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Your search keyword '"Holskin, Beverly P."' showing total 12 results
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12 results on '"Holskin, Beverly P."'

1. Phosphoregulation of mixed-lineage kinase 1 activity by multiple phosphorylation in the activation loop

Author

Durkin, John T., Holskin, Beverly P., Kopec, Karla K., Reed, Matt S., Spais, Chrysanthe M., Steffy, Brian M., Gessner, George, Angeles, Thelma S., Pohl, Jan, Ator, Mark A., and Meyer, Sheryl L.

Subjects
Threonine -- Chemical properties, Protein kinases -- Research, Phosphorylation -- Methods, Biological sciences, Chemistry
Abstract

Mixed-lineage kinase 1 (MLK1) is a mitogen-activated protein kinase kinase kinase capable of activating the c-Jun NH2-terminal kinase (JNK) pathway. Immunoblot and mass spectrometry show that MLK1 is threonine phosphorylated in or near the activation loop. A kinase dead mutant is not, consistent with autophosphorylation.

Published
2004

4. ALK mutants in the kinase domain exhibit altered kinase activity and differential sensitivity to small molecule ALK inhibitors

Author

Lihui Lu, Ghose, Arup K., Quail, Matthew R., Albom, Mark S., Durkin, John T., Holskin, Beverly P., Angeles, Thelma S., Meyer, Sheryl L., Ruggeri, Bruce A., and Mangeng Cheng

Subjects
Enzyme inhibitors -- Chemical properties, Lymphomas -- Genetic aspects, Mutation (Biology) -- Analysis, Phosphotransferases -- Chemical properties, Biological sciences, Chemistry
Abstract

Several theoretical and experimental studies are conducted to explain the kinase activity of the anaplastic lymphoma kinase (ALK) chimeric proteins. The development of active ALK mutants that are resistant to small molecule ALK inhibitors is also discussed.

Published
2009

10. Mixed-Lineage Kinase 1 and Mixed-Lineage Kinase 3 Subtype-Selective Dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: Optimization, Mixed-Lineage Kinase 1 Crystallography, and Oral in Vivo Activity in 1-Methyl-4-phenyltetrahydropyridine Models

Author

Hudkins, Robert L., primary, Diebold, James L., additional, Tao, Ming, additional, Josef, Kurt A., additional, Park, Chung Ho, additional, Angeles, Thelma S., additional, Aimone, Lisa D., additional, Husten, Jean, additional, Ator, Mark A., additional, Meyer, Sheryl L., additional, Holskin, Beverly P., additional, Durkin, John T., additional, Fedorov, Alexander A., additional, Fedorov, Elena V., additional, Almo, Steven C., additional, Mathiasen, Joanne R., additional, Bozyczko-Coyne, Donna, additional, Saporito, Michael S., additional, Scott, Richard W., additional, and Mallamo, John P., additional

Published
2008
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11. Inhibition of mixed lineage kinase 3 attenuates MPP+-induced neurotoxicity in SH-SY5Y cells

Author

Mathiasen, Joanne R., primary, McKenna, Beth Ann W., additional, Saporito, Michael S., additional, Ghadge, Ghanashyam D., additional, Roos, Raymond P., additional, Holskin, Beverly P., additional, Wu, Zhi-Liang, additional, Trusko, Stephen P., additional, Connors, Thomas C., additional, Maroney, Anna C., additional, Thomas, Beth Ann, additional, Thomas, Jeffrey C., additional, and Bozyczko-Coyne, Donna, additional

Published
2004
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12. Induction by E1A oncogene expression of cellular susceptibility to lysis by TNF

Author

Chen, Mann-Jy, Holskin, Beverly, Strickler, James, Gorniak, Joselina, Clark, Mike A., Johnson, Paul J., Mitcho, Michelle, and Shalloway, David

Abstract

Tumour necrosis factor α (ref. 1), synthesized primarily by monocytes in response to various invasive agents, induces a wide variety of biological effects relevant to regulating cell growth and differentiation2–6, including the selective killing of some tumour cells and the growth stimulation of some normal fibroblasts3. As tumour necrosis factor (TNF) appears to kill tumour cells preferentially, we asked whether TNF sensitivity correlates with the expression of specific oncogene(s). If so, by examining the cellular target(s) of the oncogene product, it might be possible to identify specific factor(s) which mediate TNF action. By using an in vitro cytotoxicity assay with NIH 3T3 and Fisher BRK-derived cells expressing exogenously introduced oncogenes, we found that adenovirus E1A proteins induce susceptibility to TNF killing.

Published
1987
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