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3. TOWARDS OPTIMIZING THE PROTOCOL FOR UNTARGETED PROFILING OF URINE VOLATILES VIA GAS CHROMATOGRAPHY-ION MOBILITY SPECTROMETRY. A PILOT STUDY.

Author

NOVAKOVA, S., CZIPPELOVA, B., BARANOVICOVA, E., SARLINOVA, M., URBANOVA, A., HATOKOVA, Z., DZIAN, A., BANOVCIN, P., STRNADEL, J., NOVAK, P., HORVATH, G., HALASOVA, E., and SKOVIEROVA, H.

Abstract

The analysis of volatile organic compounds (VOCs) present in various biological samples holds immense potential for non-invasive disease diagnostics and metabolic profiling. One of the biological fluids that are suitable for use in clinical practice is urine. Given the limited quantity of VOCs in the urine headspace, it's imperative to enhance their extraction into the gaseous phase and prevent any degradation of VOCs during the thawing process. The study aimed to test several key parameters (incubation time, temperature, and thawing) that can influence urine volatilome and monitor selected VOCs for their stability. The analysis in this study was performed using a BreathSpec® (G.A.S., Dortmund, Germany) device consisting of a gas chromatograph (GC) coupled with an ion mobility spectrometer (IMS). Testing three different temperatures and incubation times yielded a low number of VOCs (9 out of 34) that exhibited statistically significant differences. However, examining three thawing conditions revealed no VOCs with statistically significant changes. Thus, we conclude that urine composition remains relatively stable despite exposure to various thermal stresses. [ABSTRACT FROM AUTHOR]

Published
2024
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4. NLRP3 inflammasome-activating arginine-based liposomes promote antigen presentations in dendritic cells

Author

Li T, Zehner M, He J, Próchnicki T, Horvath G, Latz E, Burgdorf S, and Takeoka S

Subjects
arginine, cationic liposomes, NLRP3 inflammasome activation, antigen presentation, lysosome rupture, Medicine (General), R5-920
Abstract

Tianshu Li,1 Matthias Zehner,2 Jieyan He,3 Tomasz Próchnicki,4 Gabor Horvath,4 Eicke Latz,4 Sven Burgdorf,2 Shinji Takeoka1,31Institute for Advanced Research of Biosystem Dynamics, Waseda Research Institute for Science and Engineering, Waseda University, Tokyo, Japan; 2Molecular Immunology and Cell Biology, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany; 3Department of Life Science and Medical Bioscience, Graduate School of Advanced Science and Engineering, Waseda University, Tokyo, Japan; 4Institute of Innate Immunity, Biomedical Center, University Hospitals, University of Bonn, Bonn, GermanyPurpose: The NLRP3 inflammasome activation has been proposed as a common mechanism for some adjuvants to boost the immune system, and cationic liposomes were reported to potentially activate the NLRP3 inflammasome. Herein, we questioned whether the NLRP3 inflammasome-activating cationic liposomes could promote antigen presentation and be applied as an immune adjuvant. In addition, we aimed to investigate the structure effect of lipid on triggering these immune responses.Materials and methods: A series of structurally similar lipids, consisting of arginine (Arg) head group and varied lengths of alkyl chains or spacers in between were used to prepare cationic liposomes. Lipopolysaccharide-primed human or murine macrophages or phorbol 12-myristate 13-acetate-primed THP-1 cells were treated with these liposomes, and interleukin (IL)-1β secretion was measured to quantify the NLRP3 inflammasome activation. Lysosome rupture was examined in THP-1 cells by the fluorescence loss of acridine orange, a lysosome dye. Further, chicken ovalbumin (OVA) was loaded on the liposome surface and applied to murine bone marrow-derived dendritic cells (BMDCs), which activate OT-I and OT-II lymphocytes upon major histocompatibility complex (MHC) class I- and class II-mediated antigen presentation, respectively. OT-I and OT-II cell division and IL-2 secretion were measured to evaluate the antigen presentation efficiency. The expressions of MHC molecules and co-stimulatory molecules ie, CD80, CD86, and CD40 on BMDCs were investigated by flow cytometry.Results: All the liposomes showed size distributions of 80–200 nm and zeta potentials of around 50 mV. A3C14 liposomes, consisting of Arg-C3-Glu2C14 lipids induced the most potent lysosome rupture and NLRP3 inflammasome activation. OVA-A3C14 also exhibited the most potent MHC class I- and class II-mediated antigen presentation in BMDCs without interfering MHC and co-stimulatory molecules.Conclusion: The hydrophobic moieties of arginine-based liposomes are crucial in stimulating innate immune cells. A3C14 liposomes were non-immunogenic but strongly activated innate immune cells and promoted antigen presentation, and therefore can be applied as immune adjuvants.Keywords: arginine, cationic liposomes, NLRP3 inflammasome activation, antigen presentation, lysosome rupture

Published
2019

5. Electrical, thermal and optical characterization of power LED assemblies

Author

Poppe, A., Farkas, G., and Horvath, G.

Subjects
Condensed Matter - Materials Science
Abstract

Besides their electrical properties the optical parameters of LEDs also depend on junction temperature. For this reason thermal characterization and thermal management play important role in case of power LEDs, necessitating both physical measurements and simulation tools. The focus of this paper is a combined electrical, thermal and optical characterization of power LED assemblies. In terms of simulation a method for board-level electro-thermal simulation is presented, for measurements a combined thermal and radiometric characterization system of power LEDs and LED assemblies is discussed. Comparison of measurement and simulation results is presented in a case study., Comment: Submitted on behalf of TIMA Editions (http://irevues.inist.fr/tima-editions)

Published
2007

6. Severe accident code-to-code comparison for two accident scenarios in a spent fuel pool

Author

Coindreau, O., Jäckel, B., Rocchi, F., Alcaro, F., Angelova, D., Bandini, G., Barnak, M., Behler, M., Da Cruz, D.F., Dagan, R., Drai, P., Ederli, S., Herranz, L.E., Hollands, T., Horvath, G., Kaliatka, A., Kljenak, I., Kotsuba, O., Lind, T., López, C., Mancheva, K., Matejovic, P., Matkovič, M., Steinbrück, M., Stempniewicz, M., Thomas, R., Vileiniskis, V., Visser, D.C., Vokáč, P., Vorobyov, Y., and Zhabin, O.

Published
2018
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9. Scaling and Intermittency in Animal Behavior

Author

Harnos, A., Horvath, G., Lawrence, A. B., and Vattay, G.

Subjects
Nonlinear Sciences - Chaotic Dynamics, Quantitative Biology - Other Quantitative Biology
Abstract

Scale-invariant spatial or temporal patterns and L\'evy flight motion have been observed in a large variety of biological systems. It has been argued that animals in general might perform L\'evy flight motion with power law distribution of times between two changes of the direction of motion. Here we study the temporal behaviour of nesting gilts. The time spent by a gilt in a given form of activity has power law probability distribution without finite average. Further analysis reveals intermittent eruption of certain periodic behavioural sequences which are responsible for the scaling behaviour and indicates the existence of a critical state. We show that this behaviour is in close analogy with temporal sequences of velocity found in turbulent flows, where random and regular sequences alternate and form an intermittent sequence., Comment: 10 pages

Published
1999
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13. Long-Term Follow-up for Patients with Mitochondrial Carbonic Anhydrase 5A Deficiency

Author

Shurrab S, Horvath G, Stockler_Ispiroglu S, Salvarinova Zivkovic R, van Karnebeek C, and Pediatrics

Abstract

Introduction: Mitochondria carbonic anhydrase 5A (CA5A) deficiency (MIM # 615751) is an ultra-rare inherited metabolic disorder caused by biallelic mutations in CA5A gene. The combination of hyperammonemia, lactic acidosis and ketonuria with or without hypoglycemia is highly suggestive of CA5A deficiency. We report the long-term follow up of the first two reported cases of CA5A deficiency. Case presentation: The index patient is a 13-year-old female and her sibling, an 11-year-old male, who presented with neonatal hyperammonemia associated with hypoglycemia, elevated lactate, ketonuria, and respiratory alkalosis with decreased HCO3. The diagnosis was made in the two affected siblings through the TIDEX study that identified homozygous pathogenic variant in CA5A gene (NM_001739.1: c.697T>C, (p.Ser233Pro)). The clinical course of the index patient revealed three additional episodes of decompensation triggered by intercurrent illnesses and presented similar to her neonatal presentation, while her sibling did not experience any further episodes of decompensation. These episodes were successfully treated with parenteral dextrose, enteral carglumic acid and occasionally parenteral lipids. Management of intercurrent illness includes sick day formula high in carbohydrates and fats. Currently, they display normal growth and development suggestive of favourable prognosis and in keeping with the previously reported cases. Discussion: Early diagnosis of CA5A allows prompt treatment, thus prevents severe complications. With the proper management, the long-term outcome is reassuring, and does not seem to affect the psychomotor development or physical growth. Impact on life longevity needs to be assessed for longer durations. In addition, our cases suggest some intrafamilial variability, which requires further assessment.

Published
2023

15. Biallelic PRMT7 pathogenic variants are associated with a recognizable syndromic neurodevelopmental disorder with short stature, obesity, and craniofacial and digital abnormalities.

Author

Cali, E., Suri, M., Scala, M., Ferla, M.P., Alavi, S., Faqeih, E.A., Bijlsma, E.K., Wigby, K.M., Baralle, D., Mehrjardi, M.Y.V., Schwab, J., Platzer, K., Steindl, K., Hashem, M., Jones, M., Niyazov, Dmitriy, Jacober, J., Littlejohn, R.O., Weis, D., Zadeh, N., Rodan, L., Goldenberg, A., Lecoquierre, F., Dutra-Clarke, M., Horvath, G., Young, D., Orenstein, N., Bawazeer, S., Vulto-van Silfhout, A.T., Herenger, Y., Dehghani, M., Seyedhassani, S.M., Bahreini, A., Nasab, M.E., Ercan-Sencicek, A.G., Firoozfar, Z., Movahedinia, M., Efthymiou, S., Striano, P., Karimiani, E.G., Salpietro, V., Taylor, J.C., Redman, M., Stegmann, A.P.A., Laner, A., Abdel-Salam, G., Li, M., Bengala, M., Müller, A.J., Digilio, M.C., Rauch, A., Gunel, M., Titheradge, H., Schweitzer, D.N., Kraus, A., Valenzuela, I., McLean, S.D., Phornphutkul, C., Salih, M., Begtrup, A., Schnur, R.E., Torti, E., Haack, T.B., Prada, C.E., Alkuraya, F.S., Houlden, H., Maroofian, R., Cali, E., Suri, M., Scala, M., Ferla, M.P., Alavi, S., Faqeih, E.A., Bijlsma, E.K., Wigby, K.M., Baralle, D., Mehrjardi, M.Y.V., Schwab, J., Platzer, K., Steindl, K., Hashem, M., Jones, M., Niyazov, Dmitriy, Jacober, J., Littlejohn, R.O., Weis, D., Zadeh, N., Rodan, L., Goldenberg, A., Lecoquierre, F., Dutra-Clarke, M., Horvath, G., Young, D., Orenstein, N., Bawazeer, S., Vulto-van Silfhout, A.T., Herenger, Y., Dehghani, M., Seyedhassani, S.M., Bahreini, A., Nasab, M.E., Ercan-Sencicek, A.G., Firoozfar, Z., Movahedinia, M., Efthymiou, S., Striano, P., Karimiani, E.G., Salpietro, V., Taylor, J.C., Redman, M., Stegmann, A.P.A., Laner, A., Abdel-Salam, G., Li, M., Bengala, M., Müller, A.J., Digilio, M.C., Rauch, A., Gunel, M., Titheradge, H., Schweitzer, D.N., Kraus, A., Valenzuela, I., McLean, S.D., Phornphutkul, C., Salih, M., Begtrup, A., Schnur, R.E., Torti, E., Haack, T.B., Prada, C.E., Alkuraya, F.S., Houlden, H., and Maroofian, R.

Abstract

01 januari 2023, Item does not contain fulltext, PURPOSE: Protein arginine methyltransferase 7 (PRMT7) is a member of a family of enzymes that catalyzes the methylation of arginine residues on several protein substrates. Biallelic pathogenic PRMT7 variants have previously been associated with a syndromic neurodevelopmental disorder characterized by short stature, brachydactyly, intellectual developmental disability, and seizures. To our knowledge, no comprehensive study describes the detailed clinical characteristics of this syndrome. Thus, we aim to delineate the phenotypic spectrum of PRMT7-related disorder. METHODS: We assembled a cohort of 51 affected individuals from 39 different families, gathering clinical information from 36 newly described affected individuals and reviewing data of 15 individuals from the literature. RESULTS: The main clinical characteristics of the PRMT7-related syndrome are short stature, mild to severe developmental delay/intellectual disability, hypotonia, brachydactyly, and distinct facial morphology, including bifrontal narrowing, prominent supraorbital ridges, sparse eyebrows, short nose with full/broad nasal tip, thin upper lip, full and everted lower lip, and a prominent or squared-off jaw. Additional variable findings include seizures, obesity, nonspecific magnetic resonance imaging abnormalities, eye abnormalities (i.e., strabismus or nystagmus), and hearing loss. CONCLUSION: This study further delineates and expands the molecular, phenotypic spectrum and natural history of PRMT7-related syndrome characterized by a neurodevelopmental disorder with skeletal, growth, and endocrine abnormalities.

Published
2023

16. SARNET benchmark on Phébus FPT3 integral experiment on core degradation and fission product behaviour

Author

Di Giuli, M., Haste, T., Biehler, R., Bosland, L., Herranz, L.E., Fontanet, J., Beuzet, E., Torkhani, M., Davidovich, N., Klein-Heßling, W., Weber, S., Dickinson, S., Horváth, G., Kruse, P., Koch, M., Paci, S., Weber, S.J., Salay, M., Bujan, A., Ivanov, I., Kalychev, P., Kim, S.B., Morandi, S., Del Corno, A., Kotouč, M., Dienstbier, J., and Kim, H.-C.

Published
2016
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17. Cystinosis with Sclerotic Bone Lesions

Author

Sirrs, S., Munk, P., Mallinson, P. I., Ouellette, H., Horvath, G., Cooper, S., Da Roza, G., Rosenbaum, D., O’Riley, M., Nussbaumer, G., Hoang, L. N., Lee, C. H., Zschocke, Johannes, Editor-in-chief, Gibson, K Michael, Editor-in-chief, Gibson, K. Michael, editor, Brown, Garry, editor, Morava, Eva, editor, and Peters, Verena, editor

Published
2014
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21. Effects of pulmonary rehabilitation in post-COVID syndrome.

Author

Szarvas, Z, primary, Fekete, M, additional, Fazekas-Pongor, V, additional, Pete, K, additional, Cserjesi, R, additional, Bakos, R, additional, Gobel, O, additional, Pinter, R, additional, Kovats, Z, additional, Horvath, G, additional, Muller, V, additional, and Varga, J T, additional

Published
2022
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35. Monoamine neurotransmitters in early epileptic encephalopathies: New insights into pathophysiology and therapy

Author

Julia-Palacios, N, Molina-Anguita, C, Bondarenko, MS, Cortes-Saladelafont, E, Aparicio, J, Cuadras, D, Horvath, G, Fons, C, Artuch, R, and Garcia-Cazorla, A

Abstract

Aim To study neurotransmitter status in children with early epileptic and developmental and epileptic encephalopathy (DEE) and to explore the clinical response to dopaminergic and serotoninergic therapies in a group of patients. Method Two hundred and five patients (111 males [54.1.%] and 94 females [45.9%], mean age 10 months at the onset of epilepsy [SD 1 year 1 month], range 0-3 year) with epileptic encephalopathy/DEE were recruited, including those with West syndrome, Ohtahara syndrome, early myoclonic encephalopathy, epilepsy of infancy with migrating focal seizures, myoclonic encephalopathy in non-progressive disorders, infantile spasms, Doose syndrome, Lennox-Gastaut syndrome, Landau-Kleffner syndrome, and those unclassified. Cerebrospinal fluid (CSF) neurotransmitter studies and patients' medical records were reviewed. Additionally, we present clinical data of 10 patients with low CSF neurotransmitter levels who received dopaminergic/serotoninergic treatments. Results Abnormal neurotransmitter values were identified in 68 (33%) patients. 5-Hydroxyindoleacetic acid (5-HIAA) deficit was the most prevalent alteration (91%). Low CSF 5-HIAA levels were significantly higher in 1- to 3-year-old children. A negative significant correlation was found between 5-HIAA levels and epilepsy duration before CSF study (Spearman's rho=-0.191, p=0.007). Abnormalities in deep grey matter were associated with low levels of CSF homovanillic acid and 5-HIAA. Ten patients with low CSF neurotransmitter levels received dopamine and/or serotonin therapies. Six of them showed initial decrease of seizure frequency and severity and maintained improvement in some neurodevelopmental skills. Interpretation A considerable number of patients showed neurotransmitter abnormalities. Age at seizure onset and duration of epilepsy before CSF study were the principal factors related to neurotransmitter depletion. Early monoamine supplementation would seem advisable as a neuroprotective strategy. What this paper adds 5-Hydroxyindoleacetic acid homeostasis is especially vulnerable in patients with epileptic encephalopathy/developmental and epileptic encephalopathy. Age of seizure onset and duration of epilepsy are determinants of neurotransmitter depletion.

Published
2022

39. Brain MR patterns in inherited disorders of monoamine neurotransmitters: An analysis of 70 patients

Author

Hübschmann OK, Mohr A, Friedman J, Manti F, Horvath G, Cortés-Saladelafont E, Mercimek-Andrews S, Yildiz Y, Pons R, Kulhánek J, Oppebøen M, Koht JA, Podzamczer-Valls I, Domingo-Jimenez R, Ibáñez S, Alcoverro-Fortuny O, Gómez-Alemany T, de Castro P, Alfonsi C, Zafeiriou DI, López-Laso E, Guder P, Santer R, Honzík T, Hoffmann GF, Garbade SF, Sivri HS, Leuzzi V, Jeltsch K, Garcia-Cazorla A, Opladen T, Harting I, International Working Group on Neurotransmitter Related Disorders, [Kuseyri Hübschmann O] Department of Child Neurology and Metabolic Disorders, University Children's Hospital, Heidelberg, Germany. [Mohr A] Department of Neuroradiology, University Hospital Heidelberg, Heidelberg, Germany. [Friedman J] UCSD Departments of Neuroscience and Pediatrics, Rady Children's Hospital Division of Neurology, Rady Children's Institute for Genomic Medicine, San Diego, California. [Manti F] Unit of Child Neurology and Psychiatry, Department of Human Neuroscience, Sapienza, University of Rome, Rome, Italy. [Horvath G] University of British Columbia, Department of Pediatrics, Division of Biochemical Genetics, BC Children's Hospital, Vancouver, British Columbia, Canada. [Cortès-Saladelafont E] Inborn Errors of Metabolism Unit, Department of Neurology, Institut de Recerca Sant Joan de Déu and CIBERER-ISCIII, Barcelona, Spain. Unit of Pediatric Neurology and Metabolic Disorders, Department of Pediatrics, Hospital Germans Trias i Pujol and Faculty of Medicine,Universitat Autònoma de Barcelona, Barcelona, Spain. [Alcoverro-Fortuny O, Gómez-Alemany T] Hospital General de Granollers, Granollers, Spain, and Hospital General de Granollers

Subjects
Male, Pathology, Movement disorders, Neurotransmissors, diagnóstico::técnicas y procedimientos diagnósticos::diagnóstico::técnicas y procedimientos diagnósticos::técnicas diagnósticas neurológicas::neuroimágenes [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], monoamines, Child, Genetics (clinical), 0303 health sciences, Brain Mapping, 030305 genetics & heredity, Inherited neurotransmitter disorders, monoamines, MRI, tetrahydrobiopterin deficiency, inherited neurotransmitter disorders, Brain, watershed injury, Middle Aged, Magnetic Resonance Imaging, medicine.anatomical_structure, Child, Preschool, Female, medicine.symptom, Adult, medicine.medical_specialty, Adolescent, Encephalopathy, Diagnosis::Diagnostic Techniques and Procedures::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Techniques, Neurological::Neuroimaging [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], Grey matter, 03 medical and health sciences, Young Adult, Atrophy, enfermedades y anomalías neonatales congénitas y hereditarias::enfermedades genéticas congénitas::alteraciones congénitas del metabolismo::alteraciones congénitas del metabolismo de los aminoácidos::enfermedades y anomalías neonatales congénitas y hereditarias::enfermedades genéticas congénitas::alteraciones congénitas del metabolismo::fenilcetonurias [ENFERMEDADES], Neuroimaging, Genetics, medicine, Humans, Tetrahydrobiopterin deficiency, Amino Acid Metabolism, Inborn Errors, Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Brain Diseases, Metabolic [DISEASES], 030304 developmental biology, Retrospective Studies, enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::enfermedades cerebrales metabólicas [ENFERMEDADES], Inherited neurotransmitter disorders, Sistema nerviós - Malalties, Tyrosine hydroxylase, business.industry, Ressonància magnètica, Infant, medicine.disease, Monoamine neurotransmitter, Congenital, Hereditary, and Neonatal Diseases and Abnormalities::Genetic Diseases, Inborn::Metabolism, Inborn Errors::Amino Acid Metabolism, Inborn Errors::Congenital, Hereditary, and Neonatal Diseases and Abnormalities::Genetic Diseases, Inborn::Metabolism, Inborn Errors::Phenylketonurias [DISEASES], business
Abstract

RM; Trastornos hereditarios de neurotransmisores; Monoaminas; Deficiencia de tetrahidrobiopterina RM; Trastorns dels neurotransmissors heretats; Monoamines; Deficiència de tetrahidrobiopterina MRI; Inherited neurotransmitter disorders; Monoamines; Tetrahydrobiopterin deficiency; Inherited monoamine neurotransmitter disorders (iMNDs) are rare disorders with clinical manifestations ranging from mild infantile hypotonia, movement disorders to early infantile severe encephalopathy. Neuroimaging has been reported as non-specific. We systematically analyzed brain MRIs in order to characterize and better understand neuroimaging changes and to re-evaluate the diagnostic role of brain MRI in iMNDs. 81 MRIs of 70 patients (0.1-52.9 years, 39 patients with tetrahydrobiopterin deficiencies, 31 with primary disorders of monoamine metabolism) were retrospectively analyzed and clinical records reviewed. 33/70 patients had MRI changes, most commonly atrophy (n = 24). Eight patients, six with dihydropteridine reductase deficiency (DHPR), had a common pattern of bilateral parieto-occipital and to a lesser extent frontal and/or cerebellar changes in arterial watershed zones. Two patients imaged after acute severe encephalopathy had signs of profound hypoxic-ischemic injury and a combination of deep gray matter and watershed injury (aromatic l-amino acid decarboxylase (AADCD), tyrosine hydroxylase deficiency (THD)). Four patients had myelination delay (AADCD; THD); two had changes characteristic of post-infantile onset neuronal disease (AADCD, monoamine oxidase A deficiency), and nine T2-hyperintensity of central tegmental tracts. iMNDs are associated with MRI patterns consistent with chronic effects of a neuronal disorder and signs of repetitive injury to cerebral and cerebellar watershed areas, in particular in DHPRD. These will be helpful in the (neuroradiological) differential diagnosis of children with unknown disorders and monitoring of iMNDs. We hypothesize that deficiency of catecholamines and/or tetrahydrobiopterin increase the incidence of and the CNS susceptibility to vascular dysfunction.

Published
2021

42. Utility of whole-exome sequencing for those near the end of the diagnostic odyssey: time to address gaps in care

Author

Sawyer, S. L., Hartley, T., Dyment, D. A., Beaulieu, C. L., Schwartzentruber, J., Smith, A., Bedford, H. M., Bernard, G., Bernier, F. P., Brais, B., Bulman, D. E., Chardon, Warman J., Chitayat, D., Deladoëy, J., Fernandez, B. A., Frosk, P., Geraghty, M. T., Gerull, B., Gibson, W., Gow, R. M., Graham, G. E., Green, J. S., Heon, E., Horvath, G., Innes, A. M., Jabado, N., Kim, R. H., Koenekoop, R. K., Khan, A., Lehmann, O. J., Mendoza-Londono, R., Michaud, J. L., Nikkel, S. M., Penney, L. S., Polychronakos, C., Richer, J., Rouleau, G. A., Samuels, M. E., Siu, V. M., Suchowersky, O., Tarnopolsky, M. A., Yoon, G., Zahir, F. R., Majewski, J., and Boycott, K. M.

Published
2016
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43. The present and future disease burden of hepatitis C virus infections with todayʼs treatment paradigm – volume 3

Author

Sibley, A., Han, K. H., Abourached, A., Lesmana, L. A., Makara, M., Jafri, W., Salupere, R., Assiri, A. M., Goldis, A., Abaalkhail, F., Abbas, Z., Abdou, A., Al Braiki, F., Al Hosani, F., Al Jaberi, K., Al Khatry, M., Al Mulla, M. A., Al Quraishi, H., Al Rifai, A., Al Serkal, Y., Alam, A., Alavian, S. M., Alashgar, H. I., Alawadhi, S., Al-Dabal, L., Aldins, P., Alfaleh, F. Z., Alghamdi, A. S., Al-Hakeem, R., Aljumah, A. A., Almessabi, A., Alqutub, A. N., Alswat, K. A., Altraif, I., Alzaabi, M., Andrea, N., Babatin, M. A., Baqir, A., Barakat, M. T., Bergmann, O. M., Bizri, A. R., Blach, S., Chaudhry, A., Choi, M. S., Diab, T., Djauzi, S., El Hassan, E. S., El Khoury, S., Estes, C., Fakhry, S., Farooqi, J. I., Fridjonsdottir, H., Gani, R. A., Ghafoor Khan, A., Gheorghe, L., Gottfredsson, M., Gregorcic, S., Gunter, J., Hajarizadeh, B., Hamid, S., Hasan, I., Hashim, A., Horvath, G., Hunyady, B., Husni, R., Jeruma, A., Jonasson, J. G., Karlsdottir, B., Kim, D. Y., Kim, Y. S., Koutoubi, Z., Liakina, V., Lim, Y. S., Löve, A., Maimets, M., Malekzadeh, R., Matičič, M., Memon, M. S., Merat, S., Mokhbat, J. E., Mourad, F. H., Muljono, D. H., Nawaz, A., Nugrahini, N., Olafsson, S., Priohutomo, S., Qureshi, H., Rassam, P., Razavi, H., Razavi-Shearer, D., Razavi-Shearer, K., Rozentale, B., Sadik, M., Saeed, K., Salamat, A., Sanai, F. M., Sanityoso Sulaiman, A., Sayegh, R. A., Sharara, A. I., Siddiq, M., Siddiqui, A. M., Sigmundsdottir, G., Sigurdardottir, B., Speiciene, D., Sulaiman, A., Sultan, M. A., Taha, M., Tanaka, J., Tarifi, H., Tayyab, G., Tolmane, I., Ud din, M., Umar, M., Valantinas, J., Videčnik-Zorman, J., Yaghi, C., Yunihastuti, E., Yusuf, M. A., Zuberi, B. F., and Schmelzer, J. D.

Published
2015
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44. Historical epidemiology of hepatitis C virus (HCV) in select countries – volume 3

Author

Liakina, V., Hamid, S., Tanaka, J., Olafsson, S., Sharara, A. I., Alavian, S. M., Gheorghe, L., El Hassan, E. S., Abaalkhail, F., Abbas, Z., Abdou, A., Abourached, A., Al Braiki, F., Al Hosani, F., Al Jaberi, K., Al Khatry, M., Al Mulla, M. A., Al Quraishi, H., Al Rifai, A., Al Serkal, Y., Alam, A., Alashgar, H. I., Alawadhi, S., Al-Dabal, L., Aldins, P., Alfaleh, F. Z., Alghamdi, A. S., Al-Hakeem, R., Aljumah, A. A., Almessabi, A., Alqutub, A. N., Alswat, K. A., Altraif, I., Alzaabi, M., Andrea, N., Assiri, A. M., Babatin, M. A., Baqir, A., Barakat, M. T., Bergmann, O. M., Bizri, A. R., Blach, S., Chaudhry, A., Choi, M. S., Diab, T., Djauzi, S., El Khoury, S., Estes, C., Fakhry, S., Farooqi, J. I., Fridjonsdottir, H., Gani, R. A., Ghafoor Khan, A., Goldis, A., Gottfredsson, M., Gregorcic, S., Hajarizadeh, B., Han, K. H., Hasan, I., Hashim, A., Horvath, G., Hunyady, B., Husni, R., Jafri, W., Jeruma, A., Jonasson, J. G., Karlsdottir, B., Kim, D. Y., Kim, Y. S., Koutoubi, Z., Lesmana, L. A., Lim, Y. S., Löve, A., Maimets, M., Makara, M., Malekzadeh, R., Matičič, M., Memon, M. S., Merat, S., Mokhbat, J. E., Mourad, F. H., Muljono, D. H., Nawaz, A., Nugrahini, N., Priohutomo, S., Qureshi, H., Rassam, P., Razavi, H., Razavi-Shearer, D., Razavi-Shearer, K., Rozentale, B., Sadik, M., Saeed, K., Salamat, A., Salupere, R., Sanai, F. M., Sanityoso Sulaiman, A., Sayegh, R. A., Schmelzer, J. D., Sibley, A., Siddiq, M., Siddiqui, A. M., Sigmundsdottir, G., Sigurdardottir, B., Speiciene, D., Sulaiman, A., Sultan, M. A., Taha, M., Tarifi, H., Tayyab, G., Tolmane, I., Ud din, M., Umar, M., Valantinas, J., Videčnik-Zorman, J., Yaghi, C., Yunihastuti, E., Yusuf, M. A., Zuberi, B. F., and Gunter, J.

Published
2015
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45. Strategies to manage hepatitis C virus infection disease burden – volume 3

Author

Alfaleh, F. Z., Nugrahini, N., Matičič, M., Tolmane, I., Alzaabi, M., Hajarizadeh, B., Valantinas, J., Kim, D. Y., Hunyady, B., Abaalkhail, F., Abbas, Z., Abdou, A., Abourached, A., Al Braiki, F., Al Hosani, F., Al Jaberi, K., Al Khatry, M., Al Mulla, M. A., Al Quraishi, H., Al Rifai, A., Al Serkal, Y., Alam, A., Alashgar, H. I., Alavian, S. M., Alawadhi, S., Al-Dabal, L., Aldins, P., Alghamdi, A. S., Al-Hakeem, R., Aljumah, A. A., Almessabi, A., Alqutub, A. N., Alswat, K. A., Altraif, I., Andrea, N., Assiri, A. M., Babatin, M. A., Baqir, A., Barakat, M. T., Bergmann, O. M., Bizri, A. R., Chaudhry, A., Choi, M. S., Diab, T., Djauzi, S., El Hassan, E. S., El Khoury, S., Estes, C., Fakhry, S., Farooqi, J. I., Fridjonsdottir, H., Gani, R. A., Ghafoor Khan, A., Gheorghe, L., Goldis, A., Gottfredsson, M., Gregorcic, S., Gunter, J., Hamid, S., Han, K. H., Hasan, I., Hashim, A., Horvath, G., Husni, R., Jafri, W., Jeruma, A., Jonasson, J. G., Karlsdottir, B., Kim, Y. S., Koutoubi, Z., Lesmana, L. A., Liakina, V., Lim, Y. S., Löve, A., Maimets, M., Makara, M., Malekzadeh, R., Memon, M. S., Merat, S., Mokhbat, J. E., Mourad, F. H., Muljono, D. H., Nawaz, A., Olafsson, S., Priohutomo, S., Qureshi, H., Rassam, P., Razavi, H., Razavi-Shearer, D., Razavi-Shearer, K., Rozentale, B., Sadik, M., Saeed, K., Salamat, A., Salupere, R., Sanai, F. M., Sanityoso Sulaiman, A., Sayegh, R. A., Schmelzer, J. D., Sharara, A. I., Sibley, A., Siddiq, M., Siddiqui, A. M., Sigmundsdottir, G., Sigurdardottir, B., Speiciene, D., Sulaiman, A., Sultan, M. A., Taha, M., Tanaka, J., Tarifi, H., Tayyab, G., Ud din, M., Umar, M., Videčnik-Zorman, J., Yaghi, C., Yunihastuti, E., Yusuf, M. A., Zuberi, B. F., and Blach, S.

Published
2015
Full Text
View/download PDF

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