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1. A nucleotide resolution map of Top2-linked DNA breaks in the yeast and human genome

Author

William H. Gittens, Dominic J. Johnson, Rachal M. Allison, Tim J. Cooper, Holly Thomas, and Matthew J. Neale

Subjects
Science
Abstract

Topoisomerase 2 (Top2) is known to resolve DNA topological stress through double strand breaks (DSBs), yet Top2 inhibition has been reported to result in a significant amount of single-strand breaks (SSBs). Here the authors develop CC-seq—a method that allows direct mapping of both Top2-linked SSBs and DSBs—and reveal a significant impact of primary DNA sequence on Top2 directed cleavage.

Published
2019
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2. Systematic Evaluation of the T30 Neurostimulator Treatment for Tinnitus: A Double-Blind Randomised Placebo-Controlled Trial with Open-Label Extension

Author

Deborah Ann Hall, Robert Henryk Pierzycki, Holly Thomas, David Greenberg, Magdalena Sereda, and Derek James Hoare

Subjects
sound therapy, neuromodulation, neural synchrony, acoustic CR neuromodulation, tinnitus disorder, quality of life, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Tinnitus is often triggered by cochlear damage and has been linked with aberrant patterns of neuronal activity. Acoustic Coordinated Reset (CR®) Neuromodulation is a sound therapy hypothesised to reduce tinnitus symptoms by desynchronising pathological brain activity using a portable acoustic device (the T30 neurostimulator). We report results of a pivotal trial to test the efficacy of this intervention. This two-centre, double-blind randomised controlled trial with long-term open-label extension, was undertaken between February 2012 and February 2014 in the UK. Participants were 100 adults with tinnitus as a primary complaint, recruited through hearing clinics and media advertisements. Intervention was the device programmed either with the proprietary sound sequence or placebo algorithm, fit by one of five trained audiologists. Minimisation software provided group allocation (1:1 randomisation), with groups matched for age, gender, hearing loss and tinnitus severity. Allocation was masked from participants and assessors during the trial. The primary measure of efficacy was change in tinnitus symptom severity between groups, measured using the Tinnitus Handicap Questionnaire at 12 weeks. Secondary outcomes were other measures of tinnitus symptom severity, health-related quality of life, and perceptual characteristics (pitch, loudness, bandwidth) at 12 weeks, and Tinnitus Handicap Questionnaire at 36 weeks (open-label extension). A statistician blinded to the allocation conducted an intention-to-treat analysis that employed linear regressions on minimisation variables, trial centre and intervention group, with multiple imputations for missing data. The study was registered on clinicaltrials.gov (NCT01541969). We screened 391 individuals and assigned interventions to 100 eligible participants. The primary outcome was not statistically significant between groups (mean group = −0.45, 95% CI −5.25 to 4.35; p = 0.85), nor were any of the secondary outcomes. Four adverse events occurred during the trial. Analysis of tinnitus symptom severity data collected across the 24-week open-label extension showed no statistically significant within-group changes after 12, 24, or 36 weeks treatment with the proprietary sound sequence. While individual participants may benefit from sound therapy, Acoustic CR® Neuromodulation did not lead to group-mean reductions on tinnitus symptom severity or other measures compared to placebo, or over time.

Published
2022
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6. Transition to tolling third-party gas at Karratha Gas Plant: an attractive investment which unlocks infrastructure utilisation

Author

Tom Lukatela and Holly Thomas

Abstract

In December 2020, the North West Shelf (NWS) Project participants executed fully-termed third-party Gas Processing Agreements with Woodside Burrup Pty Ltd (Woodside Burrup), for gas from the Pluto fields, and with subsidiaries of Mitsui & Co Ltd and Beach Energy Limited (Mitsui and Beach), for the Waitsia Gas Project Stage 2. These agreements underpinned final investment decisions in the infrastructure projects, business processes, and digital tools, necessary to process third-party gas from the Pluto-Karratha Gas Plant (KGP) Interconnector, and the Burrup Extension Pipeline (BEP). Tolling operations commenced at the NWS Project in March 2022 with the processing of gas delivered from Pluto through the Interconnector. The first Liquefied Natural Gas (LNG) cargo produced from gas through the Interconnector was loaded in April 2022. KGP is also expected to commence processing Waitsia gas via the BEP from 2023. Woodside CEO Meg O’Neill stated: ‘The start-up of the Pluto-KGP Interconnector provides access to spare capacity at Karratha Gas Plant to process gas owned by other resource owners, both onshore and offshore Western Australia. The commencement of Pluto gas flowing through the Interconnector is the first example of this… The commercial agreements underpinning third-party gas processing at the North West Shelf reflect the commitment of Woodside and the North West Shelf Project to maximising value from the significant infrastructure on the Burrup Peninsula’. The development of the necessary infrastructure, business/operational processes, and digital tools is a forward looking investment which unlocks an efficient market in third-party gas processing market at KGP.

Published
2023
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7. Single Photon Emission Computed Tomography (SPECT) Myocardial Perfusion Imaging Guidelines: Instrumentation, Acquisition, Processing, and Interpretation

Author

Dorbala, Sharmila, Ananthasubramaniam, Karthik, Armstrong, Ian S., Chareonthaitawee, Panithaya, DePuey, E. Gordon, Einstein, Andrew J., Gropler, Robert J., Holly, Thomas A., Mahmarian, John J., Park, Mi-Ae, Polk, Donna M., Russell, Raymond, III, Slomka, Piotr J., Thompson, Randall C., and Wells, R. Glenn

Published
2018
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9. Severity of Remodeling, Myocardial Viability, and Survival in Ischemic LV Dysfunction After Surgical Revascularization

Author

Bonow, Robert O., Castelvecchio, Serenella, Panza, Julio A., Berman, Daniel S., Velazquez, Eric J., Michler, Robert E., She, Lilin, Holly, Thomas A., Desvigne-Nickens, Patrice, Kosevic, Dragana, Rajda, Miroslaw, Chrzanowski, Lukasz, Deja, Marek, Lee, Kerry L., White, Harvey, Oh, Jae K., Doenst, Torsten, Hill, James A., Rouleau, Jean L., and Menicanti, Lorenzo

Published
2015
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11. Comparison of Transesophageal and Transthoracic Echocardiographic Measurements of Mechanism and Severity of Mitral Regurgitation in Ischemic Cardiomyopathy (from the Surgical Treatment of Ischemic Heart Failure Trial)

Author

Grayburn, Paul A., She, Lilin, Roberts, Brad J., Golba, Krzysztof S., Mokrzycki, Krzysztof, Drozdz, Jaroslaw, Cherniavsky, Alexander, Przybylski, Roman, Wrobel, Krzysztof, Asch, Federico M., Holly, Thomas A., Haddad, Haissam, Yii, Michael, Maurer, Gerald, Kron, Irving, Schaff, Hartzell, Velazquez, Eric J., and Oh, Jae K.

Published
2015
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15. Myocardial viability and impact of surgical ventricular reconstruction on outcomes of patients with severe left ventricular dysfunction undergoing coronary artery bypass surgery: Results of the Surgical Treatment for Ischemic Heart Failure trial

Author

Holly, Thomas A., Bonow, Robert O., Arnold, J. Malcolm O., Oh, Jae K., Varadarajan, Padmini, Pohost, Gerald M., Haddad, Haissam, Jones, Robert H., Velazquez, Eric J., Birkenfeld, Bozena, Asch, Federico M., Malinowski, Marcin, Barretto, Rodrigo, Kalil, Renato A.K., Berman, Daniel S., Sun, Jie-Lena, Lee, Kerry L., and Panza, Julio A.

Published
2014
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17. Pediatric decision limits for serologic screening of Lyme disease

Author

Andrew J. Nowalk, Pooja Srivastava, Oscar Lopez-Nunez, Sarah E Wheeler, Nicole Oakes, Bradley J. Wheeler, and Holly Thomas

Subjects
Male, 030213 general clinical medicine, medicine.medical_specialty, Clinical Decision-Making, Clinical Biochemistry, 030204 cardiovascular system & hematology, Serology, 03 medical and health sciences, 0302 clinical medicine, Lyme disease, Internal medicine, medicine, Humans, Serologic Tests, Borrelia burgdorferi, Overdiagnosis, Child, Retrospective Studies, Lyme Disease, biology, business.industry, Agreement analysis, General Medicine, biology.organism_classification, medicine.disease, Antibodies, Bacterial, LYME, Immunoglobulin M, Immunoglobulin G, Female, business, Pediatric population
Abstract

Background Laboratory diagnosis of Lyme disease (LD) relies on a two-tier protocol. We have observed disproportionate equivocal serologies in children requiring reflex western blot (WB) using manufacturer-provided ranges based on adult studies. We aimed to determine appropriate ranges for our pediatric population. Methods We performed a one-year retrospective institutional review of all 2755 children with LD testing with the Vidas® Lyme IgM II/IgG II immunoassays with reflex to WB for equivocal/positive serologies. Results were assessed by frequency distributions, optimization via percent agreement analysis, and clinical adjudication. Results The proposed ranges for IgM (negative ≤0.20, equivocal ≥0.21 to 0.50) allowed for a decrease in the IgM equivocal rate (7% to 2%) and IgG positive rate (15% to 13%). There was a decrease in the positive percent agreement between tiers (95% to 83% and 98% to 95%) with increase in the negative (32% to 63% and 70% to 81%) and overall (65% to 73% and 85% to 88%) percent agreements for IgM and IgG, respectively. Of 15 IgM serologies reclassified as negative with a positive WB and not positive for IgG, 8 were clinically negative, 5 were clinically positive, and two had insufficient history. Of the 10 IgG serologies reclassified as negative with a positive WB 3 were clinically positive, 6 were clinically negative and one had insufficient history. Conclusions Our modified ranges are more suitable for our pediatric population while reducing overdiagnosis, unnecessary treatment, diagnostic uncertainty, and turnaround time.

Published
2021
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18. Mechanisms of Functional Mitral Regurgitation in Ischemic Cardiomyopathy Determined by Transesophageal Echocardiography (from the Surgical Treatment for Ischemic Heart Failure Trial)

Author

Golba, Krzysztof, Mokrzycki, Krzysztof, Drozdz, Jaroslaw, Cherniavsky, Alexander, Wrobel, Krzysztof, Roberts, Bradley J., Haddad, Haissam, Maurer, Gerald, Yii, Michael, Asch, Federico M., Handschumacher, Mark D., Holly, Thomas A., Przybylski, Roman, Kron, Irving, Schaff, Hartzell, Aston, Susan, Horton, John, Lee, Kerry L., Velazquez, Eric J., and Grayburn, Paul A.

Published
2013
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19. Insights from the STICH trial: Change in left ventricular size after coronary artery bypass grafting with and without surgical ventricular reconstruction

Author

Michler, Robert E., Rouleau, Jean L., Al-Khalidi, Hussein R., Bonow, Robert O., Pellikka, Patricia A., Pohost, Gerald M., Holly, Thomas A., Oh, Jae K., Dagenais, Francois, Milano, Carmelo, Wrobel, Krzysztof, Pirk, Jan, Ali, Imtiaz S., Jones, Robert H., Velazquez, Eric J., Lee, Kerry L., and Di Donato, Marisa

Published
2013
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21. Regional left ventricular function does not predict survival in ischaemic cardiomyopathy after cardiac surgery

Author

Prior, David L, Stevens, Susanna R, Holly, Thomas A, Krejca, Michal, Paraforos, Alexandros, Pohost, Gerald M, Byrd, Krysti, Kukulski, Tomasz, Jones, Robert H, Desvigne-Nickens, Patrice, Varadarajan, Padmini, Amanullah, Aman, Lin, Grace, Al-Khalidi, Hussein R, Aldea, Gabriel, Santambrogio, Carlo, Bochenek, Andrzej, and Berman, Daniel S

Published
2017
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23. A 14.5-million-year record of East Antarctic Ice Sheet fluctuations from the central Transantarctic Mountains, constrained with cosmogenic 3He, 10Be, 21Ne, and 26Al

Author

Margaret S. Jackson, Greg Balco, Allie Balter-Kennedy, Holly Thomas, and Gordon R.M. Bromley

Subjects
geography, geography.geographical_feature_category, 010504 meteorology & atmospheric sciences, Pleistocene, Trough (geology), Antarctic ice sheet, Glacier, Massif, 15. Life on land, 010502 geochemistry & geophysics, 01 natural sciences, Paleontology, Tectonic uplift, 13. Climate action, Moraine, Glacial period, Geology, 0105 earth and related environmental sciences, Earth-Surface Processes, Water Science and Technology
Abstract

The distribution of moraines in the Transantarctic Mountains affords direct constraint of past ice-marginal positions of the East Antarctic Ice Sheet (EAIS). Here, we describe glacial geologic observations and cosmogenic-nuclide exposure ages from Roberts Massif, an ice-free area in the central Transantarctic Mountains. We measured cosmogenic 3He, 10Be, 21Ne, and 26Al in 168 dolerite and sandstone boulders collected from 24 distinct deposits. Our data show that a cold-based EAIS was present, in a configuration similar to today, for many periods over the last ∼14.5 Myr, including the mid-Miocene, late Pliocene, and early to Middle Pleistocene. Moraine ages at Roberts Massif increase with distance from, and elevation above, the modern ice margin, which is consistent with a persistent EAIS extent during glacial maxima and slow, isostatic uplift of the massif itself in response to trough incision by outlet glaciers. We also employ the exceptionally high cosmogenic-nuclide concentrations in several boulders, along with multi-isotope measurements in sandstone boulders, to infer extremely low erosion rates (≪5 cm Myr−1) over the period covered by our record. Although our data are not a direct measure of ice volume, the Roberts Massif glacial record indicates that the EAIS was present and similar to its current configuration during at least some periods when the global temperature was believed to be warmer and/or atmospheric CO2 concentrations were likely higher than today.

Published
2020
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27. Kidney Disease, Hypertension Treatment, and Cerebral Perfusion and Structure

Author

Manjula Kurella Tamura, Sarah Gaussoin, Nicholas M. Pajewski, Greg Zaharchuk, Barry I. Freedman, Stephen R. Rapp, Alexander P. Auchus, William E. Haley, Suzanne Oparil, Jessica Kendrick, Christianne L. Roumie, Srinivasan Beddhu, Alfred K. Cheung, Jeff D. Williamson, John A. Detre, Sudipto Dolui, R. Nick Bryan, Ilya M. Nasrallah, Paul Whelton, Karen C. Johnson, Joni Snyder, Diane Bild, Denise Bonds, Nakela Cook, Jeffrey Cutler, Lawrence Fine, Peter Kaufmann, Paul Kimmel, Lenore Launer, Claudia Moy, William Riley, Laurie Ryan, Eser Tolunay, Song Yang, David Reboussin, Jeff Williamson, Walter T. Ambrosius, William Applegate, Greg Evans, Capri Foy, Dalane Kitzman, Mary Lyles, Nick Pajewski, Steve Rapp, Scott Rushing, Neel Shah, Kaycee M. Sink, Mara Vitolins, Lynne Wagenknecht, Valerie Wilson, Letitia Perdue, Nancy Woolard, Tim Craven, Katelyn Garcia, Laura Lovato, Jill Newman, James Lovato, Lingyi Lu, Chris McLouth, Greg Russell, Bobby Amoroso, Patty Davis, Jason Griffin, Darrin Harris, Mark King, Kathy Lane, Wes Roberson, Debbie Steinberg, Donna Ashford, Phyllis Babcock, Dana Chamberlain, Vickie Christensen, Loretta Cloud, Christy Collins, Delilah Cook, Katherine Currie, Debbie Felton, Stacy Harpe, Marjorie Howard, Michelle Lewis, Pamela Nance, Nicole Puccinelli-Ortega, Laurie Russell, Jennifer Walker, Brenda Craven, Candace Goode, Margie Troxler, Janet Davis, Sarah Hutchens, Anthony A. Killeen, Anna M. Lukkari, Robert Ringer, Brandi Dillard, Norbert Archibeque, Stuart Warren, Mike Sather, James Pontzer, Zach Taylor, Elsayed Z. Soliman, Zhu-Ming Zhang, Yabing Li, Chuck Campbell, Susan Hensley, Julie Hu, Lisa Keasler, Mary Barr, Tonya Taylor, Christos Davatzikos, Ilya Nasarallah, Lisa Desiderio, Mark Elliott, Ari Borthakur, Harsha Battapady, Guray Erus, Alex Smith, Ze Wang, Jimit Doshi, Jackson T. Wright, Mahboob Rahman, Alan J. Lerner, Carolyn Still, Alan Wiggers, Sara Zamanian, Alberta Bee, Renee Dancie, George Thomas, Martin Schreiber, Sankar Dass Navaneethan, John Hickner, Michael Lioudis, Michelle Lard, Susan Marczewski, Jennifer Maraschky, Martha Colman, Andrea Aaby, Stacey Payne, Melanie Ramos, Carol Horner, Paul Drawz, Pratibha P. Raghavendra, Scott Ober, Ronda Mourad, Muralidhar Pallaki, Peter Russo, Pratibha Raghavendra, Pual Fantauzzo, Lisa Tucker, Bill Schwing, John R. Sedor, Edward J. Horwitz, Jeffrey R. Schellling, John F. O’Toole, Lisa Humbert, Wendy Tutolo, Suzanne White, Alishea Gay, Walter Clark, Robin Hughes, Mirela Dobre, Carolyn H. Still, Monique Williams, Udayan Bhatt, Lee Hebert, Anil Agarwal, Melissa Brown Murphy, Nicole Ford, Cynthia Stratton, Jody Baxter, Alicia A. Lykins, Alison McKinley Neal Leena Hirmath, Osei Kwame, Kyaw Soe, William F. Miser, Colleen Sagrilla, Jan Johnston, Amber Anaya, Ashley Mintos, Angel A. Howell, Kelly Rogers, Sara Taylor, Donald Ebersbacher, Lucy Long, Beth Bednarchik, Adrian Schnall, Jonathan Smith, Lori Peysha, Lisa Leach, Megan Tribout, Carla Harwell, Pinkie Ellington, Mary Ann Banerji, Pranav Ghody, Melissa Vahídeh Rambaud, Raymond Townsend, Debbie Cohen, Yonghong Huan, Mark Duckworth, Virginia Ford, Juliet Leshner, Ann Davison, Sarah Vander Veen, Crystal A. Gadegbeku, Avi Gillespie, Anuradha Paranjape, Sandra Amoroso, Zoe Pfeffer, Sally B. Quinn, Jiang He, Jing Chen, Eva Lustigova, Erin Malone, Marie Krousel-Wood, Richard Deichmann, Patricia Ronney, Susan Muery, Donnalee Trapani, Michael Rocco, David Goff, Carlos Rodriguez, Laura Coker, Amret Hawfield, Joseph Yeboah, Lenore Crago, John Summerson, Anita Hege, Matt Diamond, Laura Mulloy, Marcela Hodges, Michelle Collins, Charlene Weathers, Heather Anderson, Emily Stone, Walida Walker, Andrew McWilliams, Michael Dulin, Lindsay Kuhn, Susan Standridge, Lindsay Lowe, Kelly Everett, Kelry Preston, Susan Norton, Silena Gaines, Ali A. Rizvi, Andrew W. Sides, Diamond Herbert, Matthew M. Hix, Melanie Whitmire, Brittany Arnold, Philip Hutchinson, Joseph Espiritu, Mark Feinglos, Eugene Kovalik, Georgianne Gedon-Lipscomb, Kathryn Evans, Connie Thacker, Ronna Zimmer, Mary Furst, MaryAnn Mason, James Powell, Paul Bolin, Junhong Zhang, Mary Pinion, Gail Davis, Winifred Bryant, Presley Phelps, Connie Garris-Sutton, Beatrice Atkinson, Gabriele Contreras, Maritza Suarez, Ivonne Schulman, Don Koggan, Jackie Vassallo, Gloria Peruyera, Sheri Whittington, Cassandra Bethea, Laura Gilliam, Carolyn Pedley, Geraldine Zurek, Miriam Baird, Charles Herring, Mary Martha Smoak, Julie Williams, Samantha Rogers, Lindsay Gordon, Erin Kennedy, Beverly Belle, Jessica McCorkle-Doomy, Jonathan Adams, Ramon Lopez, Juris Janavs, Frederic Rahbari-Oskoui, Arlene Chapman, Allen Dollar, Olubunmi Williams, Yoosun Han, William Haley, Peter Fitzpatrick, Joseph Blackshear, Brian Shapiro, Anna Harrell, Arta Palaj, Katelyn Henderson, Ashley Johnson, Heath Gonzalez, Jermaine Robinson, Leonardo Tamariz, Jennifer Denizard, Rody Barakat, Dhurga Krishnamoorthy, Frank Greenway, Ron Monce, Timothy Church, Chelsea Hendrick, Aimee Yoches, Leighanne Sones, Markee Baltazar, Priscilla Pemu, Connie Jones, Derrick Akpalu, Gordon Chelune, Jeffrey Childs, Lisa Gren, Anne Randall, Laura Dember, Denise Soares, Jerry Yee, Kausik Umanath, Naima Ogletree, Schawana Thaxton, Karen Campana, Dayna Sheldon, Krista MacArthur, J. Brent Muhlestein, Nathan Allred, Brian Clements, Ritesh Dhar, Kent Meredith, Viet Le, Edward Miner, James Orford, Erik R. Riessen, Becca Ballantyne, Ben Chisum, Kevin Johnson, Dixie Peeler, Glenn Chertow, Manju Tamura, Tara Chang, Kevin Erickson, Jenny Shen, Randall S. Stafford, Gregory Zaharchuk, Margareth Del Cid, Michelle Dentinger, Jennifer Sabino, Rukmani Sahay, Ekaterina Telminova, Daniel E. Weiner, Mark Sarnak, Lily Chan, Amanda Civiletto, Alyson Heath, Amy Kantor, Priyanka Jain, Bethany Kirkpatrick, Andrew Well, Barry Yuen, Michel Chonchol, Beverly Farmer, Heather Farmer, Carol Greenwald, Mikaela Malaczewski, James Lash, Anna Porter, Ana Ricardo, Robert T. Rosman, Janet Cohan, Nieves Lopez Barrera, Daniel Meslar, Patricia Meslar, Margaret Conroy, Mark Unruh, Rachel Hess, Manisha Jhamb, Holly Thomas, Pam Fazio, Elle Klixbull, Melissa Komlos-Weimer, LeeAnne Mandich, Tina Vita, Robert Toto, Peter Van Buren, Julia Inrig, Martha Cruz, Tammy Lightfoot, Nancy Wang, Lori Webster, Kalani Raphael, Barry Stults, Tahir Zaman, Debra Simmons, Tooran Lavasani, Rebecca Filipowicz, Guo Wei, Gracie Mary Miller, Jenice Harerra, Jeff Christensen, Ajay Giri, Xiaorui Chen, Natalie Anderton, Arianna Jensen, Julia Lewis, Anna Burgner, Jamie P. Dwyer, Gerald Schulman, Terri Herrud, Ewanda Leavell, Tiffany McCray, Edwina McNeil-Simaan, Munmun Poudel, Malia Reed, Mohammed Sika, Delia Woods, Janice L. Zirkenbach, Dominic S. Raj, Scott Cohen, Samir Patel, Manuel Velasquez, Roshni S. Bastian, Maria Wing, Akshay Roy-Chaudhury, Thomas Depner, Lorien Dalyrymple, George Kaysen, Susan Anderson, John Nord, Joachim H. Ix, Leonard Goldenstein, Cynthia M. Miracle, Nketi Forbang, Maja Mircic, Brenda Thomas, Tiffany Tran, Anjay Rastogi, Mihae Kim, Mohamad Rashid, Bianca Lizarraga, Amy Hocza, Kristine Sarmosyan, Jason Norris, Tushar Sharma, Amanda Chioy, Eric Bernard, Eleanore Cabrera, Christina Lopez, Susana Nunez, Joseph Riad, Suzanne Schweitzer, Siran Sirop, Sarah Thomas, Lauren Wada, Holly Kramer, Vinod Bansal, Corliss E. Taylor, Mark S. Segal, Karen L. Hall, Amir Kazory, Lesa Gilbert, Linda Owens, Danielle Poulton, Elaine Whidden, Jocelyn Wiggins, Caroline Blaum, Linda Nyquist, Lillian Min, Tanya Gure, Ruth Lewis, Jennifer Mawby, Eileen Robinson, Cora E. Lewis, Virginia Bradley, David Calhoun, Stephen Glasser, Kim Jenkins, Tom Ramsey, Nauman Qureshi, Karen Ferguson, Sumrah Haider, Mandy James, Christy Jones, Kim Renfroe, April Seay, Carrie Weigart, Denyse Thornley-Brown, Dana Rizik, Bari Cotton, Meredith Fitz-Gerald, Tiffany Grimes, Carolyn Johnson, Sara Kennedy, Chanel Mason, Lesa Rosato-Burson, Robin Willingham, Eric Judd, Tonya Breaux-Shropshire, Felice Cook, Julia Medina, Lama Ghazi, Hemal Bhatt, James Lewis, Roman Brantley, John Brouilette, Jeffrey Glaze, Stephanie Hall, Nancy Hiott, David Tharpe, Spencer Boddy, Catherine Mack, Catherine Womack, Keiko Asao, Beate Griffin, Carol Hendrix, Karen Johnson, Lisa Jones, Chelsea Towers, Henry Punzi, Kathy Cassidy, Kristin Schumacher, Carmen Irizarry, Ilma Colon, Pedro Colon-Ortiz, Pedro J. Colón-Hernández, Orlando J. Carrasquillo-Navarro, Merari Carrasquillo, Nivea Vazquez, Miguel Sosa-Padilla, Alex Cintron-Pinero, Mayra Ayala, Olga Pacheco, Catalina Rivera, Irma Sotomayor-Gonzalez, Jamie Claudio, Jose Lazaro, Migdalia Arce, Lourdes Heres, Alba Perez, Jose Tavarez-Valle, Ferlinda Arocho, Mercedes Torres, Melvaliz Vazquez, Gerard P. Aurigemma, Rebecca Takis-Smith, Julia Andrieni, Noelle Bodkin, Kiran Chaudhary, Paula Hu, John Kostis, Nora Cosgrove, Denise Bankowski, Monica Boleyn, Laurie Casazza, Victoria Giresi, Tosha Patel, Erin Squindo, Yan Wu, Zeb Henson, Marion Wofford, Jessica Lowery, Deborah Minor, Kimberley Harkins, Alexander Auchus, Michael Flessner, Cathy Adair, Jordan Asher, Debbie Loope, Rita Cobb, Reiner Venegas, Thomas Bigger, Natalie Bello, Shunichi Homma, Daniel Donovan, Carlos Lopez-Jimenez, Amilcar Tirado, Asqual Getaneh, Rocky Tang, Sabrina Durant, Mathew Maurer, Sergio Teruya, Stephen Helmke, Julissa Alvarez, Ruth Campbell, Roberto Pisoni, Rachel Sturdivant, Deborah Brooks, Caroline Counts, Vickie Hunt, Lori Spillers, Donald Brautigam, Timothy Kitchen, Timothy Gorman, Jessica Sayers, Sarah Button, June Chiarot, Rosemary Fischer, Melissa Lyon, Maria Resnick, Nicole Hodges, Jennifer Ferreira, William Cushman, Barry Wall, Linda Nichols, Robert Burns, Jennifer Martindale-Adams, Dan Berlowitz, Elizabeth Clark, Sandy Walsh, Terry Geraci, Carol Huff, Linda Shaw, Karen Servilla, Darlene Vigil, Terry Barrett, Mary Ellen Sweeney, Rebecca Johnson, Susan McConnell, Khadijeh Shahid Salles, Francoise Watson, Cheryl Schenk, Laura Whittington, Maxine Maher, Jonathan Williams, Stephen Swartz, Paul Conlin, George Alexis, Rebecca Lamkin, Patti Underwood, Helen Gomes, Clive Rosendorff, Stephen Atlas, Saadat Khan, Waddy Gonzalez, Samih Barcham, Lawrence Kwon, Matar Matar, Anwar Adhami, Jan Basile, Joseph John, Deborah Ham, Hadi Baig, Mohammed Saklayen, Jason Yap, Helen Neff, Carol Miller, Ling Zheng-Phelan, Saib Gappy, Shiva Rau, Arathi Raman, Vicki Berchou, Elizabeth Jones, Erin Olgren, Cynthia Marbury, Michael Yudd, Sithiporn Sastrasinh, Jennine Michaud, Jessica Fiore, Marianne Kutza, Ronald Shorr, Rattana Mount, Helen Dunn, Susan Stinson, Jessica Hunter, Addison Taylor, Jeffery Bates, Catherine Anderson, Kent Kirchner, Jodi Stubbs, Ardell Hinton, Anita Spencer, Santosh Sharma, Thomas Wiegmann, Smita Mehta, Michelle Krause, Kate Dishongh, Richard Childress, Geeta Gyamlani, Atossa Niakan, Cathy Thompson, Janelle Moody, Carolyn Gresham, Jeffrey Whittle, Gary Barnas, Dawn Wolfgram, Heidi Cortese, Jonette Johnson, Christianne Roumie, Adriana Hung, Jennifer Wharton, Kurt Niesner, Lois Katz, Elizabeth Richardson, George Brock, Joanne Holland, Troy Dixon, Athena Zias, Christine Spiller, Penelope Baker, James Felicetta, Shakaib Rehman, Kelli Bingham, Suzanne Watnick, David Cohen, Jessica Weiss, Tera Johnston, Stephen Giddings, Hala Yamout, Andrew Klein, Caroline Rowe, Kristin Vargo, Kristi Waidmann, Vasilios Papademetriou, Jean Pierre Elkhoury, Barbara Gregory, Susan Amodeo, Mary Bloom, Dalia Goldfarb-Waysman, Richard Treger, Mehran Kashefi, Christina Huang, Karen Knibloe, Areef Ishani, Yelena Slinin, Christine Olney, Jacqueline Rust, Paolo Fanti, Christopher Dyer, Shweta Bansal, Monica Dunnam, Lih-Lan Hu, and Perla Zarate-Abbott

Subjects
Male, medicine.medical_specialty, Renal function, Perfusion scanning, Blood Pressure, Article, chemistry.chemical_compound, Internal medicine, medicine, Humans, Cerebral perfusion pressure, Renal Insufficiency, Chronic, Antihypertensive Agents, Aged, Creatinine, business.industry, medicine.disease, Perfusion, Blood pressure, chemistry, Cerebral blood flow, Nephrology, Cerebrovascular Circulation, Hypertension, Albuminuria, Cardiology, Female, medicine.symptom, business, Kidney disease, Glomerular Filtration Rate
Abstract

RATIONALE AND OBJECTIVE: The safety of intensive blood pressure (BP) targets is controversial for persons with chronic kidney disease (CKD). We studied the effects of hypertension treatment on cerebral perfusion and structure in those with and without CKD. STUDY DESIGN: Neuroimaging substudy of a randomized trial. SETTING & PARTICIPANTS: A subset of participants in the Systolic Blood Pressure Intervention Trial who underwent brain MRI studies. Presence of baseline CKD was assessed by estimated glomerular filtration rate (eGFR) and urine albumin to creatinine ratio (UACR). INTERVENTION: Participants were randomly assigned to intensive (systolic BP 30 mg/g (N=151), the effects of intensive versus standard BP treatment on change in global cerebral blood flow, WMLs and total brain volume were 1.91 ml/100g/min (95% CI −3.01, 6.82), 0.003 cm(3) (asinh transformed, 95% CI −0.13, 0.13), and −7.0 cm(3) (95% CI −13.3, −0.3), respectively. The overall treatment effects on cerebral blood flow and total brain volume were not modified by baseline eGFR or UACR; however the effect on WMLs was attenuated in participants with albuminuria (interaction p-value 0.04). LIMITATIONS: Measurement variability due to multi-site design. CONCLUSIONS: Among hypertensive adults with primarily early kidney disease, intensive versus standard blood pressure treatment did not appear to have a detrimental effect on brain perfusion or structure. The findings support the safety of intensive blood pressure treatment targets on brain health in persons with early kidney disease. FUNDING: The Systolic Blood Pressure Intervention Trial was funded by the National Institutes of Health (including the National Heart, Lung, and Blood Institute, the National Institute of Diabetes and Digestive and Kidney Diseases, the National Institute on Aging, and the National Institute of Neurological Disorders and Stroke), and this substudy was funded by the National Institutes of Diabetes and Digestive and Kidney Diseases. TRIAL REGISTRATION: SPRINT was registered at ClinicalTrials.gov with the study number NCT01206062.

Published
2021

31. Patient-centered imaging

Author

DePuey, E. Gordon, Mahmarian, John J., Miller, Todd D., Einstein, Andrew J., Hansen, Christopher L., Holly, Thomas A., Miller, Edward J., Polk, Donna M., and Samuel Wann, L.

Published
2012
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34. Single photon-emission computed tomography

Author

Holly, Thomas A., Abbott, Brian G., Al-Mallah, Mouaz, Calnon, Dennis A., Cohen, Mylan C., DiFilippo, Frank P., Ficaro, Edward P., Freeman, Michael R., Hendel, Robert C., Jain, Diwakar, Leonard, Scott M., Nichols, Kenneth J., Polk, Donna M., and Soman, Prem

Published
2010
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37. A 14.5 million-year record of East Antarctic Ice Sheet fluctuations from the central Transantarctic Mountains, constrained with cosmogenic 3He, 10Be, 21Ne, and 26Al

Author

Allie Balter, Gordon Bromley, Greg Balco, Holly Thomas, and Margaret S. Jackson

Abstract

The distribution of moraines in the Transantarctic Mountains affords direct constraint of past ice-marginal positions of the East Antarctic Ice Sheet (EAIS). Here, we describe glacial-geologic observations and cosmogenic-nuclide exposure ages from Roberts Massif, an ice-free area in the central Transantarctic Mountains. We measured cosmogenic 3He, 10Be, 21Ne, and 26Al in 180 dolerite and sandstone boulders collected from 24 distinct deposits. Our data show that a cold-based EAIS was present, in a configuration similar to today, for many periods over the last ~ 14.5 Myr, including the mid-Miocene, Late Pliocene, and early-to-mid Pleistocene. Moraine ages at Roberts Massif increase with distance from, and elevation above the modern ice margin, which is consistent with a persistent EAIS extent during glacial maxima, and slow, isostatic uplift of the massif itself in response to trough incision by outlet glaciers. We also employ the exceptionally high cosmogenic-nuclide concentrations in several boulders, along with multi-isotope measurements in sandstone boulders, to infer extremely low erosion rates (

Published
2020
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42. Contributors

Author

Alexopoulos, Nikolaos, primary, Bateman, Timothy M., additional, Bax, Jeroen J., additional, Beanlands, Rob S., additional, Beller, George A., additional, Bengel, Frank M., additional, Berman, Daniel S., additional, Bonow, Robert O., additional, Brown, Kenneth A., additional, Burg, Matthew M., additional, Calnon, Dennis A., additional, Canty, John M., additional, Carrió, Ignasi, additional, Case, James A., additional, Chen, Ji, additional, Cullom, S. James, additional, Dahlberg, Seth T., additional, DeKemp, Robert A., additional, DePuey, E. Gordon, additional, Di Carli, Marcelo F., additional, Faber, Tracy L., additional, Fallavollita, James A., additional, Fernandez, Antonio B., additional, Flotats, Albert, additional, Gaemperli, Oliver, additional, Gambhir, Sanjiv Sam, additional, Garcia, Ernest V., additional, Germano, Guido, additional, Gibbons, Raymond J., additional, Glover, David K., additional, Goodman, Dennis A., additional, Gropler, Robert J., additional, Hachamovitch, Rory, additional, Heller, Gary V., additional, Holly, Thomas A., additional, Iskandrian, Ami E., additional, Jain, Diwakar, additional, Kaufmann, Philipp A., additional, Kaul, Sanjiv, additional, Kikut, Janusz K., additional, King, Michael A., additional, Knuuti, Juhani, additional, Kontos, Michael C., additional, Kramer, Christopher M., additional, Kundu, Bijoy, additional, Lahiri, Avijit, additional, Leppo, Jeffrey A., additional, Lindner, Jonathan R., additional, Mahmarian, John J., additional, McLean, Dalton S., additional, Miller, Todd D., additional, Morrison, Alan R., additional, Ford-Mukkamala, Laura, additional, Narula, Jagat, additional, Pan, Tinsu, additional, Patel, Amit R., additional, Patton, James A., additional, Peterson, Linda R., additional, Poldermans, Don, additional, Polk, Donna M., additional, Pretorius, P. Hendrik, additional, Raggi, Paolo, additional, Russell, Raymond R., additional, Saraste, Antti, additional, Schelbert, Heinrich R., additional, Schindler, Thomas Hellmut, additional, Schinkel, Arend F.L., additional, Schwaiger, Markus, additional, Shaw, Leslee J., additional, Sherif, Hossam M., additional, Sinusas, Albert J., additional, Slomka, Piotr, additional, Soman, Prem, additional, Soufer, Robert, additional, Strauss, H. William, additional, Subramanya, Raghunandan Dudda, additional, Valenta, Ines, additional, Van Kriekinge, Serge D., additional, Venuraju, Shreenidhi, additional, Verjans, Johan W.H., additional, Wackers, Frans J.Th., additional, Van Der Wall, Ernst E., additional, Watson, Denny D., additional, Wu, Joseph C., additional, Yerramasu, Ajay Kumar, additional, Yoshinaga, Keiichiro, additional, Zaret, Barry L., additional, Ziadi, Maria Cecilia, additional, and Zoghbi, Gilbert J., additional

Published
2010
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47. Myocardial Viability and Survival in Ischemic Left Ventricular Dysfunction

Author

Bonow, Robert O., Maurer, Gerald, Lee, Kerry L., Holly, Thomas A., Binkley, Philip F., Desvigne-Nickens, Patrice, Drozdz, Jaroslaw, Farsky, Pedro S., Feldman, Arthur M., Doenst, Torsten, Michler, Robert E., Berman, Daniel S., Nicolau, Jose C., Pellikka, Patricia A., Wrobel, Krzysztof, Alotti, Nasri, Asch, Federico M., Favaloro, Liliana E., She, Lilin, Velazquez, Eric J., Jones, Robert H., and Panza, Julio A.

Published
2011

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