1,837 results on '"Hoover, Donald"'
Search Results
2. Vagal Nerve Stimulation Reduces Ventricular Arrhythmias and Mitigates Adverse Neural Cardiac Remodeling Post-Myocardial Infarction.
- Author
-
Hadaya, Joseph, Dajani, Al-Hassan, Cha, Steven, Hanna, Peter, Challita, Ronald, Hoover, Donald, Ajijola, Olujimi, Shivkumar, Kalyanam, and Ardell, Jeffrey
- Subjects
myocardial infarction ,neurocardiology ,sympathetic nervous system ,vagal nerve stimulation ,ventricular tachycardia/ventricular fibrillation - Abstract
This study sought to evaluate the impact of chronic vagal nerve stimulation (cVNS) on cardiac and extracardiac neural structure/function after myocardial infarction (MI). Groups were control, MI, and MI + cVNS; cVNS was started 2 days post-MI. Terminal experiments were performed 6 weeks post-MI. MI impaired left ventricular mechanical function, evoked anisotropic electrical conduction, increased susceptibility to ventricular tachycardia and fibrillation, and altered neuronal and glial phenotypes in the stellate and dorsal root ganglia, including glial activation. cVNS improved cardiac mechanical function and reduced ventricular tachycardia/ventricular fibrillation post-MI, partly by stabilizing activation/repolarization in the border zone. MI-associated extracardiac neural remodeling, particularly glial activation, was mitigated with cVNS.
- Published
- 2023
3. Correction: PrEP Uptake and Methamphetamine Use Patterns in a 4-Year U.S. National Prospective Cohort Study of Sexual and Gender Minority People, 2017–2022
- Author
-
Guo, Yan, Westmoreland, Drew A., D’Angelo, Alexa B., Mirzayi, Chloe, Dearolf, Michelle, Ray, Meredith, Carneiro, Pedro B., Pantalone, David W., Carrico, Adam W., Patel, Viraj V., Golub, Sarit A., Hirshfield, Sabina, Hoover, Donald R., Nash, Denis, and Grov, Christian
- Published
- 2024
- Full Text
- View/download PDF
4. Association of marijuana, tobacco and alcohol use with estimated glomerular filtration rate in women living with HIV and women without HIV
- Author
-
Fisher, Molly C, Hoover, Donald R, Shi, Qiuhu, Sharma, Anjali, Estrella, Michelle M, Adimora, Adaora, Alcaide, Maria, Collins, Lauren F, French, Audrey, Gao, Wei, Koletar, Susan L, Mcfarlane, Samy I, Mckay, Heather, Dionne, Jodie A, Palella, Frank, Sarkar, Sudipa, Spence, Amanda, Witt, Mallory D, and Ross, Michael J
- Subjects
Biomedical and Clinical Sciences ,Public Health ,Health Sciences ,Clinical Sciences ,HIV/AIDS ,Drug Abuse (NIDA only) ,Sexually Transmitted Infections ,Prevention ,Cannabinoid Research ,Women's Health ,Alcoholism ,Alcohol Use and Health ,Infectious Diseases ,Substance Misuse ,Kidney Disease ,3.1 Primary prevention interventions to modify behaviours or promote wellbeing ,Renal and urogenital ,Good Health and Well Being ,Humans ,Female ,United States ,Glomerular Filtration Rate ,Cannabis ,HIV Infections ,Prospective Studies ,Substance-Related Disorders ,alcohol ,estimated glomerular filtration rate ,HIV ,kidney ,marijuana ,tobacco ,women ,Biological Sciences ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Virology ,Biomedical and clinical sciences ,Health sciences - Abstract
ObjectiveMarijuana, tobacco and alcohol use are prevalent among people with HIV and may adversely affect kidney function in this population. We determined the association of use of these substances with estimated glomerular filtration rate (eGFR) among women with HIV (WWH) and women without HIV.DesignWe undertook a repeated measures study of 1043 WWH and 469 women without HIV within the United States Women's Interagency HIV Study, a multicenter, prospective cohort of HIV-seropositive and HIV-seronegative women.MethodsWe quantified substance exposures using semi-annual questionnaires. Using pooled eGFR data from 2009 to 2019, we used linear regression models with multivariable generalized estimating equations to ascertain associations between current and cumulative substance use exposures with eGFR, adjusting for sociodemographics, chronic kidney disease risk factors and HIV-related factors.ResultsMarijuana use of 1-14 days/month versus 0 days/month was associated with 3.34 ml/min per 1.73 m 2 [95% confidence interval (CI) -6.63, -0.06] lower eGFR and marijuana use of >0.02-1.6 marijuana-years versus 0-0.2 marijuana-years was associated with 3.61 ml/min per 1.73 m 2 (95% CI -5.97, -1.24) lower eGFR. Tobacco use was not independently associated with eGFR. Alcohol use of seven or more drinks/week versus no drinks/week was associated with 5.41 ml/min per 1.73 m 2 (95% CI 2.34, 8.48) higher eGFR and alcohol use of >0.7-4.27 drink-years and >4.27 drink-years versus 0-0.7 drink-years were associated with 2.85 ml/min per 1.73 m 2 (95% CI 0.55, 5.15) and 2.26 ml/min per 1.73 m 2 (95% CI 0.33, 4.20) higher eGFR, respectively.ConclusionAmong a large cohort of WWH and women without HIV, marijuana use was associated with a lower eGFR while alcohol use was associated with a higher eGFR.
- Published
- 2023
5. Factors associated with PrEP‐era HIV seroconversion in a 4‐year U.S. national cohort of n = 6059 sexual and gender minority individuals who have sex with men, 2017−2022
- Author
-
Grov, Christian, Guo, Yan, Westmoreland, Drew A., D' Angelo, Alexa B., Mirzayi, Chloe, Dearolf, Michelle, Carneiro, Pedro, Ray, Meredith, Pantalone, David, Carrico, Adam W., Patel, Viraj V., Golub, Sarit A., Hirshfield, Sabina, Hoover, Donald R., and Nash, Denis
- Subjects
HIV (Viruses) -- Prevention -- Risk factors ,Medical research ,Medicine, Experimental ,HIV testing ,Education, Higher ,HIV seropositivity -- Prevention -- Risk factors ,Sexually transmitted diseases -- Prevention ,Methamphetamine ,Health - Abstract
: Introduction: Community‐based cohort studies of HIV seroconversion can identify important avenues for enhancing HIV prevention efforts in the era of pre‐exposure prophylaxis (PrEP). Within individuals, one can assess exposure and outcome variables repeatedly and with increased certainty regarding temporal ordering. This cohort study examined the association of several risk factors with subsequent HIV seroconversion. Methods: We report data from a 4‐year study (2017−2022) of 6059 HIV seronegative sexual and gender minority individuals who have sex with men who had indications for‐, but were not using‐, PrEP at enrolment. Participants completed repeat exposure assessments and self‐collection of biospecimens for HIV testing. We examined the roles of race and ethnicity, socio‐economic status, methamphetamine use and PrEP uptake over the course of follow‐up in relation to HIV seroconversion. Results: Over 4 years, 303 of the participants seroconverted across 18,421 person‐years (incidence rate = 1.64 [95% CI: 1.59−1.70] per 100 person‐years). In multivariable discrete‐time survival analysis, factors independently associated with elevated HIV seroconversion risk included being Black/African American (adjusted risk ratio [aRR]: 2.44, 1.79−3.28), Hispanic/Latinx (1.53, 1.19−1.96), housing instability (1.58, 1.22−2.05) and past year methamphetamine use (3.82, 2.74−5.33). Conversely, time since study enrolment (24 vs. 12 months, 0.67, 0.51−0.87; 36 months, 0.60, 0.45−0.80; 48 months, 0.48, 0.35−0.66) and higher education (master's degree or higher vs. less than or equal to high school, 0.36, 0.17−0.66) were associated with reduced seroconversion risk. Compared to non‐PrEP users in the past 2 years without a current clinical indication, those who started PrEP but then discontinued had higher seroconversion risk, irrespective of clinical indication (3.23, 1.74−6.46) or lack thereof (4.30, 1.85−9.88). However, those who initiated PrEP in the past year (0.14, 0.04−0.39) or persistently used PrEP in the past 2 years (0.33, 0.14−0.74) had a lower risk of seroconversion. Of all HIV seroconversions observed during follow‐up assessments (12, 24, 36 and 48 months), methamphetamine was reported in the 12 months prior 128 (42.2%) times (overall). Conclusions: Interventions that acknowledge race and ethnicity, economic variables such as education and housing instability, and methamphetamine use are critically needed. Not only are interventions to engage individuals in PrEP care needed, but those that retain them, and re‐engage those who may fall out of care are essential, given the exceptionally high risk of seroconversion in these groups., INTRODUCTION Sexual minority individuals represent 2−5% of the United States, yet account for more than two‐thirds of new HIV acquisitions [1−4]. Meanwhile, gender minority individuals (transgender [trans] men and trans [...]
- Published
- 2024
- Full Text
- View/download PDF
6. Catecholaminergic axon innervation and morphology in flat-mounts of atria and ventricles of mice.
- Author
-
Bizanti, Ariege, Zhang, Yuanyuan, Harden, Scott, Chen, Jin, Hoover, Donald, Gozal, David, Cheng, Zixi, and Shivkumar, Kalyanam
- Subjects
atria ,cardiac ganglia ,heart ,intrinsic cardiac nervous system ,sympathetic efferent ,tyrosine hydroxylase ,ventricles ,Mice ,Animals ,Heart Ventricles ,Immunohistochemistry ,Heart ,Axons ,Myocardium ,Tyrosine 3-Monooxygenase - Abstract
Sympathetic efferent axons regulate cardiac functions. However, the topographical distribution and morphology of cardiac sympathetic efferent axons remain insufficiently characterized due to the technical challenges involved in immunohistochemical labeling of the thick walls of the whole heart. In this study, flat-mounts of the left and right atria and ventricles of FVB mice were immunolabeled for tyrosine hydroxylase (TH), a marker of sympathetic nerves. Atrial and ventricular flat-mounts were scanned using a confocal microscope to construct montages. We found (1) In the atria: A few large TH-immunoreactive (IR) axon bundles entered both atria, branched into small bundles and then single axons that eventually formed very dense terminal networks in the epicardium, myocardium and inlet regions of great vessels to the atria. Varicose TH-IR axons formed close contact with cardiomyocytes, vessels, and adipocytes. Multiple intrinsic cardiac ganglia (ICG) were identified in the epicardium of both atria, and a subpopulation of the neurons in the ICG were TH-IR. Most TH-IR axons in bundles traveled through ICG before forming dense varicose terminal networks in cardiomyocytes. We did not observe varicose TH-IR terminals encircling ICG neurons. (2) In the left and right ventricles and interventricular septum: TH-IR axons formed dense terminal networks in the epicardium, myocardium, and vasculature. Collectively, TH labeling is achievable in flat-mounts of thick cardiac walls, enabling detailed mapping of catecholaminergic axons and terminal structures in the whole heart at single-cell/axon/varicosity scale. This approach provides a foundation for future quantification of the topographical organization of the cardiac sympathetic innervation in different pathological conditions.
- Published
- 2023
7. Topographical mapping of catecholaminergic axon innervation in the flat-mounts of the mouse atria: a quantitative analysis.
- Author
-
Zhang, Yuanyuan, Bizanti, Ariege, Harden, Scott W, Chen, Jin, Bendowski, Kohlton, Hoover, Donald B, Gozal, David, Shivkumar, Kalyanam, Heal, Maci, Tappan, Susan, and Cheng, Zixi Jack
- Subjects
Vena Cava ,Superior ,Heart Atria ,Neurons ,Axons ,Animals ,Mice ,Tyrosine 3-Monooxygenase ,Immunohistochemistry ,Heart Disease ,Cardiovascular ,Neurosciences ,Aetiology ,1.1 Normal biological development and functioning ,2.1 Biological and endogenous factors ,Underpinning research - Abstract
The sympathetic nervous system is crucial for controlling multiple cardiac functions. However, a comprehensive, detailed neuroanatomical map of the sympathetic innervation of the heart is unavailable. Here, we used a combination of state-of-the-art techniques, including flat-mount tissue processing, immunohistochemistry for tyrosine hydroxylase (TH, a sympathetic marker), confocal microscopy and Neurolucida 360 software to trace, digitize, and quantitatively map the topographical distribution of the sympathetic postganglionic innervation in whole atria of C57Bl/6 J mice. We found that (1) 4-5 major extrinsic TH-IR nerve bundles entered the atria at the superior vena cava, right atrium (RA), left precaval vein and the root of the pulmonary veins (PVs) in the left atrium (LA). Although these bundles projected to different areas of the atria, their projection fields partially overlapped. (2) TH-IR axon and terminal density varied considerably between different sites of the atria with the greatest density of innervation near the sinoatrial node region (P
- Published
- 2023
8. Sympathetic innervation of the supraclavicular brown adipose tissue: A detailed anatomical study.
- Author
-
Beyer, Ryan, Bernardes de Souza, Breno, Sorg, Julie, Hoover, Donald, Sacks, Harold, Fishbein, Michael, Chang, Grace, Peacock, Warwick, St John, Maie, Law, James, Symonds, Micheal, Ajijola, Olujimi, Shivkumar, Kalyanam, Srikanthan, Preethi, and Mori, Shumpei
- Subjects
Humans ,Adipose Tissue ,Brown ,Obesity ,Adiposity ,Thermogenesis ,Cadaver ,Glucose - Abstract
BACKGROUND: The supraclavicular fossa is the dominant location for human brown adipose tissue (BAT). Activation of BAT promotes non-shivering thermogenesis by utilization of glucose and free fatty acids and has been the focus of pharmacological and non-pharmacological approaches for modulation in order to improve body weight and glucose homeostasis. Sympathetic neural control of supraclavicular BAT has received much attention, but its innervation has not been extensively investigated in humans. METHODS: Dissection of the cervical region in human cadavers was performed to find the distribution of sympathetic nerve branches to supraclavicular fat pad. Furthermore, proximal segments of the 4th cervical nerve were evaluated histologically to assess its sympathetic components. RESULTS: Nerve branches terminating in supraclavicular fat pad were identified in all dissections, including those from the 3rd and 4th cervical nerves and from the cervical sympathetic plexus. Histology of the proximal segments of the 4th cervical nerves confirmed tyrosine hydroxylase positive thin nerve fibers in all fascicles with either a scattered or clustered distribution pattern. The scattered pattern was more predominant than the clustered pattern (80% vs. 20%) across cadavers. These sympathetic nerve fibers occupied only 2.48% of the nerve cross sectional area on average. CONCLUSIONS: Human sympathetic nerves use multiple pathways to innervate the supraclavicular fat pad. The present finding serves as a framework for future clinical approaches to activate human BAT in the supraclavicular region.
- Published
- 2023
9. Electrophysiology and Arrhythmogenesis in the Human Right Ventricular Outflow Tract
- Author
-
Aras, Kedar, Gams, Anna, Faye, Ndeye Rokhaya, Brennan, Jaclyn, Goldrick, Katherine, Li, Jinghua, Zhong, Yishan, Chiang, Chia-Han, Smith, Elizabeth H, Poston, Megan D, Chivers, Jacqueline, Hanna, Peter, Mori, Shumpei, Ajijola, Olujimi A, Shivkumar, Kalyanam, Hoover, Donald B, Viventi, Jonathan, Rogers, John A, Bernus, Olivier, and Efimov, Igor R
- Subjects
Medical Physiology ,Biomedical and Clinical Sciences ,Cardiovascular ,Heart Disease ,Neurosciences ,Acetylcholine ,Adrenergic Agents ,Cardiac Electrophysiology ,Cholinergic Agents ,Electrocardiography ,Female ,Heart Ventricles ,Human Rights ,Humans ,Isoproterenol ,Male ,Pericardium ,Tachycardia ,Ventricular ,Ventricular Premature Complexes ,acetylcholine ,arrhythmias ,cardiac ,heart ventricles ,isoproterenol ,ventricular premature complexes ,arrhythmias ,cardiac ,Cardiorespiratory Medicine and Haematology ,Clinical Sciences ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology ,Clinical sciences ,Medical physiology - Abstract
BackgroundRight ventricular outflow tract (RVOT) is a common source of ventricular tachycardia, which often requires ablation. However, the mechanisms underlying the RVOT's unique arrhythmia susceptibility remain poorly understood due to lack of detailed electrophysiological and molecular studies of the human RVOT.MethodsWe conducted optical mapping studies in 16 nondiseased donor human RVOT preparations subjected to pharmacologically induced adrenergic and cholinergic stimulation to evaluate susceptibility to arrhythmias and characterize arrhythmia dynamics.ResultsWe found that under control conditions, RVOT has shorter action potential duration at 80% repolarization relative to the right ventricular apical region. Treatment with isoproterenol (100 nM) shortened action potential duration at 80% repolarization and increased incidence of premature ventricular contractions (P=0.003), whereas acetylcholine (100 μM) stimulation alone had no effect on action potential duration at 80% repolarization or premature ventricular contractions. However, acetylcholine treatment after isoproterenol stimulation reduced the incidence of premature ventricular contractions (P=0.034) and partially reversed action potential duration at 80% repolarization shortening (P=0.029). Immunolabeling of RVOT (n=4) confirmed the presence of cholinergic marker VAChT (vesicular acetylcholine transporter) in the region. Rapid pacing revealed RVOT susceptibility to both concordant and discordant alternans. Investigation into transmural arrhythmia dynamics showed that arrhythmia wave fronts and phase singularities (rotors) were relatively more organized in the endocardium than in the epicardium (P=0.006). Moreover, there was a weak but positive spatiotemporal autocorrelation between epicardial and endocardial arrhythmic wave fronts and rotors. Transcriptome analysis (n=10 hearts) suggests a trend that MAPK (mitogen-activated protein kinase) signaling, calcium signaling, and cGMP-PKG (protein kinase G) signaling are among the pathways that may be enriched in the male RVOT, whereas pathways of neurodegeneration may be enriched in the female RVOT.ConclusionsHuman RVOT electrophysiology is characterized by shorter action potential duration relative to the right ventricular apical region. Cholinergic right ventricular stimulation attenuates the arrhythmogenic effects of adrenergic stimulation, including increase in frequency of premature ventricular contractions and shortening of wavelength. Right ventricular arrhythmia is characterized by positive spatial-temporal autocorrelation between epicardial-endocardial arrhythmic wave fronts and rotors that are relatively more organized in the endocardium.
- Published
- 2022
10. Sympathetic remodeling and altered angiotensin-converting enzyme 2 localization occur in patients with cardiac disease but are not exacerbated by severe COVID-19
- Author
-
Kellum, Creighton L., Kirkland, Logan G., Nelson, Tasha K., Jewett, Seth M., Rytkin, Eric, Efimov, Igor R., Hoover, Donald B., Benson, Paul V., and Wagener, Brant M.
- Published
- 2024
- Full Text
- View/download PDF
11. Distribution and morphology of calcitonin gene-related peptide (CGRP) innervation in flat mounts of whole rat atria and ventricles
- Author
-
Chen, Jin, Bendowski, Kohlton T., Bizanti, Ariege, Zhang, Yuanyuan, Ma, Jichao, Hoover, Donald B., Gozal, David, Shivkumar, Kalyanam, and Cheng, Zixi Jack
- Published
- 2024
- Full Text
- View/download PDF
12. A single cell transcriptomics map of paracrine networks in the intrinsic cardiac nervous system.
- Author
-
Moss, Alison, Robbins, Shaina, Achanta, Sirisha, Kuttippurathu, Lakshmi, Turick, Scott, Nieves, Sean, Hanna, Peter, Smith, Elizabeth H, Hoover, Donald B, Chen, Jin, Cheng, Zixi Jack, Ardell, Jeffrey L, Shivkumar, Kalyanam, Schwaber, James S, and Vadigepalli, Rajanikanth
- Subjects
Cardiovascular medicine ,Molecular physiology ,Systems neuroscience ,Transcriptomics ,Neurosciences ,Cardiovascular ,Heart Disease - Abstract
We developed a spatially-tracked single neuron transcriptomics map of an intrinsic cardiac ganglion, the right atrial ganglionic plexus (RAGP) that is a critical mediator of sinoatrial node (SAN) activity. This 3D representation of RAGP used neuronal tracing to extensively map the spatial distribution of the subset of neurons that project to the SAN. RNA-seq of laser capture microdissected neurons revealed a distinct composition of RAGP neurons compared to the central nervous system and a surprising finding that cholinergic and catecholaminergic markers are coexpressed, suggesting multipotential phenotypes that can drive neuroplasticity within RAGP. High-throughput qPCR of hundreds of laser capture microdissected single neurons confirmed these findings and revealed a high dimensionality of neuromodulatory factors that contribute to dynamic control of the heart. Neuropeptide-receptor coexpression analysis revealed a combinatorial paracrine neuromodulatory network within RAGP informing follow-on studies on the vagal control of RAGP to regulate cardiac function in health and disease.
- Published
- 2021
13. Innervation and Neuronal Control of the Mammalian Sinoatrial Node a Comprehensive Atlas
- Author
-
Hanna, Peter, Dacey, Michael J, Brennan, Jaclyn, Moss, Alison, Robbins, Shaina, Achanta, Sirisha, Biscola, Natalia P, Swid, Mohammed A, Rajendran, Pradeep S, Mori, Shumpei, Hadaya, Joseph E, Smith, Elizabeth H, Peirce, Stanley G, Chen, Jin, Havton, Leif A, Cheng, Zixi Jack, Vadigepalli, Rajanikanth, Schwaber, James, Lux, Robert L, Efimov, Igor, Tompkins, John D, Hoover, Donald B, Ardell, Jeffrey L, and Shivkumar, Kalyanam
- Subjects
Adrenergic Neurons ,Animals ,Atrioventricular Node ,Autonomic Nervous System ,Biomarkers ,Cholinergic Neurons ,Coronary Vessels ,Female ,Ganglia ,Autonomic ,Heart Atria ,Humans ,Male ,Medical Illustration ,Myocardial Contraction ,Phenotype ,Sinoatrial Node ,Swine ,Swine ,Miniature ,Synapses ,Ventricular Function ,Left ,Vesicular Acetylcholine Transport Proteins ,autonomic nervous system ,electrophysiology ,neuroanatomy ,neurophysiology ,sinoatrial node ,Cardiorespiratory Medicine and Haematology ,Clinical Sciences ,Cardiovascular System & Hematology - Abstract
[Figure: see text].
- Published
- 2021
14. Coprevalence and associations of diabetes mellitus and hypertension among people living with HIV/AIDS in Cameroon
- Author
-
Ebasone, Peter Vanes, Dzudie, Anastase, Peer, Nasheeta, Hoover, Donald, Shi, Qiuhu, Kim, Hae-Young, Brazier, Ellen, Ajeh, Rogers, Yotebieng, Marcel, Nash, Denis, Anastos, Kathryn, and Kengne, Andre Pascal
- Published
- 2024
- Full Text
- View/download PDF
15. Cholinergic signaling via the α7 nicotinic acetylcholine receptor regulates the migration of monocyte-derived macrophages during acute inflammation
- Author
-
Keever, Kasey R., Cui, Kui, Casteel, Jared L., Singh, Sanjay, Hoover, Donald B., Williams, David L., Pavlov, Valentin A., and Yakubenko, Valentin P.
- Published
- 2024
- Full Text
- View/download PDF
16. Enhanced Myocardial Adenylyl Cyclase Activity Alters Heart-Brain Communication
- Author
-
Agrimi, Jacopo, Menicucci, Danilo, Qu, Jia-Hua, Laurino, Marco, Mackey, Chelsea D., Hasnain, Laila, Tarasova, Yelena S., Tarasov, Kirill V., McDevitt, Ross A., Hoover, Donald B., Gemignani, Angelo, Paolocci, Nazareno, and Lakatta, Edward G.
- Published
- 2023
- Full Text
- View/download PDF
17. Neuroimmune nexus in the pathophysiology and therapy of inflammatory disorders: Role of α7 nicotinic acetylcholine receptors
- Author
-
Keever, Kasey R., Yakubenko, Valentin P., and Hoover, Donald B.
- Published
- 2023
- Full Text
- View/download PDF
18. Genetic predictors for bacterial vaginosis in women living with and at risk for HIV infection
- Author
-
Murphy, Kerry, primary, Shi, Quihu, additional, Hoover, Donald R., additional, Adimora, Adaora A., additional, Alcaide, Maria L., additional, Brockmann, Susan, additional, Daubert, Elizabeth, additional, Duggal, Priya, additional, Merenstein, Daniel, additional, Dionne, Jodie A., additional, Sheth, Anandi N., additional, Keller, Marla J., additional, Herold, Betsy C., additional, Anastos, Kathryn, additional, and Aouizerat, Bradley, additional
- Published
- 2024
- Full Text
- View/download PDF
19. Comparative specialization of intrinsic cardiac neurons in humans, mice, and pigs
- Author
-
Tompkins, John D., primary, Hoover, Donald B., additional, Havton, Leif A., additional, Patel, Janaki C., additional, Cho, Youngjin, additional, Smith, Elizabeth H., additional, Biscola, Natalia P., additional, Ajijola, Olujimi A., additional, Shivkumar, Kalyanam, additional, and Ardell, Jeffrey L., additional
- Published
- 2024
- Full Text
- View/download PDF
20. PrEP Discontinuation In A US National Cohort Of Sexual And Gender Minority Populations, 2017–22
- Author
-
Guo, Yan, primary, Westmoreland, Drew A., additional, D’Angelo, Alexa, additional, Mirzayi, Chloe, additional, Dearolf, Michelle, additional, Carneiro, Pedro B., additional, Ray, Meredith, additional, Pantalone, David W., additional, Carrico, Adam W., additional, Patel, Viraj V., additional, Golub, Sarit A., additional, Hirshfield, Sabina, additional, Hoover, Donald, additional, Nash, Denis, additional, and Grov, Christian, additional
- Published
- 2024
- Full Text
- View/download PDF
21. Sympathetic innervation of human and porcine spleens: implications for between species variation in function
- Author
-
Kirkland, Logan G., Garbe, Chloe G., Hadaya, Joseph, Benson, Paul V., Wagener, Brant M., Tankovic, Sanjin, and Hoover, Donald B.
- Published
- 2022
- Full Text
- View/download PDF
22. Bone and fat hormonal crosstalk with antiretroviral initiation
- Author
-
Olali, Arnold Z., Shi, Qiuhu, Hoover, Donald R., Bucovsky, Mariana, Shane, Elizabeth, Yin, Michael T., and Ross, Ryan D.
- Published
- 2022
- Full Text
- View/download PDF
23. Abdominal fat depots, insulin resistance, and incident diabetes mellitus in women with and without HIV infection
- Author
-
Glesby, Marshall J, Hanna, David B, Hoover, Donald R, Shi, Qiuhu, Yin, Michael T, Tien, Phyllis C, Cohen, Mardge, Anastos, Kathryn, and Sharma, Anjali
- Subjects
Infectious Diseases ,Prevention ,Diabetes ,Clinical Research ,Nutrition ,HIV/AIDS ,Metabolic and endocrine ,Infection ,Abdominal Fat ,Absorptiometry ,Photon ,Adult ,Cross-Sectional Studies ,Diabetes Mellitus ,Female ,HIV Infections ,Humans ,Incidence ,Insulin Resistance ,Intra-Abdominal Fat ,Longitudinal Studies ,Middle Aged ,diabetes mellitus ,HIV-1 ,insulin resistance ,subcutaneous adipose tissue ,visceral adipose tissue ,women ,Biological Sciences ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Virology - Abstract
ObjectiveThe aim of this study was to determine the associations between visceral adipose tissue (VAT) and abdominal subcutaneous adipose tissue (SAT) mass with homeostatic model assessment-insulin resistance (HOMA-IR) and incidence of diabetes mellitus in women with and without HIV infection.DesignCross-sectional design for associations between abdominal fat and HOMA-IR; longitudinal design for associations between abdominal fat and incident diabetes.MethodsWe assessed associations between dual X-ray absorptiometry scan-derived VAT and SAT with HOMA-IR in a subsample from the Women's Interagency HIV Study (n = 226 with and n = 100 without HIV) using linear regression. We evaluated associations of VAT, SAT and HOMA-IR with incident diabetes mellitus using Cox proportional hazards models.ResultsVAT mass was positively associated with log HOMA-IR in fully adjusted linear regression models stratified by HIV serostatus, including adjustment for SAT. During median follow-up of 10.6 years, incidence of diabetes was 1.63 [95% confidence interval (95% CI) 1.15-2.31] and 1.32 [95% CI 0.77-2.28] cases per 100 person-years in women with and without HIV (P = 0.52). In a fully adjusted model, baseline VAT (hazard ratio 2.64 per kg; 95% CI 1.14-6.12; P = 0.023) and SAT (hazard ratio 1.34 per kg; 95% CI 0.73-2.45; P = 0.35) were associated with incident diabetes, but the latter was not statistically significant.ConclusionVAT mass was independently associated with HOMA-IR in women with and without HIV and was independently associated with future development of diabetes.
- Published
- 2018
24. Abdominal Fat Depots and Subclinical Carotid Artery Atherosclerosis in Women With and Without HIV Infection
- Author
-
Glesby, Marshall J, Hanna, David B, Hoover, Donald R, Shi, Qiuhu, Yin, Michael T, Kaplan, Robert, Tien, Phyllis C, Cohen, Mardge, Anastos, Kathryn, and Sharma, Anjali
- Subjects
Atherosclerosis ,Cardiovascular ,Prevention ,HIV/AIDS ,Clinical Research ,Good Health and Well Being ,Abdominal Fat ,Absorptiometry ,Photon ,Adult ,Animals ,Carotid Arteries ,Cross-Sectional Studies ,Female ,HIV Infections ,Humans ,Intra-Abdominal Fat ,Middle Aged ,Prospective Studies ,Risk Factors ,Subcutaneous Fat ,Tunica Intima ,Tunica Media ,Vascular Stiffness ,subclinical atherosclerosis ,visceral adipose tissue ,subcutaneous adipose tissue ,HIV-1 ,women ,Clinical Sciences ,Public Health and Health Services ,Virology - Abstract
BackgroundData on associations between abdominal fat depot mass and subclinical atherosclerosis are limited, especially in women with HIV.MethodsWe assessed cross-sectional associations of dual X-ray absorptiometry scan-derived estimates of visceral adipose tissue (VAT) and abdominal subcutaneous adipose tissue (SAT) with 3 measures of subclinical carotid artery atherosclerosis-carotid artery stiffness (Young's modulus of elasticity), presence of carotid artery lesions, and carotid artery intima-media thickness-in a subsample of participants in the Women's Interagency HIV Study. Statistical models adjusted for demographic variables, HIV serostatus, behavioral variables, and cardiovascular risk factors.ResultsThere were 244 women with and 99 without HIV infection (median age 42, 62% black). VAT mass (but not SAT) was associated with greater carotid artery stiffness in a fully adjusted linear regression model, including adjustment for SAT (β = 11.3 log 10·N·m per kg VAT, 95% confidence interval: 1.0 to 21.7). Greater SAT mass was associated with lower odds of having a carotid artery lesion in a fully adjusted model, including adjustment for VAT [adjusted odds ratio, 0.49 per kg of SAT (0.25 to 0.94)]. Neither VAT nor SAT was associated with carotid artery intima-media thickness. The VAT/SAT ratio was not statistically associated with any of the outcomes after covariate adjustment.ConclusionsIn our cross-sectional study of women, the majority of whom had HIV, greater VAT mass was associated with increased carotid artery stiffness, whereas greater SAT mass was associated with a reduced odds of prevalent carotid artery lesions.
- Published
- 2018
25. Longitudinal Study of Falls among HIV-Infected and Uninfected Women: The Role of Cognition
- Author
-
Sharma, Anjali, Hoover, Donald R, Shi, Qiuhu, Holman, Susan, Plankey, Michael W, Tien, Phyllis C, Weber, Kathleen M, Floris-Moore, Michelle, Bolivar, Hector H, Vance, David E, Golub, Elizabeth T, Holstad, Marcia McDonnell, and Yin, Michael T
- Subjects
Medical Microbiology ,Biomedical and Clinical Sciences ,Substance Misuse ,Neurosciences ,Behavioral and Social Science ,Clinical Research ,Infectious Diseases ,Drug Abuse (NIDA only) ,Mental Health ,Prevention ,Aging ,HIV/AIDS ,Infection ,Good Health and Well Being ,Accidental Falls ,Adult ,Case-Control Studies ,Cognition ,Female ,HIV Infections ,Humans ,Middle Aged ,Risk Assessment ,Risk Factors ,Microbiology ,Clinical Sciences ,Virology ,Clinical sciences ,Medical microbiology - Abstract
BackgroundAlthough fracture rates are higher in HIV+ than HIV- women, whether HIV infection increases risk of falls is unclear. We determined the longitudinal occurrence and risk factors for falls in the Women's Interagency HIV Study (WIHS), and explored associations with cognitive complaints.MethodsRecent (prior 6 months) self-reported falls were collected in 1,816 (1,250 HIV+; 566 HIV-) women over 24 months. Generalized estimating equation models using stepwise selection determined odds of any fall (versus none).ResultsHIV+ women were older than HIV- women (median 49 versus 47 years; P=0.0004), more likely to report neuropathy (20% versus 16%; P=0.023), and had greater central nervous system (CNS) medication use. At least one fall was reported in 41% HIV+ versus 42% HIV- women, including ≥2 falls in 25% HIV+ and 24% HIV- (overall P=0.30). Cognitive complaints were associated with falls among HIV+ (odds ratio [OR] 2.38; 95% CI 1.83, 3.09) and HIV- women (OR 3.43; 95% CI 2.37, 4.97); in adjusted models, cognitive complaints remained significant only in HIV- women (adjusted [aOR] 2.26; 95% CI 1.46, 3.48). Factors associated with any fall in adjusted analyses included: depressive symptoms and neuropathy (both HIV+ and HIV-); age, marijuana use, multiple CNS medications, and HCV infection (HIV+ only); and cognitive complaints, quality of life, hypertension and obesity (HIV- only).ConclusionsMiddle-aged HIV+ and HIV- women had similar fall rates. Among HIV+ women, factors affecting cognition such as age, depressive symptoms, marijuana use and multiple CNS medications were important predictors of falls, however, cognitive complaints were not.
- Published
- 2018
26. Inflammation, oxidative stress, and glial cell activation characterize stellate ganglia from humans with electrical storm.
- Author
-
Ajijola, Olujimi A, Hoover, Donald B, Simerly, Thomas M, Brown, T Christopher, Yanagawa, Jane, Biniwale, Reshma M, Lee, Jay M, Sadeghi, Ali, Khanlou, Negar, Ardell, Jeffrey L, and Shivkumar, Kalyanam
- Subjects
Stellate Ganglion ,Neuroglia ,Humans ,Cardiomyopathies ,Inflammation ,Microscopy ,Electron ,Case-Control Studies ,Oxidative Stress ,Adolescent ,Adult ,Middle Aged ,Tissue Donors ,Female ,Male ,Arrhythmias ,Cardiac ,Young Adult ,Arrhythmias ,Cardiology ,Cardiovascular disease ,Neurodegeneration ,Heart Disease ,Neurosciences ,Clinical Research ,Cardiovascular ,Aetiology ,2.1 Biological and endogenous factors - Abstract
Neuronal remodeling in human heart disease is not well understood. Stellate ganglia from patients with cardiomyopathy (CMY) and refractory ventricular arrhythmias undergoing cardiac sympathetic denervation (n = 8), and from organ donors with normal hearts (n = 8) collected at the time of organ procurement were compared. Clinical data on all subjects were reviewed. Electron microscopy (EM), histologic, and immunohistochemical assessments of neurotransmitter profiles, glial activation and distribution, and lipofuscin deposition, a marker of oxidative stress, were quantified. In CMY specimens, lipofuscin deposits were larger, and present in more neurons (26.3% ± 6.3% vs. 16.7% ± 7.6%, P < 0.043), than age-matched controls. EM analysis revealed extensive mitochondrial degeneration in CMY specimens. T cell (CD3+) infiltration was identified in 60% of the CMY samples, with one case having large inflammatory nodules, while none were identified in controls. Myeloperoxidase-immunoreactive neutrophils were also identified at parenchymal sites distinct from inflammatory foci in CMY ganglia, but not in controls. The adrenergic phenotype of pathologic samples revealed a decrease in tyrosine hydroxylase staining intensity compared with controls. Evaluation of cholinergic phenotype by staining for the vesicular acetylcholine transporter revealed a low but comparable number of cholinergic neurons in ganglia from both groups and demonstrated that preganglionic cholinergic innervation was maintained in CMY ganglia. S100 staining (a glial cell marker) demonstrated no differences in glial distribution and relationship to neurons; however, glial activation demonstrated by glial fibrillary acidic protein (GFAP) staining was substantially increased in pathologic specimens compared with controls. Stellate ganglia from patients with CMY and arrhythmias demonstrate inflammation, neurochemical remodeling, oxidative stress, and satellite glial cell activation. These changes likely contribute to excessive and dysfunctional efferent sympathetic tone, and provide a rationale for sympathectomy as a treatment for arrhythmias in this population. This work was made possible by support from NIH grants HL125730 to OAA, GM107949 to DBH, and HL084261 and OT2OD023848 to KS.
- Published
- 2017
27. Trends in demographic and clinical characteristics and initiation of antiretroviral therapy among adult patients enrolling in HIV care in the Central Africa International epidemiology Database to Evaluate AIDS (CA-IeDEA) 2004 to 2018
- Author
-
Adedimeji, Adebola A Adedimeji, Hoover, Donald R, Shi, Qiuhu, Kim, Hae-Young, Brazier, Ellen, Ross, Jonathan, Murenzi, Gad, Twizere, Christella, Lelo, Patricia, Nsonde, Dominique, Ajeh, Rogers, Dzudie, Anastase, Nash, Denis, Yotebieng, Marcel, and Anastos, Kathryn
- Subjects
Highly active antiretroviral therapy -- Demographic aspects -- Patient outcomes -- Forecasts and trends ,HIV infection -- Demographic aspects -- Patient outcomes -- Forecasts and trends -- Drug therapy ,Market trend/market analysis ,Health - Abstract
Introduction: The Central Africa International epidemiology Database to Evaluate AIDS (CA-IeDEA) is an open observational cohort study investigating impact, progression and long-term outcomes of HIV/AIDS among people living with HIV (PLWH) in Burundi, Cameroon, Democratic Republic of Congo (DRC), Republic of Congo (ROC) and Rwanda. We describe trends in demographic, clinical and immunological characteristics as well as antiretroviral therapy (ART) use of patients aged > 15 years entering into HIV care in the participating CA-IeDEA site. Methods: Information on sociodemographic characteristics, height, weight, body mass index (BMI), CD4 cellcount, WHO staging and ART status at entry into care from 2004 through 2018 were extracted from clinic records of patients aged > 15 years enrolling in HIV care at participating clinics in Burundi, Cameroon, DRC, ROC and Rwanda. We assessed trends in patient characteristics at enrolment in HIV care including ART initiation within the first 30 days after enrolment in care and calculated proportions, means and medians (interquartile ranges) for the main variables of interest. Results: Among 69,176 patients in the CA-IeDEA cohort, 39% were from Rwanda, 24% from ROC, 18% from Cameroon, 14% from Burundi and 5% from DRC. More women (66%) than men enrolled in care and subsequently initiated ART. Women were also younger than men (32 vs. 38 years, P < 0.001) at enrolment and at ART initiation. Trends over time show increases in median CD4 cellcount at enrolment from 190 cells/[micro]L in 2004 to 334 cells/[micro]L in 2018 at enrolment. Among those with complete data on CD4 counts (60%), women had a higher median CD4 cell count at care entry than men (229 vs. 249 cells/[micro]L, P < 0.001). Trends in the proportion of patients using ART within 30 days of enrolment at the participating site show an increase from 16% in 2004 to 75% in 2018. Conclusions: Trends from 2004 to 2018 in the characteristics of patients participating in the CA-IeDEA cohort highlight improvements at entry into care and subsequent ART initiation including after the implementation of Treat All guidelines in the participating sites. Keywords: ARV; Africa; cohort studies; HIV epidemiology; low-and middle-income countries; HIV care continuum, 1 INTRODUCTION In 2018 over 37.9 million people aged >15 years were living with HIV globally, of whom 24.5 million (64.6%) were estimated to be accessing antiretroviral therapy (ART) [1]. [...]
- Published
- 2021
- Full Text
- View/download PDF
28. Abstract 13505: COVID-19 and Cardiovascular Disease Patient Hearts Harbor Sympathetic Remodeling and Altered Angiotensin Converting Enzyme 2 Localization
- Author
-
Kellum, Creighton L, Nelson, Tasha K, Benson, Paul V, Wagener, Brant M, and Hoover, Donald B
- Published
- 2022
- Full Text
- View/download PDF
29. Hormone therapy and fractures in postmenopausal women
- Author
-
Yin, Michael T., Hoover, Donald R., Shi, Qiuhu, Tien, Phyllis C., Cohen, Mardge H., Kassaye, Seble, Gustafson, Deborah, Adimora, Adaora, Weitzmann, M. Neale, Bolivar, Hector, Warriner, Amy, Bares, Sara H., and Sharma, Anjali
- Published
- 2022
- Full Text
- View/download PDF
30. Predicting death over 8 years in a prospective cohort of HIV-infected women: the Women's Interagency HIV Study.
- Author
-
Gustafson, Deborah R, Shi, Qiuhu, Holman, Susan, Minkoff, Howard, Cohen, Mardge H, Plankey, Michael W, Havlik, Richard, Sharma, Anjali, Gange, Stephen, Gandhi, Monica, Milam, Joel, and Hoover, Donald R
- Subjects
Humans ,HIV Infections ,Antiretroviral Therapy ,Highly Active ,Life Expectancy ,Multivariate Analysis ,Proportional Hazards Models ,Risk Assessment ,Longitudinal Studies ,Prospective Studies ,Comorbidity ,Adult ,Middle Aged ,United States ,Female ,Ageing ,Frailty ,HCV ,HIV ,Clinical Sciences ,Public Health and Health Services ,Other Medical and Health Sciences - Abstract
ObjectivesPredicting mortality in middle-aged HIV-infected (HIV+) women on antiretroviral therapies (ART) is important for understanding the impact of HIV infection. Several health indices have been used to predict mortality in women with HIV infection. We evaluated: (1) an HIV biological index, Veterans Aging Cohort Study (VACS); (2) a physical index, Fried Frailty Index (FFI); and (3) a mental health index, Center for Epidemiologic Studies-Depression (CES-D). Proportional hazards regression analyses were used to predict death and included relevant covariates.DesignProspective, observational cohort.SettingMulticentre, across six sites in the USA.Participants1385 multirace/ethnic ART-experienced HIV+ women in 2005.Primary and secondary outcomesAll deaths, AIDS deaths and non-AIDS deaths up to ~8 years from baseline.ResultsIncluded together in one model, VACS Index was the dominant, significant independent predictor of all deaths within 3 years (HR=2.20, 95% CI 1.83, 2.65, χ2=69.04, p
- Published
- 2017
31. Assessing linear CD4 decline quantifying diagnosis delay after HIV seroconversion: assessing the linearity assumption of CD4 decline
- Author
-
Robertson, McKaylee M., Braunstein, Sarah L., Hoover, Donald R., Li, Sheng, and Nash, Denis
- Published
- 2020
- Full Text
- View/download PDF
32. Differential screen and treatment of sternocleidomastoid syndrome versus eagle syndrome: a case report.
- Author
-
Udhawani, Nitin S and Hoover, Donald L.
- Subjects
- *
NECK pain treatment , *PHYSICAL diagnosis , *DIFFERENTIAL diagnosis , *EAGLE syndrome , *WOMEN , *VISION disorders , *EARACHE , *EXERCISE therapy , *MANIPULATION therapy , *MEDICAL appointments , *STERNOCLEIDOMASTOID muscle , *DEGLUTITION disorders - Abstract
Differential screening is a complex process in chronic pain conditions. There is significant uncertainty that surrounds the pathophysiology of many chronic pain syndromes that may lead to misdiagnosis and treatment failures. Such differential screening is even more challenging where there is regional overlapping from surrounding tissues. This case report chronicles the differential screening and treatment of a patient with sternocleidomastoid syndrome (SCMS) originally diagnosed as Eagle's syndrome (ES). A 55-year-old woman, referred to a physical therapist (PT) by an ear, nose and throat (ENT) physician with the diagnosis of ES. The patient complained of yearlong left-sided otalgia, blurred vision, excessive lacrimation, dysphagia, hyperesthesia on the left side of the face, unilateral temporal headaches, and both left mandibular and anterior neck pain. The PT examination revealed the patient did not exhibit hallmark findings for clinical confirmation of ES and instead demonstrated multiple signs consistent with SCMS. Manual therapy techniques and therapeutic exercises resolved the patient's year-long chronic symptoms within 6 sessions. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
33. Metabolic flexibility is impaired in women who are pregnant and overweight/obese and related to insulin resistance and inflammation
- Author
-
Tinius, Rachel A., Blankenship, Maire M., Furgal, Karen E., Cade, W. Todd, Pearson, Kevin J., Rowland, Naomi S., Pearson, Regis C., Hoover, Donald L., and Maples, Jill M.
- Published
- 2020
- Full Text
- View/download PDF
34. Heterogeneous cardiac sympathetic innervation gradients promote arrhythmogenesis in murine dilated cardiomyopathy
- Author
-
Dajani, Al-Hassan J., primary, Liu, Michael B., additional, Olaopa, Michael A., additional, Cao, Lucian, additional, Valenzuela Ripoll, Carla, additional, Davis, Timothy J., additional, Poston, Megan D., additional, Smith, Elizabeth H., additional, Contreras, Jaime, additional, Pennino, Marissa, additional, Waldmann, Christopher M., additional, Hoover, Donald B., additional, Lee, Jason T., additional, Jay, Patrick Y., additional, Javaheri, Ali, additional, Slavik, Roger, additional, Qu, Zhilin, additional, and Ajijola, Olujimi A., additional
- Published
- 2023
- Full Text
- View/download PDF
35. Sympathetic innervation of the supraclavicular brown adipose tissue: A detailed anatomical study
- Author
-
Mori, Shumpei, primary, Beyer, Ryan S., additional, Bernardes de Souza, Breno, additional, Sorg, Julie M., additional, Hoover, Donald B., additional, Sacks, Harold S., additional, Fishbein, Michael C., additional, Chang, Grace, additional, Peacock, Warwick J., additional, St. John, Maie A., additional, Law, James, additional, Symonds, Micheal E., additional, Ajijola, Olujimi A., additional, Shivkumar, Kalyanam, additional, and Srikanthan, Preethi, additional
- Published
- 2023
- Full Text
- View/download PDF
36. An mHealth Intervention for Gay and Bisexual Men’s Mental, Behavioral, and Sexual Health in a High-Stigma, Low-Resource Context (Project Comunică): Protocol for a Randomized Controlled Trial (Preprint)
- Author
-
Leluțiu-Weinberger, Corina, primary, Filimon, Mircea L, additional, Hoover, Donald, additional, Lixandru, Mihai, additional, Hanu, Lucian, additional, Dogaru, Bogdan, additional, Kovacs, Tudor, additional, Fierbințeanu, Cristina, additional, Ionescu, Florentina, additional, Manu, Monica, additional, Mariș, Alexandra, additional, Pană, Elena, additional, Dorobănțescu, Cristian, additional, Streinu-Cercel, Adrian, additional, and Pachankis, John E, additional
- Published
- 2023
- Full Text
- View/download PDF
37. Differential Diagnosis Of Lower Extremity Pain During Progressive Resistance Exercise: A Case Report
- Author
-
Bovay, Jamie, primary, Robl, Christopher, additional, and Hoover, Donald L., additional
- Published
- 2023
- Full Text
- View/download PDF
38. Cardiac AC8 Over-Expression Increases Locomotion by Altering Heart-Brain Communication
- Author
-
Agrimi, Jacopo, primary, Menicucci, Danilo, additional, Qu, Jia-Hua, additional, Laurino, Marco, additional, Mackey, Chelsea D., additional, Hasnain, Laila, additional, Tarasova, Yelena S., additional, Tarasov, Kirill V., additional, McDevitt, Ross A., additional, Hoover, Donald B., additional, Gemignani, Angelo, additional, Paolocci, Nazareno, additional, and Lakatta, Edward G., additional
- Published
- 2023
- Full Text
- View/download PDF
39. The Effects Of Bilateral Lower Extremity Blood Flood Restriction During The Wingate Anaerobic Test
- Author
-
Hoover, Steffen J., primary, Cross, Jeremy E., additional, Giammalva, Olivia J., additional, Henderson, Denzel D., additional, Whicker, Jessica, additional, Lyons, T Scott, additional, Zolp, Andrew, additional, Vidic, Zeljka, additional, and Hoover, Donald L., additional
- Published
- 2023
- Full Text
- View/download PDF
40. The Role of Social Support in HIV Testing and PrEP Awareness among Young Black Men and Transgender Women Who Have Sex with Men or Transgender Women
- Author
-
Lelutiu-Weinberger, Corina, Wilton, Leo, Koblin, Beryl A., Hoover, Donald R., Hirshfield, Sabina, Chiasson, Mary Ann, Nandi, Vijay, Usher, DaShawn, and Frye, Victoria
- Published
- 2020
- Full Text
- View/download PDF
41. Increased Fracture Incidence in Middle-Aged HIV-Infected and HIV-Uninfected Women
- Author
-
Sharma, Anjali, Shi, Qiuhu, Hoover, Donald R, Anastos, Kathryn, Tien, Phyllis C, Young, Mary A, Cohen, Mardge H, Golub, Elizabeth T, Gustafson, Deborah, and Yin, Michael T
- Subjects
Medical Microbiology ,Biomedical and Clinical Sciences ,Clinical Sciences ,Substance Misuse ,Aging ,Drug Abuse (NIDA only) ,Infectious Diseases ,Clinical Research ,HIV/AIDS ,Evaluation of treatments and therapeutic interventions ,6.1 Pharmaceuticals ,2.2 Factors relating to the physical environment ,Aetiology ,Infection ,Good Health and Well Being ,Adult ,Cohort Studies ,Female ,Follow-Up Studies ,Fractures ,Bone ,HIV Infections ,Humans ,Incidence ,Middle Aged ,Prospective Studies ,Risk Factors ,Public Health and Health Services ,Virology ,Clinical sciences ,Epidemiology ,Public health - Abstract
BackgroundWe previously reported that fracture incidence rates did not differ by HIV status among predominantly premenopausal Women's Interagency HIV Study participants. We now conduct a follow-up study with 5 additional observation years to further characterize fracture risk associated with HIV infection in women as they age.MethodsWe measured time to first new fracture at any site in 2375 (1713 HIV-infected and 662 HIV-uninfected) Women's Interagency HIV Study participants, with median 10-year follow-up. Fractures were self-reported semiannually. Proportional hazards models assessed predictors of incident fracture.ResultsAt index visit, HIV-infected women were older [median age of 40 years (IQR: 34-46) vs. 35 (27-43), P < 0.0001] and more likely to be postmenopausal, hepatitis C virus infected, and weigh less than HIV-uninfected women. Among HIV-infected women, mean CD4 count was 480 cells per microliter and 63% were taking highly active antiretroviral therapy. Unadjusted incidence rates of any fracture were higher in HIV-infected than in HIV-uninfected women [2.19/100 person-years (py) vs. 1.54/100 py, P = 0.002]. In multivariate models, HIV status, older age, white (vs. black) race, prior fracture, history of cocaine use, and history of injection drug use were significant predictors of incident fracture. Among HIV-infected women, age, white race, prior fracture, smoking, and prior AIDS were predictors of new fracture.ConclusionsMiddle-aged HIV-infected women had a higher adjusted fracture rate than HIV-uninfected women. Cocaine use and injection drug use were also associated with a greater risk of incident fracture. Further research is needed to understand whether the risk of fracture associated with cocaine use relates to increased rate of falls or direct effects on bone metabolism.
- Published
- 2015
42. High levels of viral load monitoring and viral suppression under Treat All in Rwanda--a cross-sectional study
- Author
-
Ross, Jonathan, Ribakare, Muhayimpundu, Remera, Eric, Murenzi, Gad, Munyaneza, Athanase, Hoover, Donald R., Shi, Qiuhu, Nsanzimana, Sabin, Yotebieng, Marcel, Nash, Denis, and Anastos, Kathryn
- Subjects
United States. Centers for Disease Control and Prevention -- Analysis ,Industria Confezione Abbigliamento Perugia S.p.A. ,HIV patients -- Care and treatment ,Highly active antiretroviral therapy -- Analysis -- Health aspects ,Medical research -- Analysis -- Health aspects ,Antiretroviral agents -- Health aspects -- Analysis ,Health ,World Health Organization - Abstract
Introduction: Aiming to reach UNAIDS 90-90-90 targets, nearly all sub-Saharan African countries have expanded antiretroviral therapy (ART) to all people living with HIV (PLWH) (Treat All). Few published data exist on viral load testing and viral suppression under Treat All in this region. We assessed proportions of patients with available viral load test results and who were virally suppressed, as well as factors associated with viral suppression, among PLWH in 10 Rwandan health centres after Treat All implementation. Methods: Cross-sectional study during 2018 of adults ([greater than or equal to]15 years) engaged in HIV care at 10 Rwandan health centres. Outcomes were being on ART (available ART initiation date in the study database, with no ART discontinuation prior to 1 January 2018), retained on ART ([greater than or equal to]2 post-ART health centre visits [greater than or equal to]90 days apart during 2018), available viral load test results (vira load measured in 2018 and available in study database) and virally suppressed (most recent 2018 viral load Results: Of 12,238 patients, 7050 (58%) were female and 1028 (8%) were aged 15 to 24 years. Nearly all patients (11,933; 97%) were on ART, of whom 11,198 (94%) were retained on ART. Among patients retained on ART, 10,200 (91%) had available viral load results; of these 9331 (91%) were virally suppressed. Viral suppression was less likely among patients aged 15 to 24 compared to >49 years (adjusted prevalence ratio (aPR): 0.83, 95% CI 0.76 to 0.90 and those with pre-ART CD4 counts of Conclusions: In this large cohort of Rwandan PLWH receiving HIV care after Treat All implementation, patients in study health centres have surpassed the third UNAIDS 90-90-90 target. To ensure all PLWH fully benefit from ART, additiona efforts should focus on improving ART adherence among younger persons. Keywords: Treat All; ARV; HIV care continuum; LMIC; viral load monitoring; viral suppression, 1 | INTRODUCTION With the goal of ending the global AIDS epidemic, the Joint United Nations Programme on HIV/AIDS (UNAIDS) set the 90-90-90 targets with the aim that by 2020, [...]
- Published
- 2020
- Full Text
- View/download PDF
43. Women from afar: an observational study of demographic characteristics and mortality among foreign-born women living with HIV in the Women's Interagency HIV Study (WIHS) in the United States 1994-2016
- Author
-
Adedimeji, Adebola, Shi, Qiuhu, Haddad, Lisa, Holman, Susan, Edmonds, Andrew, Weber, Kathleen, Kassaye, Seble, Karim, Roksana, Bolivar, Hector, Reid, Michael, Kempf, Mirjam-Colette, Golub, Elizabeth, Hoover, Donald R., and Anastos, Kathryn
- Subjects
HIV patients -- Analysis ,HIV infections -- Analysis ,HIV -- Analysis ,Immigrants -- Analysis ,Women -- Analysis ,Health - Abstract
Introduction: Foreign-born persons comprise ~13% of the US population. Immigrants, especially women, often face a complex set of social and structural factors that negatively impact health outcomes including greater risk of HIV infection. We described socio-demographic, clinical and immunological characteristics and AIDs and non-AIDS death among foreign-born women living with HIV (FBWLWH) participating in the US Women's Interagency HIV Study (WIHS) in the US from 1994 to 2016. We hypothesized that FBW will experience higher AIDS-related mortality compared to US-born women (USBW). Methods: The WIHS is a multicenter prospective observational cohort study of mostly women living with HIV (WLWH). The primary exposure in this analysis, which focused on 3626 WLWH, was self-reported country of birth collapsed into foreignborn and US born. We assessed the association of birthplace with categorized demographic, clinical and immunological characteristics, and AIDS/non-AIDS mortality of WLWH, using chi-squared tests. Proportional hazard models examined the association of birthplace with time from enrolment to AIDS and non-AIDS death. Results: Of the 628 FBW, 13% were born in Africa, 29% in the Caribbean and 49% in Latin America. We observed significant differences by HIV status in socio-demographic, clinical and immunological characteristics and mortality. For both AIDS and non-AIDS caused deaths FBW WLWH had lower rates of death. Adjusting for year of study enrolment and other demographic/clinical characteristics mitigated FBWs statistical survival advantage in AIDS deaths Relative Hazard (RH = 0.91 p = 0.53), but did not substantively change the survival advantage in non-AIDS deaths RH = 0.33, p < 0.0001). Conclusion: Foreign-born WLWH exhibited demographic, clinical and immunological characteristics that are significantly different compared with women born in the US or US territory. After adjusting for these characteristics, the FB WLWH had a significantly lower hazard of non-AIDS but not AIDS mortality compared to women born in the US or a US territory. These findings of non-increased mortality can help inform models of care to optimize treatment outcomes among FBWLWH in the United States. Keywords: Immigrants; Foreign-born Women; HIV; Mortality; WIHS; United States, 1 | INTRODUCTION Over 40 million individuals, about 13% of persons living in United States (US), were born outside of the US [1]. Most originate from countries in South and [...]
- Published
- 2020
- Full Text
- View/download PDF
44. Correlates of HIV Transmission Behaviors and HIV Testing in Predominately African American/Black Women with High-Risk Male Sex Partners
- Author
-
Jones, Rachel, Hoover, Donald R., Lacroix, Lorraine J., and Garvey, Casey M.
- Published
- 2020
- Full Text
- View/download PDF
45. Demographic, Behavioral, and Geographic Differences Between Men, Transmen, and Transwomen Currently on PrEP, Former PrEP Users, and Those Having Never Used PrEP
- Author
-
Westmoreland, Drew A., Pantalone, David W., Patel, Viraj V., Hoover, Donald, Nash, Denis, and Grov, Christian
- Published
- 2020
- Full Text
- View/download PDF
46. Remodeling of stellate ganglion neurons after spatially targeted myocardial infarction: Neuropeptide and morphologic changes
- Author
-
Ajijola, Olujimi A, Yagishita, Daigo, Reddy, Naveen K, Yamakawa, Kentaro, Vaseghi, Marmar, Downs, Anthony M, Hoover, Donald B, Ardell, Jeffrey L, and Shivkumar, Kalyanam
- Subjects
Heart Disease ,Cardiovascular ,Neurosciences ,Heart Disease - Coronary Heart Disease ,Animals ,Coronary Vessels ,Disease Models ,Animal ,Electrocardiography ,Myocardial Infarction ,Neuronal Plasticity ,Neurons ,Neuropeptide Y ,Spatial Analysis ,Stellate Ganglion ,Swine ,Tyrosine 3-Monooxygenase ,Autonomic nervous system ,Myocardial infarction ,Neuronal remodeling ,Neuropeptide remodeling ,Sympathetic ganglia ,Biomedical Engineering ,Cardiorespiratory Medicine and Haematology ,Cardiovascular System & Hematology - Abstract
BackgroundMyocardial infarction (MI) induces remodeling in stellate ganglion neurons (SGNs).ObjectiveWe investigated whether infarct site has any impact on the laterality of morphologic changes or neuropeptide expression in stellate ganglia.MethodsYorkshire pigs underwent left circumflex coronary artery (LCX; n = 6) or right coronary artery (RCA; n = 6) occlusion to create left- and right-sided MI, respectively (control: n = 10). At 5 ± 1 weeks after MI, left and right stellate ganglia (LSG and RSG, respectively) were collected to determine neuronal size, as well as tyrosine hydroxylase (TH) and neuropeptide Y immunoreactivity.ResultsCompared with control, LCX and RCA MIs increased mean neuronal size in the LSG (451 ± 25 vs 650 ± 34 vs 577 ± 55 μm(2), respectively; P = .0012) and RSG (433 ± 22 vs 646 ± 42 vs 530 ± 41 μm(2), respectively; P = .002). TH immunoreactivity was present in the majority of SGNs. Both LCX and RCA MIs were associated with significant decreases in the percentage of TH-negative SGNs, from 2.58% ± 0.2% in controls to 1.26% ± 0.3% and 0.7% ± 0.3% in animals with LCX and RCA MI, respectively, for LSG (P = .001) and from 3.02% ± 0.4% in controls to 1.36% ± 0.3% and 0.68% ± 0.2% in LCX and RCA MI, respectively, for RSG (P = .002). Both TH-negative and TH-positive neurons increased in size after LCX and RCA MI. Neuropeptide Y immunoreactivity was also increased significantly by LCX and RCA MI in both ganglia.ConclusionLeft- and right-sided MIs equally induced morphologic and neurochemical changes in LSG and RSG neurons, independent of infarct site. These data indicate that afferent signals transduced after MI result in bilateral changes and provide a rationale for bilateral interventions targeting the sympathetic chain for arrhythmia modulation.
- Published
- 2015
47. Correction for Feng et al., Constitutive BDNF/TrkB signaling is required for normal cardiac contraction and relaxation
- Author
-
Feng, Ning, Huke, Sabine, Zhu, Guangshuo, Tocchetti, Carlo G, Shi, Sa, Aiba, Takeshi, Kaludercic, Nina, Hoover, Donald B, Beck, Sarah E, Mankowski, Joseph L, Tomaselli, Gordon F, Bers, Donald M, Kass, DavidA, and Paolocci, Nazareno
- Subjects
Medical Physiology ,Biomedical and Clinical Sciences - Published
- 2015
48. Constitutive BDNF/TrkB signaling is required for normal cardiac contraction and relaxation
- Author
-
Feng, Ning, Huke, Sabine, Zhu, Guangshuo, Tocchetti, Carlo G, Shi, Sa, Aiba, Takeshi, Kaludercic, Nina, Hoover, Donald B, Beck, Sarah E, Mankowski, Joseph L, Tomaselli, Gordon F, Bers, Donald M, Kass, David A, and Paolocci, Nazareno
- Subjects
Medical Physiology ,Biomedical and Clinical Sciences ,Heart Disease ,Neurosciences ,Cardiovascular ,Aetiology ,2.1 Biological and endogenous factors ,Analysis of Variance ,Animals ,Brain-Derived Neurotrophic Factor ,Calcium ,Calcium Signaling ,Diastole ,Hemodynamics ,Immunohistochemistry ,Mice ,Mice ,Knockout ,Myocardial Contraction ,Patch-Clamp Techniques ,Receptor ,trkB ,BDNF ,TrkB receptor ,cardiac contractility/relaxation ,CaMKII ,neurotrophins - Abstract
BDNF and its associated tropomyosin-related kinase receptor B (TrkB) nurture vessels and nerves serving the heart. However, the direct effect of BDNF/TrkB signaling on the myocardium is poorly understood. Here we report that cardiac-specific TrkB knockout mice (TrkB(-/-)) display impaired cardiac contraction and relaxation, showing that BDNF/TrkB signaling acts constitutively to sustain in vivo myocardial performance. BDNF enhances normal cardiomyocyte Ca(2+) cycling, contractility, and relaxation via Ca(2+)/calmodulin-dependent protein kinase II (CaMKII). Conversely, failing myocytes, which have increased truncated TrkB lacking tyrosine kinase activity and chronically activated CaMKII, are insensitive to BDNF. Thus, BDNF/TrkB signaling represents a previously unidentified pathway by which the peripheral nervous system directly and tonically influences myocardial function in parallel with β-adrenergic control. Deficits in this system are likely additional contributors to acute and chronic cardiac dysfunction.
- Published
- 2015
49. Evaluation of Sex Positive! A Video eHealth Intervention for Men Living with HIV
- Author
-
Hirshfield, Sabina, Downing, Jr., Martin J., Chiasson, Mary Ann, Yoon, Irene S., Houang, Steven T., Teran, Richard A., Grov, Christian, Sullivan, Patrick S., Gordon, Rachel J., Hoover, Donald R., and Parsons, Jeffrey T.
- Published
- 2019
- Full Text
- View/download PDF
50. Scholastic Basketball Facilities: A Case Study of Schools within One Midwestern State
- Author
-
Stinnett, Brad, Hoover, Donald L., Cannady, Leah C., Lyons, Scott, and Judge, Lawrence W.
- Abstract
High school basketball facilities have long been an integral component of athletics, physical education, and community programs, yet little scientific literature exists on these vital venues. This study assessed components of scholastic basketball venues and analyzed strengths and challenges associated with these facilities. An electronic survey was sent to all boys and girls head high school basketball coaches in a Midwestern state within the United States. This study analyzed data by calculating descriptive statistics for a number of facility components. Content analysis revealed that Condition and Design were perceived as strengths associated with the scholastic basketball facilities, while Ancillary Areas and Equipment were challenges. Future research should expand this methodology to regional and national populations.
- Published
- 2018
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.