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311 results on '"Hopkins, P.M."'

6. Management of a surgical patient with a label of penicillin allergy: narrative review and consensus recommendations

Author

Savic, L.C., Khan, D.A., Kopac, P., Clarke, R.C., Cooke, P.J., Dewachter, P., Ebo, D.G., Garcez, T., Garvey, L.H., Guttormsen, A.B., Hopkins, P.M., Hepner, D.L., Kolawole, H., Krøigaard, M., Laguna, J.J., Marshall, S.D., Mertes, P.M., Platt, P.R., Rose, M.A., Sabato, V., Sadleir, P.H.M., Savic, S., Takazawa, T., Voltolini, S., and Volcheck, G.W.

Published
2019
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16. Mutations in RYR1 are a common cause of exertional myalgia and rhabdomyolysis

Author

Dlamini, N., Voermans, N.C., Lillis, S., Stewart, K., Kamsteeg, E.-J., Drost, G., Quinlivan, R., Snoeck, M., Norwood, F., Radunovic, A., Straub, V., Roberts, M., Vrancken, A.F.J.E., van der Pol, W.L., de Coo, R.I.F.M., Manzur, A.Y., Yau, S., Abbs, S., King, A., Lammens, M., Hopkins, P.M., Mohammed, S., Treves, S., Muntoni, F., Wraige, E., Davis, M.R., van Engelen, B., and Jungbluth, H.

Published
2013
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18. European Neuromuscular Centre consensus statement on anaesthesia in patients with neuromuscular disorders

Author

Bersselaar, L.R. van den, Heytens, L., Silva, H.C.A., Reimann, Jens, Tasca, G., Díaz-Cambronero, Ó., Løkken, N., Hellblom, A., Hopkins, P.M., Rueffert, H., Bastian, B., Vilchez, J.J., Gillies, R., Johannsen, S., Veyckemans, F., Muenster, T., Klein, A., Litman, R., Jungbluth, H., Riazi, S., Voermans, N.C., Snoeck, M.M.J., Bersselaar, L.R. van den, Heytens, L., Silva, H.C.A., Reimann, Jens, Tasca, G., Díaz-Cambronero, Ó., Løkken, N., Hellblom, A., Hopkins, P.M., Rueffert, H., Bastian, B., Vilchez, J.J., Gillies, R., Johannsen, S., Veyckemans, F., Muenster, T., Klein, A., Litman, R., Jungbluth, H., Riazi, S., Voermans, N.C., and Snoeck, M.M.J.

Abstract

Item does not contain fulltext, BACKGROUND AND PURPOSE: Patients with neuromuscular conditions are at increased risk of suffering perioperative complications related to anaesthesia. There is currently little specific anaesthetic guidance concerning these patients. Here, we present the European Neuromuscular Centre (ENMC) consensus statement on anaesthesia in patients with neuromuscular disorders as formulated during the 259th ENMC Workshop on Anaesthesia in Neuromuscular Disorders. METHODS: International experts in the field of (paediatric) anaesthesia, neurology, and genetics were invited to participate in the ENMC workshop. A literature search was conducted in PubMed and Embase, the main findings of which were disseminated to the participants and presented during the workshop. Depending on specific expertise, participants presented the existing evidence and their expert opinion concerning anaesthetic management in six specific groups of myopathies and neuromuscular junction disorders. The consensus statement was prepared according to the AGREE II (Appraisal of Guidelines for Research & Evaluation) reporting checklist. The level of evidence has been adapted according to the SIGN (Scottish Intercollegiate Guidelines Network) grading system. The final consensus statement was subjected to a modified Delphi process. RESULTS: A set of general recommendations valid for the anaesthetic management of patients with neuromuscular disorders in general have been formulated. Specific recommendations were formulated for (i) neuromuscular junction disorders, (ii) muscle channelopathies (nondystrophic myotonia and periodic paralysis), (iii) myotonic dystrophy (types 1 and 2), (iv) muscular dystrophies, (v) congenital myopathies and congenital dystrophies, and (vi) mitochondrial and metabolic myopathies. CONCLUSIONS: This ENMC consensus statement summarizes the most important considerations for planning and performing anaesthesia in patients with neuromuscular disorders.

Published
2022

47. A Search for EcR and RXR A/B isoform gene expression during crustacean limb regeneration and oogenesis

Author

DURICA, D.S., ANILKUMAR, G., WU, X., and HOPKINS, P.M.

Subjects
Zoological research -- Analysis, Crustacea -- Genetic aspects, Developmental genetics -- Research, Zoology and wildlife conservation
Abstract

We have previously reported the isolation of EcR and RXR gene homologs in the fiddler crab, Uca pugilator. In insects, isoforms for both the EcR and RXR/USP proteins have been identified; these isoforms arise from the splicing of alternative A/B domains onto common C and E/F domains. Expression studies and mutant analysis strongly suggest that these isoforms have different physiological roles. Detailed analyses of the recovered crustacean clones, however, recovered an invariant A/B domain open-reading frame for each gene. Ribonuclease protection assays (RPA) were employed to obtain an appraisal of the relative ratio of the recovered A/B domain-containing transcripts to common domain UpEcR and UpRXR sequences. RPAs were conducted using limb buds corresponding to limb regeneration stages used in previous studies and were also initiated with ovaries containing oocytes at different periods of oogenesis. To compare the relative steady-state abundance of A/B domain sequences to common domain sequence, RNAs were hybridized to both A/B domain and common domain probes, and the level of protection tritrated against known amounts of full-length sense cRNAs. At several stages examined, the relative level of A/B domain sequence protected is significantly less than common domain; additional bands of lower molecular weight resulting from hybridization to the A/B domain probe are also observed. Similar results were obtained using ovarian tissue samples. The difference in the abundance of A/B containing transcripts relative to total UpEcR and UpRXR mRNA suggests that alternative processing may produce A/ B receptor isoforms in Uca, similar to the situation observed in insects. The ovary also represents another potential target tissue for ecdysteroid control.

Published
2000

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