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2. 25th anniversary of the Berlin workshop on developmental toxicology: DevTox database update, challenges in risk assessment of developmental neurotoxicity and alternative methodologies in bone development and growth

Author

Marx-Stoelting, Philip, Solano, Marize de L.M., Aoyama, Hiroaki, Adams, Ralf H., Bal-Price, Anna, Buschmann, Jochen, Chahoud, Ibrahim, Clark, Ruth, Fang, Tian, Fujiwara, Michio, Gelinsky, Michael, Grote, Konstanze, Horimoto, Masao, Bennekou, Susanne Hougaard, Kellner, Rupert, Kuwagata, Makiko, Leist, Marcel, Lang, Annemarie, Li, Weihua, Mantovani, Alberto, Makris, Susan L., Paumgartten, Francisco, Perron, Monique, Sachana, Magdalini, Schmitt, Anne, Schneider, Steffen, Schönfelder, Gilbert, Schulze, Frank, Shiota, Kohei, and Solecki, Roland

Published
2021
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4. Historical control data on developmental toxicity studies in rodents

Author

Ema, Makoto, Endoh, Katsumi, Fukushima, Ryou, Fujii, Sakiko, Hara, Hiroaki, Hirata-Koizumi, Mutsuko, Hirose, Akihiko, Hojo, Hitoshi, Horimoto, Masao, Hoshino, Nobuhito, Hosokawa, Yoshinori, Imai, Yukari, Inada, Hiroshi, Inawaka, Kunifumi, Itoh, Keiichi, Katsumata, Yoshihiro, Izumi, Hiroyuki, Kato, Hirohito, Maeda, Maki, Matsumoto, Kiyoshi, Matsuo, Seiki, Matsuoka, Toshiki, Matsuura, Ikuo, Mineshima, Hiroshi, Miwa, Yoji, Nakano, Nao, Naya, Masato, Noyori, Hiroko, Ohta, Takafumi, Oku, Harutaka, Ono, Atsushi, Shimizu, Tatsuya, Shimomura, Kazuhiro, Takakura, Ikuro, Tanaka, Ryota, Tateishi, Taishi, Tominaga, Yuko, Uesugi, Tohru, Urakawa, Chizuru, Yabe, Kaoru, Yamashita, Akihito, Yamauchi, Toshiaki, and Yokoi, Ryohei

Published
2014
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5. Terminology of developmental abnormalities in common laboratory mammals (version 2)

Author

Makris, Susan L., primary, Solomon, Howard M., additional, Clark, Ruth, additional, Shiota, Kohei, additional, Barbellion, Stephane, additional, Buschmann, Jochen, additional, Ema, Makoto, additional, Fujiwara, Michio, additional, Grote, Konstanze, additional, Hazelden, Keith P., additional, Hew, Kok Wah, additional, Horimoto, Masao, additional, Ooshima, Yojiro, additional, Parkinson, Meg, additional, and Wise, L. David, additional

Published
2011
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6. Historical control data on prenatal developmental toxicity studies in rabbits

Author

Ema, Makoto, Aoyama, Hiroaki, Arima, Akihiro, Asano, Yuzo, Chihara, Kazuhiro, Endoh, Katsumi, Fujii, Sakiko, Hara, Hiroaki, Higuchi, Hashihiro, Hishikawa, Atsuko, Hojo, Hitoshi, Horimoto, Masao, Hoshino, Nobuhito, Hosokawa, Yoshinori, Inada, Hiroshi, Inoue, Ayumi, Itoh, Keiichi, Izumi, Hiroyuki, Maeda, Maki, Matsumoto, Kiyoshi, Matsuo, Seiki, Matsuura, Ikuo, Mineshima, Hiroshi, Miwa, Yoji, Miyata, Hidenori, Mizoguchi, Yasumoto, Nakano, Nao, Naya, Masato, Nishizawa, Hanako, Noritake, Ken-ichi, Noyori, Hiroko, Ohta, Takafumi, Oku, Harutaka, Shimizu, Tatsuya, Shimomura, Kazuhiro, Shiozawa, Kei, Takakura, Ikuro, Tanaka, Ryota, Uesugi, Tohru, Yabe, Kaoru, Yamauchi, Toshiaki, and Yokoi, Ryohei

Published
2012
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9. Historical control data on developmental toxicity studies in rats

Author

Kuwagata, Makiko, primary, Sakai, Yuko, additional, Tanaka, Sho, additional, Takashima, Hiromasa, additional, Katagiri, Ryuichi, additional, Matsuoka, Toshiki, additional, Noritake, Kenichi, additional, Senuma, Mika, additional, Shimizu, Tatsuya, additional, Hojo, Hitoshi, additional, Ibi, Kanata, additional, Kudo, Satoshi, additional, Oota, Takafumi, additional, Ube, Masayuki, additional, Miwa, Yoji, additional, Kajita, Shimpei, additional, Uesugi, Tohru, additional, Yabe, Kaoru, additional, Tateishi, Taishi, additional, Nakano, Nao, additional, Taniguchi, Terumasa, additional, Yamashita, Akihito, additional, Hirano, Takayuki, additional, Kirihata, Yuka, additional, Sakai, Yumi, additional, Nishizawa, Shino, additional, Fujiwara, Michio, additional, Mineshima, Hiroshi, additional, Horimoto, Masao, additional, and Ema, Makoto, additional

Published
2018
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11. Developmental toxicity of flucytosine following administration to pregnant rats at a specific time point of organogenesis.

Author

Fujii, Sakiko, Yabe, Kaoru, Kariwano‐Kimura, Yuki, Furukawa, Masatoshi, Itoh, Kouta, Matsuura, Masao, and Horimoto, Masao

Abstract

To investigate the abnormalities that are specific to administration of flucytosine at one time point during embryonic organogenesis, flucytosine was administered orally to pregnant Sprague Dawley (SD) rats in a single dose on day 11 of pregnancy at 25 or 35 mg/kg. Fetuses on day 20 of pregnancy were externally, viscerally, and skeletally examined. Maternal body weight gain and food consumption were suppressed the day after administration of a 35 mg/kg. Fetal examinations revealed various alterations in both dose groups: externally preaxial polydactyly in the hind limb; skeletally fused lumbar centrum, absent sacral centrum, supernumerary sacral vertebra, and absent ribs. Our findings indicated that specific types of external and skeletal anomalies were induced following flucytosine administration on day 11 of pregnancy. [ABSTRACT FROM AUTHOR]

Published
2019
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12. Erratum to “Terminology of developmental abnormalities in common laboratory mammals (version 2)” [Reprod. Toxicol. 28 (2009) 371–434]

Author

Makris, Susan L., primary, Solomon, Howard M., additional, Clark, Ruth, additional, Shiota, Kohei, additional, Barbellion, Stephane, additional, Buschmann, Jochen, additional, Ema, Makoto, additional, Fujiwara, Michio, additional, Grote, Konstanze, additional, Hazelden, Keith P., additional, Hew, Kok Wah, additional, Horimoto, Masao, additional, Ooshima, Yojiro, additional, Parkinson, Meg, additional, and Wise, L. David, additional

Published
2012
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13. Terminology of Developmental Abnormalities in Common Laboratory Mammals (Version 2)

Author

Makris, Susan L., primary, Solomon, Howard M., additional, Clark, Ruth, additional, Shiota, Kohei, additional, Barbellion, Stephane, additional, Buschmann, Jochen, additional, Ema, Makoto, additional, Fujiwara, Michio, additional, Grote, Konstanze, additional, Hazelden, Keith P., additional, Hew, Kok Wah, additional, Horimoto, Masao, additional, Ooshima, Yojiro, additional, Parkinson, Meg, additional, and Wise, L. David, additional

Published
2009
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18. Terminology of Developmental Abnormalities in Common Laboratory Mammals (Japanese Version 1)

Author

HORIMOTO, Masao, primary, ARIYUKI, Fumio, additional, DAIDOHJI, Syunpei, additional, FUJII, Toshiyuki, additional, FUKUNISHI, Katsuhiro, additional, HANADA, Satoshi, additional, IKEGAWA, Sunao, additional, ISHII, Hiroyuki, additional, INOUE, Tatsuo, additional, IWASE, Takayuki, additional, MATSUURA, Masao, additional, MATSUZAWA, Toshiaki, additional, NISHI, Naoki, additional, OHKUBO, Yasutaka, additional, SANBUISSHO, Atsushi, additional, SEKIYA, Kiminori, additional, TANI, Mizuno, additional, TANIGUCHI, Hidemi, additional, YOKOMOTO, Yasuki, additional, YOSHIDA, Jun-ichi, additional, TAKAHASHI, Michihito, additional, and YASUDA, Mineo, additional

Published
1998
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25. Terminology of developmental abnormalities in common laboratory mammals Version 2Disclaimer: The views expressed in this document are those of the authors and do not necessarily reflect the views or policies of the U.S. Environmental Protection Agency.Conflict of Interest Statement: The authors declare that there are no conflicts of interest.This article, as a collaborative product of the U.S., European, and Japanese Teratology Societies, is being published simultaneously in Birth Defects Research Part BDOI:10.1002bdrb.20200, Reproductive ToxicologyDOI:10.1016j.reprotox.2009.06.010, and Congenital AnomaliesDOI:10.1111j.17414520.2009.00239.xand may be referenced by any of these citations.

Author

Makris, Susan L., Solomon, Howard M., Clark, Ruth, Shiota, Kohei, Barbellion, Stephane, Buschmann, Jochen, Ema, Makoto, Fujiwara, Michio, Grote, Konstanze, Hazelden, Keith P., Hew, Kok Wah, Horimoto, Masao, Ooshima, Yojiro, Parkinson, Meg, and Wise, L. David

Abstract

This update Version 2 of the Terminology of Developmental Abnormalities in Common Laboratory MammalsVersion 1 by Wise et al. 1997 incorporates improvements and enhancements to both content and organization of the terminology, to enable greater flexibility in its application, while maintaining a consistent approach to the description of findings. The revisions are the result of an international collaboration among interested organizations, advised by individual experts and the outcomes of several workshops. The terminology remains organized into tables under the broad categories of external, visceral, and skeletal observations, following the manner in which data are typically collected and recorded in developmental toxicity studies. This arrangement of the tables, as well as other information provided in appendices, is intended to facilitate the process of specimen evaluation at the laboratory bench level. Only the commonly used laboratory mammals i.e., rats, mice, rabbits are addressed in the current terminology tables. The inclusion of other species that are used in developmental toxicity testing, such as primates, is considered outside the scope of the present update. Similarly, categorization of findings as, for example, “malformation” or “variation” remains unaddressed, in accordance with the overall principle that the focus of this document is descriptive terminology and not diagnosisinterpretation. The skeletal terms have been augmented to accommodate cartilage findings. Birth Defects Res Part B86:227–327, 2009. © 2009 WileyLiss, Inc.

Published
2009
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30. Historical control data on developmental toxicity studies in rats.

Author

Kuwagata M, Sakai Y, Tanaka S, Takashima H, Katagiri R, Matsuoka T, Noritake K, Senuma M, Shimizu T, Hojo H, Ibi K, Kudo S, Oota T, Ube M, Miwa Y, Kajita S, Uesugi T, Yabe K, Tateishi T, Nakano N, Taniguchi T, Yamashita A, Hirano T, Kirihata Y, Sakai Y, Nishizawa S, Fujiwara M, Mineshima H, Horimoto M, and Ema M

Subjects
Animals, Disease Models, Animal, Female, Immunohistochemistry, Male, Phenotype, Pregnancy, Rats, Rats, Sprague-Dawley, Rats, Wistar, Reproducibility of Results, Developmental Disabilities etiology, Developmental Disabilities pathology
Abstract

Historical control data from prenatal developmental toxicity studies in rats have been used to evaluate whether toxicology outcomes were induced by exposure to a chemical or were within the range of spontaneous variation. These data are also important for monitoring animal characteristics. As a follow-up to historical control data from 1998 to 2010, this study analyzed control data from prenatal developmental studies performed in rats from 2011 to 2015. Data were collected from studies performed by 24 Japanese laboratories, including 15 pharmaceutical and chemical companies and nine contract research organizations, in Sprague-Dawley and two-sub-strains of Wistar Hannover rats. The data included maternal reproductive findings at terminal cesarean section and fetal findings, including incidences of spontaneous external, visceral, and skeletal anomalies. No noticeable differences in maternal reproductive data were observed among laboratories. The inter-laboratory variations in the incidences of fetal anomalies seemed to be due to differences in the selection of observation parameters, observation criteria, and classification of the findings, as well as to differences in terminology of fetal alterations. These historical control data may be helpful for adequate interpretation of experimental results and for evaluating the reproductive and developmental toxicities of various chemicals., (© 2018 Japanese Teratology Society.)

Published
2019
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