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2. Distinctive duodenal microbiomes and bile acid profiles in duodenal tumor patients revealed by prospective observational study

Author

Kubosawa, Yoko, Sujino, Tomohisa, Miyamoto, Kentaro, Kayashima, Atsuto, Minezaki, Daisuke, Morioka, Kohei, Iwata, Kentaro, Miyazaki, Kurato, Masunaga, Teppei, Mizutani, Mari, Akimoto, Teppei, Takatori, Yusaku, Matsuura, Noriko, Nakayama, Atsushi, Takabayashi, Kaoru, Nakamoto, Nobuhiro, Honda, Akira, Kato, Motohiko, Yahagi, Naohisa, and Kanai, Takanori

Published
2024
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17. Impaired Bile Acid Synthesis in a Taurine-Deficient Cat Model

Author

Miyazaki, Teruo, Sasaki, Sei-ich, Toyoda, Atsushi, Shirai, Mutsumi, Ikegami, Tadashi, Honda, Akira, Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Steinlein, Ortrud, Series Editor, Xiao, Junjie, Series Editor, Schaffer, Stephen W., editor, El Idrissi, Abdeslem, editor, and Murakami, Shigeru, editor

Published
2022
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18. Blood Taurine Dynamics in Captive Lions: Relationship with Feed and Bile Acid Composition

Author

Kohari, Daisuke, Kobayashi, Shiori, Akiba, Yuki, Kawase, Keisuke, Miyakawa, Yoshinaka, Honda, Akira, Miyazaki, Teruo, Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Steinlein, Ortrud, Series Editor, Xiao, Junjie, Series Editor, Schaffer, Stephen W., editor, El Idrissi, Abdeslem, editor, and Murakami, Shigeru, editor

Published
2022
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22. Unique bile acid profiles in the bile ducts of patients with primary sclerosing cholangitis

Author

Kayashima, Atsuto, primary, Sujino, Tomohisa, additional, Fukuhara, Seiichiro, additional, Miyamoto, Kentaro, additional, Kubosawa, Yoko, additional, Ichikawa, Masataka, additional, Kawasaki, Shintaro, additional, Takabayashi, Kaoru, additional, Iwasaki, Eisuke, additional, Kato, Motohiko, additional, Honda, Akira, additional, Kanai, Takanori, additional, and Nakamoto, Nobuhiro, additional

Published
2024
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27. Environmental factors, medical and family history, and comorbidities associated with primary biliary cholangitis in Japan: a multicenter case–control study

Author

Matsumoto, Kosuke, Ohfuji, Satoko, Abe, Masanori, Komori, Atsumasa, Takahashi, Atsushi, Fujii, Hideki, Kawata, Kazuhito, Noritake, Hidenao, Tadokoro, Tomoko, Honda, Akira, Asami, Maiko, Namisaki, Tadashi, Ueno, Masayuki, Sato, Ken, Kakisaka, Keisuke, Arakawa, Mie, Ito, Takanori, Tanaka, Kazunari, Matsui, Takeshi, Setsu, Toru, Takamura, Masaaki, Yasuda, Satoshi, Katsumi, Tomohiro, Itakura, Jun, Sano, Tomoya, Tamura, Yamato, Miura, Ryo, Arizumi, Toshihiko, Asaoka, Yoshinari, Uno, Kiyoko, Nishitani, Ai, Ueno, Yoshiyuki, Terai, Shuji, Takikawa, Yasuhiro, Morimoto, Youichi, Yoshiji, Hitoshi, Mochida, Satoshi, Ikegami, Tadashi, Masaki, Tsutomu, Kawada, Norifumi, Ohira, Hiromasa, and Tanaka, Atsushi

Published
2022
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31. Association Between Early Surgery and Postoperative Opioid Use in Patients With Lumbar Disc Herniation: A Propensity Score-Matching Analysis Using an Administrative Claims Database in Japan.

Author

Honda, Akira, Iizuka, Yoichi, Tokue, Mieda, Takasawa, Eiji, Ishiwata, Sho, Tomomatsu, Yusuke, Ito, Shunsuke, Inomata, Kazuhiro, Okada, Akira, Matsui, Hiroki, Yasunaga, Hideo, and Chikuda, Hirotaka

Subjects
SPINAL surgery, DATABASES, HERNIA, OPIOIDS, SURGERY, DELAYED diagnosis
Abstract

Study Design: Retrospective cohort study Objectives: This study aimed to investigate whether early surgery shortens the duration of opioid use in patients who underwent surgery with lumbar disc herniation. Methods: We extracted patients who underwent surgery at least 2 weeks after they were diagnosed with lumbar disc herniation between April 2014 and May 2021. Opioid use after surgery was compared between patients who underwent surgery within 90 days (early surgery group) and 90 days or later (late surgery group). Propensity-score-matching analysis and multivariable Cox hazard regression analysis with a restricted cubic spline model were conducted to evaluate the association between the timing of surgery and termination of opioid use after surgery. Results: A total of 1597 eligible patients were identified, with 807 (51%) in the early surgery group. In the propensity-score-matched cohort, the early surgery group had a significantly lower proportion of opioid use than the control group (28% vs 48%, percent difference −20%, P <.001). Multivariable Cox hazard regression analysis showed that early surgery was significantly associated with the earlier termination of opioid use (HR, 3.13; 95% CI, 1.97-4.97; P <.001). Restricted cubic spline model showed a monotonically decreased hazard ratio and decreased hazard ratio of.50 in patients who underwent surgery 111 days or later after the diagnosis. Conclusions: Early surgery, especially within 90 days, was associated with earlier opioid use termination after surgery. Regarding the duration of opioid use following surgery, surgical treatment may be preferable to perform within around 4 months after the diagnosis. [ABSTRACT FROM AUTHOR]

Published
2024
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34. Clinical characteristics of immunoglobulin IgG4-related sclerosing cholangitis: Comparison of cases with and without autoimmune pancreatitis in a large cohort

Author

Furumatsu, Keisuke, Sawai, Shigeaki, Goto, Takuma, Okumura, Toshikatsu, Suzuki, Daisuke, Otsuka, Masayuki, Kobori, Ikuhiro, Tamano, Masaya, Koizumi, Mitsuhito, Hiasa, Yoichi, Kawabe, Naoto, Hirooka, Yoshiki, Yamamoto, Satoshi, Asano, Yukio, Inui, Kazuo, Horiguchi, Akihiko, Watanabe, Hiroyuki, Toya, Daishu, Hatayama, Katsuko, Ueki, Toshiharu, Kinoshita, Norikatsu, Sugimoto, Mitsuru, Ohira, Hiromasa, Mukai, Tsuyoshi, Tomita, Eiichi, Iwata, Keisuke, Shimizu, Shogo, Suetsugu, Jun, Shimizu, Masahito, Tsuji, Keiji, Ishida, Ryoko, Ito, Masanori, Furukawa, Ryutaro, Sakamoto, Naoya, Araki, Masahiro, Tanno, Satoshi, Sakamoto, Yasunari, Ito, Tetsuhide, Takai, Satoshi, Ikeya, Shinichi, Yamada, Takanori, Kudara, Norihiko, Shimizu, Akinori, Hanada, Keiji, Ichiki, Yasunori, Kitada, Hideki, Hifumi, Michio, Kimura, Hiroyuki, Kurosaki, Masayuki, Izumi, Namiki, Sumi, Hajime, Haruta, Jun-ichi, Hayashi, Katsumi, Harada, Ryo, Inoue, Masafumi, Nakamura, Shinichiro, Ito, Tetsuya, Tomishima, Ko, Isayama, Hiroyuki, Oura, Kyoko, Masaki, Tsutomu, Shimokawahara, Naoto, Tanoue, Shirou, Maemura, Kousei, Ido, Akio, Mizushima, Ichiro, Kawano, Mitsuhiro, Yoshida, Katsunori, Naganuma, Makoto, Murata, Miki, Nishio, Akiyoshi, Fujita, Yuji, Teratani, Takuma, Matsubara, Shohei, Tamai, Hironao, Yoshida, Yuu, Azemoto, Ryousaku, Kamata, Ken, Watanabe, Tomohiro, Kurosu, Takahiro, Koizumi, Wasaburou, Fujita, Jun, Seki, Hideyuki, Ueda, Yasuhiro, Fukumoto, Takumi, Kousaki, Takuhiro, Uchida, Kazushige, Ochiai, Toshimasa, Kawasaki, Takeshi, Tanaka, Motohiko, Ishida, Etsuji, Notohara, Kenji, Mori, Hideaki, Mori, Toshiyuki, Kawabata, Hideaki, Miyata, Masatoshi, Sakagami, Junichi, Itoh, Yoshito, Shiokawa, Masahiro, Seno, Hiroshi, Watanabe, Noriko, Naitoh, Itaru, Kataoka, Hiromi, Aoki, Toshinori, Fujishiro, Mitsuhiro, Niihara, Toru, Nishimata, Hiroto, Mitoro, Akira, Yoshiji, Hitoshi, Yoshida, Motoyuki, Ikeda, Masafumi, Tomita, Kengo, Hokari, Ryota, Hayasaka, Kenji, Amano, Yuji, Shioji, Kazuhiko, Hayashi, Kazunao, Terai, Shuji, Nakajima, Michiko, Yamahana, Junya, Matsumoto, Ryusuke, Kikuchi, Hideaki, Kanamori, Akira, Kiriyama, Seiki, Iwatsu, Shinichi, Kato, Yuji, Horiguchi, Shigeru, Yagi, Takahito, Okada, Hiroyuki, Ohkawa, Kazuyoshi, Hirao, Motohiro, Hiramatsu, Naoki, Oza, Noriko, Imamura, Haruo, Baba, Takeshi, Nakano, Shigeru, Shinobi, Tetsuya, Ryozawa, Shomei, Motoya, Masayo, Nakase, Hiroshi, Kinoshita, Noboru, Ito, Kei, Miyake, Tatsuya, Kohge, Naruaki, Tobita, Hiroshi, Joshita, Satoru, Umemura, Takeji, Kawaguchi, Shinya, Ohno, Kazuya, Sonobe, Koichi, Satoh, Akihiko, Shimosegawa, Tooru, Miura, Fumihiko, Yagi, Minami, Sano, Keiji, Tanaka, Atsushi, Kin, Toshifumi, Katanuma, Akio, Koike, Kazuhiko, Miura, Shin, Masamune, Atsushi, Kawashima, Youhei, Kagawa, Tatehiro, Azuma, Seishin, Watanabe, Mamoru, Honjyo, Mitsuyoshi, Itoi, Takao, Honda, Akira, Kobayashi, Katsumasa, Asano, Toru, Kamisawa, Terumi, Mizuno, Suguru, Nishino, Takayoshi, Taniguchi, Hideaki, Tajiri, Kazuto, Yasuda, Ichiro, Tanaka, Yoshiya, Oe, Shinji, Harada, Masaru, Kurata, Masanao, Fukasawa, Mituharu, Enomoto, Nobuyuki, Kawaji, Yuki, Kitano, Masayuki, Nishise, Yuko, Hirakawa, Hidetoshi, Ishizawa, Tetsuya, Ueno, Yoshiyuki, Kaino, Miyuki, Fujimoto, Yuko, Sakaida, Isao, Kubota, Kensuke, Nakazawa, Takahiro, Takikawa, Hajime, Unno, Michiaki, Kawa, Shigeyuki, Nakamura, Seiji, and Okazaki, Kazuichi

Published
2021
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36. Primary epidural extra-osseous Ewing sarcoma/peripheral primitive neuroectodermal tumor of the cervical spine curatively treated by surgery and adjuvant chemoradiotherapy: A case report and review of the literature

Author

Ito, Shunsuke, Iizuka, Yoichi, Nishinome, Masahiro, Yanagawa, Takashi, Koshi, Hiromi, Tokue, Azusa, Mieda, Tokue, Takasawa, Eiji, Tsunoda, Daisuke, Ishiwata, Sho, Honda, Akira, Inomata, Kazuhiro, Tajika, Tsuyoshi, and Chikuda, Hirotaka

Published
2021
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38. Association of Serum and Fecal Bile Acid Patterns With Liver Fibrosis in Biopsy-Proven Nonalcoholic Fatty Liver Disease: An Observational Study

Author

Kasai, Yuki, Kessoku, Takaomi, Tanaka, Kosuke, Yamamoto, Atsushi, Takahashi, Kota, Kobayashi, Takashi, Iwaki, Michihiro, Ozaki, Anna, Nogami, Asako, Honda, Yasushi, Ogawa, Yuji, Kato, Shingo, Imajo, Kento, Higurashi, Takuma, Hosono, Kunihiro, Yoneda, Masato, Usuda, Haruki, Wada, Koichiro, Kawanaka, Miwa, Kawaguchi, Takumi, Torimura, Takuji, Kage, Masayoshi, Hyogo, Hideyuki, Takahashi, Hirokazu, Eguchi, Yuichiro, Aishima, Shinichi, Kobayashi, Noritoshi, Sumida, Yoshio, Honda, Akira, Oyamada, Shunsuke, Shinoda, Satoru, Saito, Satoru, and Nakajima, Atsushi

Published
2022
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39. Long-term remission after upfront autologous hematopoietic stem cell transplant for CD5+ diffuse large-B cell lymphoma.

Author

Masamoto, Yosuke, Honda, Akira, Shinozaki-Ushiku, Aya, Ushiku, Tetsuo, and Kurokawa, Mineo

Abstract

AbstractCD5+ diffuse large B-cell lymphoma (DLBCL) is a rare subtype characterized by an inferior outcome. While dose-dense therapy shows promising activity, the optimal management remains to be determined. To evaluate the benefit of consolidative autologous hematopoietic stem cell transplantation (ASCT), we retrospectively reviewed the medical records of 47 consecutive patients with newly diagnosed de novo CD5+ DLBCL. Of 19 patients ≤ 70 of age with age-adjusted International Prognostic Index 2–3, eight underwent upfront ASCT, and nine did not, despite preserved organ function and response after induction therapy. The remaining two, ineligible for ASCT due to early progression or comorbidities, had a dismal clinical course. Among younger 17 high-risk patients eligible for ASCT, ASCT was associated with better overall (p = 0.0327) and progression-free survival (p = 0.0184). Younger patients without ASCT demonstrated similar outcomes to older patients with similar risk profiles. ASCT could be considered for high-risk CD5+ DLBCL with a response after induction therapy. [ABSTRACT FROM AUTHOR]

Published
2024
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40. Effect of Intraoperative Tranexamic Acid on Perioperative Major Hemorrhage Requiring Transfusion in Patients Undergoing Elective Spine Surgery: A Propensity Score-Matched Analysis Using a National Inpatient Database.

Author

Honda, Akira, Iizuka, Yoichi, Michihata, Nobuaki, Uda, Kazuaki, Mieda, Tokue, Takasawa, Eiji, Ishiwata, Sho, Kakuta, Yohei, Tomomatsu, Yusuke, Ito, Shunsuke, Inomata, Kazuhiro, Matsui, Hiroki, Fushimi, Kiyohide, Yasunaga, Hideo, and Chikuda, Hirotaka

Subjects
SPINAL surgery, ELECTIVE surgery, BLOOD transfusion, TRANEXAMIC acid, DATABASES, ACUTE coronary syndrome
Abstract

Study Design: Retrospective cohort study. Objectives: This study aimed to examine whether the use of intravenous TXA in elective spine surgery is associated with reduced perioperative massive hemorrhage requiring transfusion. Methods: We extracted all patients who underwent decompression with or without fusion surgery for the cervical, thoracic, and lumbar spine between April 2012 and March 2019. The primary outcome was the occurrence of massive hemorrhage requiring transfusion, defined as at least 560 mL of blood transfusion within 2 days of spine surgery or the requirement of additional blood transfusion from 3-7 days postoperatively. Secondary outcomes were the occurrence of thrombotic complications (pulmonary embolism, acute coronary syndrome, and stroke) and postoperative hematoma requiring additional surgery. Results: We identified 83,821 eligible patients, with 9747 (12%) patients in the TXA group. Overall, massive hemorrhage requiring transfusion occurred in 781 (.9%) patients. Propensity score matching yielded 8394 pairs. In the matched cohort, the TXA group had a lower proportion of massive hemorrhage requiring transfusion than the control group (.7% vs 1.1%; P =.002). There was no significant difference in the occurrence of thrombotic complications and postoperative hematoma requiring additional surgery between both groups. The multivariable regression analysis also showed that the use of TXA was associated with significantly lower proportions of massive hemorrhage requiring transfusion (odds ratio,.62; 95% confidence interval,.43-.90; P =.012). Conclusions: In this analysis using real-world data, TXA use in elective spinal surgery was associated with reduced perioperative massive hemorrhage requiring transfusion without increasing thrombotic complications. Level of evidence: Prognostic Level Ⅲ [ABSTRACT FROM AUTHOR]

Published
2024
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41. Serum Amino Acid Profiling in Citrin-Deficient Children Exhibiting Normal Liver Function During the Apparently Healthy Period

Author

Miyazaki, Teruo, Nagasaka, Hironori, Komatsu, Haruki, Inui, Ayano, Morioka, Ichiro, Tsukahara, Hirokazu, Kaji, Shunsaku, Hirayama, Satoshi, Miida, Takashi, Kondou, Hiroki, Ihara, Kenji, Yagi, Mariko, Kizaki, Zenro, Bessho, Kazuhiko, Kodama, Takahiro, Iijima, Kazumoto, Yorifuji, Tohru, Matsuzaki, Yasushi, Honda, Akira, Baumgartner, Matthias, Series Editor, Patterson, Marc, Series Editor, Rahman, Shamima, Series Editor, Peters, Verena, Series Editor, Morava, Eva, Editor-in-Chief, and Zschocke, Johannes, Series Editor

Published
2019
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42. Influences of Taurine Deficiency on Bile Acids of the Bile in the Cat Model

Author

Miyazaki, Teruo, Sasaki, Sei-ich, Toyoda, Atsushi, Shirai, Mutsumi, Ikegami, Tadashi, Matsuzaki, Yasushi, Honda, Akira, LAMBRIS, JOHN D., Editorial Board Member, REZAEI, NIMA, Editorial Board Member, Hu, Jianmin, editor, Piao, Fengyuan, editor, Schaffer, Stephen W., editor, El Idrissi, Abdeslem, editor, and Wu, Jang-Yen, editor

Published
2019
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43. Proteinuria screening and risk of bone fracture: a retrospective cohort study using a nationwide population-based database

Author

Okada, Akira, primary, Honda, Akira, additional, Watanabe, Hideaki, additional, Sasabuchi, Yusuke, additional, Aso, Shotaro, additional, Kurakawa, Kayo Ikeda, additional, Nangaku, Masaomi, additional, Yamauchi, Toshimasa, additional, Yasunaga, Hideo, additional, Chikuda, Hirotaka, additional, Kadowaki, Takashi, additional, and Yamaguchi, Satoko, additional

Published
2023
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49. Proteinuria screening and risk of bone fracture: a retrospective cohort study using a nationwide population-based database.

Author

Okada, Akira, Honda, Akira, Watanabe, Hideaki, Sasabuchi, Yusuke, Aso, Shotaro, Kurakawa, Kayo Ikeda, Nangaku, Masaomi, Yamauchi, Toshimasa, Yasunaga, Hideo, Chikuda, Hirotaka, Kadowaki, Takashi, and Yamaguchi, Satoko

Subjects
*BONE fractures, *DATABASES, *PROTEINURIA, *HIP fractures, *VERTEBRAL fractures
Abstract

Background and hypothesis Proteinuria is associated with an increased risk of kidney function deterioration, cardiovascular disease, or cancer. Previous reports suggesting an association between kidney dysfunction and bone fracture may be confounded by concomitant proteinuria and were inconsistent regarding the association between proteinuria and bone fracture. Therefore, we aimed to evaluate the association using a large administrative claims database in Japan. Methods Using the DeSC database, we retrospectively identified individuals with laboratory data including urine dipstick test between August 2014 and February 2021. We evaluated the association between proteinuria and vertebral or hip fracture using multivariable Cox regression analyses adjusted for various background factors including kidney function. We also performed subgroup analyses stratified by sex and kidney function and sensitivity analyses with Fine & Gray models considering death as a competing risk. Results We identified 603   766 individuals and observed 21   195 fractures. With reference to the negative proteinuria group, the hazard ratio for hip or vertebral fracture was 1.10 [95% confidence interval (CI), 1.05–1.14] and 1.16 (95%CI, 1.11–1.22) in the trace and positive proteinuria group, respectively, in the Cox regression analysis. The subgroup analyses showed similar trends. The Fine & Gray model showed a subdistribution hazard ratio of 1.09 (95%CI, 1.05–1.14) in the trace proteinuria group and 1.15 (95% CI, 1.10–1.20) in the positive proteinuria group. Conclusions Proteinuria was associated with an increased risk of developing hip or vertebral fractures after adjustment for kidney function. Our results highlight the clinical importance of checking proteinuria for predicting bone fractures. [ABSTRACT FROM AUTHOR]

Published
2024
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