1. Effect of Body Refrigeration Time on Cornea Donor Tissue.
- Author
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Munir WM, Brown CH, Munir SZ, and Hoover CK
- Subjects
- Cell Count, Endothelium, Corneal transplantation, Female, Follow-Up Studies, Graft Survival, Humans, Male, Middle Aged, Retrospective Studies, Corneal Transplantation methods, Endothelium, Corneal cytology, Eye Banks, Organ Preservation methods, Refrigeration methods
- Abstract
Purpose: To determine how early body refrigeration affects corneal donor transplant suitability and endothelial cell density., Methods: Donor information was obtained from the CorneaGen Eye Bank including demographics, time of death to preservation, and body refrigeration status, for donors between 2012 and 2016. The death to preservation interval was classified into 3 categories: 0 to 10, 10 to 20, and 20+ hours. Two primary logistic method models were fit using a main effects model and an interaction model to determine the association of body refrigeration on unsuitability of transplantation and endothelial cell density., Results: Analysis was from 42,929 donor eyes, with a mean (standard deviation) endothelial cell count of 2743 (415) cells/mm2. Fifty-nine percent of donor eyes were from male donors in the eye bank data set, and the mean death to preservation interval was 11.0 (5.6) hours for all eyes. Unsuitability for transplantation demonstrated a reduced adjusted odds ratio by 22% (OR = 0.78, P = 0.009) when the body was refrigerated during the death to preservation interval versus when the body was not refrigerated. Eyes that were refrigerated, however, exhibited no statistically significant difference in endothelial cell count from eyes that were not refrigerated (P = 0.12)., Conclusions: We demonstrate an appreciable effect of early body refrigeration on transplant suitability in this large cohort of eye bank eyes. There was no beneficial effect of body refrigeration on endothelial cell count., Competing Interests: The authors have no conflicts of interest to disclose., (Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.)
- Published
- 2021
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