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Your search keyword '"Horii, Takayuki"' showing total 17 results
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17 results on '"Horii, Takayuki"'

4. A Cluster of Paragonimiasis with Delayed Diagnosis Due to Difficulty Distinguishing Symptoms from Post-COVID-19 Respiratory Symptoms: A Report of Five Cases

Author

Sasaki, Jun, primary, Matsuoka, Masanobu, additional, Kinoshita, Takashi, additional, Horii, Takayuki, additional, Tsuneyoshi, Shingo, additional, Murata, Daiki, additional, Takaki, Reiko, additional, Tominaga, Masaki, additional, Tanaka, Mio, additional, Maruyama, Haruhiko, additional, Kawayama, Tomotaka, additional, and Hoshino, Tomoaki, additional

Published
2023
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12. Peptidoglycan-Like Components in Z-100, Extracted from Strain Aoyama B, Increase IL-12p40 via NOD2.

Author

Horii, Takayuki, Orikawa, Yuki, Ohira, Yuta, Eta, Runa, Tominaga, Uiko, Sato, Takanori, and Tanaka, Takao

Subjects
*MYCOBACTERIUM tuberculosis, *GRANULOCYTE-macrophage colony-stimulating factor, *PRODUCTION increases, *POLYSACCHARIDES, *ANIMAL experimentation, *CELL receptors, *TUMOR necrosis factors, *LIPIDS, *MICE
Abstract

Background: Z-100 is a hot-water extract of the human-type Mycobacterium tuberculosis strain Aoyama B. While Z-100's macrophage-mediated immunomodulatory effects have been reported, the mechanistic details have not been fully clarified. Here, we studied the immunomodulatory effects of Z-100 on mouse bone marrow-derived cells, human CD14+ cells, and skin.Methods: Mouse bone marrow-derived cells and CD14+ cells were cultured in the presence of granulocyte-macrophage colony-stimulating factor, differentiated into macrophage-like cells, and then stimulated with Z-100. Furthermore, since Z-100 is subcutaneously administered clinically, we injected Z-100 into mice and measured gene expression in the skin.Results: While Z-100 stimulation increased the production of interleukin- (IL-) 12p40 and IL-1β in mouse bone marrow-derived macrophages, levels of IL-1β were low. In contrast, TNF-α production did not increase. Meanwhile, stimulation of human CD14+ cells with Z-100 increased production of IL-12p40, TNF-α, and IL-1β. Because Z-100 appeared to have the most stable effect on IL-12p40, we examined the components of Z-100 that induce IL-12p40 production. We found that Z-100 contained peptidoglycan-like components. In addition, an siRNA study showed that Z-100 increased the production of IL-12p40 via nucleotide-binding oligomerization domain 2 (NOD2). Further, subcutaneous administration of Z-100 to mice significantly elevated expression of IL-12p40 and IL-1β and showed a trend towards increasing TNF-α in the skin.Conclusion: Z-100 induced the production of immunomodulatory cytokines from various types of macrophages and specifically increased IL-12p40 production through peptidoglycan-like components via NOD2. [ABSTRACT FROM AUTHOR]

Published
2022
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14. Z-100, an Immunomodulatory Extract of Mycobacterium tuberculosis Strain Aoyama B, Prevents Spontaneous Lymphatic Metastasis of B16-BL6 Melanoma

Author

Horii, Takayuki, primary, Yoshinaga, Koji, additional, Kobayashi, Nobuyoshi, additional, Seto, Koichi, additional, Orikawa, Yuki, additional, Okamoto, Masahiro, additional, Eta, Runa, additional, Ohira, Yuta, additional, Katsunuma, Kokichi, additional, Hori, Yuko, additional, Tanaka, Takao, additional, and Takei, Mineo, additional

Published
2014
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16. Pharmacological Evaluation of Analgesic Effects of the Cholecystokinin2 Receptor Antagonist Z-360 in Mouse Models of Formalin- and Cancer-Induced Pain

Author

Yoshinaga, Koji, primary, Horii, Takayuki, additional, Hamano, Hiroki, additional, Eta, Runa, additional, Ozaki, Tomoko, additional, Orikawa, Yuki, additional, Yoshii, Kazuyoshi, additional, Kawabata, Yoshihiro, additional, Hori, Yuko, additional, Seto, Koichi, additional, Takei, Mineo, additional, and Kuraishi, Yasushi, additional

Published
2010
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