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16 results on '"Horikawa, Hiroto"'

3. Staphylococcus cohnii is a potentially biotherapeutic skin commensal alleviating skin inflammation

Author

Ito, Yoshihiro, Sasaki, Takashi, Li, Youxian, Tanoue, Takeshi, Sugiura, Yuki, Skelly, Ashwin N., Suda, Wataru, Kawashima, Yusuke, Okahashi, Nobuyuki, Watanabe, Eiichiro, Horikawa, Hiroto, Shiohama, Aiko, Kurokawa, Rina, Kawakami, Eiryo, Iseki, Hachiro, Kawasaki, Hiroshi, Iwakura, Yoichiro, Shiota, Atsushi, Yu, Liansheng, Hisatsune, Junzo, Koseki, Haruhiko, Sugai, Motoyuki, Arita, Makoto, Ohara, Osamu, Matsui, Takeshi, Suematsu, Makoto, Hattori, Masahira, Atarashi, Koji, Amagai, Masayuki, and Honda, Kenya

Published
2021
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4. Identification of a rare MET variant in three siblings with extramammary Paget disease

Author

Kobayashi, Yuki, primary, Nakamura, Yoshio, additional, Tahara, Umi, additional, Nakamura, Kohei, additional, Nakanishi, Kuniaki, additional, Miyagawa, Akihiro, additional, Horikawa, Hiroto, additional, Kobayashi, Kenta, additional, Funakoshi, Takeru, additional, Sugano, Kokichi, additional, Ushiama, Mineko, additional, Yoshida, Teruhiko, additional, and Inazumi, Toyoko, additional

Published
2024
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13. Staphylococcus cohniiis a potentially biotherapeutic skin commensal alleviating skin inflammation

Author

Ito, Yoshihiro, Sasaki, Takashi, Li, Youxian, Tanoue, Takeshi, Sugiura, Yuki, Skelly, Ashwin N., Suda, Wataru, Kawashima, Yusuke, Okahashi, Nobuyuki, Watanabe, Eiichiro, Horikawa, Hiroto, Shiohama, Aiko, Kurokawa, Rina, Kawakami, Eiryo, Iseki, Hachiro, Kawasaki, Hiroshi, Iwakura, Yoichiro, Shiota, Atsushi, Yu, Liansheng, Hisatsune, Junzo, Koseki, Haruhiko, Sugai, Motoyuki, Arita, Makoto, Ohara, Osamu, Matsui, Takeshi, Suematsu, Makoto, Hattori, Masahira, Atarashi, Koji, Amagai, Masayuki, and Honda, Kenya

Abstract

Host-microbe interactions orchestrate skin homeostasis, the dysregulation of which has been implicated in chronic inflammatory conditions such as atopic dermatitis and psoriasis. Here, we show that Staphylococcus cohniiis a skin commensal capable of beneficially inhibiting skin inflammation. We find that Tmem79−/−mice spontaneously develop interleukin-17 (IL-17)-producing T-cell-driven skin inflammation. Comparative skin microbiome analysis reveals that the disease activity index is negatively associated with S. cohnii. Inoculation with S. cohniistrains isolated from either mouse or human skin microbiota significantly prevents and ameliorates dermatitis in Tmem79−/−mice without affecting pathobiont burden. S. cohniicolonization is accompanied by activation of host glucocorticoid-related pathways and induction of anti-inflammatory genes in the skin and is therefore effective at suppressing inflammation in diverse pathobiont-independent dermatitis models, including chemically induced, type 17, and type 2 immune-driven models. As such, S. cohniistrains have great potential as effective live biotherapeutics for skin inflammation.

Published
2021
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14. Tense blisters and haemorrhagic bullae as the first manifestation of eosinophilic granulomatosis with polyangiitis.

Author

Inokuchi H, Akiyama M, Horikawa H, Kondo Y, Saito S, Kikuchi J, Hanaoka H, and Kaneko Y

Subjects
Humans, Female, Middle Aged, Glucocorticoids therapeutic use, Glucocorticoids administration & dosage, Granulomatosis with Polyangiitis diagnosis, Granulomatosis with Polyangiitis complications, Granulomatosis with Polyangiitis drug therapy, Churg-Strauss Syndrome diagnosis, Churg-Strauss Syndrome complications, Treatment Outcome, Hemorrhage etiology, Hemorrhage diagnosis, Antibodies, Antineutrophil Cytoplasmic blood, Blister etiology, Blister diagnosis, Cyclophosphamide therapeutic use, Cyclophosphamide administration & dosage
Abstract

Eosinophilic granulomatosis with polyangiitis poses a significant diagnostic challenge due to its varied clinical presentation. Here, we present a case of a 59-year-old female with a history of asthma and sinusitis, who manifested with an extremely rare presentation of drastic tense blisters and haemorrhagic bullae alongside purpuric lesions and peripheral neuropathy. Examinations revealed eosinophilia, positive antineutrophil cytoplasmic antibody, and characteristic pathological findings with small-vessel vasculitis in the purpura. Treatment with glucocorticoids and cyclophosphamide led to rapid improvement in peripheral eosinophilia, skin manifestations, and motor neuron deficits. Although rare, our case underscores that bullous skin lesions should be recognised as a potential cutaneous hallmark of eosinophilic granulomatosis with polyangiitis to aid timely diagnosis, since prompt treatment initiation is crucial given the potential irreversible organ damage and poor prognosis of eosinophilic granulomatosis with polyangiitis., (© Japan College of Rheumatology 2024. Published by Oxford University Press.)

Published
2025
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