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1. The Influence of Body Mass Index on Clinical Interpretation of Established and Novel Biomarkers in Acute Heart Failure.

Author: Horiuchi, Y, Wettersten, Nicholas, Vanveldhuisen, Dirk, Mueller, Christian, Nowak, Richard, Hogan, Christopher, Kontos, Michael, Cannon, Chad, Birkhahn, Robert, Vilke, Gary, Mahon, Niall, Nuñez, Julio, Briguori, Carlo, Duff, Stephen, Murray, Patrick, and Maisel, Alan
Subjects: acute heart failure, biomarker, body mass index, cardiac troponin, natriuretic peptide, Humans, Lipocalin-2, Heart Failure, Body Mass Index, Galectin 3, Biomarkers, Prognosis, Obesity, Natriuretic Peptide, Brain
Abstract: BACKGROUND: Body mass index (BMI) is a known confounder for natriuretic peptides, but its influence on other biomarkers is less well described. We investigated whether BMI interacts with biomarkers association with prognosis in patients with acute heart failure (AHF). METHODS AND RESULTS: B-type natriuretic peptide (BNP), high-sensitivity cardiac troponin I (hs-cTnI), galectin-3, serum neutrophil gelatinase-associated lipocalin (sNGAL), and urine NGAL were measured serially in patients with AHF during hospitalization in the AKINESIS (Acute Kidney Injury Neutrophil gelatinase-associated lipocalin Evaluation of Symptomatic Heart Failure) study. Cox regression analysis was used to determine the association of biomarkers and their interaction with BMI for 30-day, 90-day and 1-year composite outcomes of death or HF readmission. Among 866 patients, 21.2%, 29.7% and 46.8% had normal (18.5-24.9 kg/m2), overweight (25-29.9 kg/m2) or obese (≥ 30 kg/m2) BMIs on admission, respectively. Admission values of BNP and hs-cTnI were negatively associated with BMI, whereas galectin-3 and sNGAL were positively associated with BMI. Admission BNP and hs-cTnI levels were associated with the composite outcome within 30 days, 90 days and 1 year. Only BNP had a significant interaction with BMI. When BNP was analyzed by BMI category, its association with the composite outcome attenuated at higher BMIs and was no longer significant in obese individuals. Findings were similar when evaluated by the last-measured biomarkers and BMIs. CONCLUSIONS: In patients with AHF, only BNP had a significant interaction with BMI for the outcomes, with its association attenuating as BMI increased; hs-cTnI was prognostic, regardless of BMI.
Published: 2023

2. Galectin-3, Acute Kidney Injury and Myocardial Damage in Patients With Acute Heart Failure.

Author: Horiuchi, Y, Wettersten, Nicholas, VAN Veldhuisen, Dirk, Mueller, Christian, Filippatos, Gerasimos, Nowak, Richard, Hogan, Christopher, Kontos, Michael, Cannon, Chad, Müeller, Gerhard, Birkhahn, Robert, Taub, Pam, Vilke, Gary, McDonald, Kenneth, Mahon, Niall, Nuñez, Julio, Briguori, Carlo, Passino, Claudio, Duff, Stephen, Maisel, Alan, and Murray, Patrick
Subjects: acute heart failure, acute kidney injury, galectin-3, myocardial injury, prognosis, renal tubular damage, Humans, Acute Disease, Acute Kidney Injury, Biomarkers, Cardiomyopathies, Galectin 3, Heart Failure, Kidney, Lipocalin-2, Natriuretic Peptide, Brain, Prognosis, Retrospective Studies, Troponin I
Abstract: BACKGROUND: Galectin-3, a biomarker of inflammation and fibrosis, can be associated with renal and myocardial damage and dysfunction in patients with acute heart failure (AHF). METHODS AND RESULTS: We retrospectively analyzed 790 patients with AHF who were enrolled in the AKINESIS study. During hospitalization, patients with galectin-3 elevation (> 25.9 ng/mL) on admission more commonly had acute kidney injury (assessed by KDIGO criteria), renal tubular damage (peak urine neutrophil gelatinase-associated lipocalin [uNGAL] > 150 ng/dL) and myocardial injury (≥ 20% increase in the peak high-sensitivity cardiac troponin I [hs-cTnI] values compared to admission). They less commonly had ≥ 30% reduction in B-type natriuretic peptide from admission to last measured value. In multivariable linear regression analysis, galectin-3 was negatively associated with estimated glomerular filtration rate and positively associated with uNGAL and hs-cTnI. Higher galectin-3 was associated with renal replacement therapy, inotrope use and mortality during hospitalization. In univariable Cox regression analysis, higher galectin-3 was associated with increased risk for the composite of death or rehospitalization due to HF and death alone at 1 year. After multivariable adjustment, higher galectin-3 levels were associated only with death. CONCLUSIONS: In patients with AHF, higher galectin-3 values were associated with renal dysfunction, renal tubular damage and myocardial injury, and they predicted worse outcomes.
Published: 2023

3. Social and moral psychology of COVID-19 across 69 countries

Author: Azevedo, F, Pavlovic, T, Rego, G, Ay, F, Gjoneska, B, Etienne, T, Ross, R, Schonegger, P, Riano-Moreno, J, Cichocka, A, Capraro, V, Cian, L, Longoni, C, Chan, H, Van Bavel, J, Sjastad, H, Nezlek, J, Alfano, M, Gelfand, M, Birtel, M, Cislak, A, Lockwood, P, Abts, K, Agadullina, E, Aruta, J, Besharati, S, Bor, A, Choma, B, Crabtree, C, Cunningham, W, De, K, Ejaz, W, Elbaek, C, Findor, A, Flichtentrei, D, Franc, R, Gruber, J, Gualda, E, Horiuchi, Y, Huynh, T, Ibanez, A, Imran, M, Israelashvili, J, Jasko, K, Kantorowicz, J, Kantorowicz-Reznichenko, E, Krouwel, A, Laakasuo, M, Lamm, C, Leygue, C, Lin, M, Mansoor, M, Marie, A, Mayiwar, L, Mazepus, H, Mchugh, C, Minda, J, Mitkidis, P, Olsson, A, Otterbring, T, Packer, D, Perry, A, Petersen, M, Puthillam, A, Rothmund, T, Santamaria-Garcia, H, Schmid, P, Stoyanov, D, Tewari, S, Todosijevic, B, Tsakiris, M, Tung, H, Umbres, R, Vanags, E, Vlasceanu, M, Vonasch, A, Yucel, M, Zhang, Y, Abad, M, Adler, E, Akrawi, N, Mdarhri, H, Amara, H, Amodio, D, Antazo, B, Apps, M, Ba, M, Barbosa, S, Bastian, B, Berg, A, Bernal-Zarate, M, Bernstein, M, Bialek, M, Bilancini, E, Bogatyreva, N, Boncinelli, L, Booth, J, Borau, S, Buchel, O, Cameron, C, Carvalho, C, Celadin, T, Cerami, C, Chalise, H, Cheng, X, Cockcroft, K, Conway, J, Cordoba-Delgado, M, Crespi, C, Crouzevialle, M, Cutler, J, Cypryanska, M, Dabrowska, J, Daniels, M, Davis, V, Dayley, P, Delouvee, S, Denkovski, O, Dezecache, G, Dhaliwal, N, Diato, A, Di Paolo, R, Drosinou, M, Dulleck, U, Ekmanis, J, Ertan, A, Farhana, H, Farkhari, F, Farmer, H, Fenwick, A, Fidanovski, K, Flew, T, Fraser, S, Frempong, R, Fugelsang, J, Gale, J, Garcia-Navarro, E, Garladinne, P, Ghajjou, O, Gkinopoulos, T, Gray, K, Griffin, S, Gronfeldt, B, Gumren, M, Gurung, R, Halperin, E, Harris, E, Herzon, V, Hruska, M, Huang, G, Hudecek, M, Isler, O, Jangard, S, Jorgensen, F, Kachanoff, F, Kahn, J, Dangol, A, Keudel, O, Koppel, L, Koverola, M, Kubin, E, Kunnari, A, Kutiyski, Y, Laguna, O, Leota, J, Lermer, E, Levy, J, Levy, N, Li, C, Long, E, Maglic, M, Mccashin, D, Metcalf, A, Miklousic, I, El Mimouni, S, Miura, A, Molina-Paredes, J, Monroy-Fonseca, C, Morales-Marente, E, Moreau, D, Muda, R, Myer, A, Nash, K, Nesh-Nash, T, Nitschke, J, Nurse, M, Ohtsubo, Y, de Mello, V, O'Madagain, C, Onderco, M, Palacios-Galvez, M, Palomoki, J, Pan, Y, Papp, Z, Parnamets, P, Paruzel-Czachura, M, Pavlovic, Z, Payan-Gomez, C, Perander, S, Pitman, M, Prasad, R, Pyrkosz-Pacyna, J, Rathje, S, Raza, A, Rhee, K, Robertson, C, Rodriguez-Pascual, I, Saikkonen, T, Salvador-Ginez, O, Santi, G, Santiago-Tovar, N, Savage, D, Scheffer, J, Schultner, D, Schutte, E, Scott, A, Sharma, M, Sharma, P, Skali, A, Stadelmann, D, Stafford, C, Stanojevic, D, Stefaniak, A, Sternisko, A, Stoica, A, Stoyanova, K, Strickland, B, Sundvall, J, Thomas, J, Tinghog, G, Torgler, B, Traast, I, Tucciarelli, R, Tyrala, M, Ungson, N, Uysal, M, Van Lange, P, van Prooijen, J, van Rooy, D, Vastfjall, D, Verkoeijen, P, Vieira, J, von Sikorski, C, Walker, A, Watermeyer, J, Wetter, E, Whillans, A, White, K, Habib, R, Willardt, R, Wohl, M, Wojcik, A, Wu, K, Yamada, Y, Yilmaz, O, Yogeeswaran, K, Ziemer, C, Zwaan, R, Boggio, P, Sampaio, W, Azevedo F., Pavlovic T., Rego G. G., Ay F. C., Gjoneska B., Etienne T. W., Ross R. M., Schonegger P., Riano-Moreno J. C., Cichocka A., Capraro V., Cian L., Longoni C., Chan H. F., Van Bavel J. J., Sjastad H., Nezlek J. B., Alfano M., Gelfand M. J., Birtel M. D., Cislak A., Lockwood P. L., Abts K., Agadullina E., Aruta J. J. B., Besharati S. N., Bor A., Choma B. L., Crabtree C. D., Cunningham W. A., De K., Ejaz W., Elbaek C. T., Findor A., Flichtentrei D., Franc R., Gruber J., Gualda E., Horiuchi Y., Huynh T. L. D., Ibanez A., Imran M. A., Israelashvili J., Jasko K., Kantorowicz J., Kantorowicz-Reznichenko E., Krouwel A., Laakasuo M., Lamm C., Leygue C., Lin M. -J., Mansoor M. S., Marie A., Mayiwar L., Mazepus H., McHugh C., Minda J. P., Mitkidis P., Olsson A., Otterbring T., Packer D. J., Perry A., Petersen M. B., Puthillam A., Rothmund T., Santamaria-Garcia H., Schmid P. C., Stoyanov D., Tewari S., Todosijevic B., Tsakiris M., Tung H. H., Umbres R. G., Vanags E., Vlasceanu M., Vonasch A., Yucel M., Zhang Y., Abad M., Adler E., Akrawi N., Mdarhri H. A., Amara H., Amodio D. M., Antazo B. G., Apps M., Ba M. H., Barbosa S., Bastian B., Berg A., Bernal-Zarate M. P., Bernstein M., Bialek M., Bilancini E., Bogatyreva N., Boncinelli L., Booth J. E., Borau S., Buchel O., Cameron C. D., Carvalho C. F., Celadin T., Cerami C., Chalise H. N., Cheng X., Cockcroft K., Conway J., Cordoba-Delgado M. A., Crespi C., Crouzevialle M., Cutler J., Cypryanska M., Dabrowska J., Daniels M. A., Davis V. H., Dayley P. N., Delouvee S., Denkovski O., Dezecache G., Dhaliwal N. A., Diato A. B., Di Paolo R., Drosinou M., Dulleck U., Ekmanis J., Ertan A. S., Farhana H. H., Farkhari F., Farmer H., Fenwick A., Fidanovski K., Flew T., Fraser S., Frempong R. B., Fugelsang J. A., Gale J., Garcia-Navarro E. B., Garladinne P., Ghajjou O., Gkinopoulos T., Gray K., Griffin S. M., Gronfeldt B., Gumren M., Gurung R. L., Halperin E., Harris E., Herzon V., Hruska M., Huang G., Hudecek M. F. C., Isler O., Jangard S., Jorgensen F. J., Kachanoff F., Kahn J., Dangol A. K., Keudel O., Koppel L., Koverola M., Kubin E., Kunnari A., Kutiyski Y., Laguna O. M., Leota J., Lermer E., Levy J., Levy N., Li C., Long E. U., Maglic M., McCashin D., Metcalf A. L., Miklousic I., El Mimouni S., Miura A., Molina-Paredes J., Monroy-Fonseca C., Morales-Marente E., Moreau D., Muda R., Myer A., Nash K., Nesh-Nash T., Nitschke J. P., Nurse M. S., Ohtsubo Y., de Mello V. O., O'Madagain C., Onderco M., Palacios-Galvez M. S., Palomoki J., Pan Y., Papp Z., Parnamets P., Paruzel-Czachura M., Pavlovic Z., Payan-Gomez C., Perander S., Pitman M. M., Prasad R., Pyrkosz-Pacyna J., Rathje S., Raza A., Rhee K., Robertson C. E., Rodriguez-Pascual I., Saikkonen T., Salvador-Ginez O., Santi G. C., Santiago-Tovar N., Savage D., Scheffer J. A., Schultner D. T., Schutte E. M., Scott A., Sharma M., Sharma P., Skali A., Stadelmann D., Stafford C. A., Stanojevic D., Stefaniak A., Sternisko A., Stoica A., Stoyanova K. K., Strickland B., Sundvall J., Thomas J. P., Tinghog G., Torgler B., Traast I. J., Tucciarelli R., Tyrala M., Ungson N. D., Uysal M. S., Van Lange P. A. M., van Prooijen J. -W., van Rooy D., Vastfjall D., Verkoeijen P., Vieira J. B., von Sikorski C., Walker A. C., Watermeyer J., Wetter E., Whillans A., White K., Habib R., Willardt R., Wohl M. J. A., Wojcik A. D., Wu K., Yamada Y., Yilmaz O., Yogeeswaran K., Ziemer C. -T., Zwaan R. A., Boggio P. S., Sampaio W. M., Azevedo, F, Pavlovic, T, Rego, G, Ay, F, Gjoneska, B, Etienne, T, Ross, R, Schonegger, P, Riano-Moreno, J, Cichocka, A, Capraro, V, Cian, L, Longoni, C, Chan, H, Van Bavel, J, Sjastad, H, Nezlek, J, Alfano, M, Gelfand, M, Birtel, M, Cislak, A, Lockwood, P, Abts, K, Agadullina, E, Aruta, J, Besharati, S, Bor, A, Choma, B, Crabtree, C, Cunningham, W, De, K, Ejaz, W, Elbaek, C, Findor, A, Flichtentrei, D, Franc, R, Gruber, J, Gualda, E, Horiuchi, Y, Huynh, T, Ibanez, A, Imran, M, Israelashvili, J, Jasko, K, Kantorowicz, J, Kantorowicz-Reznichenko, E, Krouwel, A, Laakasuo, M, Lamm, C, Leygue, C, Lin, M, Mansoor, M, Marie, A, Mayiwar, L, Mazepus, H, Mchugh, C, Minda, J, Mitkidis, P, Olsson, A, Otterbring, T, Packer, D, Perry, A, Petersen, M, Puthillam, A, Rothmund, T, Santamaria-Garcia, H, Schmid, P, Stoyanov, D, Tewari, S, Todosijevic, B, Tsakiris, M, Tung, H, Umbres, R, Vanags, E, Vlasceanu, M, Vonasch, A, Yucel, M, Zhang, Y, Abad, M, Adler, E, Akrawi, N, Mdarhri, H, Amara, H, Amodio, D, Antazo, B, Apps, M, Ba, M, Barbosa, S, Bastian, B, Berg, A, Bernal-Zarate, M, Bernstein, M, Bialek, M, Bilancini, E, Bogatyreva, N, Boncinelli, L, Booth, J, Borau, S, Buchel, O, Cameron, C, Carvalho, C, Celadin, T, Cerami, C, Chalise, H, Cheng, X, Cockcroft, K, Conway, J, Cordoba-Delgado, M, Crespi, C, Crouzevialle, M, Cutler, J, Cypryanska, M, Dabrowska, J, Daniels, M, Davis, V, Dayley, P, Delouvee, S, Denkovski, O, Dezecache, G, Dhaliwal, N, Diato, A, Di Paolo, R, Drosinou, M, Dulleck, U, Ekmanis, J, Ertan, A, Farhana, H, Farkhari, F, Farmer, H, Fenwick, A, Fidanovski, K, Flew, T, Fraser, S, Frempong, R, Fugelsang, J, Gale, J, Garcia-Navarro, E, Garladinne, P, Ghajjou, O, Gkinopoulos, T, Gray, K, Griffin, S, Gronfeldt, B, Gumren, M, Gurung, R, Halperin, E, Harris, E, Herzon, V, Hruska, M, Huang, G, Hudecek, M, Isler, O, Jangard, S, Jorgensen, F, Kachanoff, F, Kahn, J, Dangol, A, Keudel, O, Koppel, L, Koverola, M, Kubin, E, Kunnari, A, Kutiyski, Y, Laguna, O, Leota, J, Lermer, E, Levy, J, Levy, N, Li, C, Long, E, Maglic, M, Mccashin, D, Metcalf, A, Miklousic, I, El Mimouni, S, Miura, A, Molina-Paredes, J, Monroy-Fonseca, C, Morales-Marente, E, Moreau, D, Muda, R, Myer, A, Nash, K, Nesh-Nash, T, Nitschke, J, Nurse, M, Ohtsubo, Y, de Mello, V, O'Madagain, C, Onderco, M, Palacios-Galvez, M, Palomoki, J, Pan, Y, Papp, Z, Parnamets, P, Paruzel-Czachura, M, Pavlovic, Z, Payan-Gomez, C, Perander, S, Pitman, M, Prasad, R, Pyrkosz-Pacyna, J, Rathje, S, Raza, A, Rhee, K, Robertson, C, Rodriguez-Pascual, I, Saikkonen, T, Salvador-Ginez, O, Santi, G, Santiago-Tovar, N, Savage, D, Scheffer, J, Schultner, D, Schutte, E, Scott, A, Sharma, M, Sharma, P, Skali, A, Stadelmann, D, Stafford, C, Stanojevic, D, Stefaniak, A, Sternisko, A, Stoica, A, Stoyanova, K, Strickland, B, Sundvall, J, Thomas, J, Tinghog, G, Torgler, B, Traast, I, Tucciarelli, R, Tyrala, M, Ungson, N, Uysal, M, Van Lange, P, van Prooijen, J, van Rooy, D, Vastfjall, D, Verkoeijen, P, Vieira, J, von Sikorski, C, Walker, A, Watermeyer, J, Wetter, E, Whillans, A, White, K, Habib, R, Willardt, R, Wohl, M, Wojcik, A, Wu, K, Yamada, Y, Yilmaz, O, Yogeeswaran, K, Ziemer, C, Zwaan, R, Boggio, P, Sampaio, W, Azevedo F., Pavlovic T., Rego G. G., Ay F. C., Gjoneska B., Etienne T. W., Ross R. M., Schonegger P., Riano-Moreno J. C., Cichocka A., Capraro V., Cian L., Longoni C., Chan H. F., Van Bavel J. J., Sjastad H., Nezlek J. B., Alfano M., Gelfand M. J., Birtel M. D., Cislak A., Lockwood P. L., Abts K., Agadullina E., Aruta J. J. B., Besharati S. N., Bor A., Choma B. L., Crabtree C. D., Cunningham W. A., De K., Ejaz W., Elbaek C. T., Findor A., Flichtentrei D., Franc R., Gruber J., Gualda E., Horiuchi Y., Huynh T. L. D., Ibanez A., Imran M. A., Israelashvili J., Jasko K., Kantorowicz J., Kantorowicz-Reznichenko E., Krouwel A., Laakasuo M., Lamm C., Leygue C., Lin M. -J., Mansoor M. S., Marie A., Mayiwar L., Mazepus H., McHugh C., Minda J. P., Mitkidis P., Olsson A., Otterbring T., Packer D. J., Perry A., Petersen M. B., Puthillam A., Rothmund T., Santamaria-Garcia H., Schmid P. C., Stoyanov D., Tewari S., Todosijevic B., Tsakiris M., Tung H. H., Umbres R. G., Vanags E., Vlasceanu M., Vonasch A., Yucel M., Zhang Y., Abad M., Adler E., Akrawi N., Mdarhri H. A., Amara H., Amodio D. M., Antazo B. G., Apps M., Ba M. H., Barbosa S., Bastian B., Berg A., Bernal-Zarate M. P., Bernstein M., Bialek M., Bilancini E., Bogatyreva N., Boncinelli L., Booth J. E., Borau S., Buchel O., Cameron C. D., Carvalho C. F., Celadin T., Cerami C., Chalise H. N., Cheng X., Cockcroft K., Conway J., Cordoba-Delgado M. A., Crespi C., Crouzevialle M., Cutler J., Cypryanska M., Dabrowska J., Daniels M. A., Davis V. H., Dayley P. N., Delouvee S., Denkovski O., Dezecache G., Dhaliwal N. A., Diato A. B., Di Paolo R., Drosinou M., Dulleck U., Ekmanis J., Ertan A. S., Farhana H. H., Farkhari F., Farmer H., Fenwick A., Fidanovski K., Flew T., Fraser S., Frempong R. B., Fugelsang J. A., Gale J., Garcia-Navarro E. B., Garladinne P., Ghajjou O., Gkinopoulos T., Gray K., Griffin S. M., Gronfeldt B., Gumren M., Gurung R. L., Halperin E., Harris E., Herzon V., Hruska M., Huang G., Hudecek M. F. C., Isler O., Jangard S., Jorgensen F. J., Kachanoff F., Kahn J., Dangol A. K., Keudel O., Koppel L., Koverola M., Kubin E., Kunnari A., Kutiyski Y., Laguna O. M., Leota J., Lermer E., Levy J., Levy N., Li C., Long E. U., Maglic M., McCashin D., Metcalf A. L., Miklousic I., El Mimouni S., Miura A., Molina-Paredes J., Monroy-Fonseca C., Morales-Marente E., Moreau D., Muda R., Myer A., Nash K., Nesh-Nash T., Nitschke J. P., Nurse M. S., Ohtsubo Y., de Mello V. O., O'Madagain C., Onderco M., Palacios-Galvez M. S., Palomoki J., Pan Y., Papp Z., Parnamets P., Paruzel-Czachura M., Pavlovic Z., Payan-Gomez C., Perander S., Pitman M. M., Prasad R., Pyrkosz-Pacyna J., Rathje S., Raza A., Rhee K., Robertson C. E., Rodriguez-Pascual I., Saikkonen T., Salvador-Ginez O., Santi G. C., Santiago-Tovar N., Savage D., Scheffer J. A., Schultner D. T., Schutte E. M., Scott A., Sharma M., Sharma P., Skali A., Stadelmann D., Stafford C. A., Stanojevic D., Stefaniak A., Sternisko A., Stoica A., Stoyanova K. K., Strickland B., Sundvall J., Thomas J. P., Tinghog G., Torgler B., Traast I. J., Tucciarelli R., Tyrala M., Ungson N. D., Uysal M. S., Van Lange P. A. M., van Prooijen J. -W., van Rooy D., Vastfjall D., Verkoeijen P., Vieira J. B., von Sikorski C., Walker A. C., Watermeyer J., Wetter E., Whillans A., White K., Habib R., Willardt R., Wohl M. J. A., Wojcik A. D., Wu K., Yamada Y., Yilmaz O., Yogeeswaran K., Ziemer C. -T., Zwaan R. A., Boggio P. S., and Sampaio W. M.
Abstract: The COVID-19 pandemic has affected all domains of human life, including the economic and social fabric of societies. One of the central strategies for managing public health throughout the pandemic has been through persuasive messaging and collective behaviour change. To help scholars better understand the social and moral psychology behind public health behaviour, we present a dataset comprising of 51,404 individuals from 69 countries. This dataset was collected for the International Collaboration on Social & Moral Psychology of COVID-19 project (ICSMP COVID-19). This social science survey invited participants around the world to complete a series of moral and psychological measures and public health attitudes about COVID-19 during an early phase of the COVID-19 pandemic (between April and June 2020). The survey included seven broad categories of questions: COVID-19 beliefs and compliance behaviours; identity and social attitudes; ideology; health and well-being; moral beliefs and motivation; personality traits; and demographic variables. We report both raw and cleaned data, along with all survey materials, data visualisations, and psychometric evaluations of key variables.
Published: 2023

4. Diagnostic accuracy of vessel fractional flow reserve compared to conventional diagnostic tools in patients with coronary artery stenosis

Author: Sekiguchi, M, primary, Asami, M, additional, Nonaka, H, additional, Ishizawa, T, additional, Horiuchi, Y, additional, Yahagi, K, additional, Yuzawa, H, additional, Komiyama, K, additional, Tanaka, J, additional, Aoki, J, additional, and Tanabe, K, additional
Published: 2023
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5. A-209 Application of Bilirubin Oxidase for Improvement of False Positive Error Caused by Bilirubin on Cholesterol Efflux Capacity Assay by Immobilize Liposome-Bound Gel Beads method

Author: Miyakoshi, T, primary, Mutsuda, Y, additional, Horiuchi, Y, additional, Kameda, T, additional, Tozuka, M, additional, and Ohkawa, R, additional
Published: 2023
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6. LB1771 miR-4521 regulates the autophagic pathway in keratinocytes

Author: Maeno, H., primary, Suzuki-Horiuchi, Y., additional, Funakoshi, A., additional, Sato, Y., additional, Ishii, T., additional, and Seykora, J.T., additional
Published: 2023
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7. National identity predicts public health support during a global pandemic

Author: Van Bavel, J, Cichocka, A, Capraro, V, Sjastad, H, Nezlek, J, Pavlovic, T, Alfano, M, Gelfand, M, Azevedo, F, Birtel, M, Cislak, A, Lockwood, P, Ross, R, Abts, K, Agadullina, E, Aruta, J, Besharati, S, Bor, A, Choma, B, Crabtree, C, Cunningham, W, De, K, Ejaz, W, Elbaek, C, Findor, A, Flichtentrei, D, Franc, R, Gjoneska, B, Gruber, J, Gualda, E, Horiuchi, Y, Huynh, T, Ibanez, A, Imran, M, Israelashvili, J, Jasko, K, Kantorowicz, J, Kantorowicz-Reznichenko, E, Krouwel, A, Laakasuo, M, Lamm, C, Leygue, C, Lin, M, Mansoor, M, Marie, A, Mayiwar, L, Mazepus, H, Mchugh, C, Minda, J, Mitkidis, P, Olsson, A, Otterbring, T, Packer, D, Perry, A, Petersen, M, Puthillam, A, Riano-Moreno, J, Rothmund, T, Santamaria-Garcia, H, Schmid, P, Stoyanov, D, Tewari, S, Todosijevic, B, Tsakiris, M, Tung, H, Umbres, R, Vanags, E, Vlasceanu, M, Vonasch, A, Yucel, M, Zhang, Y, Abad, M, Adler, E, Akrawi, N, Mdarhri, H, Amara, H, Amodio, D, Antazo, B, Apps, M, Ay, F, Ba, M, Barbosa, S, Bastian, B, Berg, A, Bernal-Zarate, M, Bernstein, M, Bialek, M, Bilancini, E, Bogatyreva, N, Boncinelli, L, Booth, J, Borau, S, Buchel, O, Cameron, C, Carvalho, C, Celadin, T, Cerami, C, Chalise, H, Cheng, X, Cian, L, Cockcroft, K, Conway, J, Cordoba-Delgado, M, Crespi, C, Crouzevialle, M, Cutler, J, Cypryanska, M, Dabrowska, J, Daniels, M, Davis, V, Dayley, P, Delouvee, S, Denkovski, O, Dezecache, G, Dhaliwal, N, Diato, A, Di Paolo, R, Drosinou, M, Dulleck, U, Ekmanis, J, Ertan, A, Etienne, T, Farhana, H, Farkhari, F, Farmer, H, Fenwick, A, Fidanovski, K, Flew, T, Fraser, S, Frempong, R, Fugelsang, J, Gale, J, Garcia-Navarro, E, Garladinne, P, Ghajjou, O, Gkinopoulos, T, Gray, K, Griffin, S, Gronfeldt, B, Gumren, M, Gurung, R, Halperin, E, Harris, E, Herzon, V, Hruska, M, Huang, G, Hudecek, M, Isler, O, Jangard, S, Jorgensen, F, Kachanoff, F, Kahn, J, Dangol, A, Keudel, O, Koppel, L, Koverola, M, Kubin, E, Kunnari, A, Kutiyski, Y, Laguna, O, Leota, J, Lermer, E, Levy, J, Levy, N, Li, C, Long, E, Longoni, C, Maglic, M, Mccashin, D, Metcalf, A, Miklousic, I, El Mimouni, S, Miura, A, Molina-Paredes, J, Monroy-Fonseca, C, Morales-Marente, E, Moreau, D, Muda, R, Myer, A, Nash, K, Nesh-Nash, T, Nitschke, J, Nurse, M, Ohtsubo, Y, Oldemburgo de Mello, V, O'Madagain, C, Onderco, M, Palacios-Galvez, M, Palomaki, J, Pan, Y, Papp, Z, Parnamets, P, Paruzel-Czachura, M, Pavlovic, Z, Payan-Gomez, C, Perander, S, Pitman, M, Prasad, R, Pyrkosz-Pacyna, J, Rathje, S, Raza, A, Rego, G, Rhee, K, Robertson, C, Rodriguez-Pascual, I, Saikkonen, T, Salvador-Ginez, O, Sampaio, W, Santi, G, Santiago-Tovar, N, Savage, D, Scheffer, J, Schonegger, P, Schultner, D, Schutte, E, Scott, A, Sharma, M, Sharma, P, Skali, A, Stadelmann, D, Stafford, C, Stanojevic, D, Stefaniak, A, Sternisko, A, Stoica, A, Stoyanova, K, Strickland, B, Sundvall, J, Thomas, J, Tinghog, G, Torgler, B, Traast, I, Tucciarelli, R, Tyrala, M, Ungson, N, Uysal, M, Van Lange, P, van Prooijen, J, van Rooy, D, Vastfjall, D, Verkoeijen, P, Vieira, J, von Sikorski, C, Walker, A, Watermeyer, J, Wetter, E, Whillans, A, Willardt, R, Wohl, M, Wojcik, A, Wu, K, Yamada, Y, Yilmaz, O, Yogeeswaran, K, Ziemer, C, Zwaan, R, Boggio, P, Van Bavel J. J., Cichocka A., Capraro V., Sjastad H., Nezlek J. B., Pavlovic T., Alfano M., Gelfand M. J., Azevedo F., Birtel M. D., Cislak A., Lockwood P. L., Ross R. M., Abts K., Agadullina E., Aruta J. J. B., Besharati S. N., Bor A., Choma B. L., Crabtree C. D., Cunningham W. A., De K., Ejaz W., Elbaek C. T., Findor A., Flichtentrei D., Franc R., Gjoneska B., Gruber J., Gualda E., Horiuchi Y., Huynh T. L. D., Ibanez A., Imran M. A., Israelashvili J., Jasko K., Kantorowicz J., Kantorowicz-Reznichenko E., Krouwel A., Laakasuo M., Lamm C., Leygue C., Lin M. -J., Mansoor M. S., Marie A., Mayiwar L., Mazepus H., McHugh C., Minda J. P., Mitkidis P., Olsson A., Otterbring T., Packer D. J., Perry A., Petersen M. B., Puthillam A., Riano-Moreno J. C., Rothmund T., Santamaria-Garcia H., Schmid P. C., Stoyanov D., Tewari S., Todosijevic B., Tsakiris M., Tung H. H., Umbres R. G., Vanags E., Vlasceanu M., Vonasch A., Yucel M., Zhang Y., Abad M., Adler E., Akrawi N., Mdarhri H. A., Amara H., Amodio D. M., Antazo B. G., Apps M., Ay F. C., Ba M. H., Barbosa S., Bastian B., Berg A., Bernal-Zarate M. P., Bernstein M., Bialek M., Bilancini E., Bogatyreva N., Boncinelli L., Booth J. E., Borau S., Buchel O., Cameron C. D., Carvalho C. F., Celadin T., Cerami C., Chalise H. N., Cheng X., Cian L., Cockcroft K., Conway J., Cordoba-Delgado M. A., Crespi C., Crouzevialle M., Cutler J., Cypryanska M., Dabrowska J., Daniels M. A., Davis V. H., Dayley P. N., Delouvee S., Denkovski O., Dezecache G., Dhaliwal N. A., Diato A. B., Di Paolo R., Drosinou M., Dulleck U., Ekmanis J., Ertan A. S., Etienne T. W., Farhana H. H., Farkhari F., Farmer H., Fenwick A., Fidanovski K., Flew T., Fraser S., Frempong R. B., Fugelsang J. A., Gale J., Garcia-Navarro E. B., Garladinne P., Ghajjou O., Gkinopoulos T., Gray K., Griffin S. M., Gronfeldt B., Gumren M., Gurung R. L., Halperin E., Harris E., Herzon V., Hruska M., Huang G., Hudecek M. F. C., Isler O., Jangard S., Jorgensen F. J., Kachanoff F., Kahn J., Dangol A. K., Keudel O., Koppel L., Koverola M., Kubin E., Kunnari A., Kutiyski Y., Laguna O., Leota J., Lermer E., Levy J., Levy N., Li C., Long E. U., Longoni C., Maglic M., McCashin D., Metcalf A. L., Miklousic I., El Mimouni S., Miura A., Molina-Paredes J., Monroy-Fonseca C., Morales-Marente E., Moreau D., Muda R., Myer A., Nash K., Nesh-Nash T., Nitschke J. P., Nurse M. S., Ohtsubo Y., Oldemburgo de Mello V., O'Madagain C., Onderco M., Palacios-Galvez M. S., Palomaki J., Pan Y., Papp Z., Parnamets P., Paruzel-Czachura M., Pavlovic Z., Payan-Gomez C., Perander S., Pitman M. M., Prasad R., Pyrkosz-Pacyna J., Rathje S., Raza A., Rego G. G., Rhee K., Robertson C. E., Rodriguez-Pascual I., Saikkonen T., Salvador-Ginez O., Sampaio W. M., Santi G. C., Santiago-Tovar N., Savage D., Scheffer J. A., Schonegger P., Schultner D. T., Schutte E. M., Scott A., Sharma M., Sharma P., Skali A., Stadelmann D., Stafford C. A., Stanojevic D., Stefaniak A., Sternisko A., Stoica A., Stoyanova K. K., Strickland B., Sundvall J., Thomas J. P., Tinghog G., Torgler B., Traast I. J., Tucciarelli R., Tyrala M., Ungson N. D., Uysal M. S., Van Lange P. A. M., van Prooijen J. -W., van Rooy D., Vastfjall D., Verkoeijen P., Vieira J. B., von Sikorski C., Walker A. C., Watermeyer J., Wetter E., Whillans A., Willardt R., Wohl M. J. A., Wojcik A. D., Wu K., Yamada Y., Yilmaz O., Yogeeswaran K., Ziemer C. -T., Zwaan R. A., Boggio P. S., Van Bavel, J, Cichocka, A, Capraro, V, Sjastad, H, Nezlek, J, Pavlovic, T, Alfano, M, Gelfand, M, Azevedo, F, Birtel, M, Cislak, A, Lockwood, P, Ross, R, Abts, K, Agadullina, E, Aruta, J, Besharati, S, Bor, A, Choma, B, Crabtree, C, Cunningham, W, De, K, Ejaz, W, Elbaek, C, Findor, A, Flichtentrei, D, Franc, R, Gjoneska, B, Gruber, J, Gualda, E, Horiuchi, Y, Huynh, T, Ibanez, A, Imran, M, Israelashvili, J, Jasko, K, Kantorowicz, J, Kantorowicz-Reznichenko, E, Krouwel, A, Laakasuo, M, Lamm, C, Leygue, C, Lin, M, Mansoor, M, Marie, A, Mayiwar, L, Mazepus, H, Mchugh, C, Minda, J, Mitkidis, P, Olsson, A, Otterbring, T, Packer, D, Perry, A, Petersen, M, Puthillam, A, Riano-Moreno, J, Rothmund, T, Santamaria-Garcia, H, Schmid, P, Stoyanov, D, Tewari, S, Todosijevic, B, Tsakiris, M, Tung, H, Umbres, R, Vanags, E, Vlasceanu, M, Vonasch, A, Yucel, M, Zhang, Y, Abad, M, Adler, E, Akrawi, N, Mdarhri, H, Amara, H, Amodio, D, Antazo, B, Apps, M, Ay, F, Ba, M, Barbosa, S, Bastian, B, Berg, A, Bernal-Zarate, M, Bernstein, M, Bialek, M, Bilancini, E, Bogatyreva, N, Boncinelli, L, Booth, J, Borau, S, Buchel, O, Cameron, C, Carvalho, C, Celadin, T, Cerami, C, Chalise, H, Cheng, X, Cian, L, Cockcroft, K, Conway, J, Cordoba-Delgado, M, Crespi, C, Crouzevialle, M, Cutler, J, Cypryanska, M, Dabrowska, J, Daniels, M, Davis, V, Dayley, P, Delouvee, S, Denkovski, O, Dezecache, G, Dhaliwal, N, Diato, A, Di Paolo, R, Drosinou, M, Dulleck, U, Ekmanis, J, Ertan, A, Etienne, T, Farhana, H, Farkhari, F, Farmer, H, Fenwick, A, Fidanovski, K, Flew, T, Fraser, S, Frempong, R, Fugelsang, J, Gale, J, Garcia-Navarro, E, Garladinne, P, Ghajjou, O, Gkinopoulos, T, Gray, K, Griffin, S, Gronfeldt, B, Gumren, M, Gurung, R, Halperin, E, Harris, E, Herzon, V, Hruska, M, Huang, G, Hudecek, M, Isler, O, Jangard, S, Jorgensen, F, Kachanoff, F, Kahn, J, Dangol, A, Keudel, O, Koppel, L, Koverola, M, Kubin, E, Kunnari, A, Kutiyski, Y, Laguna, O, Leota, J, Lermer, E, Levy, J, Levy, N, Li, C, Long, E, Longoni, C, Maglic, M, Mccashin, D, Metcalf, A, Miklousic, I, El Mimouni, S, Miura, A, Molina-Paredes, J, Monroy-Fonseca, C, Morales-Marente, E, Moreau, D, Muda, R, Myer, A, Nash, K, Nesh-Nash, T, Nitschke, J, Nurse, M, Ohtsubo, Y, Oldemburgo de Mello, V, O'Madagain, C, Onderco, M, Palacios-Galvez, M, Palomaki, J, Pan, Y, Papp, Z, Parnamets, P, Paruzel-Czachura, M, Pavlovic, Z, Payan-Gomez, C, Perander, S, Pitman, M, Prasad, R, Pyrkosz-Pacyna, J, Rathje, S, Raza, A, Rego, G, Rhee, K, Robertson, C, Rodriguez-Pascual, I, Saikkonen, T, Salvador-Ginez, O, Sampaio, W, Santi, G, Santiago-Tovar, N, Savage, D, Scheffer, J, Schonegger, P, Schultner, D, Schutte, E, Scott, A, Sharma, M, Sharma, P, Skali, A, Stadelmann, D, Stafford, C, Stanojevic, D, Stefaniak, A, Sternisko, A, Stoica, A, Stoyanova, K, Strickland, B, Sundvall, J, Thomas, J, Tinghog, G, Torgler, B, Traast, I, Tucciarelli, R, Tyrala, M, Ungson, N, Uysal, M, Van Lange, P, van Prooijen, J, van Rooy, D, Vastfjall, D, Verkoeijen, P, Vieira, J, von Sikorski, C, Walker, A, Watermeyer, J, Wetter, E, Whillans, A, Willardt, R, Wohl, M, Wojcik, A, Wu, K, Yamada, Y, Yilmaz, O, Yogeeswaran, K, Ziemer, C, Zwaan, R, Boggio, P, Van Bavel J. J., Cichocka A., Capraro V., Sjastad H., Nezlek J. B., Pavlovic T., Alfano M., Gelfand M. J., Azevedo F., Birtel M. D., Cislak A., Lockwood P. L., Ross R. M., Abts K., Agadullina E., Aruta J. J. B., Besharati S. N., Bor A., Choma B. L., Crabtree C. D., Cunningham W. A., De K., Ejaz W., Elbaek C. T., Findor A., Flichtentrei D., Franc R., Gjoneska B., Gruber J., Gualda E., Horiuchi Y., Huynh T. L. D., Ibanez A., Imran M. A., Israelashvili J., Jasko K., Kantorowicz J., Kantorowicz-Reznichenko E., Krouwel A., Laakasuo M., Lamm C., Leygue C., Lin M. -J., Mansoor M. S., Marie A., Mayiwar L., Mazepus H., McHugh C., Minda J. P., Mitkidis P., Olsson A., Otterbring T., Packer D. J., Perry A., Petersen M. B., Puthillam A., Riano-Moreno J. C., Rothmund T., Santamaria-Garcia H., Schmid P. C., Stoyanov D., Tewari S., Todosijevic B., Tsakiris M., Tung H. H., Umbres R. G., Vanags E., Vlasceanu M., Vonasch A., Yucel M., Zhang Y., Abad M., Adler E., Akrawi N., Mdarhri H. A., Amara H., Amodio D. M., Antazo B. G., Apps M., Ay F. C., Ba M. H., Barbosa S., Bastian B., Berg A., Bernal-Zarate M. P., Bernstein M., Bialek M., Bilancini E., Bogatyreva N., Boncinelli L., Booth J. E., Borau S., Buchel O., Cameron C. D., Carvalho C. F., Celadin T., Cerami C., Chalise H. N., Cheng X., Cian L., Cockcroft K., Conway J., Cordoba-Delgado M. A., Crespi C., Crouzevialle M., Cutler J., Cypryanska M., Dabrowska J., Daniels M. A., Davis V. H., Dayley P. N., Delouvee S., Denkovski O., Dezecache G., Dhaliwal N. A., Diato A. B., Di Paolo R., Drosinou M., Dulleck U., Ekmanis J., Ertan A. S., Etienne T. W., Farhana H. H., Farkhari F., Farmer H., Fenwick A., Fidanovski K., Flew T., Fraser S., Frempong R. B., Fugelsang J. A., Gale J., Garcia-Navarro E. B., Garladinne P., Ghajjou O., Gkinopoulos T., Gray K., Griffin S. M., Gronfeldt B., Gumren M., Gurung R. L., Halperin E., Harris E., Herzon V., Hruska M., Huang G., Hudecek M. F. C., Isler O., Jangard S., Jorgensen F. J., Kachanoff F., Kahn J., Dangol A. K., Keudel O., Koppel L., Koverola M., Kubin E., Kunnari A., Kutiyski Y., Laguna O., Leota J., Lermer E., Levy J., Levy N., Li C., Long E. U., Longoni C., Maglic M., McCashin D., Metcalf A. L., Miklousic I., El Mimouni S., Miura A., Molina-Paredes J., Monroy-Fonseca C., Morales-Marente E., Moreau D., Muda R., Myer A., Nash K., Nesh-Nash T., Nitschke J. P., Nurse M. S., Ohtsubo Y., Oldemburgo de Mello V., O'Madagain C., Onderco M., Palacios-Galvez M. S., Palomaki J., Pan Y., Papp Z., Parnamets P., Paruzel-Czachura M., Pavlovic Z., Payan-Gomez C., Perander S., Pitman M. M., Prasad R., Pyrkosz-Pacyna J., Rathje S., Raza A., Rego G. G., Rhee K., Robertson C. E., Rodriguez-Pascual I., Saikkonen T., Salvador-Ginez O., Sampaio W. M., Santi G. C., Santiago-Tovar N., Savage D., Scheffer J. A., Schonegger P., Schultner D. T., Schutte E. M., Scott A., Sharma M., Sharma P., Skali A., Stadelmann D., Stafford C. A., Stanojevic D., Stefaniak A., Sternisko A., Stoica A., Stoyanova K. K., Strickland B., Sundvall J., Thomas J. P., Tinghog G., Torgler B., Traast I. J., Tucciarelli R., Tyrala M., Ungson N. D., Uysal M. S., Van Lange P. A. M., van Prooijen J. -W., van Rooy D., Vastfjall D., Verkoeijen P., Vieira J. B., von Sikorski C., Walker A. C., Watermeyer J., Wetter E., Whillans A., Willardt R., Wohl M. J. A., Wojcik A. D., Wu K., Yamada Y., Yilmaz O., Yogeeswaran K., Ziemer C. -T., Zwaan R. A., and Boggio P. S.
Abstract: Changing collective behaviour and supporting non-pharmaceutical interventions is an important component in mitigating virus transmission during a pandemic. In a large international collaboration (Study 1, N = 49,968 across 67 countries), we investigated self-reported factors associated with public health behaviours (e.g., spatial distancing and stricter hygiene) and endorsed public policy interventions (e.g., closing bars and restaurants) during the early stage of the COVID-19 pandemic (April-May 2020). Respondents who reported identifying more strongly with their nation consistently reported greater engagement in public health behaviours and support for public health policies. Results were similar for representative and non-representative national samples. Study 2 (N = 42 countries) conceptually replicated the central finding using aggregate indices of national identity (obtained using the World Values Survey) and a measure of actual behaviour change during the pandemic (obtained from Google mobility reports). Higher levels of national identification prior to the pandemic predicted lower mobility during the early stage of the pandemic (r = −0.40). We discuss the potential implications of links between national identity, leadership, and public health for managing COVID-19 and future pandemics.
Published: 2022

8. 299 Biomarkers of early UV-induced skin cancer

Author: Suzuki-Horiuchi, Y., primary, Hedberg, M.L., additional, Zheng, Q., additional, Ko, E., additional, Maeno, H., additional, Kuri, P., additional, Prouty, S.M., additional, Dentchev, T., additional, Rompolas, P., additional, Grice, E., additional, Capell, B., additional, Lee, V., additional, and Seykora, J.T., additional
Published: 2023
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9. Excavation cycle times recorded during sinking of a deep shaft in crystalline rock – A case example at Ventilation Shaft of Mizunami URL, Japan

Author: Sanada, H., Sato, T., Horiuchi, Y., Mikake, S., Okihara, M., Yahagi, R., and Kobayashi, S.
Published: 2015
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10. LB1004 miR-4521 is over-expressed in human lentigos and downregulates components of the autophagic pathway in keratinocytes

Author: Maeno, H., primary, Suzuki-Horiuchi, Y., additional, Funakoshi, A., additional, Shimizu, T., additional, Satou, Y., additional, Ishii, T., additional, and Seykora, J.T., additional
Published: 2022
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11. 078 Transcript profiling for TSLP in human squamous cell carcinoma in situ

Author: Suzuki-Horiuchi, Y., primary, Prouty, S., additional, Wushanley, L., additional, Lee, V., additional, and Seykora, J.T., additional
Published: 2022
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12. 847 Biomarkers of early UV-induced skin cancer

Author: Suzuki-Horiuchi, Y., Hedberg, M.L., Zheng, Q., Navarro, J., Ko, E., Maeno, H., Kuri, P., Prouty, S., Dentchev, T., Rompolas, P., Grice, E., Capell, B., Lee, V., and Seykora, J.T.
Published: 2024
Full Text: View/download PDF

13. National identity predicts public health support during a global pandemic

Author: Van Bavel, J.J., Cichocka, A., Capraro, V., Sjåstad, H., Nezlek, J.B., Pavlović, T., Alfano, M., Gelfand, M.J., Azevedo, F., Birtel, M.D., Cislak, A., Lockwood, P.L., Ross, R.M., Abts, K., Agadullina, E., Aruta, J.J.B., Besharati, S.N., Bor, A., Choma, B.L., Crabtree, C.D., Cunningham, W.A., De, K., Ejaz, W., Elbaek, C.T., Findor, A., Flichtentrei, D., Franc, R., Gjoneska, B., Gruber, J., Gualda, E., Horiuchi, Y., Huynh, T.L.D., Ibanez, A., Imran, M.A., Israelashvili, J., Jasko, K., Kantorowicz, J., Kantorowicz-Reznichenko, E., Krouwel, A., Laakasuo, M., Lamm, C., Leygue, C., Lin, M.-J., Mansoor, M.S., Marie, A., Mayiwar, L., Mazepus, H., McHugh, C., Minda, J.P., Mitkidis, P., Olsson, A., Otterbring, T., Packer, D.J., Perry, A., Petersen, M.B., Puthillam, A., Riaño-Moreno, J.C., Rothmund, T., Santamaría-García, H., Schmid, P.C., Stoyanov, D., Tewari, S., Todosijević, B., Tsakiris, M., Tung, H.H., Umbreș, R.G., Vanags, E., Vlasceanu, M., Vonasch, A., Yucel, M., Zhang, Y., Abad, M., Adler, E., Akrawi, N., Mdarhri, H.A., Amara, H., Amodio, D.M., Antazo, B.G., Apps, M., Ay, F.C., Ba, M.H., Barbosa, S., Bastian, B., Berg, A., Bernal-Zárate, M.P., Bernstein, M., Białek, M., Bilancini, E., Bogatyreva, N., Boncinelli, L., Booth, J.E., Borau, S., Buchel, O., Cameron, C.D., Carvalho, C.F., Celadin, T., Cerami, C., Chalise, H.N., Cheng, X., Cian, L., Cockcroft, K., Conway, J., Córdoba-Delgado, M.A., Crespi, C., Crouzevialle, M., Cutler, J., Cypryańska, M., Dabrowska, J., Daniels, M.A., Davis, V.H., Dayley, P.N., Delouvee, S., Denkovski, O., Dezecache, G., Dhaliwal, N.A., Diato, A.B., Di Paolo, R., Drosinou, M., Dulleck, U., Ekmanis, J., Ertan, A.S., Etienne, T.W., Farhana, H.H., Farkhari, F., Farmer, H., Fenwick, A., Fidanovski, K., Flew, T., Fraser, S., Frempong, R.B., Fugelsang, J.A., Gale, J., Garcia-Navarro, E.B., Garladinne, P., Ghajjou, O., Gkinopoulos, T., Gray, K., Griffin, S.M., Gronfeldt, B., Gümren, M., Gurung, R.L., Halperin, E., Harris, E., Herzon, V., Hruška, M., Huang, G., Hudecek, M.F.C., Isler, O., Jangard, S., Jørgensen, F.J., Kachanoff, F., Kahn, J., Dangol, A.K., Keudel, O., Koppel, L., Koverola, M., Kubin, E., Kunnari, A., Kutiyski, Y., Laguna, O., Leota, J., Lermer, E., Levy, J., Levy, N., Li, C., Long, E.U., Longoni, C., Maglić, M., McCashin, D., Metcalf, A.L., Mikloušić, I., El Mimouni, S., Miura, A., Molina-Paredes, J., Monroy-Fonseca, C., Morales-Marente, E., Moreau, D., Muda, R., Myer, A., Nash, K., Nesh-Nash, T., Nitschke, J.P., Nurse, M.S., Ohtsubo, Y., Oldemburgo de Mello, V., O’Madagain, C., Onderco, M., Palacios-Galvez, M.S., Palomäki, J., Pan, Y., Papp, Z., Pärnamets, P., Paruzel-Czachura, M., Pavlović, Z., Payán-Gómez, C., Perander, S., Pitman, M.M., Prasad, R., Pyrkosz-Pacyna, J., Rathje, S., Raza, A., Rêgo, G.G., Rhee, K., Robertson, C.E., Rodríguez-Pascual, I., Saikkonen, T., Salvador-Ginez, O., Sampaio, W.M., Santi, G.C., Santiago-Tovar, N., Savage, D., Scheffer, J.A., Schönegger, P., Schultner, D.T., Schutte, E.M., Scott, A., Sharma, M., Sharma, P., Skali, A., Stadelmann, D., Stafford, C.A., Stanojević, D., Stefaniak, A., Sternisko, A., Stoica, A., Stoyanova, K.K., Strickland, B., Sundvall, J., Thomas, J.P., Tinghög, G., Torgler, B., Traast, I.J., Tucciarelli, R., Tyrala, M., Ungson, N.D., Uysal, M.S., Van Lange, P.A.M., van Prooijen, J.-W., van Rooy, D., Västfjäll, D., Verkoeijen, P., Vieira, J.B., von Sikorski, C., Walker, A.C., Watermeyer, J., Wetter, E., Whillans, A., Willardt, R., Wohl, M.J.A., Wójcik, A.D., Wu, K., Yamada, Y., Yilmaz, O., Yogeeswaran, K., Ziemer, C.-T., Zwaan, R.A., Boggio, P.S., Van Bavel, J.J., Cichocka, A., Capraro, V., Sjåstad, H., Nezlek, J.B., Pavlović, T., Alfano, M., Gelfand, M.J., Azevedo, F., Birtel, M.D., Cislak, A., Lockwood, P.L., Ross, R.M., Abts, K., Agadullina, E., Aruta, J.J.B., Besharati, S.N., Bor, A., Choma, B.L., Crabtree, C.D., Cunningham, W.A., De, K., Ejaz, W., Elbaek, C.T., Findor, A., Flichtentrei, D., Franc, R., Gjoneska, B., Gruber, J., Gualda, E., Horiuchi, Y., Huynh, T.L.D., Ibanez, A., Imran, M.A., Israelashvili, J., Jasko, K., Kantorowicz, J., Kantorowicz-Reznichenko, E., Krouwel, A., Laakasuo, M., Lamm, C., Leygue, C., Lin, M.-J., Mansoor, M.S., Marie, A., Mayiwar, L., Mazepus, H., McHugh, C., Minda, J.P., Mitkidis, P., Olsson, A., Otterbring, T., Packer, D.J., Perry, A., Petersen, M.B., Puthillam, A., Riaño-Moreno, J.C., Rothmund, T., Santamaría-García, H., Schmid, P.C., Stoyanov, D., Tewari, S., Todosijević, B., Tsakiris, M., Tung, H.H., Umbreș, R.G., Vanags, E., Vlasceanu, M., Vonasch, A., Yucel, M., Zhang, Y., Abad, M., Adler, E., Akrawi, N., Mdarhri, H.A., Amara, H., Amodio, D.M., Antazo, B.G., Apps, M., Ay, F.C., Ba, M.H., Barbosa, S., Bastian, B., Berg, A., Bernal-Zárate, M.P., Bernstein, M., Białek, M., Bilancini, E., Bogatyreva, N., Boncinelli, L., Booth, J.E., Borau, S., Buchel, O., Cameron, C.D., Carvalho, C.F., Celadin, T., Cerami, C., Chalise, H.N., Cheng, X., Cian, L., Cockcroft, K., Conway, J., Córdoba-Delgado, M.A., Crespi, C., Crouzevialle, M., Cutler, J., Cypryańska, M., Dabrowska, J., Daniels, M.A., Davis, V.H., Dayley, P.N., Delouvee, S., Denkovski, O., Dezecache, G., Dhaliwal, N.A., Diato, A.B., Di Paolo, R., Drosinou, M., Dulleck, U., Ekmanis, J., Ertan, A.S., Etienne, T.W., Farhana, H.H., Farkhari, F., Farmer, H., Fenwick, A., Fidanovski, K., Flew, T., Fraser, S., Frempong, R.B., Fugelsang, J.A., Gale, J., Garcia-Navarro, E.B., Garladinne, P., Ghajjou, O., Gkinopoulos, T., Gray, K., Griffin, S.M., Gronfeldt, B., Gümren, M., Gurung, R.L., Halperin, E., Harris, E., Herzon, V., Hruška, M., Huang, G., Hudecek, M.F.C., Isler, O., Jangard, S., Jørgensen, F.J., Kachanoff, F., Kahn, J., Dangol, A.K., Keudel, O., Koppel, L., Koverola, M., Kubin, E., Kunnari, A., Kutiyski, Y., Laguna, O., Leota, J., Lermer, E., Levy, J., Levy, N., Li, C., Long, E.U., Longoni, C., Maglić, M., McCashin, D., Metcalf, A.L., Mikloušić, I., El Mimouni, S., Miura, A., Molina-Paredes, J., Monroy-Fonseca, C., Morales-Marente, E., Moreau, D., Muda, R., Myer, A., Nash, K., Nesh-Nash, T., Nitschke, J.P., Nurse, M.S., Ohtsubo, Y., Oldemburgo de Mello, V., O’Madagain, C., Onderco, M., Palacios-Galvez, M.S., Palomäki, J., Pan, Y., Papp, Z., Pärnamets, P., Paruzel-Czachura, M., Pavlović, Z., Payán-Gómez, C., Perander, S., Pitman, M.M., Prasad, R., Pyrkosz-Pacyna, J., Rathje, S., Raza, A., Rêgo, G.G., Rhee, K., Robertson, C.E., Rodríguez-Pascual, I., Saikkonen, T., Salvador-Ginez, O., Sampaio, W.M., Santi, G.C., Santiago-Tovar, N., Savage, D., Scheffer, J.A., Schönegger, P., Schultner, D.T., Schutte, E.M., Scott, A., Sharma, M., Sharma, P., Skali, A., Stadelmann, D., Stafford, C.A., Stanojević, D., Stefaniak, A., Sternisko, A., Stoica, A., Stoyanova, K.K., Strickland, B., Sundvall, J., Thomas, J.P., Tinghög, G., Torgler, B., Traast, I.J., Tucciarelli, R., Tyrala, M., Ungson, N.D., Uysal, M.S., Van Lange, P.A.M., van Prooijen, J.-W., van Rooy, D., Västfjäll, D., Verkoeijen, P., Vieira, J.B., von Sikorski, C., Walker, A.C., Watermeyer, J., Wetter, E., Whillans, A., Willardt, R., Wohl, M.J.A., Wójcik, A.D., Wu, K., Yamada, Y., Yilmaz, O., Yogeeswaran, K., Ziemer, C.-T., Zwaan, R.A., and Boggio, P.S.
Abstract: Changing collective behaviour and supporting non-pharmaceutical interventions is an important component in mitigating virus transmission during a pandemic. In a large international collaboration (Study 1, N = 49,968 across 67 countries), we investigated self-reported factors associated with public health behaviours (e.g., spatial distancing and stricter hygiene) and endorsed public policy interventions (e.g., closing bars and restaurants) during the early stage of the COVID-19 pandemic (April-May 2020). Respondents who reported identifying more strongly with their nation consistently reported greater engagement in public health behaviours and support for public health policies. Results were similar for representative and non-representative national samples. Study 2 (N = 42 countries) conceptually replicated the central finding using aggregate indices of national identity (obtained using the World Values Survey) and a measure of actual behaviour change during the pandemic (obtained from Google mobility reports). Higher levels of national identification prior to the pandemic predicted lower mobility during the early stage of the pandemic (r = −0.40). We discuss the potential implications of links between national identity, leadership, and public health for managing COVID-19 and future pandemics.
Published: 2022

14. National identity predicts public health support during a global pandemic

Author: Van Bavel, JJ, Cichocka, A, Capraro, V, Sjastad, H, Nezlek, JB, Pavlovic, T, Alfano, M, Gelfand, MJ, Azevedo, F, Birtel, MD, Cislak, A, Lockwood, PL, Ross, RM, Abts, K, Agadullina, E, Aruta, JJB, Besharati, SN, Bor, A, Choma, BL, Crabtree, CD, Cunningham, WA, De, K, Ejaz, W, Elbaek, CT, Findor, A, Flichtentrei, D, Franc, R, Gjoneska, B, Gruber, J, Gualda, E, Horiuchi, Y, Toan, LDH, Ibanez, A, Imran, MA, Israelashvili, J, Jasko, K, Kantorowicz, J, Kantorowicz-Reznichenko, E, Krouwel, A, Laakasuo, M, Lamm, C, Leygue, C, Lin, M-J, Mansoor, MS, Marie, A, Mayiwar, L, Mazepus, H, McHugh, C, Minda, JP, Mitkidis, P, Olsson, A, Otterbring, T, Packer, DJ, Perry, A, Petersen, MB, Puthillam, A, Riano-Moreno, JC, Rothmund, T, Santamaria-Garcia, H, Schmid, PC, Stoyanov, D, Tewari, S, Todosijevic, B, Tsakiris, M, Tung, HH, Umbres, RG, Vanags, E, Vlasceanu, M, Vonasch, A, Yucel, M, Zhang, Y, Abad, M, Adler, E, Akrawi, N, Mdarhri, HA, Amara, H, Amodio, DM, Antazo, BG, Apps, M, Ay, FC, Ba, MH, Barbosa, S, Bastian, B, Berg, A, Bernal-Zarate, MP, Bernstein, M, Bialek, M, Bilancini, E, Bogatyreva, N, Boncinelli, L, Booth, JE, Borau, S, Buchel, O, Cameron, CD, Carvalho, CF, Celadin, T, Cerami, C, Chalise, HN, Cheng, X, Cian, L, Cockcroft, K, Conway, J, Andres Cordoba-Delgado, M, Crespi, C, Crouzevialle, M, Cutler, J, Dabrowska, J, Cypryanska, M, Daniels, MA, Davis, VH, Dayley, PN, Delouvee, S, Denkovski, O, Dezecache, G, Dhaliwal, NA, Diato, AB, Di Paolo, R, Drosinou, M, Dulleck, U, Ekmanis, J, Ertan, AS, Etienne, TW, Farhana, HH, Farkhari, F, Farmer, H, Fenwick, A, Fidanovski, K, Flew, T, Fraser, S, Frempong, RB, Fugelsang, JA, Gale, J, Begona Garcia-Navarro, E, Garladinne, P, Ghajjou, O, Gkinopoulos, T, Gray, K, Griffin, SM, Gronfeldt, B, Gumren, M, Gurung, RL, Halperin, E, Harris, E, Herzon, V, Hruska, M, Huang, G, Hudecek, MFC, Isler, O, Jangard, S, Jorgensen, FJ, Kachanoff, F, Kahn, J, Dangol, AK, Keudel, O, Koppel, L, Koverola, M, Kubin, E, Kunnari, A, Kutiyski, Y, Laguna, O, Leota, J, Lermer, E, Levy, J, Levy, N, Li, C, Long, EU, Longoni, C, Maglic, M, McCashin, D, Metcalf, AL, Miklousic, I, El Mimouni, S, Miura, A, Molina-Paredes, J, Monroy-Fonseca, C, Morales-Marente, E, Moreau, D, Muda, R, Myer, A, Nash, K, Nesh-Nash, T, Nitschke, JP, Nurse, MS, Ohtsubo, Y, de Mello, VO, O'Madagain, C, Onderco, M, Soledad Palacios-Galvez, M, Palomaki, J, Pan, Y, Papp, Z, Parnamets, P, Paruzel-Czachura, M, Pavlovic, Z, Payan-Gomez, C, Perander, S, Pitman, MM, Prasad, R, Pyrkosz-Pacyna, J, Rathje, S, Raza, A, Rego, GG, Rhee, K, Robertson, CE, Rodriguez-Pascual, I, Saikkonen, T, Salvador-Ginez, O, Sampaio, WM, Santi, GC, Santiago-Tovar, N, Savage, D, Scheffer, JA, Schonegger, P, Schultner, DT, Schutte, EM, Scott, A, Sharma, M, Sharma, P, Skali, A, Stadelmann, D, Stafford, CA, Stanojevic, D, Stefaniak, A, Sternisko, A, Stoica, A, Stoyanova, KK, Strickland, B, Sundvall, J, Thomas, JP, Tinghog, G, Torgler, B, Traast, IJ, Tucciarelli, R, Tyrala, M, Ungson, ND, Uysal, MS, Van Lange, PAM, van Prooijen, J-W, van Rooy, D, Vastfjall, D, Verkoeijen, P, Vieira, JB, von Sikorski, C, Walker, AC, Watermeyer, J, Wetter, E, Whillans, A, Willardt, R, Wohl, MJA, Wojcik, AD, Wu, K, Yamada, Y, Yilmaz, O, Yogeeswaran, K, Ziemer, C-T, Zwaan, RA, Boggio, PS, Van Bavel, JJ, Cichocka, A, Capraro, V, Sjastad, H, Nezlek, JB, Pavlovic, T, Alfano, M, Gelfand, MJ, Azevedo, F, Birtel, MD, Cislak, A, Lockwood, PL, Ross, RM, Abts, K, Agadullina, E, Aruta, JJB, Besharati, SN, Bor, A, Choma, BL, Crabtree, CD, Cunningham, WA, De, K, Ejaz, W, Elbaek, CT, Findor, A, Flichtentrei, D, Franc, R, Gjoneska, B, Gruber, J, Gualda, E, Horiuchi, Y, Toan, LDH, Ibanez, A, Imran, MA, Israelashvili, J, Jasko, K, Kantorowicz, J, Kantorowicz-Reznichenko, E, Krouwel, A, Laakasuo, M, Lamm, C, Leygue, C, Lin, M-J, Mansoor, MS, Marie, A, Mayiwar, L, Mazepus, H, McHugh, C, Minda, JP, Mitkidis, P, Olsson, A, Otterbring, T, Packer, DJ, Perry, A, Petersen, MB, Puthillam, A, Riano-Moreno, JC, Rothmund, T, Santamaria-Garcia, H, Schmid, PC, Stoyanov, D, Tewari, S, Todosijevic, B, Tsakiris, M, Tung, HH, Umbres, RG, Vanags, E, Vlasceanu, M, Vonasch, A, Yucel, M, Zhang, Y, Abad, M, Adler, E, Akrawi, N, Mdarhri, HA, Amara, H, Amodio, DM, Antazo, BG, Apps, M, Ay, FC, Ba, MH, Barbosa, S, Bastian, B, Berg, A, Bernal-Zarate, MP, Bernstein, M, Bialek, M, Bilancini, E, Bogatyreva, N, Boncinelli, L, Booth, JE, Borau, S, Buchel, O, Cameron, CD, Carvalho, CF, Celadin, T, Cerami, C, Chalise, HN, Cheng, X, Cian, L, Cockcroft, K, Conway, J, Andres Cordoba-Delgado, M, Crespi, C, Crouzevialle, M, Cutler, J, Dabrowska, J, Cypryanska, M, Daniels, MA, Davis, VH, Dayley, PN, Delouvee, S, Denkovski, O, Dezecache, G, Dhaliwal, NA, Diato, AB, Di Paolo, R, Drosinou, M, Dulleck, U, Ekmanis, J, Ertan, AS, Etienne, TW, Farhana, HH, Farkhari, F, Farmer, H, Fenwick, A, Fidanovski, K, Flew, T, Fraser, S, Frempong, RB, Fugelsang, JA, Gale, J, Begona Garcia-Navarro, E, Garladinne, P, Ghajjou, O, Gkinopoulos, T, Gray, K, Griffin, SM, Gronfeldt, B, Gumren, M, Gurung, RL, Halperin, E, Harris, E, Herzon, V, Hruska, M, Huang, G, Hudecek, MFC, Isler, O, Jangard, S, Jorgensen, FJ, Kachanoff, F, Kahn, J, Dangol, AK, Keudel, O, Koppel, L, Koverola, M, Kubin, E, Kunnari, A, Kutiyski, Y, Laguna, O, Leota, J, Lermer, E, Levy, J, Levy, N, Li, C, Long, EU, Longoni, C, Maglic, M, McCashin, D, Metcalf, AL, Miklousic, I, El Mimouni, S, Miura, A, Molina-Paredes, J, Monroy-Fonseca, C, Morales-Marente, E, Moreau, D, Muda, R, Myer, A, Nash, K, Nesh-Nash, T, Nitschke, JP, Nurse, MS, Ohtsubo, Y, de Mello, VO, O'Madagain, C, Onderco, M, Soledad Palacios-Galvez, M, Palomaki, J, Pan, Y, Papp, Z, Parnamets, P, Paruzel-Czachura, M, Pavlovic, Z, Payan-Gomez, C, Perander, S, Pitman, MM, Prasad, R, Pyrkosz-Pacyna, J, Rathje, S, Raza, A, Rego, GG, Rhee, K, Robertson, CE, Rodriguez-Pascual, I, Saikkonen, T, Salvador-Ginez, O, Sampaio, WM, Santi, GC, Santiago-Tovar, N, Savage, D, Scheffer, JA, Schonegger, P, Schultner, DT, Schutte, EM, Scott, A, Sharma, M, Sharma, P, Skali, A, Stadelmann, D, Stafford, CA, Stanojevic, D, Stefaniak, A, Sternisko, A, Stoica, A, Stoyanova, KK, Strickland, B, Sundvall, J, Thomas, JP, Tinghog, G, Torgler, B, Traast, IJ, Tucciarelli, R, Tyrala, M, Ungson, ND, Uysal, MS, Van Lange, PAM, van Prooijen, J-W, van Rooy, D, Vastfjall, D, Verkoeijen, P, Vieira, JB, von Sikorski, C, Walker, AC, Watermeyer, J, Wetter, E, Whillans, A, Willardt, R, Wohl, MJA, Wojcik, AD, Wu, K, Yamada, Y, Yilmaz, O, Yogeeswaran, K, Ziemer, C-T, Zwaan, RA, and Boggio, PS
Abstract: Changing collective behaviour and supporting non-pharmaceutical interventions is an important component in mitigating virus transmission during a pandemic. In a large international collaboration (Study 1, N = 49,968 across 67 countries), we investigated self-reported factors associated with public health behaviours (e.g., spatial distancing and stricter hygiene) and endorsed public policy interventions (e.g., closing bars and restaurants) during the early stage of the COVID-19 pandemic (April-May 2020). Respondents who reported identifying more strongly with their nation consistently reported greater engagement in public health behaviours and support for public health policies. Results were similar for representative and non-representative national samples. Study 2 (N = 42 countries) conceptually replicated the central finding using aggregate indices of national identity (obtained using the World Values Survey) and a measure of actual behaviour change during the pandemic (obtained from Google mobility reports). Higher levels of national identification prior to the pandemic predicted lower mobility during the early stage of the pandemic (r = -0.40). We discuss the potential implications of links between national identity, leadership, and public health for managing COVID-19 and future pandemics.
Published: 2022

15. National identity predicts public health support during a global pandemic (vol 13, 517, 2022)

Author: Van Bavel, JJ, Cichocka, A, Capraro, V, Sjastad, H, Nezlek, JB, Pavlovic, T, Alfano, M, Gelfand, MJ, Azevedo, F, Birtel, MD, Cislak, A, Lockwood, PL, Ross, RM, Abts, K, Agadullina, E, Aruta, JJB, Besharati, SN, Bor, A, Choma, BL, Crabtree, CD, Cunningham, WA, De, K, Ejaz, W, Elbaek, CT, Findor, A, Flichtentrei, D, Franc, R, Gjoneska, B, Gruber, J, Gualda, E, Horiuchi, Y, Huynh, TLD, Ibanez, A, Imran, MA, Israelashvili, J, Jasko, K, Kantorowicz, J, Kantorowicz-Reznichenko, E, Krouwel, A, Laakasuo, M, Lamm, C, Leygue, C, Lin, M-J, Mansoor, MS, Marie, A, Mayiwar, L, Mazepus, H, McHugh, C, Minda, JP, Mitkidis, P, Olsson, A, Otterbring, T, Packer, DJ, Perry, A, Petersen, MB, Puthillam, A, Riano-Moreno, JC, Rothmund, T, Santamaria-Garcia, H, Schmid, PC, Stoyanov, D, Tewari, S, Todosijevic, B, Tsakiris, M, Tung, HH, Umbres, RG, Vanags, E, Vlasceanu, M, Vonasch, A, Yucel, M, Zhang, Y, Abad, M, Adler, E, Akrawi, N, Mdarhri, HA, Amara, H, Amodio, DM, Antazo, BG, Apps, M, Ay, FC, Ba, MH, Barbosa, S, Bastian, B, Berg, A, Bernal-Zarate, MP, Bernstein, M, Bialek, M, Bilancini, E, Bogatyreva, N, Boncinelli, L, Booth, JE, Borau, S, Buchel, O, Cameron, CD, Carvalho, CF, Celadin, T, Cerami, C, Chalise, HN, Cheng, X, Cian, L, Cockcroft, K, Conway, J, Cordoba-Delgado, MA, Crespi, C, Crouzevialle, M, Cutler, J, Cypryanska, M, Dabrowska, J, Daniels, MA, Davis, VH, Dayley, PN, Delouvee, S, Denkovski, O, Dezecache, G, Dhaliwal, NA, Diato, AB, Di Paolo, R, Drosinou, M, Dulleck, U, Ekmanis, J, Ertan, AS, Etienne, TW, Farhana, HH, Farkhari, F, Farmer, H, Fenwick, A, Fidanovski, K, Flew, T, Fraser, S, Frempong, RB, Fugelsang, JA, Gale, J, Garcia-Navarro, EB, Garladinne, P, Ghajjou, O, Gkinopoulos, T, Gray, K, Griffin, SM, Gronfeldt, B, Gumren, M, Gurung, RL, Halperin, E, Harris, E, Herzon, V, Hruska, M, Huang, G, Hudecek, MFC, Isler, O, Jangard, S, Jorgensen, FJ, Kachanoff, F, Kahn, J, Dangol, AK, Keudel, O, Koppel, L, Koverola, M, Kubin, E, Kunnari, A, Kutiyski, Y, Laguna, O, Leota, J, Lermer, E, Levy, J, Levy, N, Li, C, Long, EU, Longoni, C, Maglic, M, McCashin, D, Metcalf, AL, Miklousic, I, El Mimouni, S, Miura, A, Molina-Paredes, J, Monroy-Fonseca, C, Morales-Marente, E, Moreau, D, Muda, R, Myer, A, Nash, K, Nesh-Nash, T, Nitschke, JP, Nurse, MS, Ohtsubo, Y, Oldemburgo de Mello, V, O'Madagain, C, Onderco, M, Palacios-Galvez, MS, Palomaki, J, Pan, Y, Papp, Z, Parnamets, P, Paruzel-Czachura, M, Pavlovic, Z, Payan-Gomez, C, Perander, S, Pitman, MM, Prasad, R, Pyrkosz-Pacyna, J, Rathje, S, Raza, A, Rego, GG, Rhee, K, Robertson, CE, Rodriguez-Pascual, I, Saikkonen, T, Salvador-Ginez, O, Sampaio, WM, Santi, GC, Santiago-Tovar, N, Savage, D, Scheffer, JA, Schonegger, P, Schultner, DT, Schutte, EM, Scott, A, Sharma, M, Sharma, P, Skali, A, Stadelmann, D, Stafford, CA, Stanojevic, D, Stefaniak, A, Sternisko, A, Stoica, A, Stoyanova, KK, Strickland, B, Sundvall, J, Thomas, JP, Tinghog, G, Torgler, B, Traast, IJ, Tucciarelli, R, Tyrala, M, Ungson, ND, Uysal, MS, Van Lange, PAM, van Prooijen, J-W, van Rooy, D, Vastfjall, D, Verkoeijen, P, Vieira, JB, von Sikorski, C, Walker, AC, Watermeyer, J, Wetter, E, Whillans, A, Willardt, R, Wohl, MJA, Wojcik, AD, Wu, K, Yamada, Y, Yilmaz, O, Yogeeswaran, K, Ziemer, C-T, Zwaan, RA, Boggio, PS, Van Bavel, JJ, Cichocka, A, Capraro, V, Sjastad, H, Nezlek, JB, Pavlovic, T, Alfano, M, Gelfand, MJ, Azevedo, F, Birtel, MD, Cislak, A, Lockwood, PL, Ross, RM, Abts, K, Agadullina, E, Aruta, JJB, Besharati, SN, Bor, A, Choma, BL, Crabtree, CD, Cunningham, WA, De, K, Ejaz, W, Elbaek, CT, Findor, A, Flichtentrei, D, Franc, R, Gjoneska, B, Gruber, J, Gualda, E, Horiuchi, Y, Huynh, TLD, Ibanez, A, Imran, MA, Israelashvili, J, Jasko, K, Kantorowicz, J, Kantorowicz-Reznichenko, E, Krouwel, A, Laakasuo, M, Lamm, C, Leygue, C, Lin, M-J, Mansoor, MS, Marie, A, Mayiwar, L, Mazepus, H, McHugh, C, Minda, JP, Mitkidis, P, Olsson, A, Otterbring, T, Packer, DJ, Perry, A, Petersen, MB, Puthillam, A, Riano-Moreno, JC, Rothmund, T, Santamaria-Garcia, H, Schmid, PC, Stoyanov, D, Tewari, S, Todosijevic, B, Tsakiris, M, Tung, HH, Umbres, RG, Vanags, E, Vlasceanu, M, Vonasch, A, Yucel, M, Zhang, Y, Abad, M, Adler, E, Akrawi, N, Mdarhri, HA, Amara, H, Amodio, DM, Antazo, BG, Apps, M, Ay, FC, Ba, MH, Barbosa, S, Bastian, B, Berg, A, Bernal-Zarate, MP, Bernstein, M, Bialek, M, Bilancini, E, Bogatyreva, N, Boncinelli, L, Booth, JE, Borau, S, Buchel, O, Cameron, CD, Carvalho, CF, Celadin, T, Cerami, C, Chalise, HN, Cheng, X, Cian, L, Cockcroft, K, Conway, J, Cordoba-Delgado, MA, Crespi, C, Crouzevialle, M, Cutler, J, Cypryanska, M, Dabrowska, J, Daniels, MA, Davis, VH, Dayley, PN, Delouvee, S, Denkovski, O, Dezecache, G, Dhaliwal, NA, Diato, AB, Di Paolo, R, Drosinou, M, Dulleck, U, Ekmanis, J, Ertan, AS, Etienne, TW, Farhana, HH, Farkhari, F, Farmer, H, Fenwick, A, Fidanovski, K, Flew, T, Fraser, S, Frempong, RB, Fugelsang, JA, Gale, J, Garcia-Navarro, EB, Garladinne, P, Ghajjou, O, Gkinopoulos, T, Gray, K, Griffin, SM, Gronfeldt, B, Gumren, M, Gurung, RL, Halperin, E, Harris, E, Herzon, V, Hruska, M, Huang, G, Hudecek, MFC, Isler, O, Jangard, S, Jorgensen, FJ, Kachanoff, F, Kahn, J, Dangol, AK, Keudel, O, Koppel, L, Koverola, M, Kubin, E, Kunnari, A, Kutiyski, Y, Laguna, O, Leota, J, Lermer, E, Levy, J, Levy, N, Li, C, Long, EU, Longoni, C, Maglic, M, McCashin, D, Metcalf, AL, Miklousic, I, El Mimouni, S, Miura, A, Molina-Paredes, J, Monroy-Fonseca, C, Morales-Marente, E, Moreau, D, Muda, R, Myer, A, Nash, K, Nesh-Nash, T, Nitschke, JP, Nurse, MS, Ohtsubo, Y, Oldemburgo de Mello, V, O'Madagain, C, Onderco, M, Palacios-Galvez, MS, Palomaki, J, Pan, Y, Papp, Z, Parnamets, P, Paruzel-Czachura, M, Pavlovic, Z, Payan-Gomez, C, Perander, S, Pitman, MM, Prasad, R, Pyrkosz-Pacyna, J, Rathje, S, Raza, A, Rego, GG, Rhee, K, Robertson, CE, Rodriguez-Pascual, I, Saikkonen, T, Salvador-Ginez, O, Sampaio, WM, Santi, GC, Santiago-Tovar, N, Savage, D, Scheffer, JA, Schonegger, P, Schultner, DT, Schutte, EM, Scott, A, Sharma, M, Sharma, P, Skali, A, Stadelmann, D, Stafford, CA, Stanojevic, D, Stefaniak, A, Sternisko, A, Stoica, A, Stoyanova, KK, Strickland, B, Sundvall, J, Thomas, JP, Tinghog, G, Torgler, B, Traast, IJ, Tucciarelli, R, Tyrala, M, Ungson, ND, Uysal, MS, Van Lange, PAM, van Prooijen, J-W, van Rooy, D, Vastfjall, D, Verkoeijen, P, Vieira, JB, von Sikorski, C, Walker, AC, Watermeyer, J, Wetter, E, Whillans, A, Willardt, R, Wohl, MJA, Wojcik, AD, Wu, K, Yamada, Y, Yilmaz, O, Yogeeswaran, K, Ziemer, C-T, Zwaan, RA, and Boggio, PS
Published: 2022

16. Country Risks and Brain Drain: The Emigration Potential of Japanese Skilled Workers

Author: HORIUCHI, Y, OISHI, N, HORIUCHI, Y, and OISHI, N
Abstract: While most existing research attributes contemporary Japanese emigration to the pursuit of a better lifestyle, recent qualitative studies point out that concern about country risks is a significant driver . We explore Japan’s brain-drain potential and factors shaping Japanese skilled workers’ interest in emigrating to other countries based on our original survey with an experimental component. We first undertake descriptive analysis using respondents in the (baseline) control group and examine what types of Japanese skilled workers are interested in emigration. We then use respondents in the control and treatment groups to test our preregistered hypotheses regarding the impact of information about Japan’s country risks on their attitudes. The results of our descriptive analysis show that respondents with overseas experience and younger respondents are particularly motivated to consider emigration. Another notable finding is that respondents who distrust the government and media are also more likely to consider leaving Japan than those who do not. Furthermore, through our randomized survey experiment, we find that exposure to information about long-term economic risk encourages people to consider living abroad in the future. These results suggest that the brain drain from Japan is likely to continue, pointing to a need for policy actions to tackle it.
Published: 2022

17. Decongestion, kidney injury and prognosis in patients with acute heart failure

Author: Horiuchi, Y. Wettersten, N. van Veldhuisen, D.J. Mueller, C. Filippatos, G. Nowak, R. Hogan, C. Kontos, M.C. Cannon, C.M. Müeller, G.A. Birkhahn, R. Taub, P. Vilke, G.M. Barnett, O. McDonald, K. Mahon, N. Nuñez, J. Briguori, C. Passino, C. Duff, S. Maisel, A. Murray, P.T.
Abstract: Background: In patients with acute heart failure (AHF), the development of worsening renal function with appropriate decongestion is thought to be a benign functional change and not associated with poor prognosis. We investigated whether the benefit of decongestion outweighs the risk of concurrent kidney tubular damage and leads to better outcomes. Methods: We retrospectively analyzed data from the AKINESIS study, which enrolled AHF patients requiring intravenous diuretic therapy. Urine neutrophil gelatinase-associated lipocalin (uNGAL) and B-type natriuretic peptide (BNP) were serially measured during the hospitalization. Decongestion was defined as ≥30% BNP decrease at discharge compared to admission. Univariable and multivariable Cox models were assessed for one-year mortality. Results: Among 736 patients, 53% had ≥30% BNP decrease at discharge. Levels of uNGAL and BNP at each collection time point had positive but weak correlations (r ≤ 0.133). Patients without decongestion and with higher discharge uNGAL values had worse one-year mortality, while those with decongestion had better outcomes regardless of uNGAL values (p for interaction 0.018). This interaction was also significant when the change in BNP was analyzed as a continuous variable (p < 0.001). Although higher peak and discharge uNGAL were associated with mortality in univariable analysis, only ≥30% BNP decrease was a significant predictor after multivariable adjustment. Conclusions: Among AHF patients treated with diuretic therapy, decongestion was generally not associated with kidney tubular damage assessed by uNGAL. Kidney tubular damage with adequate decongestion does not impact outcomes; however, kidney injury without adequate decongestion is associated with a worse prognosis. © 2022 Elsevier B.V.
Published: 2022

18. Modified intra-cerebral challenge assay for acellular pertussis vaccines: Comparisons among whole cell and acellular vaccines

Author: Gaines-Das, R., Horiuchi, Y., Zhang, S.M., Newland, P., Kim, Y., Corbel, M., and Xing, D.
Published: 2009
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19. DPP6 as a candidate gene for neuroleptic-induced tardive dyskinesia

Author: Tanaka, S, Syu, A, Ishiguro, H, Inada, T, Horiuchi, Y, Ishikawa, M, Koga, M, Noguchi, E, Ozaki, N, Someya, T, Kakita, A, Takahashi, H, Nawa, H, and Arinami, T
Published: 2013
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20. Potential Utility of Cardio-Renal Biomarkers For Prediction and Prognostication of Worsening Renal Function in Acute Heart Failure: Cardio-Renal Biomarkers and WRF in AHF

Author: Horiuchi Y, Wettersten N, van Veldhuisen D, Mueller C, Filippatos G, Nowak R, Hogan C, Kontos M, Cannon C, Mueller G, Birkhahn R, Taub P, Vilke G, Barnett O, McDonald K, Mahon N, Nunez J, Briguori C, Passino C, Maisel A, and Murray P
Abstract: BACKGROUND: Multiple different pathophysiologic processes can contribute to worsening renal function (WRF) in acute heart failure (AHF). METHODS AND RESULTS: We retrospectively analyzed 787 AHF patients for the relationship between changes in serum creatinine and biomarkers including brain natriuretic peptide (BNP), high sensitivity cardiac troponin I (hscTnI), galectin 3, serum neutrophil gelatinase-associated lipocalin (NGAL) and urine NGAL. WRF was defined as an increase of = 0.3 mg/dl or 50% in creatinine within first 5 days of hospitalization. WRF was observed in 25% of patients. Changes in biomarkers and creatinine were poorly correlated (r = 0.21) and no biomarker predicted WRF better than creatinine. In the multivariable Cox analysis, BNP and hscTnI, but not WRF, were significantly associated with the one-year composite of death or HF hospitalization. WRF with an increasing urine NGAL predicted an increased risk of HF hospitalization. CONCLUSIONS: Biomarkers were not able to predict WRF better than creatinine. One-year outcomes were associated with biomarkers of cardiac stress and injury but not with WRF, while a kidney injury biomarker may prognosticate WRF for HF hospitalization.
Published: 2021

21. Relation of Decongestion and Time to Diuretics to Biomarker Changes and Outcomes in Acute Heart Failure

Author: Horiuchi, Y. Wettersten, N. van Veldhuisen, D.J. Mueller, C. Filippatos, G. Nowak, R. Hogan, C. Kontos, M.C. Cannon, C.M. Müeller, G.A. Birkhahn, R. Taub, P. Vilke, G.M. Barnett, O. McDonald, K. Mahon, N. Nuñez, J. Briguori, C. Passino, C. Maisel, A. Murray, P.T.
Abstract: Prompt treatment may mitigate the adverse effects of congestion in the early phase of heart failure (HF) hospitalization, which may lead to improved outcomes. We analyzed 814 acute HF patients for the relationships between time to first intravenous loop diuretics, changes in biomarkers of congestion and multiorgan dysfunction, and 1-year composite end point of death or HF hospitalization. B-type natriuretic peptide (BNP), high sensitivity cardiac troponin I (hscTnI), urine and serum neutrophil gelatinase–associated lipocalin, and galectin 3 were measured at hospital admission, hospital day 1, 2, 3 and discharge. Time to diuretics was not correlated with the timing of decongestion defined as BNP decrease ≥ 30% compared with admission. Earlier BNP decreases but not time to diuretics were associated with earlier and greater decreases in hscTnI and urine neutrophil gelatinase–associated lipocalin, and lower incidence of the composite end point. After adjustment for confounders, only no BNP decrease at discharge was significantly associated with mortality but not the composite end point (p = 0.006 and p = 0.062, respectively). In conclusion, earlier time to decongestion but not the time to diuretics was associated with better biomarker trajectories. Residual congestion at discharge rather than the timing of decongestion predicted a worse prognosis. © 2021 The Authors
Published: 2021

22. Decongestion discriminates risk for one-year mortality in patients with improving renal function in acute heart failure

Author: Wettersten, N. Horiuchi, Y. van Veldhuisen, D.J. Ix, J.H. Mueller, C. Filippatos, G. Nowak, R. Hogan, C. Kontos, M.C. Cannon, C.M. Müeller, G.A. Birkhahn, R. Taub, P. Vilke, G.M. Duff, S. McDonald, K. Mahon, N. Nuñez, J. Briguori, C. Passino, C. Maisel, A. Murray, P.T.
Abstract: Aims: Improving renal function (IRF) is paradoxically associated with worse outcomes in acute heart failure (AHF), but outcomes may differ based on response to decongestion. We explored if the relationship of IRF with mortality in hospitalized AHF patients differs based on successful decongestion. Methods and results: We evaluated 760 AHF patients from AKINESIS for the relationship between IRF, change in B-type natriuretic peptide (BNP), and 1-year mortality. IRF was defined as a ≥20% increase in estimated glomerular filtration rate (eGFR) relative to admission. Adequate decongestion was defined as a ≥40% decrease in last measured BNP relative to admission. IRF occurred in 22% of patients who had a mean age of 69 years, 58% were men, 72% were white, and median admission eGFR was 49 mL/min/1.73 m2. IRF patients had more severe heart failure reflected by lower admission eGFR, higher blood urea nitrogen, lower systolic blood pressure, lower sodium, and higher use of inotropes. IRF patients had higher 1-year mortality (25%) than non-IRF patients (15%) (P < 0.01). However, this relationship differed by BNP trajectory (P-interaction = 0.03). When stratified by BNP change, non-IRF patients and IRF patients with decreasing BNP had lower 1-year mortality than either non-IRF and IRF patients without decreasing BNP. However, in multivariate analysis, IRF was not associated with mortality [adjusted hazard ratio (HR) 1.0, 95% confidence interval (CI) 0.7–1.5] while BNP was (adjusted HR 0.5, 95% CI 0.3–0.7). When IRF was evaluated as transiently occurring or persisting at discharge, again only BNP change was significantly associated with mortality. Conclusion: Improving renal function is associated with mortality in AHF but not independent of other variables and congestion status. Achieving adequate decongestion, as reflected by lower BNP, in AHF is more strongly associated with mortality than IRF. © 2021 European Society of Cardiology.
Published: 2021

23. Decongestion discriminates risk for one-year mortality in patients with improving renal function in acute heart failure.

Author: Wettersten, N, Horiuchi, Y, van Veldhuisen, DJ, Ix, JH, Mueller, C, Filippatos, G, Nowak, R, Hogan, C, Kontos, MC, Cannon, CM, Müeller, GA, Birkhahn, R, Taub, P, Vilke, GM, Duff, S, McDonald, K, Mahon, N, Nuñez, J, Briguori, C, Passino, C, Maisel, A, Murray, PT, Wettersten, N, Horiuchi, Y, van Veldhuisen, DJ, Ix, JH, Mueller, C, Filippatos, G, Nowak, R, Hogan, C, Kontos, MC, Cannon, CM, Müeller, GA, Birkhahn, R, Taub, P, Vilke, GM, Duff, S, McDonald, K, Mahon, N, Nuñez, J, Briguori, C, Passino, C, Maisel, A, and Murray, PT
Abstract: AIMS: Improving renal function (IRF) is paradoxically associated with worse outcomes in acute heart failure (AHF), but outcomes may differ based on response to decongestion. We explored if the relationship of IRF with mortality in hospitalized AHF patients differs based on successful decongestion. METHODS AND RESULTS: We evaluated 760 AHF patients from AKINESIS for the relationship between IRF, change in B-type natriuretic peptide (BNP), and 1-year mortality. IRF was defined as a ≥20% increase in estimated glomerular filtration rate (eGFR) relative to admission. Adequate decongestion was defined as a ≥40% decrease in last measured BNP relative to admission. IRF occurred in 22% of patients who had a mean age of 69 years, 58% were men, 72% were white, and median admission eGFR was 49 mL/min/1.73 m2 . IRF patients had more severe heart failure reflected by lower admission eGFR, higher blood urea nitrogen, lower systolic blood pressure, lower sodium, and higher use of inotropes. IRF patients had higher 1-year mortality (25%) than non-IRF patients (15%) (P < 0.01). However, this relationship differed by BNP trajectory (P-interaction = 0.03). When stratified by BNP change, non-IRF patients and IRF patients with decreasing BNP had lower 1-year mortality than either non-IRF and IRF patients without decreasing BNP. However, in multivariate analysis, IRF was not associated with mortality [adjusted hazard ratio (HR) 1.0, 95% confidence interval (CI) 0.7-1.5] while BNP was (adjusted HR 0.5, 95% CI 0.3-0.7). When IRF was evaluated as transiently occurring or persisting at discharge, again only BNP change was significantly associated with mortality. CONCLUSION: Improving renal function is associated with mortality in AHF but not independent of other variables and congestion status. Achieving adequate decongestion, as reflected by lower BNP, in AHF is more strongly associated with mortality than IRF.
Published: 2021

24. Relation of Decongestion and Time to Diuretics to Biomarker Changes and Outcomes in Acute Heart Failure.

Author: Horiuchi, Y, Wettersten, N, van Veldhuisen, DJ, Mueller, C, Filippatos, G, Nowak, R, Hogan, C, Kontos, MC, Cannon, CM, Müeller, GA, Birkhahn, R, Taub, P, Vilke, GM, Barnett, O, McDonald, K, Mahon, N, Nuñez, J, Briguori, C, Passino, C, Maisel, A, Murray, PT, Horiuchi, Y, Wettersten, N, van Veldhuisen, DJ, Mueller, C, Filippatos, G, Nowak, R, Hogan, C, Kontos, MC, Cannon, CM, Müeller, GA, Birkhahn, R, Taub, P, Vilke, GM, Barnett, O, McDonald, K, Mahon, N, Nuñez, J, Briguori, C, Passino, C, Maisel, A, and Murray, PT
Abstract: Prompt treatment may mitigate the adverse effects of congestion in the early phase of heart failure (HF) hospitalization, which may lead to improved outcomes. We analyzed 814 acute HF patients for the relationships between time to first intravenous loop diuretics, changes in biomarkers of congestion and multiorgan dysfunction, and 1-year composite end point of death or HF hospitalization. B-type natriuretic peptide (BNP), high sensitivity cardiac troponin I (hscTnI), urine and serum neutrophil gelatinase-associated lipocalin, and galectin 3 were measured at hospital admission, hospital day 1, 2, 3 and discharge. Time to diuretics was not correlated with the timing of decongestion defined as BNP decrease ≥ 30% compared with admission. Earlier BNP decreases but not time to diuretics were associated with earlier and greater decreases in hscTnI and urine neutrophil gelatinase-associated lipocalin, and lower incidence of the composite end point. After adjustment for confounders, only no BNP decrease at discharge was significantly associated with mortality but not the composite end point (p = 0.006 and p = 0.062, respectively). In conclusion, earlier time to decongestion but not the time to diuretics was associated with better biomarker trajectories. Residual congestion at discharge rather than the timing of decongestion predicted a worse prognosis.
Published: 2021

25. Determining Subsequent Yield Surface of Pure Titanium Sheet by Use of Abrupt Strain Path Change

Author: Kuwabara, T. and Horiuchi, Y.
Published: 2008
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26. Variation of 7Be concentration in surface air at Nagano, Japan

Author: Muramatsu, H., Yoshizawa, S., Abe, T., Ishii, T., Wada, M., Horiuchi, Y., and Kanekatsu, R.
Published: 2008
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27. Involvement of cannabinoid CB2 receptor in alcohol preference in mice and alcoholism in humans

Author: Ishiguro, H, Iwasaki, S, Teasenfitz, L, Higuchi, S, Horiuchi, Y, Saito, T, Arinami, T, and Onaivi, E S
Published: 2007
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28. Short-term prognostic implications of serum and urine neutrophil gelatinase-associated lipocalin in acute heart failure: findings from the AKINESIS study

Author: Wettersten, N. Horiuchi, Y. van Veldhuisen, D.J. Mueller, C. Filippatos, G. Nowak, R. Hogan, C. Kontos, M.C. Cannon, C.M. Müeller, G.A. Birkhahn, R. Taub, P. Vilke, G.M. Barnett, O. McDonald, K. Mahon, N. Nuñez, J. Briguori, C. Passino, C. Maisel, A. Murray, P.T.
Abstract: Aims: Kidney impairment has been associated with worse outcomes in acute heart failure (AHF), although recent studies challenge this association. Neutrophil gelatinase-associated lipocalin (NGAL) is a novel biomarker of kidney tubular injury. Its prognostic role in AHF has not been evaluated in large cohorts. The present study aimed to determine if serum NGAL (sNGAL) or urine NGAL (uNGAL) is superior to creatinine for predicting short-term outcomes in AHF. Methods and results: The study was conducted in an international, multicentre, prospective cohort consisting of 927 patients with AHF. Admission and peak values of sNGAL, uNGAL and uNGAL/urine creatinine (uCr) ratio were compared to admission and peak serum creatinine (sCr). The composite endpoints were death, initiation of renal replacement therapy, heart failure (HF) readmission and any emergent HF-related outpatient visit within 30 and 60 days, respectively. The mean age of the cohort was 69 years and 62% were male. The median length of stay was 6 days. The composite endpoint occurred in 106 patients and 154 patients within 30 and 60 days, respectively. Serum NGAL was more predictive than uNGAL and the uNGAL/uCr ratio but was not superior to sCr [area under the curve: admission sNGAL 0.61, 95% confidence interval (CI) 0.55–0.67, and 0.59, 95% CI 0.54–0.65; peak sNGAL: 0.60, 95% CI 0.54–0.66, and 0.57, 95% CI 0.52–0.63; admission sCr: 0.60, 95% CI 0.54–0.64, and 0.59, 95% CI 0.53–0.64; peak sCr: 0.61, 95% CI 0.55–0.67, and 0.59, 95% CI 0.54–0.64, at 30 and 60 days, respectively]. NGAL was not predictive of the composite endpoint in multivariate analysis. Conclusions: Serum NGAL outperformed uNGAL but neither was superior to admission or peak sCr for predicting adverse events. © 2019 The Authors. European Journal of Heart Failure © 2019 European Society of Cardiology
Published: 2020

29. Cholesterol transport between red blood cells and lipoproteins contributes to cholesterol metabolism in blood

Author: Ohkawa, R, Low, H, Mukhamedova, N, Fu, Y, Lai, S-J, Sasaoka, M, Hara, A, Yamazaki, A, Kameda, T, Horiuchi, Y, Meikle, PJ, Pernes, G, Lancaster, G, Ditiatkovski, M, Nestel, P, Vaisman, B, Sviridov, D, Murphy, A, Remaley, AT, Tozuka, M, Ohkawa, R, Low, H, Mukhamedova, N, Fu, Y, Lai, S-J, Sasaoka, M, Hara, A, Yamazaki, A, Kameda, T, Horiuchi, Y, Meikle, PJ, Pernes, G, Lancaster, G, Ditiatkovski, M, Nestel, P, Vaisman, B, Sviridov, D, Murphy, A, Remaley, AT, and Tozuka, M
Abstract: Lipoproteins play a key role in transport of cholesterol to and from tissues. Recent studies have also demonstrated that red blood cells (RBCs), which carry large quantities of free cholesterol in their membrane, play an important role in reverse cholesterol transport. However, the exact role of RBCs in systemic cholesterol metabolism is poorly understood. RBCs were incubated with autologous plasma or isolated lipoproteins resulting in a significant net amount of cholesterol moved from RBCs to HDL, while cholesterol from LDL moved in the opposite direction. Furthermore, the bi-directional cholesterol transport between RBCs and plasma lipoproteins was saturable and temperature-, energy-, and time-dependent, consistent with an active process. We did not find LDLR, ABCG1, or scavenger receptor class B type 1 in RBCs but found a substantial amount of ABCA1 mRNA and protein. However, specific cholesterol efflux from RBCs to isolated apoA-I was negligible, and ABCA1 silencing with siRNA or inhibition with vanadate and Probucol did not inhibit the efflux to apoA-I, HDL, or plasma. Cholesterol efflux from and cholesterol uptake by RBCs from Abca1+/+ and Abca1-/- mice were similar, arguing against the role of ABCA1 in cholesterol flux between RBCs and lipoproteins. Bioinformatics analysis identified ABCA7, ABCG5, lipoprotein lipase, and mitochondrial translocator protein as possible candidates that may mediate the cholesterol flux. Together, these results suggest that RBCs actively participate in cholesterol transport in the blood, but the role of cholesterol transporters in RBCs remains uncertain.
Published: 2020

30. RGS4 is not a susceptibility gene for schizophrenia in Japanese: Association study in a large case-control population

Author: Ishiguro, H., Horiuchi, Y., Koga, M., Inada, T., Iwata, N., Ozaki, N., Ujike, H., Muratake, T., Someya, T., and Arinami, T.
Published: 2007
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31. PICK1 is not a susceptibility gene for schizophrenia in a Japanese population: Association study in a large case–control population

Author: Ishiguro, H., Koga, M., Horiuchi, Y., Inada, T., Iwata, N., Ozaki, N., Ujike, H., Muratake, T., Someya, T., and Arinami, T.
Published: 2007
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32. Floral and pollination characteristics of Eriocaulon heleocharioides, an extinct species in the wild, for evidence‐based conservation management

Author: Horiuchi, Y., primary, Kamijo, T., additional, and Tanaka, N., additional
Published: 2021
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33. HfN multi charge trapping layers for Hf-based metal-oxide-nitride-oxide-Si nonvolatile memory

Author: Ohmi, S., primary, Horiuchi, Y., additional, Morita, H., additional, Ihara, A., additional, and Pyo, J.Y., additional
Published: 2021
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34. Induction of cyclooxygenase-1 in cultured synovial cells isolated from rheumatoid arthritis patients

Author: Onodera, M., Horiuchi, Y., Nakahama, K., Muneta, T., Mano, Y., and Morita, I.
Published: 2004
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35. Optical label switching networks

Author: International Conference on Optical Internet (3rd : 2004 : Kanagawa, Japan) and Horiuchi, Y
Published: 2004

36. Effects of Si addition on superelastic properties of Ti–Nb–Al biomedical shape memory alloys

Author: Masumoto, K., Horiuchi, Y., Inamura, T., Hosoda, H., Wakashima, K., Kim, H.Y., and Miyazaki, S.
Published: 2006
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37. Effect of boron addition on transformation behavior and tensile properties of Ti–Nb–Al alloy

Author: Horiuchi, Y., Inamura, T., Hosoda, H., Wakashima, K., Kim, H.Y., and Miyazaki, S.
Published: 2006
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38. Usefulness of MRA-DWI mismatch in neuroendovascular therapy for acute cerebral infarction

Author: Deguchi, I., Dembo, T., Fukuoka, T., Nagoya, H., Maruyama, H., Kato, Y., Oe, Y., Horiuchi, Y., Takeda, H., and Tanahashi, N.
Published: 2012
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39. Experimental and analytical studies on mechanical behavior of superconducting coil for SMES

Author: Shimada, K., Hanai, S., Kushida, L., Hirabayashi, K., Kobayashi, T., Shimonosono, T., Hayashi, H., Tsutsumi, K., Irie, F., Horiuchi, Y., and Ezaki, T.
Subjects: Superconductors -- Research, Business, Electronics, Electronics and electrical industries
Abstract: The mechanical behavior of superconducting coil for SMES was investigated both experimentally and analaytically.
Published: 2001

40. Surgical treatment of spontaneous posterior interosseous nerve palsy

Author: Ochi, K., Horiuchi, Y., Tazaki, K., Takayama, S., Nakamura, T., Ikegami, H., Matsumura, T., and Toyama, Y.
Published: 2011
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41. Novel cholesterol efflux assay using immobilized liposome-bound gel beads: Comparison to conventional method

Author: Horiuchi, Y., primary, Lai, S.-J., additional, Shimano, S., additional, Kameda, T., additional, Ichimura, N., additional, Tohda, S., additional, Tozuka, M., additional, and Ohkawa, R., additional
Published: 2020
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42. EFFICACY OF THE DIAGNOSTIC ACCURACY USING MAGNIFYING ENDOSCOPY WITH NARROW-BAND IMAGING FOR PURE SIGNET RING CELL CARCINOMA AND POORLY DIFFERENTIATED-TYPE COMPONENT MIXED WITH UNDIFFERENTIATED-TYPE ADENOCARCINOMA

Author: Inuyama, M, additional, Horiuchi, Y, additional, and Fujisaki, J, additional
Published: 2020
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43. Clopidogrel resistance in patients with ischemic stroke assessed using verifynow P2Y12 assay: PO20308

Author: Maruyama, H, Furuya, D, Takeda, H, Dembo, T, Nagoya, H, Kato, Y, Ito, Y, Fukuoka, T, Horiuchi, Y, and Tanahashi, N
Published: 2010

44. Diversity of molecular forms of plasma brain natriuretic peptide in heart failure—different proBNP-108 to BNP-32 ratios in atrial and ventricular overload

Author: Nishikimi, T, Minamino, N, Ikeda, M, Takeda, Y, Tadokoro, K, Shibasaki, I, Fukuda, H, Horiuchi, Y, Oikawa, S, Ieiri, T, Matsubara, M, and Ishimitsu, T
Published: 2010
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45. Support for association of the PPP3CC gene with schizophrenia

Author: Horiuchi, Y, Ishiguro, H, Koga, M, Inada, T, Iwata, N, Ozaki, N, Ujike, H, Muratake, T, Someya, T, and Arinami, T
Published: 2007
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46. Utility of Urine Neutrophil Gelatinase-Associated Lipocalin for Worsening Renal Function during Hospitalization for Acute Heart Failure: Primary Findings of the Urine N-gal Acute Kidney Injury N-gal Evaluation of Symptomatic Heart Failure Study (AKINESIS)

Author: Murray, P.T. Wettersten, N. van Veldhuisen, D.J. Mueller, C. Filippatos, G. Nowak, R. Hogan, C. Kontos, M.C. Cannon, C.M. Müeller, G.A. Birkhahn, R. Horiuchi, Y. Clopton, P. Taub, P. Vilke, G.M. Barnett, O. McDonald, K. Mahon, N. NuÑez, J. Briguori, C. Passino, C. Maisel, A.
Abstract: Background: Worsening renal function (WRF) during acute heart failure (AHF) occurs frequently and has been associated with adverse outcomes, though this association has been questioned. WRF is now evaluated by function and injury. We evaluated whether urine neutrophil gelatinase-associated lipocalin (uNGAL) is superior to creatinine for prediction and prognosis of WRF in patients with AHF. Methods and Results: We performed a multicenter, international, prospective cohort of patients with AHF requiring IV diuretics. The primary outcome was whether uNGAL predicted development of WRF, defined as a sustained increase in creatinine of 0.5 mg/dL or ≥50% above first value or initiation of renal replacement therapy, within the first 5 days. The main secondary outcome was a composite of in-hospital adverse events. We enrolled 927 patients (mean 68.5 years of age, 62% men). The primary outcome occurred in 72 patients (7.8%). The first, peak and the ratio of uNGAL to urine creatinine (area under curves (AUC) ≤ 0.613) did not have diagnostic utility over the first creatinine (AUC 0.662). There were 235 adverse events in 144 patients. uNGAL did not predict (AUCs ≤ 0.647) adverse clinical events better than creatinine (AUC 0.695). Conclusions: uNGAL was not superior to creatinine for predicting WRF or adverse in-hospital outcomes and cannot be recommended for WRF in AHF. © 2019 Elsevier Inc.
Published: 2019

47. B-type natriuretic peptide trend predicts clinical significance of worsening renal function in acute heart failure

Author: Wettersten, N. Horiuchi, Y. van Veldhuisen, D.J. Mueller, C. Filippatos, G. Nowak, R. Hogan, C. Kontos, M.C. Cannon, C.M. Müeller, G.A. Birkhahn, R. Taub, P. Vilke, G.M. Barnett, O. McDonald, K. Mahon, N. Nuñez, J. Briguori, C. Passino, C. Murray, P.T. Maisel, A.
Subjects: hormones, hormone substitutes, and hormone antagonists
Abstract: Aims: In acute heart failure (AHF), relationships between changes in B-type natriuretic peptide (BNP) and worsening renal function (WRF) and its prognostic implications have not been fully determined. We investigated the relationship between WRF and a decrease in BNP with in-hospital and 1-year mortality in AHF. Methods and results: The Acute Kidney Injury NGAL Evaluation of Symptomatic heart faIlure Study (AKINESIS) was a prospective, international, multicentre study of AHF patients. Severe WRF (sWRF) was a sustained increase of ≥44.2 μmol/L (0.5 mg/dL) or ≥50% in creatinine, non-severe WRF (nsWRF) was a non-sustained increase of ≥26.5 μmol/L (0.3 mg/dL) or ≥50% in creatinine, and WRF with clinical deterioration was nsWRF with renal replacement therapy, inotrope use, or mechanical ventilation. Decreased BNP was defined as a ≥30% reduction in the last measured BNP compared to admission BNP. Among 814 patients, the incidence of WRF was not different between patients with or without decreased BNP (nsWRF: 33% vs. 31%, P = 0.549; sWRF: 11% vs. 9%, P = 0.551; WRF with clinical deterioration: 8% vs. 10%, P = 0.425). Decreased BNP was associated with better in-hospital and 1-year mortality regardless of WRF, while WRF was associated with worse outcomes only in patients without decreased BNP. In multivariate Cox regression analysis, decreased BNP, sWRF, and WRF with clinical deterioration were significantly associated with 1-year mortality. Conclusions: Decreased BNP was associated with better in-hospital and long-term outcomes. WRF was only associated with adverse outcomes in patients without decreased BNP. © 2019 The Authors. European Journal of Heart Failure © 2019 European Society of Cardiology
Published: 2019

48. Overexpression of the suppressor of cytokine signalling 3 (SOCS3) in severe atopic dermatitis

Author: Horiuchi, Y., Bae, S-J., and Katayama, I.
Published: 2006

49. Large haematoxylin-stainable keratohyaline granules in solar keratoses: immunohistochemical comparison using anti-Ted-H-1 antibody and antiloricrin antibody

Author: Takahashi, M., Horiuchi, Y., and Tezuka, T.
Published: 2005

50. Microstructure of montmorillonite/silica sand mixture and its effects on the diffusion of strontium ions

Author: Liu, J., Kozaki, T., Horiuchi, Y., and Sato, S.
Published: 2003
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