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5 results on '"Holl, Myriam"'

1. Human tissue-resident peritoneal macrophages reveal resistance towards oxidative cell stress induced by non-invasive physical plasma

Author

Schultze-Rhonhof, Laura, primary, Marzi, Julia, additional, Carvajal Berrio, Daniel Alejandro, additional, Holl, Myriam, additional, Braun, Theresa, additional, Schäfer-Ruoff, Felix, additional, Andress, Jürgen, additional, Bachmann, Cornelia, additional, Templin, Markus, additional, Brucker, Sara Y., additional, Schenke-Layland, Katja, additional, and Weiss, Martin, additional

Published
2024
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2. Noninvasive Physical Plasma as Innovative and Tissue-Preserving Therapy for Women Positive for Cervical Intraepithelial Neoplasia

Author

Marzi, Julia, Stope, Matthias B., Henes, Melanie, Koch, André, Wenzel, Thomas, Holl, Myriam, Layland, Shannon L., Neis, Felix, Bösmüller, Hans, Ruoff, Felix, Templin, Markus, Krämer, Bernhard, Staebler, Annette, Barz, Jakob Philipp, Carvajal Berrio, Daniel A., Enderle, Markus, Loskill, Peter M., Brucker, Sara Y., Schenke-Layland, Katja, Weiss, Martin, and Publica

Subjects
physical atmospheric pressure plasma, low- and high-grade squamous intraepithelial lesions (LSILs and HSILs), Raman imaging, cervical intraepithelial neoplasia (CIN), clinical plasma application
Abstract

(1) Background: Cervical intraepithelial neoplasia (CIN) of long-term persistence or associated with individual treatment indications often requires highly invasive treatments. These are associated with risks of bleeding, infertility, and pregnancy complications. For low- and middle-income countries (LMICs), standard treatment procedures are difficult to implement and manage. We characterized the application of the highly energized gas "noninvasive physical plasma" (NIPP) for tissue devitalization and the treatment of CIN. (2) Methods: We report the establishment of a promising tissue devitalization procedure by NIPP application. The procedure was characterized at the in vitro, ex vivo and in vivo levels. We performed the first prospective, single-armed phase-IIb trial in 20 CIN1/2 patients (NCT03218436). (3) Results: NIPP-treated cervical cancer cells used as dysplastic in vitro model exhibited significant cell growth retardation due to DNA damage, cell cycle arrest and apoptosis. Ex vivo and in vivo tissue assessments showed a highly noninvasive and tissue-preserving treatment procedure which induces transmucosal tissue devitalization. Twenty participants were treated with NIPP and attended a 24-week follow-up. Treatment success was achieved in 19 (95%) participants without postinterventional complications other than mild to moderate discomfort during application. (4) Conclusions: The results from this study preliminarily suggest that NIPP could be used for an effective and tissue-preserving treatment for CIN without the disadvantages of standard treatments. However, randomized controlled trials must confirm the efficacy and noninferiority of NIPP compared to standard treatments.

Published
2022

3. Cell Type-Specific Anti-Adhesion Properties of Peritoneal Cell Treatment with Plasma-Activated Media (PAM)

Author

Holl, Myriam, primary, Rasch, Marie-Lena, additional, Becker, Lucas, additional, Keller, Anna-Lena, additional, Schultze-Rhonhof, Laura, additional, Ruoff, Felix, additional, Templin, Markus, additional, Keller, Silke, additional, Neis, Felix, additional, Keßler, Franziska, additional, Andress, Jürgen, additional, Bachmann, Cornelia, additional, Krämer, Bernhard, additional, Schenke-Layland, Katja, additional, Brucker, Sara, additional, Marzi, Julia, additional, and Weiss, Martin, additional

Published
2022
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4. Noninvasive Physical Plasma as Innovative and Tissue-Preserving Therapy for Women Positive for Cervical Intraepithelial Neoplasia

Author

Marzi, Julia, primary, Stope, Matthias B., additional, Henes, Melanie, additional, Koch, André, additional, Wenzel, Thomas, additional, Holl, Myriam, additional, Layland, Shannon L., additional, Neis, Felix, additional, Bösmüller, Hans, additional, Ruoff, Felix, additional, Templin, Markus, additional, Krämer, Bernhard, additional, Staebler, Annette, additional, Barz, Jakob, additional, Carvajal Berrio, Daniel A., additional, Enderle, Markus, additional, Loskill, Peter M., additional, Brucker, Sara Y., additional, Schenke-Layland, Katja, additional, and Weiss, Martin, additional

Published
2022
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5. Laparoscopic Peritoneal Wash Cytology-Derived Primary Human Mesothelial Cells for In Vitro Cell Culture and Simulation of Human Peritoneum

Author

Holl, Myriam, primary, Becker, Lucas, additional, Keller, Anna-Lena, additional, Feuerer, Nora, additional, Marzi, Julia, additional, Carvajal Berrio, Daniel A., additional, Jakubowski, Peter, additional, Neis, Felix, additional, Pauluschke-Fröhlich, Jan, additional, Brucker, Sara Y., additional, Schenke-Layland, Katja, additional, Krämer, Bernhard, additional, and Weiss, Martin, additional

Published
2021
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