, additional, Santina, Charles C. Della, additional, Denlinger, Chadrick, additional, Derkay, Craig S., additional, Diaz, Rodney C., additional, Dobie, Robert A., additional, Galli, Suzanne K. Doud, additional, Duncan, Newton O., additional, Eggers, Scott D.Z., additional, Eisbruch, Avraham, additional, Eisele, David W., additional, El-Kashlan, Hussam K., additional, Elluru, Ravindhra G., additional, Ende, Kevin H., additional, Erman, Audrey B., additional, Fakhri, Samer, additional, Fakhry, Carole, additional, Farrior, Edward H., additional, Farrior, Richard T., additional, Faust, Russell A., additional, Ferguson, Berrylin J., additional, Flint, Paul W., additional, Francis, Howard W., additional, Fried, Marvin P., additional, Friedland, David R., additional, Friedman, Oren, additional, Frodel, John L., additional, Funk, Gerry F., additional, Gantz, Bruce J., additional, Garrett, C. Gaelyn, additional, Gartner-Schmidt, Jackie, additional, Gay, William Donald, additional, Ge, Norman N., additional, Gillespie, M. Boyd, additional, Girod, Douglas A., additional, Goding, George S., additional, Goldberg, Andrew N., additional, Goldenberg, David, additional, Graney, Daniel O., additional, Grant, Nazaneen N., additional, Grégoire, Vincent, additional, Gries, Heike, additional, Gubbels, Samuel P., additional, Guss, Joel, additional, Ha, Patrick, additional, Hamilton, Grant S., additional, Hanna, Ehab Y., additional, Harker, Lee A., additional, Harréus, Uli, additional, Harrison, Robert V., additional, Haughey, Bruce H., additional, Hellstein, John W., additional, Herzer, Kurt, additional, Hildebrand, Michael S., additional, Hilgers, Frans J.M., additional, Hill, Justin D., additional, Hinni, Michael L., additional, Hoffman, Henry T., additional, Holbrook, Eric H., additional, Holinger, Lauren D., additional, Holzapfel, Allison MacGregor, additional, Hom, David B., additional, House, John W., additional, House, Joyce Colton, additional, Hullar, Timothy E., additional, Husein, Murad, additional, Ing, Steven, additional, Iseli, Tim A., additional, Ishman, Stacey, additional, Jackler, Robert K., additional, Jameson, Brian, additional, Jenkins, Herman A., additional, Jin, Hong-Ryol, additional, Joe, John K., additional, Joe, Stephanie A., additional, Johnson, Gary, additional, Johnson, Rhonda, additional, Johnson, Tiffany A., additional, Johnson, Timothy M., additional, Jones, Nick S., additional, Kabaker, Sheldon S., additional, Karnell, Lucy H., additional, Kashima, Matthew L., additional, Kellman, Robert M., additional, Kelly, Paul E., additional, Kennedy, David W., additional, Khalid, Ayesha N., additional, Kies, Merrill S., additional, Kileny, Paul R., additional, Kim, David W., additional, Kim, Jason H., additional, Kim, Theresa B., additional, Kimberling, William J., additional, Koh, Jeffrey, additional, Kokot, Niels, additional, Koltai, Peter J., additional, Kozak, Frederick K., additional, Krakovitz, Paul R., additional, Kridel, Russell W.H., additional, Kumar, Parvesh, additional, Kunduk, Melda, additional, Laccourreye, Ollivier, additional, Lacey, JoAnne, additional, Lai, Stephen Y., additional, Lal, Devyani, additional, Lalwani, Anil K., additional, Lambert, Paul R., additional, Lassig, Amy Anne, additional, Latchaw, Richard E., additional, Leahy, Kevin P., additional, Lee, Daniel J., additional, Lee, Ken K., additional, Lee, Nancy, additional, Lefebvre, Jean-Louis, additional, Lefton-Greif, Maureen A., additional, Leopold, Donald A., additional, Lewis, James S., additional, Li, Daqing, additional, Lian, Timothy S., additional, Licameli, Greg R., additional, Limb, Charles J., additional, Logemann, Jeri A., additional, Loh, Thomas, additional, Lonsbury-Martin, Brenda L., additional, Lopez, Manuel A., additional, Lusk, Rodney P., additional, Lustig, Lawrence R., additional, Lysakowski, Anna, additional, MacArthur, Carol J., additional, Maisel, Robert H., additional, Malone, James P., additional, Mandel, Ellen M., additional, Mandel, Susan J., additional, Manning, Scott C., additional, Mark, Lynette, additional, Markt, Jeffery C., additional, Marsh, Michael, additional, Martin, Glen K., additional, Mattox, Douglas E., additional, McCaffrey, Thomas V., additional, McCulloch, Timothy M., additional, McGee, JoAnn, additional, McGuire, John F., additional, McJunkin, Jonathan, additional, McMurray, J. Scott, additional, Merati, Albert L., additional, Merchant, Saumil N., additional, Messner, Anna H., additional, Michelson, James, additional, Milczuk, Henry A., additional, Minor, Lloyd B., additional, Mobley, Steven Ross, additional, Muntz, Harlan, additional, Murakami, Craig S., additional, Myer, Charles M., additional, Naclerio, Robert M., additional, Nadol, Joseph B., additional, Nassif, Paul S., additional, Nedzelski, Julian, additional, Nicolai, Piero, additional, Nielsen, David R., additional, Niparko, John K., additional, Norton, Susan J., additional, Nouraei, S.A. Reza, additional, Nuss, Daniel W., additional, Nussenbaum, Brian, additional, Odland, Rick M., additional, O'Donoghue, Gerard, additional, Oliver, Eric R., additional, O’Malley, Bert W., additional, O’Reilly, Robert C., additional, Ospina, Juan Camilo, additional, Ossoff, Robert H., additional, Otto, Kristen J., additional, Packer, Mark D., additional, Pallanch, John, additional, Palmer, James N., additional, Park, Stephen S., additional, Patel, Sundip, additional, Patterson, G. Alexander, additional, Pearson, Bruce W., additional, Pellitteri, Phillip K., additional, Perkins, Jonathan A., additional, Perkins, Stephen W., additional, Pero, Colin D., additional, Pignatari, Shirley S.N., additional, Pletcher, Steven D., additional, Popovtzer, Aron, additional, Postma, Gregory N., additional, Potsic, William P., additional, Poznanovic, Sheri A., additional, Quatela, Vito C., additional, Rabinov, C. Rose, additional, Ramachandran, Virginia, additional, Randolph, Gregory W., additional, Rassekh, Christopher H., additional, Rauch, Steven D., additional, Reinisch, Lou, additional, Richardson, Mark, A., additional, Richter, Gresham T., additional, Ridgway, James M., additional, Robbins, K. Thomas, additional, Roediger, Frederick C., additional, Rogers, Jeremy, additional, Ronen, Ohad, additional, Rosenfeld, Richard M., additional, Rotter, Bruce E., additional, Rubinstein, Jay T., additional, Ruckenstein, Michael J., additional, Rumboldt, Zoran, additional, Runge-Samuelson, Christina L., additional, Rybak, Leonard P., additional, Sadoughi, Babak, additional, Salassa, John R., additional, Salinas, Thomas J., additional, Samant, Sandeep, additional, Samlan, Robin A., additional, Samy, Ravi N., additional, Sandel, Henry D., additional, Sandhu, Guri S., additional, Sando, Isamu, additional, Sauder, Cara, additional, Scarlett, Jeremy A., additional, Scher, Richard L., additional, Schessel, David A., additional, Schmalbach, Cecelia E., additional, Schwedt, Todd J., additional, Sciubba, James J., additional, Sequeira, Sunitha, additional, Seshamani, Meena, additional, Shelton, Clough, additional, Shepard, Neil T., additional, Ship, Jonathan A., additional, Shirley, W. Peyton, additional, Shnayder, Yelizaveta, additional, Shvidler, Joseph, additional, Sie, Kathleen C.Y., additional, Simmen, Daniel B., additional, Smith, Marshall E., additional, Smith, Richard J.H., additional, Sofferman, Robert A., additional, Soma, Marlene, additional, Stach, Brad A., additional, Staecker, Hinrich, additional, Stamm, Aldo Cassol, additional, Stankiewicz, James A., additional, Stavinoha, Rose, additional, Sterni, Laura M., additional, Steward, David L., additional, Stocks, Rose Mary S., additional, Sudhoff, Holger H., additional, Sunwoo, John B., additional, Swanson, Neil A., additional, Swanson, Veronica C., additional, Swarm, Robert A., additional, Sykes, Jonathan M., additional, Tan, Luke, additional, Tardy, M. Eugene, additional, Tatum, Sherard A., additional, Taylor, S. Mark, additional, Teissier, Natacha, additional, Telian, Steven A., additional, Terris, David J., additional, Teufert, Karen B., additional, Thomas, J. Regan, additional, Thompson, James N., additional, Toriumi, Dean M., additional, Torres, Alejandro I., additional, Travers, Joseph B., additional, Travers, Susan P., additional, Tsue, Terance T., additional, Tufano, Ralph P., additional, Tunkel, David E., additional, Turner, Michael D., additional, Uppaluri, Ravindra, additional, Vaezi, Michael F., additional, Van den Abbeele, Thierry, additional, van den Brekel, Michiel W.M., additional, Vaysberg, Mikhail, additional, Vokes, David E., additional, Wackym, P. Ashley, additional, Wakefield, Tamekia L., additional, Walner, David L., additional, Walsh, Edward J., additional, Walvekar, Rohan R., additional, Wang, Tom D., additional, Warren, Frank M., additional, Weber, Randal S., additional, Wein, Richard O., additional, Weinstein, Gregory S., additional, Weitzel, Erik Kent, additional, Welling, D. Bradley, additional, Wemer, Richard D., additional, Wetmore, Ralph F., additional, Weymuller, Ernest A., additional, Wiatrak, Brian J., additional, Wiet, Gregory J., additional, Wiggins, Richard H., additional, Willey, Andrea, additional, William, William N., additional, Williams, Glenn B., additional, Wippold, Franz J., additional, Woodson, Gayle Ellen, additional, Woolley, Audie L., additional, Wootten, Christopher T., additional, Wormald, Peter-John, additional, Yingling, Charles D., additional, Yueh, Bevan, additional, Yung, Rex C., additional, Zaldívar, Renzo A., additional, Zalzal, George H., additional, Zee, David S., additional, Zimbler, Marc S., additional, Zinreich, S. James, additional, and Zwolan, Teresa A., additional

Published
2010
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47. Smell and taste dysfunction in patients with COVID-19

Author

Xydakis, Michael S, primary, Dehgani-Mobaraki, Puya, additional, Holbrook, Eric H, additional, Geisthoff, Urban W, additional, Bauer, Christian, additional, Hautefort, Charlotte, additional, Herman, Philippe, additional, Manley, Geoffrey T, additional, Lyon, Dina M, additional, and Hopkins, Claire, additional

Published
2020
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48. Innate immune signaling in the olfactory epithelium reduces odorant receptor levels: modeling transient smell loss in COVID-19 patients

Author

Rodriguez, Steven, primary, Cao, Luxiang, additional, Rickenbacher, Gregory T., additional, Benz, Eric G., additional, Magdamo, Colin, additional, Gomez, Liliana Ramirez, additional, Holbrook, Eric H., additional, Albers, Alefiya D., additional, Gallagher, Rose, additional, Westover, M. Brandon, additional, Evans, Kyle E., additional, Tatar, Daniel J., additional, Mukerji, Shibani, additional, Zafonte, Ross, additional, Boyer, Edward W, additional, Yu, C. Ron, additional, and Albers, Mark W., additional

Published
2020
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