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157 results on '"Hollander, Georg A."'

1. Structural and non-coding variants increase the diagnostic yield of clinical whole genome sequencing for rare diseases

Author

Pagnamenta, Alistair T., Camps, Carme, Giacopuzzi, Edoardo, Taylor, John M., Hashim, Mona, Calpena, Eduardo, Kaisaki, Pamela J., Hashimoto, Akiko, Yu, Jing, Sanders, Edward, Schwessinger, Ron, Hughes, Jim R., Lunter, Gerton, Dreau, Helene, Ferla, Matteo, Lange, Lukas, Kesim, Yesim, Ragoussis, Vassilis, Vavoulis, Dimitrios V., Allroggen, Holger, Ansorge, Olaf, Babbs, Christian, Banka, Siddharth, Baños-Piñero, Benito, Beeson, David, Ben-Ami, Tal, Bennett, David L., Bento, Celeste, Blair, Edward, Brasch-Andersen, Charlotte, Bull, Katherine R., Cario, Holger, Cilliers, Deirdre, Conti, Valerio, Davies, E. Graham, Dhalla, Fatima, Dacal, Beatriz Diez, Dong, Yin, Dunford, James E., Guerrini, Renzo, Harris, Adrian L., Hartley, Jane, Hollander, Georg, Javaid, Kassim, Kane, Maureen, Kelly, Deirdre, Kelly, Dominic, Knight, Samantha J. L., Kreins, Alexandra Y., Kvikstad, Erika M., Langman, Craig B., Lester, Tracy, Lines, Kate E., Lord, Simon R., Lu, Xin, Mansour, Sahar, Manzur, Adnan, Maroofian, Reza, Marsden, Brian, Mason, Joanne, McGowan, Simon J., Mei, Davide, Mlcochova, Hana, Murakami, Yoshiko, Németh, Andrea H., Okoli, Steven, Ormondroyd, Elizabeth, Ousager, Lilian Bomme, Palace, Jacqueline, Patel, Smita Y., Pentony, Melissa M., Pugh, Chris, Rad, Aboulfazl, Ramesh, Archana, Riva, Simone G., Roberts, Irene, Roy, Noémi, Salminen, Outi, Schilling, Kyleen D., Scott, Caroline, Sen, Arjune, Smith, Conrad, Stevenson, Mark, Thakker, Rajesh V., Twigg, Stephen R. F., Uhlig, Holm H., van Wijk, Richard, Vona, Barbara, Wall, Steven, Wang, Jing, Watkins, Hugh, Zak, Jaroslav, Schuh, Anna H., Kini, Usha, Wilkie, Andrew O. M., Popitsch, Niko, and Taylor, Jenny C.

Published
2023
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4. Expanding the Nude SCID/CID Phenotype Associated with FOXN1 Homozygous, Compound Heterozygous, or Heterozygous Mutations

Author

Giardino, Giuliana, Sharapova, Svetlana O., Ciznar, Peter, Dhalla, Fatima, Maragliano, Luca, Radha Rama Devi, Akella, Islamoglu, Candan, Ikinciogullari, Aydan, Haskologlu, Sule, Dogu, Figen, Hanna-Wakim, Rima, Dbaibo, Ghassan, Chou, Janet, Cirillo, Emilia, Borzacchiello, Carla, Kreins, Alexandra Y., Worth, Austen, Rota, Ioanna A., Marques, José G., Sayitoglu, Muge, Firtina, Sinem, Mahdi, Moaffaq, Geha, Raif, Neven, Bénédicte, Sousa, Ana E., Benfenati, Fabio, Hollander, Georg A., Davies, E. Graham, and Pignata, Claudio

Published
2021
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8. Diversity in Cortical Thymic Epithelial Cells Occurs through Loss of a Foxn1-Dependent Gene Signature Driven by Stage-Specific Thymocyte Cross-Talk

Author

White, Andrea J., primary, Parnell, Sonia M., additional, Handel, Adam, additional, Maio, Stefano, additional, Bacon, Andrea, additional, Cosway, Emilie J., additional, Lucas, Beth, additional, James, Kieran D., additional, Cowan, Jennifer E., additional, Jenkinson, William E., additional, Hollander, Georg A., additional, and Anderson, Graham, additional

Published
2023
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12. P63 targeted deletion under the FOXN1 promoter disrupts pre-and post-natal thymus development, function and maintenance as well as induces severe hair loss

Author

Stefanski, Heather E., primary, Xing, Yan, additional, Nicholls, Jemma, additional, Jonart, Leslie, additional, Goren, Emily, additional, Taylor, Patricia A., additional, Mills, Alea A., additional, Riddle, Megan, additional, McGrath, John, additional, Tolar, Jakub, additional, Hollander, Georg A., additional, and Blazar, Bruce R., additional

Published
2022
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13. Combined immunodeficiency with autoimmunity caused by a homozygous missense mutation in inhibitor of nuclear factor 𝛋B kinase alpha (IKKα)

Author

Bainter, Wayne, primary, Lougaris, Vassilios, additional, Wallace, Jacqueline G., additional, Badran, Yousef, additional, Hoyos-Bachiloglu, Rodrigo, additional, Peters, Zachary, additional, Wilkie, Hazel, additional, Das, Mrinmoy, additional, Janssen, Erin, additional, Beano, Abdallah, additional, Farhat, Khaoula Ben, additional, Kam, Christy, additional, Bercich, Luisa, additional, Incardona, Paolo, additional, Villanacci, Vincenzo, additional, Bondioni, Maria Pia, additional, Meini, Antonella, additional, Baronio, Manuela, additional, Abarzua, Phammela, additional, Parolini, Silvia, additional, Tabellini, Giovanna, additional, Maio, Stefano, additional, Schmidt, Birgitta, additional, Goldsmith, Jeffrey D., additional, Murphy, George, additional, Hollander, Georg, additional, Plebani, Alessandro, additional, Chou, Janet, additional, and Geha, Raif S., additional

Published
2021
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14. Autoimmune polyendocrine syndrome type 1 and NALP5, a parathyroid autoantigen

Author

Alimohammadi, Mohammad, Bjorklund, Peyman, Hallgren, Asa, Pontynen, Nora, Szinnai, Gabor, Shikama, Noriko, Keller, Marcel P., Ekwall, Olov, Kinkel, Sarah A., Husebye, Eystein S., Gustafsson, Jan, Rorsman, Fredrik, Peltonen, Leena, Betterle, Corrado, Perheentupa, Jaakko, Akerstrom, Goran, Westin, Gunnar, Scott, Hamish S., Hollander, Georg A., and Kampe, Ollev

Subjects
Antigens -- Research, Autoimmune diseases -- Genetic aspects, Genetic regulation -- Research, Hypoparathyroidism -- Genetic aspects
Abstract

A study to determine the role of AIRE, the autoimmune regulator gene that could be the cause of autoimmune polyendocrine syndrome type 1 (APS-1) and role of NALP5 autoantibodies is conducted. Results reveal that NALP5 was a tissue-specific autoantigen, which caused a manifestation of hypoparathyroidism in patients with APS-1.

Published
2008

15. High-resolution 3D imaging uncovers organ-specific vascular control of tissue aging

Author

Chen, Junyu, primary, Sivan, Unnikrishnan, additional, Tan, Sin Lih, additional, Lippo, Luciana, additional, De Angelis, Jessica, additional, Labella, Rossella, additional, Singh, Amit, additional, Chatzis, Alexandros, additional, Cheuk, Stanley, additional, Medhghalchi, Mino, additional, Gil, Jesus, additional, Hollander, Georg, additional, Marsden, Brian D., additional, Williams, Richard, additional, Ramasamy, Saravana K., additional, and Kusumbe, Anjali P., additional

Published
2021
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16. [beta] cells are responsible for CXCR3-mediated T-cell infiltration in insulitis

Author

Frigerio, Simona, Junt, Tobias, Lu, Bao, Gerard, Craig, Zumsteg, Urs, Hollander, Georg A., and Piali, Luca

Abstract

T cell-mediated loss of insulin-secreting [beta] cells in the islets of Langerhans is the hallmark of type 1 diabetes. The molecular basis for the directed migration of autoreactive T cells leading to insulitis is presently unknown. Here we demonstrate that in response to inflammation, [beta] cells secrete the chemokines CXC ligand 10 and CXC ligand 9, which specifically attract T-effector cells via the CXC chemokine receptor 3. In mice deficient for this receptor, the onset of type 1 diabetes is substantially delayed. Thus, in the absence of known etiological agents, CXC receptor 3 represents a novel target for therapeutic interference early in type 1 diabetes., Author(s): Simona Frigerio [1]; Tobias Junt [2]; Bao Lu [3]; Craig Gerard [3]; Urs Zumsteg [1]; Georg A. Hollander (corresponding author) [1, 4]; Luca Piali [1, 4] Type 1 diabetes [...]

Published
2002
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18. Monoallelic expression of the Interleukin-2 locus

Author

Hollander, Georg A., Zuklys, Saulius, and Morel, Corinne

Subjects
Interleukin-2 -- Research, Gene expression -- Research
Abstract

IL-2 is a growth factor important in the regulation and differentiation of lymphocytes. and natural killer cells (1). Produced by a subpopulation of activated T cells, IL-2 also plays a […]

Published
1998

19. Induction of alloantigen-specific tolerance by B cells from CD40-deficient mice

Author

Hollander, Georg A., Castigli, Emanuela, Kulbacki, Robert, Su, Michael, Burakoff, Steven J., Gutierrez-Ramos, Jose-Carlos, and Geha, Raif S.

Subjects
Mice -- Genetic aspects, B cells -- Physiological aspects, T cells -- Physiological aspects, Immunological tolerance -- Research, Antigen-antibody reactions -- Research, Science and technology
Abstract

Interaction between CD40 on B cells and CD40 ligand molecules on T cells is pivotal for the generation of a thymus-dependent antibody response. Here we show that B cells deficient in CD40 expression are unable to elicit the proliferation of allogeneic T cells in vitro. More importantly, mice immunized with [CD40.sup.-/-] B cells become tolerant to allogeneic major histocompatibility complex (MHC) antigens as measured by a mixed lymphocyte reaction and cytotoxic T-cell assay. The failure of [CD40.sup.-/-] B cells to serve as antigen presenting cells in vitro was corrected by the addition of anti-CD28 mAb. Moreover, lipopolysaccharide stimulation, which upregulates B7 expression, reversed the inability of [CD40.sup.-/-] B cells to stimulate an alloresponse in vitro and abrogated the capacity of these B cells to induce tolerance in vivo. These results suggest that CD40 engagement by CD40 ligand expressed on antigen-activated T cells is critical for the upregulation of B7 molecules on antigen-presenting B cells that subsequently deliver the costimulatory signals necessary for T-cell proliferation and differentiation. Our experiments suggest a novel strategy for the induction of antigen-specific tolerance in vivo.

Published
1996

20. Activation of CD4+ T lymphocytes from interleukin 2-deficient mice by costimulatory B7 molecules

Author

Razi-Wolf, Ziba, Hollander, Georg A., and Reiser, Hans

Subjects
T cells -- Research, Interleukin-2 -- Research, Inflammatory bowel diseases -- Research, Science and technology
Abstract

Interleukin 2 (IL-2)-deficient ([IL-2.sup.-/-]) mice develop hemolytic anemia and chronic inflammatory bowel disease. Importantly, the induction of disease in IL-2-deficient mice is critically dependent on [CD4.sup.+] T cells. We have studied the requirements of T cells from IL-2-deficient mice for costimulation with B7 antigens. Stable B7-1 or B7-2 chinese hamster ovary (CHO) cell transfectants could synergize with anti-CD3 monoclonal antibody (mAb) to induce the proliferation of [CD4.sup.+] T cells from [IL-2.sup.-/-] mutant mice. Further mechanistic studies established that B7-induced activation resulted in surface expression of the [Alpha] chain of the IL-2 receptor. B7-induced proliferation occurred independently of IL-4 and was largely independent of the common [Gamma] chain of the IL-2, IL-4, IL-7, IL-9, and IL-15 receptors. Finally, anti-B7-2 but not anti-B7-1 mAb was able to inhibit the activation of [IL-2.sup.-/-] T cells induced by anti-CD3 mAb in the presence of syngeneic antigen-presenting cells. The results of our experiments indicate that [IL-2.sup.-/-] [CD4.sup.+] T cells remain responsive to B7 stimulation and raise the possibility that B7 antagonists have a role in the prevention/treatment of inflammatory bowel disease.

Published
1996

21. Developmental control point in induction of thymic cortex regulated by a subpopulation of prothymocytes

Author

Hollander, Georg A., Wang, Baoping, Nichogiannopoulou, Aliki, Platenburg, Peter Paul, Ewijk, Willem van, Burakoff, Steven J., Gutierrez-Ramos, Jose-Carlos, and Terhorst, Cox

Subjects
T cells -- Receptors, Cerebral cortex -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

The characteristics of early prothymocytes when incorporated into the thymic cortex is analyzed using mutant mouse strains. The analysis reveals that the functional thymic cortex is absent in animals, suggesting a developmental block at the initial stages of the T-lineage formation. The transplantation of fetal or adult hematopoietic cells into the animals lacking thymic cortex results in the elimination of this abnormality.

Published
1995

23. Gene Modification and Three-Dimensional Scaffolds as Novel Tools to Allow the Use of Postnatal Thymic Epithelial Cells for Thymus Regeneration Approaches

Author

Bortolomai, Ileana, primary, Sandri, Monica, additional, Draghici, Elena, additional, Fontana, Elena, additional, Campodoni, Elisabetta, additional, Marcovecchio, Genni Enza, additional, Ferrua, Francesca, additional, Perani, Laura, additional, Spinelli, Antonello, additional, Canu, Tamara, additional, Catucci, Marco, additional, Di Tomaso, Tiziano, additional, Sergi Sergi, Lucia, additional, Esposito, Antonio, additional, Lombardo, Angelo, additional, Naldini, Luigi, additional, Tampieri, Anna, additional, Hollander, Georg A., additional, Villa, Anna, additional, and Bosticardo, Marita, additional

Published
2019
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24. Thymic Epithelial Cell Support of Thymopoiesis Does Not Require Klotho

Author

Xing, Yan, primary, Smith, Michelle J., additional, Goetz, Christine A., additional, McElmurry, Ron T., additional, Parker, Sarah L., additional, Min, Dullei, additional, Hollander, Georg A., additional, Weinberg, Kenneth I., additional, Tolar, Jakub, additional, Stefanski, Heather E., additional, and Blazar, Bruce R., additional

Published
2018
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25. Engineering Regenerative Thymic Tissues to Restore Long-Term T Cell Lymphopoiesis

Author

Gai, Hui, primary, Gras~Pena, Rafa, additional, Verma, Yogendra, additional, Fateh, Vincent, additional, Ikeda, Kazuya, additional, Dejene, Beruh, additional, Min, Dullei, additional, Wang, Jing, additional, Swigut, Tomek, additional, Weinberg, Ken I., additional, Hollander, Georg A., additional, Heilshorn, Sarah, additional, Roncarolo, Maria-Grazia, additional, Sebastiano, Vittorio, additional, and Weinacht, Katja G., additional

Published
2018
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28. Thymic microenvironments, 3-D versus 2-D?

Author

van Ewijk, Willem, Wang, BaoPing, Hollander, Georg, Kawamoto, Hiroshi, Spanopoulou, Eugenia, Itoi, Manami, Amagai, Takashi, Jiang, Yu-Fei, Germeraad, Wilfred T.V., Chen, Wei-Fung, and Katsura, Yoshimoto

Published
1999
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29. Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling

Author

Daniels, Mark A., Teixeiro, Emma, Gill, Jason, Hausmann, Barbara, Roubaty, Dominique, Holmberg, Kaisa, Werlen, Guy, Hollander, Georg A., Gascoigne, Nicholas R. J., and Palmer, Ed

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Mark A. Daniels [1]; Emma Teixeiro [1]; Jason Gill [2]; Barbara Hausmann [1]; Dominique Roubaty [1]; Kaisa Holmberg [3]; Guy Werlen [4]; Georg A. Holländer [2]; Nicholas R. J. [...]

Published
2006
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30. Requirement of Stat3 Signaling in the Postnatal Development of Thymic Medullary Epithelial Cells

Author

00343228, Satoh, Rumi, Kakugawa, Kiyokazu, Yasuda, Takuwa, Yoshida, Hisahiro, Sibilia, Maria, Katsura, Yoshimoto, Levi, Ben, Abramson, Jakub, Koseki, Yoko, Koseki, Haruhiko, van Ewijk, Willem, Hollander, Georg A., Kawamoto, Hiroshi, 00343228, Satoh, Rumi, Kakugawa, Kiyokazu, Yasuda, Takuwa, Yoshida, Hisahiro, Sibilia, Maria, Katsura, Yoshimoto, Levi, Ben, Abramson, Jakub, Koseki, Yoko, Koseki, Haruhiko, van Ewijk, Willem, Hollander, Georg A., and Kawamoto, Hiroshi

Published
2016

31. Alloreactive Natural Killer Cells Initiate a Unique Cellular and Molecular Pathway That Greatly Accelerates Immune Reconstitution after Allogeneic Bone Marrow Transplantation

Author

Ruggeri, Loredana, primary, Urbani, Elena, additional, Chiasserini, Davide, additional, Susta, Federica, additional, Orvietani, Pierluigi, additional, Burchielli, Emanuela, additional, Ramarli, Dunia, additional, Binaglia, Luciano, additional, Jimenez, Connie, additional, Hollander, Georg A., additional, and Velardi, Andrea, additional

Published
2016
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34. Requirement of Stat3 Signaling in the Postnatal Development of Thymic Medullary Epithelial Cells

Author

Satoh, Rumi, primary, Kakugawa, Kiyokazu, additional, Yasuda, Takuwa, additional, Yoshida, Hisahiro, additional, Sibilia, Maria, additional, Katsura, Yoshimoto, additional, Levi, Ben, additional, Abramson, Jakub, additional, Koseki, Yoko, additional, Koseki, Haruhiko, additional, van Ewijk, Willem, additional, Hollander, Georg A., additional, and Kawamoto, Hiroshi, additional

Published
2016
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35. Nitric Oxide Production and Fas Surface Expression Mediate Two Independent Pathways of Cytokine-Induced Murine Β-Cell Damage

Author

Zumsteg, Urs, Frigerio, Simona, and Hollander, Georg A.

Subjects
Cell death -- Causes of -- Physiological aspects, Biological transport -- Physiological aspects, Pancreas -- Secretions, Type 1 diabetes -- Development and progression, Pancreatic beta cells -- Physiological aspects, Insulin -- Physiological aspects, Nitric oxide -- Physiological aspects, Health, Physiological aspects, Development and progression, Causes of
Abstract

Activated T-cells and macrophages infiltrate pancreatic islets early in the pathogenesis of type 1 diabetes. Their secretion of different pro-inflammatory cytokines such as interleukin (IL)-1Β, interferon (IFN)-[Gamma] and tumor necrosis [...]

Published
2000

38. Violation of the 12/23 rule of genomic V(D)J recombination is common in lymphocytes

Author

Parkinson, Nicholas J., primary, Roddis, Matthew, additional, Ferneyhough, Ben, additional, Zhang, Gang, additional, Marsden, Adam J., additional, Maslau, Siarhei, additional, Sanchez-Pearson, Yasmin, additional, Barthlott, Thomas, additional, Humphreys, Ian R., additional, Ladell, Kristin, additional, Price, David A., additional, Ponting, Chris P., additional, Hollander, Georg, additional, and Fischer, Michael D., additional

Published
2014
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42. The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-α receptor

Author

Papadopoulou, Aikaterini S, primary, Dooley, James, additional, Linterman, Michelle A, additional, Pierson, Wim, additional, Ucar, Olga, additional, Kyewski, Bruno, additional, Zuklys, Saulius, additional, Hollander, Georg A, additional, Matthys, Patrick, additional, Gray, Daniel H D, additional, De Strooper, Bart, additional, and Liston, Adrian, additional

Published
2011
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50. Keratinocyte Growth Factor Increases Thymic Output of Naïve T-Cells after Total Body Irradiation and Autologous Peripheral Blood Progenitor Cell Transplantation in Rhesus Macaques.

Author

Seggewiss, Ruth, primary, Lore, Karin, additional, Guenaga, F. Javier, additional, Pittaluga, Stefania, additional, Matappallil, Joseph J., additional, Ambrozak, David, additional, Bailer, Robert T., additional, Koup, Richard A., additional, Donahue, Robert E., additional, Blazar, Bruce R., additional, Hollander, Georg A., additional, Douek, Daniel C., additional, and Dunbar, Cynthia E., additional

Published
2005
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