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246 results on '"Hong, Ming-Yuan"'

9. Genetically modified pigs with CD163 point mutation are resistant to HP-PRRSV infection.

Author

Ying Liu, Lin Yang, Hong-Yong Xiang, Ming Niu, Jia-Cheng Deng, Xue-Yuan Li, Wen-Jie Hao, Hong-Sheng OuYang, Tong-Yu Liu, Xiao-Chun Tang, Da-Xin Pang, and Hong-Ming Yuan

Subjects
PORCINE reproductive & respiratory syndrome, SWINE, COMMUNICABLE diseases, AFRICAN swine fever, CIRCOVIRUS diseases
Abstract

Porcine reproductive and respiratory syndrome (PRRS) is a globally prevalent contagious disease caused by the positive-strand RNA PRRS virus (PRRSV), resulting in substantial economic losses in the swine industry. Modifying the CD163 SRCR5 domain, either through deletion or substitution, can eff1ectively confer resistance to PRRSV infection in pigs. However, large fragment modifications in pigs inevitably raise concerns about potential adverse effects on growth performance. Reducing the impact of genetic modifications on normal physiological functions is a promising direction for developing PRRSV-resistant pigs. In the current study, we identified a specific functional amino acid in CD163 that influences PRRSV proliferation. Viral infection experiments conducted on Marc145 and PK-15CD163 cells illustrated that the mE535G or corresponding pE529G mutations markedly inhibited highly pathogenic PRRSV (HP-PRRSV) proliferation by preventing viral binding and entry. Furthermore, individual viral challenge tests revealed that pigs with the E529G mutation had viral loads two orders of magnitude lower than wild-type (WT) pigs, confirming effective resistance to HP-PRRSV. Examination of the physiological indicators and scavenger function of CD163 verified no significant differences between the WT and E529G pigs. These findings suggest that E529G pigs can be used for breeding PRRSV-resistant pigs, providing novel insights into controlling future PRRSV outbreaks. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Comparing the Prognostic Impacts of Delayed Administration of Appropriate Antimicrobials in Older Patients with Afebrile and Febrile Community-Onset Bacteremia.

Author

Hsueh, Shu-Chun, Chen, Po-Lin, Ho, Ching-Yu, Hong, Ming-Yuan, Lee, Ching-Chi, and Ko, Wen-Chien

Subjects
OLDER patients, BACTEREMIA, OLDER people, LOGISTIC regression analysis, ANTI-infective agents
Abstract

Although prompt administration of an appropriate antimicrobial therapy (AAT) is crucial for reducing mortality in the general population with community-onset bacteremia, the prognostic effects of delayed AAT in older individuals with febrile and afebrile bacteremia remain unclear. A stepwise and backward logistic regression analysis was used to identify independent predictors of 30-day mortality. In a 7-year multicenter cohort study involving 3424 older patients (≥65 years) with community-onset bacteremia, febrile bacteremia accounted for 27.1% (912 patients). A crucial association of afebrile bacteremia and 30-day mortality (adjusted hazard ratio [AHR], 1.69; p < 0.001) was revealed using Cox regression and Kaplan–Meier curves after adjusting for the independent predictors of mortality. Moreover, each hour of delayed AAT was associated with an average increase of 0.3% (adjusted odds ratio [AOR], 1.003; p < 0.001) and 0.2% (AOR, 1.002; p < 0.001) in the 30-day crude mortality rates among patients with afebrile and febrile bacteremia, respectively, after adjusting for the independent predictors of mortality. Similarly, further analysis based on Cox regression and Kaplan–Meier curves revealed that inappropriate empirical therapy (i.e., delayed AAT administration > 24 h) had a significant prognostic impact, with AHRs of 1.83 (p < 0.001) and 1.76 (p < 0.001) in afebrile and febrile patients, respectively, after adjusting for the independent predictors of mortality. In conclusion, among older individuals with community-onset bacteremia, the dissimilarity of the prognostic impacts of delayed AAT between afebrile and febrile presentation was evident. [ABSTRACT FROM AUTHOR]

Published
2024
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42. A Simple Scoring Algorithm That Predicts Abscesses in Adults with Community-Onset Klebsiella pneumoniae Bacteremia: Hypermucoviscosity Matters

Author

Hong,Ming-Yuan, Hsieh,Chih-Chia, Yang,Chao-Yung, Lee,Chung-Hsun, Ko,Wen-Chien, and Lee,Ching-Chi

Subjects
Infection and Drug Resistance
Abstract

Ming-Yuan Hong,1,2 Chih-Chia Hsieh,1,2 Chao-Yung Yang,1 Chung-Hsun Lee,1,2 Wen-Chien Ko,2,3 Ching-Chi Lee1,3– 5 1Department of Emergency Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; 2Department of Medicine, National Cheng Kung University Medical College, Tainan, Taiwan; 3Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; 4Department of Adult Critical Care Medicine, Tainan Sin-Lau Hospital, Tainan, Taiwan; 5Graduate Institute of Medical Sciences, College of Health Sciences, Chang Jung Christian University, Tainan, TaiwanCorrespondence: Wen-Chien KoDivision of Infectious Disease, Department of Internal Medicine, National Cheng Kung University Hospital, No. 138, Sheng Li Road, Tainan 70403, TaiwanTel +886-6-2353535 ext. 3596Fax +886-6-2752038Email winston3415@gmail.comChing-Chi LeeGraduate Institute of Medical Sciences, College of Health Sciences, Chang Jung Christian University, No.1, Changda Rd., Gueiren District., Tainan City 71101, TaiwanTel +886-6-2785123 Ext 3326Fax +886-6-2990586Email chichingbm85@gmail.comIntroduction: Klebsiella pneumoniae is a pathogen commonly found in community-onset bacteremia. It causes an invasive syndrome that is frequently presented by metastatic infections and abscesses elsewhere and that is necessary for surgical or drainage intervention. To achieve a scoring algorithm to identify patients with community-onset K. pneumoniae bacteremia (CoKPB) who are at risk for abscess occurrences, a retrospective cohort study consisting of adults with CoKPB was conducted.Methods: A 6-year cohort study consisting of adults having community-onset monomicrobial K. pneumoniae bacteremia was conducted. In addition to clinical variables collected from medical records, the hypermucoviscosity (HMV)-related gene (rmpA and magA) and an HMV phenotype were integrated into the proposed scoring algorithm.Results: Of the 258 eligible adults, only 79 (30.6%) had abscesses related to bacteremia. Besides the presence of magA (ie, capsular serotype K1) and the HMV-phenotype, five clinical predictors were significantly associated with abscesses in a multivariate analysis: male gender, comorbidities with diabetes mellitus or neurological disorders, recent chemotherapy, and high c-reactive protein levels. Together, these predictors were used to calculate the CoKPB abscess score. Based on the scoring algorithm, a cut-off value of +2 yielded the high sensitivity (93.7%) and the acceptable specificity (50.8%); the area under the ROC curve was 0.83.Conclusion: A simple scoring algorithm that has substantial sensitivity and satisfactory specificity was proposed and the importance of the HMV phenotype or capsular K1 serotype was emphasized. The proposed predictive model needs external validation, but this scoring algorithm might be convenient and useful for clinicians.Keywords: Klebsiella pneumoniae, bacteremia, hepatic abscesses, extrahepatic abscesses

Published
2020

43. Peptidoglycan Endopeptidase Spr of Uropathogenic Escherichia coli Contributes to Kidney Infections and Competitive Fitness During Bladder Colonization

Author

Huang, Wen-Chun, primary, Hashimoto, Masayuki, additional, Shih, Yu-Ling, additional, Wu, Chia-Ching, additional, Lee, Mei-Feng, additional, Chen, Ya-Lei, additional, Wu, Jiunn-Jong, additional, Wang, Ming-Cheng, additional, Lin, Wei-Hung, additional, Hong, Ming-Yuan, additional, and Teng, Ching-Hao, additional

Published
2020
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