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Breast cancer is the most common cancer observed in adult females, worldwide. Due to the heterogeneity and varied molecular subtypes of breast cancer, the molecular mechanisms underlying carcinogenesis in different subtypes of breast cancer are distinct. Recently, long noncoding RNAs (lncRNAs) have been shown to be oncogenic or play important roles in cancer suppression and are used as biomarkers for diagnosis and therapy. In this study, we identified 134 lncRNAs and 6,414 coding genes were differentially expressed in triple-negative (TN), human epidermal growth factor receptor 2- (HER2-) positive, luminal A-positive, and luminal B-positive breast cancer. Of these, 37 lncRNAs were found to be dysregulated in all four subtypes of breast cancers. Subtypes of breast cancer special modules and lncRNA-mRNA interaction networks were constructed through weighted gene coexpression network analysis (WGCNA). Survival analysis of another public datasets was used to verify the identified lncRNAs exhibiting potential indicative roles in TN prognosis. Results from heat map analysis of the identified lncRNAs revealed that five blocks were significantly displayed. High expressions of lncRNAs, including LINC00911, CSMD2-AS1, LINC01192, SNHG19, DSCAM-AS1, PCAT4, ACVR28-AS1, and CNTFR-AS1, and low expressions of THAP9-AS1, MALAT1, TUG1, CAHM, FAM2011, NNT-AS1, COX10-AS1, and RPARP-AS1 were associated with low survival possibility in TN breast cancers. This study provides novel lncRNAs as potential biomarkers for the therapeutic and prognostic classification of different breast cancer subtypes.

Micro-arc oxidation has become a focus of research on the surface of metal processing. But do not understand the load characteristics of the application of the micro-arc oxidation. In order to get the load characteristics of DC power supply which work in the process of micro-arc oxidation, a muti-waveform frequency sweeping power and DC voltage source series circuit is researched. This method uses the load frequency response can realize the online test load characteristics, load test result is good.

the micro-arc oxidation technology is introduced in this paper firstly. The main circuit is designed according to the design demand. The main circuit is made up by chopper circuit and inverter circuit, the chopper circuit regulates the output voltage. Then the control circuit is designed, the control circuit include the key circuit, A/D converter circuit, driver circuit and LED display circuit.

For the strong external interference and system nonlinearity and other characteristics in mineral inverter system, we propose a simple auto disturbance rejection controller. The dynamic observation of the uncertain factors and external interference in the system model can be made possible by the use of the extended state observer of the auto disturbances rejection so as to improve the system adaptability to the interference. The simulation tests show that the controller has less overshoot, more adjustable transience and wider selection domain in the stable range to the controlling parameters, meanwhile, the controller has greater adaptability to the inverter power system.

Coordinated target tracking for a team of two heterogeneous Unmanned Aerial Vehicles (UAVs) is discussed. In order to study the coordinated relationship by means of distances of UAV-to-target and UAV-to-UAV, a constraint of distances coordination is proposed. Differing from the traditional studies that focus on angular separation or communication connectivity for UAVs, this constraint takes the effect of geometric configuration for two UAVs coordination into account. Specifically, the constraint only applies to follower UAV, aiming to obtain its optimal coordinated distance to target. In this way, accuracy of target state estimation and optimal geometric configuration of target tracking for UAVs are guaranteed. Extended Information filter is used to estimate the target location on a 2-D plane, and a receding horizon approach is applied to generate the optimal control policy for two UAVs' coordination. Simulation results illustrated the effectiveness.

Maintenance strategy impacts the reliability of distribution network directly. Common distribution network maintenance strategies contain corrective maintenance and preventive maintenance. However, the existing reliability assessment methods ignore the effects of preventive maintenance. This study showed the influence of preventive maintenance on the system failure rate by describing the preventive maintenance strategy with a reliability function and proposed a reliability evaluation method considering preventive maintenance of the distribution network. The method adopted the Sequential Monte Carlo method to simulate changes of elements lifetime and the operation condition of distribution network elements and used two kinds of clocks to simulate the state change and the reliability of elements respectively. The proposed method was used to evaluate the reliability of IEEE RBTS BUS6 system with preventive maintenance strategy. Finally, the effects of reliability threshold on the frequency and cost of maintenance and distribution network reliability index were analyzed. A reasonable range of reliability threshold is given.

Two kinds of multiple carrier-wave PWM schemes are analyzed and compared in detail. The phase-shifted PWM method is proved to be suitable to the cascaded H-bridge (CHB) inverter-based STATCOM because of the same device switching frequency and conduction time. More harmonics can be eliminated and device power losses can be reduced. Based on this modulation scheme, a novel dc capacitor voltage detection and balance control is developed. The simulation is performed in Simulink environment and the experiment prototype based on DSP is built. The simulation and experiment results show the correctness and feasibility of the proposed methods.

Two novel copper(II) thiocyanate complexes with 4-( N , N -dimethylamino) pyridine and N , N -dimethylformamide( 1 ) and with4-( N , N -dimethylamino) pyridine ( 2 ) have been synthesized and characterized. The crystal and molecular structures of complexes 1 and 2 were determined by single-crystal X-ray diffraction. Antioxidative activity tests in vitro showed that complex 1 has significant antioxidative activity against hydroxyl free radicals from the Fenton reaction and also oxygen free radicals, which is better than standard antioxidants like vitamin C and mannitol. The interaction of complex 1 with calf thymus DNA was investigated by spectroscopic, cyclic voltammetry, and viscosity measurements. Results suggest that complex 1 can bind to DNA via partial intercalation mode. Moreover, complex 1 has been found to cleavage of plasmid DNA pBR322.

The temperature field distribution and thermal stress distribution in concrete has been studied by finite elements method to establish the relationship between the thermal stress and the temperature in this paper. The results show that the maximum thermal gradient and the maximum thermal stress in the concrete appears on the direction of greater structural dimension, and the thermal stress value is positively correlated with thermal gradient or saying temperature difference and elastic modulus, and is negatively correlated with the water content and air content.

Thymoquinone is the main active monomer extracted from black cumin and has anti‑inflammatory, antioxidant and anti‑apoptotic functions. However, the protective effects of thymoquinone on cardiovascular function in diabetes remain to be fully elucidated. The present study aimed to investigate the molecular mechanisms underling the beneficial effects of thymoquinone on the cardiovascular function in streptozotocin‑induced diabetes mellitus (DM) rats. Supplement thymoquinone may recover the insulin levels and body weight, inhibit blood glucose levels and reduce the heart rate in DM‑induced rats. The results indicated that the heart, liver and lung to body weight ratios, in addition to the blood pressure levels, were similar for each experimental group. Treatment with thymoquinone significantly reduced oxidative stress damage, inhibited the increased endothelial nitric oxide synthase protein expression and suppressed the elevation of cyclooxygenase‑2 levels in DM‑induced rats. In addition, thymoquinone significantly suppressed the promotion of tumor necrosis factor‑α and interleukin‑6 levels in the DM‑induced rats. Furthermore, administration of thymoquinone significantly reduced caspase‑3 activity and the promotion of phosphorylated‑protein kinase B (Akt) protein expression levels in DM‑induced rats. These results suggest that the protective effect of thymoquinone improves cardiovascular function and attenuates oxidative stress, inflammation and apoptosis by mediating the phosphatidylinositol 3‑kinase/Akt pathway in DM‑induced rats.

Background Cognitive deficits have been identified as an important core feature of schizophrenia. Single nucleotide polymorphisms in the transcription factor 4 (TCF4) gene have been reported to be involved in the susceptibility to schizophrenia and be significantly related to cognitive deficits of schizophrenia and controls. This study examines whether the TCF4 rs2958182 polymorphism influences cognitive functions in chronic schizophrenia and controls. Methods The presence of the TCF4 rs2958182 was determined in 976 patients and 420 controls using a case–control design. We assessed all the patients' psychopathology using the Positive and Negative Syndrome Scale (PANSS). Cognition was assessed in 777 patients and 399 controls by using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Results There were marginally significant differences in the TCF4 rs2958182 allelic and genotypic distributions between patients and controls (χ2 = 3.48, p = 0.062 and χ2 = 0.036, p = 0.036, respectively). Cognitive test scores were significantly lower in patients than in controls on all scales (all p 0.05). There were significant genotype effects on delayed memory score (p = 0.013), the RBANS total score (p = 0.028) and language score (p = 0.034). Further analysis showed that the language score significantly differed according to the genotypic groups (A/A+T/A group versus T/T group) (p = 0.007) in patients but not in controls (p > 0.05), and the delayed memory score also significantly differed according to the genotypic groups (A/A+T/A group versus T/T group) (p = 0.021) in controls but not in patients (p > 0.05). Conclusions This study found that the A allele of the TCF4 rs2958182 polymorphism was the risk allele of schizophrenia, and was associated with lower cognitive performance in language in schizophrenia and delayed memory in controls. In contrast, the T allele of this polymorphism was found to be the schizophrenia risk allele in another study in Han Chinese people.

Ketonic/quinonic C=O groups on the surface of a carbon matrix are capable of abstracting hydrogen in C=H bonds from hydrocarbons and enable them to selectively convert into corresponding unsaturated hydrocarbons; this process is the oxidative dehydrogenation (ODH) reaction. However, a variety of inevitable defects or graphene edges and other oxygen-containing groups on the carbon matrix are detrimental to the selective production of alkenes due to their high activity towards overoxidation. Herein, we show that phosphate can not only impede the total oxidation but also cover the selective C=O groups, hence allowing its use as a modulator to defects and oxygen-containing functional groups on the multiwalled carbon nanotubes, regulating the distribution of active sites and related catalytic targets.

The limit equilibrium method is usually used in stability analysis of reinforced roadbed. It considers the function of reinforcing material as equivalent tension and neglects Interaction betweens oil and reinforcing material. Based on the roadbed engineering construction of phase III engineering in Beijing-Chengde Highway, a grid-soil contact element has been constructed to research the application of geogrid in semi-filling and semi-excavating roadbed, and the failure mode and stability of roadbed according to the numerical simulation result is also discussed in this study. We put forward the optimization scheme of reinforcement of using geogrid in semi-filling and semi-excavating roadbed engineering.