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2,615 results on '"Horton, A. R."'

5. TREM2+ and interstitial-like macrophages orchestrate airway inflammation in SARS-CoV-2 infection in rhesus macaques

Author

Upadhyay, Amit A., Viox, Elise G., Hoang, Timothy N., Boddapati, Arun K., Pino, Maria, Lee, Michelle Y.-H., Corry, Jacqueline, Strongin, Zachary, Cowan, David A., Beagle, Elizabeth N., Horton, Tristan R., Hamilton, Sydney, Aoued, Hadj, Harper, Justin L., Edwards, Christopher T., Nguyen, Kevin, Pellegrini, Kathryn L., Tharp, Gregory K., Piantadosi, Anne, Levit, Rebecca D., Amara, Rama R., Barratt-Boyes, Simon M., Ribeiro, Susan P., Sekaly, Rafick P., Vanderford, Thomas H., Schinazi, Raymond F., Paiardini, Mirko, and Bosinger, Steven E.

Published
2023
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8. Suppression of tumor-associated neutrophils by lorlatinib attenuates pancreatic cancer growth and improves treatment with immune checkpoint blockade

Author

Nielsen, Sebastian R, Strøbech, Jan E, Horton, Edward R, Jackstadt, Rene, Laitala, Anu, Bravo, Marina C, Maltese, Giorgia, Jensen, Adina RD, Reuten, Raphael, Rafaeva, Maria, Karim, Saadia A, Hwang, Chang-Il, Arnes, Luis, Tuveson, David A, Sansom, Owen J, Morton, Jennifer P, and Erler, Janine T

Subjects
Cancer, Rare Diseases, Digestive Diseases, Pancreatic Cancer, 5.1 Pharmaceuticals, Aetiology, 2.1 Biological and endogenous factors, Development of treatments and therapeutic interventions, Aminopyridines, Animals, Antineoplastic Combined Chemotherapy Protocols, CD8-Positive T-Lymphocytes, Carcinoma, Pancreatic Ductal, Cell Line, Tumor, Disease Models, Animal, Drug Synergism, Female, Humans, Immune Checkpoint Inhibitors, Lactams, Lactams, Macrocyclic, Lymphocyte Activation, Lymphocytes, Tumor-Infiltrating, Male, Mice, Mice, Transgenic, Neutrophils, Pancreatic Neoplasms, Programmed Cell Death 1 Receptor, Pyrazoles, Tumor Microenvironment
Abstract

Pancreatic ductal adenocarcinoma (PDAC) patients have a 5-year survival rate of only 8% largely due to late diagnosis and insufficient therapeutic options. Neutrophils are among the most abundant immune cell type within the PDAC tumor microenvironment (TME), and are associated with a poor clinical prognosis. However, despite recent advances in understanding neutrophil biology in cancer, therapies targeting tumor-associated neutrophils are lacking. Here, we demonstrate, using pre-clinical mouse models of PDAC, that lorlatinib attenuates PDAC progression by suppressing neutrophil development and mobilization, and by modulating tumor-promoting neutrophil functions within the TME. When combined, lorlatinib also improves the response to anti-PD-1 blockade resulting in more activated CD8 + T cells in PDAC tumors. In summary, this study identifies an effect of lorlatinib in modulating tumor-associated neutrophils, and demonstrates the potential of lorlatinib to treat PDAC.

Published
2021

10. Academic–Clinical Collaborations to Build Undergraduate Nursing Education in Hospice and Palliative Care

Author

Osakwe, Zainab Toteh, Horton, Jay R., Ottah, Jane, Eisner, Jill, Atairu, Minne, and Stefancic, Ana

Subjects
Palliative treatment -- Study and teaching, Medical personnel -- Training, Nursing education -- Curricula, Hospice care -- Study and teaching, Learning communities, Health, Seniors
Abstract

With the current shortage of hospice/palliative care (HPC) workforce, there is an urgent need to train a generation of nurses with clinical competency in HPC to ensure equitable access and optimal care for patients living with serious illness or at the end of life. The recent demand for HPC teaching in nursing education calls for innovation in establishing clinical placements. Palliative care nursing experts in New York State were surveyed between June and August 2022 about facilitators of academic–clinical partnerships between nursing schools and clinical settings. Inductive content analysis of open-ended responses revealed six major interconnected themes: (a) Increase Awareness of HPC in the Nursing Program, (b) Build a Relationship With Administrators, (c) Look Beyond Acute Care Partnerships, (d) Offer Incentives, (e) Develop Direct Care Experiential Opportunities, and (f) Develop Non-Direct Care Experiential Opportunities. Findings provide rich insights into key considerations for successful collaboration between nursing schools and clinical sites. [Journal of Gerontological Nursing, 49(6), 13–18.], The need for palliative care is growing in the United States (Dumanovsky et al., 2016) due, in part, to the growing number of individuals living with serious illness and increasing [...]

Published
2023
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11. Bibliography

Author

Halloran, Vivian Nun, Horton, Owen R., Kendall-Morwick, Karalyn, Jeong Lee, Mi, Tung, Charles M., Newman, Marleen, Battaglia, Andrew, Nestor, Mary, Dallis-Comentale, Edward P., Jaffe, Aaron, Willman, Skip, Wong, Wayne, Steimer, Lauren, Steenberg, Lindsay, Coulthard, Lisa, Watt, Stephen, and Watt, Caitlin G.

Published
2022

12. Index

Author

Halloran, Vivian Nun, Horton, Owen R., Kendall-Morwick, Karalyn, Jeong Lee, Mi, Tung, Charles M., Newman, Marleen, Battaglia, Andrew, Nestor, Mary, Dallis-Comentale, Edward P., Jaffe, Aaron, Willman, Skip, Wong, Wayne, Steimer, Lauren, Steenberg, Lindsay, Coulthard, Lisa, Watt, Stephen, and Watt, Caitlin G.

Published
2022

13. 14. Professionalism and Gender Performance in the John Wickverse

Author

Halloran, Vivian Nun, Horton, Owen R., Kendall-Morwick, Karalyn, Jeong Lee, Mi, Tung, Charles M., Newman, Marleen, Battaglia, Andrew, Nestor, Mary, Dallis-Comentale, Edward P., Jaffe, Aaron, Willman, Skip, Wong, Wayne, Steimer, Lauren, Steenberg, Lindsay, Coulthard, Lisa, Watt, Stephen, and Watt, Caitlin G.

Published
2022

14. 13. Masculinity, Isolation, and Revenge: John Wick's Liminal Body

Author

Halloran, Vivian Nun, Horton, Owen R., Kendall-Morwick, Karalyn, Jeong Lee, Mi, Tung, Charles M., Newman, Marleen, Battaglia, Andrew, Nestor, Mary, Dallis-Comentale, Edward P., Jaffe, Aaron, Willman, Skip, Wong, Wayne, Steimer, Lauren, Steenberg, Lindsay, Coulthard, Lisa, Watt, Stephen, and Watt, Caitlin G.

Published
2022

15. Part V. Gender and the Body in John Wick

Author

Halloran, Vivian Nun, Horton, Owen R., Kendall-Morwick, Karalyn, Jeong Lee, Mi, Tung, Charles M., Newman, Marleen, Battaglia, Andrew, Nestor, Mary, Dallis-Comentale, Edward P., Jaffe, Aaron, Willman, Skip, Wong, Wayne, Steimer, Lauren, Steenberg, Lindsay, Coulthard, Lisa, Watt, Stephen, and Watt, Caitlin G.

Published
2022

16. 15. Style and the Sacrificial Body in John Wick 3

Author

Halloran, Vivian Nun, Horton, Owen R., Kendall-Morwick, Karalyn, Jeong Lee, Mi, Tung, Charles M., Newman, Marleen, Battaglia, Andrew, Nestor, Mary, Dallis-Comentale, Edward P., Jaffe, Aaron, Willman, Skip, Wong, Wayne, Steimer, Lauren, Steenberg, Lindsay, Coulthard, Lisa, Watt, Stephen, and Watt, Caitlin G.

Published
2022

17. 12. John Wick's Multiply Signifying Dogs

Author

Halloran, Vivian Nun, Horton, Owen R., Kendall-Morwick, Karalyn, Jeong Lee, Mi, Tung, Charles M., Newman, Marleen, Battaglia, Andrew, Nestor, Mary, Dallis-Comentale, Edward P., Jaffe, Aaron, Willman, Skip, Wong, Wayne, Steimer, Lauren, Steenberg, Lindsay, Coulthard, Lisa, Watt, Stephen, and Watt, Caitlin G.

Published
2022

18. 10. Out of Time and Going Sideways: John Wick, Time Traveler

Author

Halloran, Vivian Nun, Horton, Owen R., Kendall-Morwick, Karalyn, Jeong Lee, Mi, Tung, Charles M., Newman, Marleen, Battaglia, Andrew, Nestor, Mary, Dallis-Comentale, Edward P., Jaffe, Aaron, Willman, Skip, Wong, Wayne, Steimer, Lauren, Steenberg, Lindsay, Coulthard, Lisa, Watt, Stephen, and Watt, Caitlin G.

Published
2022

19. 11. John Wick's Blank Cosmopolitanism and the Global Spatiality of the Wickverse

Author

Halloran, Vivian Nun, Horton, Owen R., Kendall-Morwick, Karalyn, Jeong Lee, Mi, Tung, Charles M., Newman, Marleen, Battaglia, Andrew, Nestor, Mary, Dallis-Comentale, Edward P., Jaffe, Aaron, Willman, Skip, Wong, Wayne, Steimer, Lauren, Steenberg, Lindsay, Coulthard, Lisa, Watt, Stephen, and Watt, Caitlin G.

Published
2022

21. Part IV. John Wick's Matrix: Space and Time

Author

Halloran, Vivian Nun, Horton, Owen R., Kendall-Morwick, Karalyn, Jeong Lee, Mi, Tung, Charles M., Newman, Marleen, Battaglia, Andrew, Nestor, Mary, Dallis-Comentale, Edward P., Jaffe, Aaron, Willman, Skip, Wong, Wayne, Steimer, Lauren, Steenberg, Lindsay, Coulthard, Lisa, Watt, Stephen, and Watt, Caitlin G.

Published
2022

23. 8. Captain Dead Wick: Grief and the Monstrous in the John Wick and Deadpool Films

Author

Halloran, Vivian Nun, Horton, Owen R., Kendall-Morwick, Karalyn, Jeong Lee, Mi, Tung, Charles M., Newman, Marleen, Battaglia, Andrew, Nestor, Mary, Dallis-Comentale, Edward P., Jaffe, Aaron, Willman, Skip, Wong, Wayne, Steimer, Lauren, Steenberg, Lindsay, Coulthard, Lisa, Watt, Stephen, and Watt, Caitlin G.

Published
2022

24. 4. The Continental Abyss: John Wick versus the Frankfurt School

Author

Halloran, Vivian Nun, Horton, Owen R., Kendall-Morwick, Karalyn, Jeong Lee, Mi, Tung, Charles M., Newman, Marleen, Battaglia, Andrew, Nestor, Mary, Dallis-Comentale, Edward P., Jaffe, Aaron, Willman, Skip, Wong, Wayne, Steimer, Lauren, Steenberg, Lindsay, Coulthard, Lisa, Watt, Stephen, and Watt, Caitlin G.

Published
2022

25. Part III. John Wick: Other Cultural Forms and Genres

Author

Halloran, Vivian Nun, Horton, Owen R., Kendall-Morwick, Karalyn, Jeong Lee, Mi, Tung, Charles M., Newman, Marleen, Battaglia, Andrew, Nestor, Mary, Dallis-Comentale, Edward P., Jaffe, Aaron, Willman, Skip, Wong, Wayne, Steimer, Lauren, Steenberg, Lindsay, Coulthard, Lisa, Watt, Stephen, and Watt, Caitlin G.

Published
2022

27. 6. Fortune Favors the Bold: The State of Games and Play in the John Wick Films

Author

Halloran, Vivian Nun, Horton, Owen R., Kendall-Morwick, Karalyn, Jeong Lee, Mi, Tung, Charles M., Newman, Marleen, Battaglia, Andrew, Nestor, Mary, Dallis-Comentale, Edward P., Jaffe, Aaron, Willman, Skip, Wong, Wayne, Steimer, Lauren, Steenberg, Lindsay, Coulthard, Lisa, Watt, Stephen, and Watt, Caitlin G.

Published
2022

28. Part II. The Economies and Phenomenology of the Wickverse

Author

Halloran, Vivian Nun, Horton, Owen R., Kendall-Morwick, Karalyn, Jeong Lee, Mi, Tung, Charles M., Newman, Marleen, Battaglia, Andrew, Nestor, Mary, Dallis-Comentale, Edward P., Jaffe, Aaron, Willman, Skip, Wong, Wayne, Steimer, Lauren, Steenberg, Lindsay, Coulthard, Lisa, Watt, Stephen, and Watt, Caitlin G.

Published
2022

29. 5. Bitcoin, Shitcoin, Wickcoin: The Hidden Phenomenology of John Wick

Author

Halloran, Vivian Nun, Horton, Owen R., Kendall-Morwick, Karalyn, Jeong Lee, Mi, Tung, Charles M., Newman, Marleen, Battaglia, Andrew, Nestor, Mary, Dallis-Comentale, Edward P., Jaffe, Aaron, Willman, Skip, Wong, Wayne, Steimer, Lauren, Steenberg, Lindsay, Coulthard, Lisa, Watt, Stephen, and Watt, Caitlin G.

Published
2022

30. 3. Killing in Equanimity: Theorizing John Wick's Action Aesthetics

Author

Halloran, Vivian Nun, Horton, Owen R., Kendall-Morwick, Karalyn, Jeong Lee, Mi, Tung, Charles M., Newman, Marleen, Battaglia, Andrew, Nestor, Mary, Dallis-Comentale, Edward P., Jaffe, Aaron, Willman, Skip, Wong, Wayne, Steimer, Lauren, Steenberg, Lindsay, Coulthard, Lisa, Watt, Stephen, and Watt, Caitlin G.

Published
2022

31. 1. Red Circle of Revenge: Anatomy of the Fight Sequence in John Wick

Author

Halloran, Vivian Nun, Horton, Owen R., Kendall-Morwick, Karalyn, Jeong Lee, Mi, Tung, Charles M., Newman, Marleen, Battaglia, Andrew, Nestor, Mary, Dallis-Comentale, Edward P., Jaffe, Aaron, Willman, Skip, Wong, Wayne, Steimer, Lauren, Steenberg, Lindsay, Coulthard, Lisa, Watt, Stephen, and Watt, Caitlin G.

Published
2022

32. Part I. John Wick and Action Cinema

Author

Halloran, Vivian Nun, Horton, Owen R., Kendall-Morwick, Karalyn, Jeong Lee, Mi, Tung, Charles M., Newman, Marleen, Battaglia, Andrew, Nestor, Mary, Dallis-Comentale, Edward P., Jaffe, Aaron, Willman, Skip, Wong, Wayne, Steimer, Lauren, Steenberg, Lindsay, Coulthard, Lisa, Watt, Stephen, and Watt, Caitlin G.

Published
2022

33. Introduction: The Worlds of John Wick

Author

Halloran, Vivian Nun, Horton, Owen R., Kendall-Morwick, Karalyn, Jeong Lee, Mi, Tung, Charles M., Newman, Marleen, Battaglia, Andrew, Nestor, Mary, Dallis-Comentale, Edward P., Jaffe, Aaron, Willman, Skip, Wong, Wayne, Steimer, Lauren, Steenberg, Lindsay, Coulthard, Lisa, Watt, Stephen, and Watt, Caitlin G.

Published
2022

34. Cover

Author

Halloran, Vivian Nun, Horton, Owen R., Kendall-Morwick, Karalyn, Jeong Lee, Mi, Tung, Charles M., Newman, Marleen, Battaglia, Andrew, Nestor, Mary, Dallis-Comentale, Edward P., Jaffe, Aaron, Willman, Skip, Wong, Wayne, Steimer, Lauren, Steenberg, Lindsay, Coulthard, Lisa, Watt, Stephen, and Watt, Caitlin G.

Published
2022

35. Acknowledgments

Author

Halloran, Vivian Nun, Horton, Owen R., Kendall-Morwick, Karalyn, Jeong Lee, Mi, Tung, Charles M., Newman, Marleen, Battaglia, Andrew, Nestor, Mary, Dallis-Comentale, Edward P., Jaffe, Aaron, Willman, Skip, Wong, Wayne, Steimer, Lauren, Steenberg, Lindsay, Coulthard, Lisa, Watt, Stephen, and Watt, Caitlin G.

Published
2022

36. Half-title, Series information, Title Page, Copyright

Author

Halloran, Vivian Nun, Horton, Owen R., Kendall-Morwick, Karalyn, Jeong Lee, Mi, Tung, Charles M., Newman, Marleen, Battaglia, Andrew, Nestor, Mary, Dallis-Comentale, Edward P., Jaffe, Aaron, Willman, Skip, Wong, Wayne, Steimer, Lauren, Steenberg, Lindsay, Coulthard, Lisa, Watt, Stephen, and Watt, Caitlin G.

Published
2022

41. Host plants and Wolbachia shape the population genetics of sympatric herbivore populations

Author

Fu, Zhen, Meier, Amanda R, Epstein, Brendan, Bergland, Alan O, Carrillo, Carmen I Castillo, Cooper, William R, Cruzado, Regina K, Horton, David R, Jensen, Andrew S, Kelley, Joanna L, Rashed, Arash, Reitz, Stuart R, Rondon, Silvia I, Thinakaran, Jenita, Wenninger, Erik J, Wohleb, Carrie H, Crowder, David W, and Snyder, William E

Subjects
Biological Sciences, Ecology, Genetics, herbivore interactions, interbreeding, pest management, plant, population genomics, Wolbachia, Medicinal and Biomolecular Chemistry, Evolutionary Biology, Evolutionary biology
Abstract

Changing climate and land-use practices have the potential to bring previously isolated populations of pest insects into new sympatry. This heightens the need to better understand how differing patterns of host-plant association, and unique endosymbionts, serve to promote genetic isolation or integration. We addressed these factors in populations of potato psyllid, Bactericera cockerelli (Šulc), a generalist herbivore that vectors a bacterial pathogen (Candidatus Liberibacter solanacearum, causal pathogen of zebra chip disease) of potato (Solanum tuberosum L.). Genome-wide SNP data revealed two major genetic clusters-psyllids collected from potato crops were genetically similar to psyllids found on a common weed, Lycium spp., but dissimilar from those found on another common non-crop host, Solanum dulcamara L. Most psyllids found on Lycium spp. and potato represented a single mitochondrial cytochrome oxidase I (COI) haplotype that has been suggested to not be native to the region, and whose arrival may have been concurrent with zebra chip disease first emerging. The putatively introduced COI haplotype usually co-occurred with endosymbiotic Wolbachia, while the putatively resident COI haplotype generally did not. Genetic intermediates between the two genetic populations of insects were rare, consistent with recent sympatry or reproductive isolation, although admixture patterns of apparent hybrids were consistent with introgression of genes from introduced into resident populations. Our results suggest that both host-plant associations and endosymbionts are shaping the population genetic structure of sympatric psyllid populations associated with different non-crop hosts. It is of future interest to explicitly examine vectorial capacity of the two populations and their potential hybrids, as population structure and hybridization might alter regional vector capacity and disease outbreaks.

Published
2020

47. SETD3 is an actin histidine methyltransferase that prevents primary dystocia

Author

Wilkinson, Alex W, Diep, Jonathan, Dai, Shaobo, Liu, Shuo, Ooi, Yaw Shin, Song, Dan, Li, Tie-Mei, Horton, John R, Zhang, Xing, Liu, Chao, Trivedi, Darshan V, Ruppel, Katherine M, Vilches-Moure, José G, Casey, Kerriann M, Mak, Justin, Cowan, Tina, Elias, Joshua E, Nagamine, Claude M, Spudich, James A, Cheng, Xiaodong, Carette, Jan E, and Gozani, Or

Subjects
Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Biological Sciences, 2.1 Biological and endogenous factors, Aetiology, Generic health relevance, Actins, Animals, Cell Line, Dystocia, Female, Histidine, Histone Methyltransferases, Histones, Litter Size, Male, Methylation, Methyltransferases, Mice, Models, Molecular, Muscle, Smooth, Pregnancy, Proteomics, Uterine Contraction, Uterus, General Science & Technology
Abstract

For more than 50 years, the methylation of mammalian actin at histidine 73 has been known to occur1. Despite the pervasiveness of His73 methylation, which we find is conserved in several model animals and plants, its function remains unclear and the enzyme that generates this modification is unknown. Here we identify SET domain protein 3 (SETD3) as the physiological actin His73 methyltransferase. Structural studies reveal that an extensive network of interactions clamps the actin peptide onto the surface of SETD3 to orient His73 correctly within the catalytic pocket and to facilitate methyl transfer. His73 methylation reduces the nucleotide-exchange rate on actin monomers and modestly accelerates the assembly of actin filaments. Mice that lack SETD3 show complete loss of actin His73 methylation in several tissues, and quantitative proteomics analysis shows that actin His73 methylation is the only detectable physiological substrate of SETD3. SETD3-deficient female mice have severely decreased litter sizes owing to primary maternal dystocia that is refractory to ecbolic induction agents. Furthermore, depletion of SETD3 impairs signal-induced contraction in primary human uterine smooth muscle cells. Together, our results identify a mammalian histidine methyltransferase and uncover a pivotal role for SETD3 and actin His73 methylation in the regulation of smooth muscle contractility. Our data also support the broader hypothesis that protein histidine methylation acts as a common regulatory mechanism.

Published
2019

50. Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia

Author

Pappalardi, Melissa B., Keenan, Kathryn, Cockerill, Mark, Kellner, Wendy A., Stowell, Alexandra, Sherk, Christian, Wong, Kristen, Pathuri, Sarath, Briand, Jacques, Steidel, Michael, Chapman, Philip, Groy, Arthur, Wiseman, Ashley K., McHugh, Charles F., Campobasso, Nino, Graves, Alan P., Fairweather, Emma, Werner, Thilo, Raoof, Ali, Butlin, Roger J., Rueda, Lourdes, Horton, John R., Fosbenner, David T., Zhang, Cunyu, Handler, Jessica L., Muliaditan, Morris, Mebrahtu, Makda, Jaworski, Jon-Paul, McNulty, Dean E., Burt, Charlotte, Eberl, H. Christian, Taylor, Amy N., Ho, Thau, Merrihew, Susan, Foley, Shawn W., Rutkowska, Anna, Li, Mei, Romeril, Stuart P., Goldberg, Kristin, Zhang, Xing, Kershaw, Christopher S., Bantscheff, Marcus, Jurewicz, Anthony J., Minthorn, Elisabeth, Grandi, Paola, Patel, Mehul, Benowitz, Andrew B., Mohammad, Helai P., Gilmartin, Aidan G., Prinjha, Rab K., Ogilvie, Donald, Carpenter, Christopher, Heerding, Dirk, Baylin, Stephen B., Jones, Peter A., Cheng, Xiaodong, King, Bryan W., Luengo, Juan I., Jordan, Allan M., Waddell, Ian, Kruger, Ryan G., and McCabe, Michael T.

Published
2021
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