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253 results on '"Hong, Jinsheng"'

15. Efficacy and safety of KL-A167 in previously treated recurrent or metastatic nasopharyngeal carcinoma: a multicenter, single-arm, phase 2 study

Author

Shi, Yuankai, Qin, Xintian, Peng, Xingchen, Zeng, Aiping, Li, Jingao, Chen, Chuanben, Qiu, Sufang, Pan, Suming, Zheng, Yulong, Cai, Jing, Chen, Xiaopin, Qu, Shenhong, Lin, Lizhu, Huang, Jianli, Wu, Hui, Lu, Ying, Wang, Wei, Hu, Changlu, He, Xia, Yu, Zhonghua, Liu, Xiaojian, Xie, Bo, Liu, Anwen, Hu, Guangyuan, Jing, Shanghua, Zhang, Qingyuan, Guo, Renhua, Li, Qi, Hong, Jinsheng, Jin, Feng, Meng, Juan, Shi, Jianhua, Wang, Peiguo, Cui, Jiuwei, Yang, Kunyu, Zhang, Xuebang, Li, Xiaojiang, Shen, Liangfang, He, Yuxiang, Zhai, Limin, Sun, Xiuhua, Ge, Junyou, Qing, Yan, and Zong, Dekang

Published
2023
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20. Clinical results of definitive radiotherapy for local recurrent kimura disease in the head and neck after surgery: A retrospective study.

Author

Lv, Wenlong, Li, Shan, Liu, Feng, Xue, Wangui, Guo, Feibao, and Hong, Jinsheng

Subjects
PATIENT safety, RESEARCH funding, ACADEMIC medical centers, T-test (Statistics), TREATMENT effectiveness, RETROSPECTIVE studies, DESCRIPTIVE statistics, KIMURA disease, DISEASE relapse, RADIATION doses, DATA analysis software, COMPARATIVE studies, EOSINOPHILS
Abstract

Objective: To evaluate the efficacy and safety of definitive radiotherapy in selected patients with local recurrence of Kimura disease of the head and neck after surgery. Methods: This retrospective study collected the clinical data of 14 patients with postoperative recurrence of Kimura disease of the head and neck who received definitive radiotherapy at the First Affiliated Hospital of Fujian Medical University between 2006 and 2022. The radiation dose ranged from 28 to 40 Gy. Its efficacy and safety were analyzed. Results: During follow‐up, ranging from 17 to 168 months, local control was achieved in 13 (92.9%) of the 14 patients with postoperative recurrence. There were no serious late toxicities except for mild xerostomia in four (28.6%) patients; the patients' peripheral blood eosinophil count dropped from 1.73×109/L before treatment to 0.42×109/L after treatment, and the eosinophil percentage dropped from 20.64% to 9.78%. Both changes were statistically significant (p<0.001). Conclusions: The findings of the study suggest that definitive radiotherapy is a viable and effective alternative to repeated surgery for managing recurrent Kimura disease of the head and neck, with significant response rates and a good safety profile. Peripheral blood eosinophil counts and percentages serve as simple and reliable biomarkers for monitoring Kimura disease progression and treatment responses. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Camrelizumab versus placebo in combination with gemcitabine and cisplatin as first-line treatment for recurrent or metastatic nasopharyngeal carcinoma (CAPTAIN-1st): a multicentre, randomised, double-blind, phase 3 trial

Author

Yang, Yunpeng, Qu, Song, Li, Jingao, Hu, Chaosu, Xu, Mingjun, Li, Weidong, Zhou, Ting, Shen, Liangfang, Wu, Hui, Lang, Jinyi, Hu, Guangyuan, Luo, Zhanxiong, Fu, Zhichao, Qu, Shenhong, Feng, Weineng, Chen, Xiaozhong, Lin, Shaojun, Zhang, Weimin, Li, Xiaojiang, Sun, Yan, Lin, Zhixiong, Lin, Qin, Lei, Feng, Long, Jianting, Hong, Jinsheng, Huang, Xiaoming, Zeng, Lingzhi, Wang, Peiguo, He, Xiaohui, Zhang, Ben, Yang, Qing, Zhang, Xiaojing, Zou, Jianjun, Fang, Wenfeng, and Zhang, Li

Published
2021
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24. The Effect of Intracranial Control After Intracranial Local Therapy on the Prognosis of Patients with Brain Metastasis of Lung Adenocarcinoma.

Author

Shen, Minmin, Lin, Qiaojing, Zou, Xi, Wu, Yufan, Lin, Zhihong, Shao, Linglong, Hong, JinSheng, and Chen, Jinmei

Subjects
ANAPLASTIC lymphoma kinase, EPIDERMAL growth factor receptors, PROPORTIONAL hazards models, OVERALL survival, PROGRESSION-free survival
Abstract

Purpose: The aim of the present study was to assess the clinical outcomes and prognostic factors of lung adenocarcinoma patients with brain metastases (BMs) after intracranial local therapy. Patients and Methods: A total of 83 lung adenocarcinoma patients with BMs who underwent craniotomy combined with radiotherapy or intracranial radiotherapy alone were retrospectively analyzed. The intracranial tumor response was determined according to the Response Assessment in Neuro-Oncology of Brain Metastases (RANO-BM) criteria. The median overall survival (OS), intracranial progression-free survival (iPFS), and related prognostic factors were analyzed with the Kaplan‒Meier estimator method and Cox proportional hazards regression model. Results: Among 83 patients, 20 patients received craniotomy combined with radiotherapy, and 63 patients received intracranial radiotherapy alone. Following intracranial local therapy, 11 patients (13.3%) achieved complete response (CR); among them, 8 patients underwent neurosurgical resection. In addition, 32 patients (38.55%) achieved partial response (PR), 32 patients (38.55%) experienced stable disease (SD), and 8 (9.6%) experienced progressive disease (PD). The median follow-up period was 25.4 months (range 0.8– 49.6 months). The median follow-up time for the iPFS was 16.2 months (range 0.6– 41.2 months). The median OS, iPFS were 28.2 months and 24.7 months. Epidermal growth factor receptor (EGFR) / anaplastic lymphoma kinase (ALK) mutations (HR 3.216, 95% confidence interval (CI) 1.269– 8.150, p = 0.014) and iPFS (HR 0.881, 95% CI 0.836– 0.929, p < 0.001) were found to be beneficial factors for OS. An intracranial-tumor CR was associated with a longer iPFS (PR: HR 0.052, 95% CI 0.009– 0.297, p = 0.001; SD: HR 0.081, 95% CI 0.025– 0.259, p < 0.001; PD: HR 0.216, 95% CI 0.077– 0.606, p = 0.004). Conclusion: Prolonged iPFS was associated with better OS in lung adenocarcinoma patients with BMs following intracranial local therapy, and mutations of EGFR / ALK or an intracranial-tumor CR are independent prognostic factors for prolonged survival. [ABSTRACT FROM AUTHOR]

Published
2024
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37. Additional file 1 of The prognostic significance of tumor-associated neutrophils and circulating neutrophils in glioblastoma (WHO CNS5 classification)

Author

Wang, Xuezhen, Li, Xiaoxia, Wu, Yufan, Hong, Jinsheng, and Zhang, Mingwei

Abstract

Additional file 1: Fig. S1. KM survival curves of patients based on TANs levels (A), age (B), sex (C), MGMT promoter status (D), radiation status (E), chemotherapy status (F). The univariate and multivariate Cox analyses of TANs levels and patient survival in the whole-cohort GBM(CNS5) patients in dataset of CGGA (G).

Published
2023
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42. Interleukin 11 Protects Bone Marrow Mitochondria from Radiation Damage

Author

Huang, Luqiang, Zhang, Zhenhuan, Lv, Wenlong, Zhang, Mei, Yang, Shanmin, Yin, Liangjie, Hong, Jinsheng, Han, Deping, Chen, Chun, Swarts, Steve, Vidyasagar, Sadasivan, Okunieff, Paul, Zhang, Lurong, Cohen, Irun R., Series Editor, Lajtha, Abel, Series Editor, Paoletti, Rodolfo, Series Editor, Lambris, John D., Series Editor, Van Huffel, Sabine, editor, Naulaers, Gunnar, editor, Caicedo, Alexander, editor, Bruley, Duane F., editor, and Harrison, David K., editor

Published
2013
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43. Radiation Affects the Responsiveness of Bone Marrow to G-CSF

Author

Zhang, Zhenhuan, Zhang, Mei, Lv, Wenlong, Huang, Luqiang, Yin, Liangjie, Yang, Shanmin, Hong, Jinsheng, Han, Deping, Chen, Chun, Zhang, Amy, Vidyasagar, Sadasivan, Okunieff, Paul, Zhang, Lurong, Cohen, Irun R., Series Editor, Lajtha, Abel, Series Editor, Paoletti, Rodolfo, Series Editor, Lambris, John D., Series Editor, Van Huffel, Sabine, editor, Naulaers, Gunnar, editor, Caicedo, Alexander, editor, Bruley, Duane F., editor, and Harrison, David K., editor

Published
2013
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44. Amifostine Acts Upon Mitochondria to Stimulate Growth of Bone Marrow and Regulate Cytokines

Author

Lv, Wenlong, Zhang, Mei, Zhang, Zhenhuan, Huang, Luqiang, Yang, Shanmin, Yin, Liangjie, Hong, Jinsheng, Han, Deping, Chen, Chun, Vidyasagar, Sadasivan, Okunieff, Paul, Zhang, Lurong, Cohen, Irun R., Series Editor, Lajtha, Abel, Series Editor, Paoletti, Rodolfo, Series Editor, Lambris, John D., Series Editor, Van Huffel, Sabine, editor, Naulaers, Gunnar, editor, Caicedo, Alexander, editor, Bruley, Duane F., editor, and Harrison, David K., editor

Published
2013
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