Search

Your search keyword '"Holdsworth, David W."' showing total 733 results
Start Over Author "Holdsworth, David W."
733 results on '"Holdsworth, David W."'

24. Quantitative Magnetic Resonance Imaging of Lateral Compartment Articular Cartilage After Lateral Extra-articular Tenodesis.

Author

Firth, Andrew D., Pritchett, Stephany L., Milner, Jaques S., Atkinson, Hayden F., Bryant, Dianne M., Holdsworth, David W., and Getgood, Alan M.J.

Subjects
TENODESIS, MENISCUS injuries, ANTERIOR cruciate ligament injuries, ARTICULAR cartilage, ANTERIOR cruciate ligament surgery, RESEARCH funding, STATISTICAL sampling, MAGNETIC resonance imaging, TREATMENT effectiveness, DESCRIPTIVE statistics, RANDOMIZED controlled trials, ANALYSIS of variance, RESEARCH, POSTOPERATIVE period, COMPARATIVE studies, MUSCLE contraction
Abstract

Background: Concerns have arisen that anterior cruciate ligament reconstruction (ACLR) with lateral extra-articular tenodesis (LET) may accelerate the development of posttraumatic osteoarthritis in the lateral compartment of the knee. Purpose/Hypothesis: The purpose of this study was to evaluate whether the augmentation of ACLR with LET affects the quality of lateral compartment articular cartilage on magnetic resonance imaging (MRI) at 2 years postoperatively. We hypothesized that there would be no difference in T1rho and T2 relaxation times when comparing ACLR alone with ACLR + LET. Study Design: Randomized controlled trial; Level of evidence, 1. Methods: A consecutive subgroup of patients at the Fowler Kennedy Sport Medicine Clinic participating in the STABILITY 1 Study underwent bilateral 3-T MRI at 2 years after surgery. The primary outcome was T1rho and T2 relaxation times. Articular cartilage in the lateral compartment was manually segmented into 3 regions of the tibia (lateral tibia [LT]–1 to LT-3) and 5 regions of the femur (lateral femoral condyle [LFC]–1 to LFC-5). Analysis of covariance was used to compare relaxation times between groups, adjusted for lateral meniscal tears and treatment, cartilage and bone marrow lesions, contralateral relaxation times, and time since surgery. Semiquantitative MRI scores according to the Anterior Cruciate Ligament OsteoArthritis Score were compared between groups. Correlations were used to determine the association between secondary outcomes (including results of the International Knee Documentation Committee score, Knee injury and Osteoarthritis Outcome Score, Lower Extremity Functional Scale, 4-Item Pain Intensity Measure, hop tests, and isokinetic quadriceps and hamstring strength tests) and cartilage relaxation. Results: A total of 95 participants (44 ACLR alone, 51 ACLR + LET) with a mean age of 18.8 years (61.1% female [58/95]) underwent 2-year MRI (range, 20-36 months). T1rho relaxation times were significantly elevated for the ACLR + LET group in LT-1 (37.3 ± 0.7 ms vs 34.1 ± 0.8 ms, respectively; P =.005) and LFC-2 (43.9 ± 0.9 ms vs 40.2 ± 1.0 ms, respectively; P =.008) compared with the ACLR alone group. T2 relaxation times were significantly elevated for the ACLR + LET group in LFC-1 (51.2 ± 0.7 ms vs 49.1 ± 0.7 ms, respectively; P =.03) and LFC-4 (45.9 ± 0.5 ms vs 44.2 ± 0.6 ms, respectively; P =.04) compared with the ACLR alone group. All effect sizes were small to medium. There was no difference in Anterior Cruciate Ligament OsteoArthritis Scores between groups (P =.99). Weak negative associations (rs = –0.27 to –0.22; P <.05) were found between relaxation times and quadriceps and hamstring strength in the anterolateral knee, while all other correlations were nonsignificant (P >.05). Conclusion: Increased relaxation times demonstrating small to medium effect sizes suggested early biochemical changes in articular cartilage of the anterolateral compartment in the ACLR + LET group compared with the ACLR alone group. Further evidence and long-term follow-up are needed to better understand the association between these results and the potential risk of the development of osteoarthritis in our patient cohort. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

33. Supplementary Figure Legends 1-6 from Functional Neoangiogenesis Imaging of Genetically Engineered Mouse Prostate Cancer Using Three-Dimensional Power Doppler Ultrasound

Author

Xuan, Jim W., primary, Bygrave, Michael, primary, Jiang, Hongyi, primary, Valiyeva, Fatma, primary, Dunmore-Buyze, Joy, primary, Holdsworth, David W., primary, Izawa, Jonathan I., primary, Bauman, Glenn, primary, Moussa, Madeleine, primary, Winter, Scott F., primary, Greenberg, Norman M., primary, Chin, Joseph L., primary, Drangova, Maria, primary, Fenster, Aaron, primary, and Lacefield, James C., primary

Published
2023
Full Text
View/download PDF

34. Supplementary Movie 1 from Functional Neoangiogenesis Imaging of Genetically Engineered Mouse Prostate Cancer Using Three-Dimensional Power Doppler Ultrasound

Author

Xuan, Jim W., primary, Bygrave, Michael, primary, Jiang, Hongyi, primary, Valiyeva, Fatma, primary, Dunmore-Buyze, Joy, primary, Holdsworth, David W., primary, Izawa, Jonathan I., primary, Bauman, Glenn, primary, Moussa, Madeleine, primary, Winter, Scott F., primary, Greenberg, Norman M., primary, Chin, Joseph L., primary, Drangova, Maria, primary, Fenster, Aaron, primary, and Lacefield, James C., primary

Published
2023
Full Text
View/download PDF

35. Supplementary Figure 2 from Functional Neoangiogenesis Imaging of Genetically Engineered Mouse Prostate Cancer Using Three-Dimensional Power Doppler Ultrasound

Author

Xuan, Jim W., primary, Bygrave, Michael, primary, Jiang, Hongyi, primary, Valiyeva, Fatma, primary, Dunmore-Buyze, Joy, primary, Holdsworth, David W., primary, Izawa, Jonathan I., primary, Bauman, Glenn, primary, Moussa, Madeleine, primary, Winter, Scott F., primary, Greenberg, Norman M., primary, Chin, Joseph L., primary, Drangova, Maria, primary, Fenster, Aaron, primary, and Lacefield, James C., primary

Published
2023
Full Text
View/download PDF

36. Supplementary Figure 3 from Functional Neoangiogenesis Imaging of Genetically Engineered Mouse Prostate Cancer Using Three-Dimensional Power Doppler Ultrasound

Author

Xuan, Jim W., primary, Bygrave, Michael, primary, Jiang, Hongyi, primary, Valiyeva, Fatma, primary, Dunmore-Buyze, Joy, primary, Holdsworth, David W., primary, Izawa, Jonathan I., primary, Bauman, Glenn, primary, Moussa, Madeleine, primary, Winter, Scott F., primary, Greenberg, Norman M., primary, Chin, Joseph L., primary, Drangova, Maria, primary, Fenster, Aaron, primary, and Lacefield, James C., primary

Published
2023
Full Text
View/download PDF

37. Supplementary Figure 4 from Functional Neoangiogenesis Imaging of Genetically Engineered Mouse Prostate Cancer Using Three-Dimensional Power Doppler Ultrasound

Author

Xuan, Jim W., primary, Bygrave, Michael, primary, Jiang, Hongyi, primary, Valiyeva, Fatma, primary, Dunmore-Buyze, Joy, primary, Holdsworth, David W., primary, Izawa, Jonathan I., primary, Bauman, Glenn, primary, Moussa, Madeleine, primary, Winter, Scott F., primary, Greenberg, Norman M., primary, Chin, Joseph L., primary, Drangova, Maria, primary, Fenster, Aaron, primary, and Lacefield, James C., primary

Published
2023
Full Text
View/download PDF

38. Supplementary Procedures from Functional Neoangiogenesis Imaging of Genetically Engineered Mouse Prostate Cancer Using Three-Dimensional Power Doppler Ultrasound

Author

Xuan, Jim W., primary, Bygrave, Michael, primary, Jiang, Hongyi, primary, Valiyeva, Fatma, primary, Dunmore-Buyze, Joy, primary, Holdsworth, David W., primary, Izawa, Jonathan I., primary, Bauman, Glenn, primary, Moussa, Madeleine, primary, Winter, Scott F., primary, Greenberg, Norman M., primary, Chin, Joseph L., primary, Drangova, Maria, primary, Fenster, Aaron, primary, and Lacefield, James C., primary

Published
2023
Full Text
View/download PDF

39. Supplementary Figure 5 from Functional Neoangiogenesis Imaging of Genetically Engineered Mouse Prostate Cancer Using Three-Dimensional Power Doppler Ultrasound

Author

Xuan, Jim W., primary, Bygrave, Michael, primary, Jiang, Hongyi, primary, Valiyeva, Fatma, primary, Dunmore-Buyze, Joy, primary, Holdsworth, David W., primary, Izawa, Jonathan I., primary, Bauman, Glenn, primary, Moussa, Madeleine, primary, Winter, Scott F., primary, Greenberg, Norman M., primary, Chin, Joseph L., primary, Drangova, Maria, primary, Fenster, Aaron, primary, and Lacefield, James C., primary

Published
2023
Full Text
View/download PDF

40. Supplementary Figure 6 from Functional Neoangiogenesis Imaging of Genetically Engineered Mouse Prostate Cancer Using Three-Dimensional Power Doppler Ultrasound

Author

Xuan, Jim W., primary, Bygrave, Michael, primary, Jiang, Hongyi, primary, Valiyeva, Fatma, primary, Dunmore-Buyze, Joy, primary, Holdsworth, David W., primary, Izawa, Jonathan I., primary, Bauman, Glenn, primary, Moussa, Madeleine, primary, Winter, Scott F., primary, Greenberg, Norman M., primary, Chin, Joseph L., primary, Drangova, Maria, primary, Fenster, Aaron, primary, and Lacefield, James C., primary

Published
2023
Full Text
View/download PDF

43. Three-Dimensional Ultrasound Probe Pose Estimation from Single-Perspective X-Rays for Image-Guided Interventions

Author

Lang, Pencilla, Seslija, Petar, Habets, Damiaan F., Chu, Michael W. A., Holdsworth, David W., Peters, Terry M., Hutchison, David, Kanade, Takeo, Kittler, Josef, Kleinberg, Jon M., Mattern, Friedemann, Mitchell, John C., Naor, Moni, Nierstrasz, Oscar, Pandu Rangan, C., Steffen, Bernhard, Sudan, Madhu, Terzopoulos, Demetri, Tygar, Doug, Vardi, Moshe Y., Weikum, Gerhard, Liao, Hongen, editor, Edwards, P. J. 'Eddie", editor, Pan, Xiaochuan, editor, Fan, Yong, editor, and Yang, Guang-Zhong, editor

Published
2010
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results