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4. ARDS clinical practice guideline 2021

Author

Nakashima, Takuro, Masunaga, Aiko, Tanaka, Aiko, Inoue, Akihiko, Higashi, Akiko, Tanikawa, Atsushi, Ujiro, Atsushi, Takayama, Chihiro, Kasugai, Daisuke, Kawakami, Daisuke, Ueno, Daisuke, Satoh, Daizoh, Kai, Shinichi, Ota, Kohei, Hagiwara, Yoshihiro, Hamaguchi, Jun, Fujii, Ryo, Hongo, Takashi, Kishihara, Yuki, Masunaga, Naohisa, Yamamoto, Ryohei, Okazaki, Satoru Robert, Uchimido, Ryo, Terayama, Tetsuro, Hokari, Satoshi, Sakamoto, Hitoshi, Dongli, Nakataki, Emiko, Tabata, Erina, Okazawa, Seisuke, Kotajima, Futoshi, Ishimaru, Go, Hoshino, Haruhiko, Yoshida, Hideki, Iwai, Hidetaka, Nakagawa, Hiroaki, Sugimura, Hiroko, Narumiya, Hiromichi, Okano, Hiromu, Nakamura, Hiroshi, Sugimoto, Hiroshi, Hashimoto, Hiroyuki, Ito, Hiroyuki, Dote, Hisashi, Imahase, Hisashi, Sato, Hitoshi, Katsurada, Masahiro, Osawa, Ichiro, Kamei, Jun, Maki, Jun, Sugihara, Jun, Takeshita, Jun, Fujimoto, Junichi, Ishikawa, Junichi, Kosaka, Junko, Shibata, Junpei, Hashimoto, Katsuhiko, Nakano, Yasushi, Kikuyama, Kazuki, Shimizu, Kazushige, Okada, Kazuya, Kawano, Keishi, Anan, Keisuke, Ota, Keisuke, Kano, Ken-ichi, Asano, Kengo, Hondo, Kenichi, Ishii, Kenji, Fujita, Kensuke, Ogawa, Kenta, Ito, Kentaro, Tokunaga, Kentaro, Ishii, Kenzo, Kusumoto, Kohei, Takimoto, Kohei, Yamada, Kohei, Naito, Koichi, Yamashita, Koichi, Yoshinaga, Koichi, Yamauchi, Kota, Murata, Maki, Konda, Makiko, Hamamoto, Manabu, Aga, Masaharu, Kashiura, Masahiro, Ishikawa, Masami, Ozaki, Masayuki, Kono, Michihiko, Kyo, Michihito, Hayashi, Minoru, Abe, Mitsuhiro, Sato, Mitsunori, Sakai, Mizu, Kainuma, Motoshi, Tominaga, Naoki, Iguchi, Naoya, Nakagawa, Natsuki, Aoki, Nobumasa, Nishioka, Norihiro, Miyashita, Norihisa, Seki, Nozomu, Ikebe, Ryo, Imai, Ryosuke, Tate, Ryota, Sato, Ryuhei, Miyakawa, Sachiko, Kazuma, Satoshi, Nakano, Satoshi, Tetsumoto, Satoshi, Yoshimura, Satoshi, Yoshitake, Shigenori, Hoshi, Shin-etsu, Ohki, Shingo, Sato, Shintaro, Yoshihiro, Shodai, Ihara, Shoichi, Yamamoto, Shota, Koide, Shunichi, Kimata, Shunsuke, Saito, Shunsuke, Yasuo, Shunsuke, Sekine, Shusuke, Mimuro, Soichiro, Wada, Soichiro, Sugimura, Sosuke, Ishihara, Tadashi, Kaneko, Tadashi, Nagato, Tadashi, Maruhashi, Takaaki, Tamura, Takahiro, Ohno, Takanori, Ichiyama, Takashi, Niwa, Takashi, Ueji, Takashi, Ogura, Takayuki, Kawasaki, Takeshi, Tanaka, Takeshi, Umegaki, Takeshi, Furukawa, Taku, Omura, Taku, Nagao, Takumi, Mayumi, Takuya, Taniguchi, Takuya, Yoshida, Takuya, Shimatani, Tatsutoshi, Murata, Teppei, Sato, Tetsuya, Sawamoto, Tohru, Koukei, Yoshifumi, Takehara, Tomohiro, Ueda, Tomomi, Katsuta, Tomoya, Nishino, Tomoya, Yokoyama, Toshiki, Higashijima, Ushio, Iwanaga, Wataru, Inoue, Yasushi, Iwashita, Yoshiaki, Yamada, Yoshie, Kubota, Yoshifumi, Suido, Yoshihiro, Tomioka, Yoshihiro, Fujimoto, Yoshihisa, Fujita, Yoshihito, Yamaguchi, Yoshikazu, Nakamura, Yoshimi, Abe, Yoshinobu, Eguchi, Yoshitomo, Oshima, Yoshiyasu, Fukuda, Yosuke, Iwasaki, Yudai, Yasufuku, Yuichi, Shono, Yuji, Nakatani, Yuka, Nakamori, Yuki, Ito, Yukie, Tanabe, Yuko, Nagamine, Yusuke, Nakamura, Yuta, Kurihara, Yutaro, Tasaka, Sadatomo, Ohshimo, Shinichiro, Takeuchi, Muneyuki, Yasuda, Hideto, Ichikado, Kazuya, Tsushima, Kenji, Egi, Moritoki, Hashimoto, Satoru, Shime, Nobuaki, Saito, Osamu, Matsumoto, Shotaro, Nango, Eishu, Okada, Yohei, Hayashi, Kenichiro, Sakuraya, Masaaki, Nakajima, Mikio, Okamori, Satoshi, Miura, Shinya, Fukuda, Tatsuma, Kamo, Tetsuro, Yatabe, Tomoaki, Norisue, Yasuhiro, Aoki, Yoshitaka, Iizuka, Yusuke, Kondo, Yutaka, Narita, Chihiro, Taito, Shunsuke, Hayashi, Takuya, Terayama, Takero, Kataoka, Jun, Nishimura, Tetsuro, Yonekura, Hiroshi, Ando, Koichi, Yoshida, Takuo, Masuyama, Tomoyuki, and Sanui, Masamitsu

Published
2022
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5. Dual Antiplatelet Therapy With Cilostazol for Secondary Prevention in Lacunar Stroke: Subanalysis of the CSPS.com Trial

Author

Nishiyama, Yasuhiro, Kimura, Kazumi, Otsuka, Toshiaki, Toyoda, Kazunori, Uchiyama, Shinichiro, Hoshino, Haruhiko, Sakai, Nobuyuki, Okada, Yasushi, Origasa, Hideki, Naritomi, Hiroaki, Houkin, Kiyohiro, Yamaguchi, Keiji, Minematsu, Kazuo, Matsumoto, Masayasu, Tominaga, Teiji, Tomimoto, Hidekazu, Terayama, Yasuo, Yasuda, Satoshi, and Yamaguchi, Takenori

Published
2023
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8. Cerebral Small Vessel Disease Burden for Bleeding Risk during Antithrombotic Therapy: Bleeding with Antithrombotic Therapy 2 Study.

Author

Tanaka, Kanta, Miwa, Kaori, Koga, Masatoshi, Yoshimura, Sohei, Kamiyama, Kenji, Yagita, Yoshiki, Nagakane, Yoshinari, Hoshino, Haruhiko, Terasaki, Tadashi, Okada, Yasushi, Yakushiji, Yusuke, Takahashi, Shinichi, Ueda, Toshihiro, Hasegawa, Yasuhiro, Shiozawa, Masayuki, Sasaki, Makoto, Kudo, Kohsuke, Tanaka, Jun, Nishihara, Masashi, and Yamaguchi, Yoshitaka

Subjects
CEREBRAL small vessel diseases, FIBRINOLYTIC agents, INTRACRANIAL hemorrhage, GASTROINTESTINAL hemorrhage, CEREBROVASCULAR disease
Abstract

Objective: This study was undertaken to determine the excess risk of antithrombotic‐related bleeding due to cerebral small vessel disease (SVD) burden. Methods: In this observational, prospective cohort study, patients with cerebrovascular or cardiovascular diseases taking oral antithrombotic agents were enrolled from 52 hospitals across Japan between 2016 and 2019. Baseline multimodal magnetic resonance imaging acquired under prespecified conditions was assessed by a central diagnostic radiology committee to calculate total SVD score. The primary outcome was major bleeding. Secondary outcomes included bleeding at each site and ischemic events. Results: Of the analyzed 5,250 patients (1,736 women; median age = 73 years, 9,933 patient‐years of follow‐up), antiplatelets and anticoagulants were administered at baseline in 3,948 and 1,565, respectively. Median SVD score was 2 (interquartile range = 1–3). Incidence rate of major bleeding was 0.39 (per 100 patinet‐years) in score 0, 0.56 in score 1, 0.91 in score 2, 1.35 in score 3, and 2.24 in score 4 (adjusted hazard ratio [aHR] for score 4 vs 0 = 5.47, 95% confidence interval [CI] = 2.26–13.23), that of intracranial hemorrhage was 0.11, 0.33, 0.58, 0.99, and 1.06, respectively (aHR = 9.29, 95% CI = 1.99–43.35), and that of ischemic event was 1.82, 2.27, 3.04, 3.91, and 4.07, respectively (aHR = 1.76, 95% CI = 1.08–2.86). In addition, extracranial major bleeding (aHR = 3.43, 95% CI = 1.13–10.38) and gastrointestinal bleeding (aHR = 2.54, 95% CI = 1.02–6.35) significantly increased in SVD score 4 compared to score 0. Interpretation: Total SVD score was predictive for intracranial hemorrhage and probably for extracranial bleeding, suggesting the broader clinical relevance of cerebral SVD as a marker for safe implementation of antithrombotic therapy. ANN NEUROL 2024;95:774–787 [ABSTRACT FROM AUTHOR]

Published
2024
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9. Soluble C-type lectin-like receptor 2 in stroke (CLECSTRO) study: protocol of a multicentre, prospective cohort of a novel platelet activation marker in acute ischaemic stroke and transient ischaemic attack

Author

Uchiyama, Shinichiro, primary, Suzuki-Inoue, Katsue, additional, Wada, Hideo, additional, Okada, Yasushi, additional, Hirano, Teruyuki, additional, Nagao, Takehiko, additional, Kinouchi, Hiroyuki, additional, Itabashi, Ryo, additional, Hoshino, Haruhiko, additional, Oki, Koichi, additional, Honma, Yutaka, additional, Ito, Nobuo, additional, Sugimori, Hiroshi, additional, and Kawamura, Masahide, additional

Published
2023
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10. The Influence of Age on the Outcomes of Traumatic Brain Injury: Findings from a Japanese Nationwide Survey (J-ASPECT Study-Traumatic Brain Injury)

Author

Takigami, Masayoshi, Kamiyama, Kenji, Houkin, Kiyohiro, Nishi, Shougo, Yoshimoto, Tetsuyuki, Kaneko, Sadao, Oka, Koji, Ooyama, Hiroshi, Kamada, Kyousuke, Makino, Kenichi, Tokumitsu, Naoki, Sako, Kazuhiro, Suzuki, Susumu, Suzuki, Nozomi, Izumi, Naoto, Nitta, Kazumi, Ootaki, Masahumi, Isobe, Masanori, Nishiya, Mikio, Yamazaki, Takaaki, Mabuchi, Syouji, Ogasawara, Kuniaki, Kubo, Naohiko, Shimizu, Yukihiko, Saito, Keiichi, Yamanome, Tatumi, Yoshino, Atsuo, Fujitsuka, Mitsuyuki, Takami, Masaaki, Ohtaka, Hirotoshi, Hirano, Teruyuki, Shiokawa, Yosiaki, Okada, Takaharu, Suzuki, Ichiro, Kohno, Michihiro, Haraoka, Jou, Arai, Yoshinori, Kawamura, Noriyoshi, Isoshima, Akira, Yasue, Masaharu, Takayoshi Kobayashi, Mitsuhiko Hokari, Kawai, Kensuke, Maehara, Taketoshi, Arai, Hajime, Noguchi, Makoto, Hoshino, Haruhiko, Hiyama, Hirofumi, Yoshida, Kensaku, Utsugi, Osamu, Takeda, Yasuaki, Tamaki, Kouichi, Karasudani, Hirohide, Urabe, Takao, Kobayashi, Shiro, Nakamura, Michio, Koguchi, Yorio, Ono, Junichi, Suda, Sumio, Hadeishi, Hiromu, Fukutake, Toshio, Wakui, Kenji, Tanno, Hirokazu, Ishige, Naoki, Ohasi, Takashi, Sakai, Hideki, Nishimura, Yasuaki, Watanabe, Takayuki, Matsumoto, Takashi, Koketsu, Naoki, Hirose, Yuichi, Doyu, Manabu, Hasegawa, Toshinori, Kuwayama, Naoto, Terao, Shinichi, Mizutani, Nobuhiko, Suzaki, Noriyuki, Okuda, Satoshi, Yasui, Keizo, Seki, Yukio, Hasegawa, Yasuhiro, Ikeda, Akira, Takeuchi, Youtarou, Ohara, Sigeki, Araki, Yoshio, Wakabayashi, Toshihiko, Tanaka, Hisashi, Yoshimoto, Junpei, Sugiura, Makoto, Koichiro, Ogura, Kobayashi, Nozomu, Yamada, Tomonori, Kato, Amami, Toshiho, Ohtsuki, Wakayama, Akatsuki, Takahashi, Jun, Kataoka, Hiroharu, Yoshimine, Toshiki, Nakajima, Yoshikazu, Gi, Hidehuku, Uranishi, Ryunosuke, Nakamura, Yusaku, Yamanaka, Kazunori, Ohmori, Kazumi, Matsumoto, Hiroyuki, Oiwa, Yoshitugu, Uemura, Yosihiko, Fujiwara, Hiroaki, Iwai, Yoshiyasu, Morikawa, Masashi, Tane, Kazuyuki, Hashikawa, Kazuo, Fujinaka, Toshiyuki, Yoneda, Shunichi, Yamashita, Kohsuke, Kitano, Masahiko, Tominaga, Shinsuke, Nakamura, Kazuhito, Kono, Katsuhiko, Ohata, Kenji, Taniguchi, Hirokatsu, Hazama, Takanori, Kuroiwa, Toshihiko, Tamura, Yoji, Maeno, Kazusige, Arai, Motohiro, Iwase, Masaaki, Hashimoto, Kenji, Yamada, Keisuke, Turuno, Takashi, Ichinose, Tsutomu, Kurokawa, Shinichiro, Matsuyama, Takeshi, Fujita, Toshiaki, Yuguchi, Takamichi, Teramoto, Yoshihumi, Kakita, Hiroto, Matsuo, Takayuki, Izumo, Tsuyoshi, Ryu, Nobutoshi, Naoki Kitagawa, Wataru Haraguchi, Kaminogo, Makio, Sakamoto, Seisaburo, Tokunaga, Yosiharu, Urasaki, Ei-Ichirou, Kuratsu, Junichi, Takada, Akira, Terasaki, Tadashi, Hisami Oosima, Isao Fuwa, Yamashiro, Shigeo, Hiromasa Tsuiki, Makoto Yoshikawa, Koga, Kazunari, Egami, Hiroshi, Kawamura, Tadao, Mitsuo, Kunihiko, Masaki Morisige, Takamitu Hikawa, Takeda, Yuu, Yamaguchi, Yutaka, Shunro Uchinokura, Shiro Miyata, Goya, Tomokazu, Takeshima, Hideo, Yatsushiro, Kazutaka, Ohta, Hajime, Nagadou, Tatsui, Hirahara, Kazuho, Obara, Souichi, Seto, Hiroshi, Moroki, Koiti, Arita, Kazunori, Ishiuchi, Shogo, Uchihara, Toshimitsu, Mekaru, Susumu, Nagamine, Tomoaki, Jin Momoji, Naoki Tomiyama, Atusi Kimoto, Kouzi Idomari, Kadekaru, Tsutomu, Syamoto, Hirosi, Sasaki, Osamu, Minagawa, Makoto, Takahashi, Hideaki, Hiroyuki Arai, Kiyoshi Onda, Takeuchi, Shigekazu, Abe, Hiroshi, Fukuda, Osamu, Kouno, Mitsuo, Tamura, Tetsuro, Michiya Kubo, Yukio Horie, Hondo, Hiroaki, Takada, Hisashi, Masuoka, Toru, Shirasaki, Naoki, Nitta, Hisashi, Yasuo Katsuki, Makoto Kimura, Hisato Minamide, Yutaka Hayashi, Munemoto, Shigeru, Ikeda, Kiyonobu, Yutaka Hayashi, Mitsutoshi Nakada, Sato, Syuji, Hatano, Taketo, Yamamura, Osamu, Kabuto, Masanori, Jyunya Hayashi, Takahiro Sakuma, Kinouchi, Hiroyuki, Koizumi, Hidehito, Imae, Syougo, Fujita, Manabu, Suga, Masakazu, Kanehisa Kohno, Shinji Iwata, Zenke, Kiichiro, Fujisawa, Mutsuo, Mizobuchi, Hikaru, Hayashi, Satoru, Morimoto, Masanori, Ueba, Tetsuya, Nishimura, Hiroyuki, Ikawa, Naoki, Matsumoto, Yuzo, Kannuki, Seiji, Kagawa, Masahiro, Hayashi, Naoki, Atsushi Shindo, Takashi Tamiya, Yoshino, Kimihiro, Masaoka, Tetsuya, Nakahara, Ichiro, Satoshi Suzuki, Akira Nakamizo, Okamoto, Yuji, Takahashi, Haruki, Iihara, Koji, Hirakawa, Katsuyuki, Nagata, Shinji, Ookura, Akio, Yoshiro Kaneko, Hidenori Yoshida, Nakane, Hiroshi, Inoue, Isao, Hitotsumatsu, Tsutomu, Kouichi Kuramoto, Terukazu Kuramoto, Hiromichi Ooishi, Yoshihisa Matumoto, Masani Nonaka, Tooru Inoue, Morioka, Motohiro, Shuji Sakata, Hiroshi Sugimori, Takashima, Hiroshi, Ishihara, Shin-Ichiro, Suzuyama, Kenji, Miyazono, Masayuki, Itaro Hattori, Masafumi Morimoto, Ozaki, Satoshi, Hirota, Nobuo, Yasuhiko Mochimatsu, Yasunori Takemoto, Takagi, Makoto, Kenji Nakayama, Isao Yamamoto, Hiroshi Tanaka, Yoshinori Uchida, Sakata, Katsumi, Nobutaka, Kawahara, Nomura, Motohiro, Ozawa, Hitoshi, Tsumura, Kotaro, Michiyuki Maruyama, Makoto Inaba, Mori, Tatsuro, Mori, Takahisa, Sugitani, Masato, Tanaka, Yuichiro, Yamada, Masaru, Matsumae, Mitsunori, Onitsuka, Keiichirou, Tatsuya Takahashi, Kosuke Miyahara, Endou, Sumio, Takahashi, Hidekazu, Kaidu, Hiroyuki, Chikashi Maruki, Akira Tsunoda, Fujimaki, Takamitsu, Ooigawa, Hidetoshi, Masatsugu Uchida, Masahiko Tanaka, Kouiti Katoh, Hiroshi Wanihuti, Hyodo, Akio, Asakura, Ken, Nakajima, Shigeyoshi, Kanzawa, Takao, Kurihara, Hideyuki, Ohmori, Sigehiro, Hiroshi Kusunoki, Mitsugi Yoshinao, Magarisawa, Satoshi, Okabe, Shinichi, Kujiraoka, Yuuji, Tsuruoka, Shin, Takeshita, Mikihiko, Akira Matsumura, Tetsuya Yamamoto, Uemura, Kazuya, Tabata, Hitoshi, Sonobe, Makoto, Ryoji Yoshida, Masashi Nakatsukasa, Shimoeda, Norifumi, Kunimine, Hideo, Ishihara, Masayuki, Murai, Nozomu, Murakami, Nobukuni, Kidooka, Minoru, Iwamoto, Yoshihiro, Tenjin, Hiroshi, Masahiko Takamasu, Kouji Shiga, Mori, Nobuhito, Kose, Shigeru, Kohmura, Eiji, Matsumoto, Keigo, Sakaki, Takayuki, Miyake, Hiroji, Mabuchi, Eiichiro, Yokota, Masayuki, Yosihiro Kuga, Hideyuki Ohnishi, Kimura, Mitsuru, Masaaki Saiki, Osamu Narumi, Nakajima, Norio, Asahi, Minoru, Koyama, Junji, Noda, Shinya, Iida, Junichi, Fujita, Toyohisa, Nakase, Hiroyuki, Toru Hoshida, Hidehiro Hirabayashi, Fujimoto, Takayoshi, Nakao, Naoyuki, Tanaka, Yoshiyuki, Ozaki, Fuminori, Nakamura, Yoshinari, Miki, Kazuhito, Watanabe, Takashi, Hasegawa, Seiko, Konno, Hiromu, Takemura, Atsuhito, Okubo, Atsuya, Saito, Hitoshi, Taizen Nakase, Tatsuya Ishikawa, Toshio Sasajima, Hiroaki Shimizu, Sasou, Masayuki, Watanabe, Yoichi, Kiyoshi Saito, Taku Sato, Masahiro Satoh, Satoshi Taira, Koizumi, Takayuki, Shoji Mashiyama, Yasuhiro Suzuki, Oikawa, Tomoyoshi, Sonoda, Yukihiko, Shinjiro Saito, Rei Kondo, Shinoda, Atsuo, Kamatsuka, Eiichiro, So, Keiten, Kinjo, Toshihiko, Kennji Itou, Tooru Sasaki, Hiroaki Shimizu, Hidenori Endo, Karibe, Hirosi, Takahashi, Kou, Nakajima, Masayuki, Watanabe, Kazuyoshi, Takayama, Motohiro, Komuro, Taro, Fumio Suzuki, Hisao Hirai, Suzuki, Hidenori, Murata, Hiroto, Miya, Fumitaka, Kanamaru, Kenji, Tamura, Akira, Harada, Kiyoshi, Fukazawa, Seiji, Takehara, Seiya, Watanabe, Yoshihiko, Nakayama, Teiji, Hiroshi Nagura, Haruhiko Sato, Chiharu Tanoi, Shinji Amano, Kuroda, Katsuhiro, Morooka, Satoru, Masashi Kitagawa, Takafumi Wataya, Koide, Kazuo, Tanigawara, Tetsuya, Iwama, Toru, Ito, Junki, Noda, Shinji, Kouno, Kazuyuki, Kitazawa, Kazuo, Toshiki Takemae, Yoshikazu Kusano, Hokama, Masanobu, Yoshihisa Nishiyama, Hiroki Sato, Seguchi, Tatsuya, Yoshihiko Inui, Sumio Kobayashi, Oohigashi, Youji, Muraoka, Shinsuke, Miyatake, Masaki, Nakagawa Shinichi, Kensuke Hayashida, Inoue, Atsushi, Sakai, Keiichi, Yamaguchi, Shuhei, Fusao Ikawa, Tatsuya Mizoue, Hideki Irie, Gen Ishida, Kagawa, Takato, Namba, Yoichiro, Nakashima, Hiroyuki, Koji Abe, Isao Date, Uno, Masaaki, Sen Yamagata, Masaki Chin, Soitiro Takao, Hidemiti Sasayama, Kouji Muneda, Hideyuki Yoshida, Watanebe, Akira, Katou, Syouichi, Hamada, Yasuhiro, Suzuki, Michiyasu, Nishizaki, Takafumi, Yamashita, Katsuhiro, Ryuji Nakamura, Takaharu Nakamura, Wakabayashi, Shinichi, Okazaki, Takahito, Kurisu, Kaoru, Matsumoto, Masayasu, Katsuzo Kiya, Atsushi Tominaga, Syuichi Oki, Masaaki Shibukawa, Nakahara, Toshinori, Okita, Shinji, Torii, Tuyosi, Kenjirou Fujiwara, Minoru Nakagawa, Syuuhei Nishimura, Takashi Matsuoka, Naoyuki Isobe, Osamu Hamasaki, Shinji Nagahiro, Junichiro Satomi, Agawa, Masahito, Oka, Hirofumi, Yoshimura, Kunikazu, Kato, Tsutomu, Satoshi Minoshima, Nobuaki Kobayasi, Mikuni, Nobuhiro, Tanikawa, Rokuya, Sasaki, Jyunkou, Otawara, Yasunari, Tominaga, Teiji, Sasaki, Tatsuya, Takemura, Sunao, Kawakami, Masahisa, Ihara, Satoshi, Shibata, Yasushi, Saegusa, Takashi, Iuchi, Toshihiko, Ito, Chiaki, Okuda, Osamu, Yoshida, Kazunari, Masateru Katayama, Sadao Suga, Akihiro, Oikawa, Miura, Naohisa, Ota, Takahiro, Kumabe, Toshihiro, Suzuki, Sachio, Kumagai, Takashi, Nishimaki, Keiichi, Hongo, Kazuhiro, Shigeta, Hiroaki, Hattori, Kazuyoshi, Uozumi, Yoichi, Nakahara, Norimoto, Hashimoto, Nobukazu, Shu Imai, Shinichi Shirakami, Okumura, Yoshinari, Kazuhiro Yokoyama, Ryo Tamaki, Miyamoto, Susumu, Yamamoto, Kazuo, Ichioka, Tsugumichi, Inoue, Tsuyoshi, Kinoshita, Manabu, Saitoh, Minoru, Aihara, Hideo, Miyake, Hajimu, Tukasa Nishiura, Kotaro Ogihara, Nishino, Shigeki, Miyoshi, Yasuyuki, Arisawa, Tadashi, Shoji Tsuchimoto, Shigeru Daido, Kinoshita, Kimihisa, Keisuke Migita, Kiyoshi Yuki, Akatsuka, Keiichi, Fujisawa, Hirosuke, Shono, Tadahisa, Tsugu, Hitoshi, Hayashi, Shuji, Toshio Matsushima, Tatsuya Abe, Nakashima, Susumu, Tuji, Takehisa, Kaga, Akihiko, Kanemaru, Reizou, Takasaki, Koji, Imamura, Junichi, Noha, Masahiro, Watanabe, Saburo, Sakai, Nobuyuki, Hiroaki Minami, Yasuhisa Yoshida, Okumura, Tomoyoshi, Nishimura, Shinjitsu, Numazawa, Shinichi, Masanori Tsutsumi, Kiyoshi Kazekawa, Fukuyama, Kouzou, Fujimoto, Yasuhiro, Yamagami, Keitaro, Kurogi, Ryota, Kurogi, Ai, Nishimura, Kunihiro, Onozuka, Daisuke, Ren, Nice, Kada, Akiko, Nishimura, Ataru, Arimura, Koichi, Ido, Keisuke, Mizoguchi, Masahiro, Sakamoto, Tetsuya, Kayama, Takamasa, and Hagihara, Akihito

Published
2019
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11. Dual antiplatelet therapy using cilostazol for secondary prevention in patients with high-risk ischaemic stroke in Japan: a multicentre, open-label, randomised controlled trial

Author

Goto, Shinya, Isomura, Tatsuya, Matsumoto, Masayasu, Terayama, Yasuo, Tomimoto, Hidekazu, Tominaga, Teiji, Yasuda, Satoshi, Kumagai, Naoko, Toyoda, Kazunori, Uchiyama, Shinichiro, Yamaguchi, Takenori, Easton, J Donald, Kimura, Kazumi, Hoshino, Haruhiko, Sakai, Nobuyuki, Okada, Yasushi, Tanaka, Kortaro, Origasa, Hideki, Naritomi, Hiroaki, Houkin, Kiyohiro, Yamaguchi, Keiji, Isobe, Masanori, and Minematsu, Kazuo

Published
2019
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13. National trends in the outcomes of subarachnoid haemorrhage and the prognostic influence of stroke centre capability in Japan: retrospective cohort study

Author

Kurogi, Ryota, primary, Kada, Akiko, additional, Ogasawara, Kuniaki, additional, Nishimura, Kunihiro, additional, Kitazono, Takanari, additional, Iwama, Toru, additional, Matsumaru, Yuji, additional, Sakai, Nobuyuki, additional, Shiokawa, Yoshiaki, additional, Miyachi, Shigeru, additional, Kuroda, Satoshi, additional, Shimizu, Hiroaki, additional, Yoshimura, Shinichi, additional, Osato, Toshiaki, additional, Horie, Nobutaka, additional, Nagata, Izumi, additional, Nozaki, Kazuhiko, additional, Date, Isao, additional, Hashimoto, Yoichiro, additional, Hoshino, Haruhiko, additional, Nakase, Hiroyuki, additional, Kataoka, Hiroharu, additional, Ohta, Tsuyoshi, additional, Fukuda, Hitoshi, additional, Tamiya, Nanako, additional, Kurogi, AI, additional, Ren, Nice, additional, Nishimura, Ataru, additional, Arimura, Koichi, additional, Shimogawa, Takafumi, additional, Yoshimoto, Koji, additional, Onozuka, Daisuke, additional, Ogata, Soshiro, additional, Hagihara, Akihito, additional, Saito, Nobuhito, additional, Arai, Hajime, additional, Miyamoto, Susumu, additional, Tominaga, Teiji, additional, and Iihara, Koji, additional

Published
2023
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16. Abstract 3: Cerebral Small Vessel Disease Burden For Bleeding Risk During Antithrombotic Therapy -BAT2-

Author

Tanaka, Kanta, primary, Miwa, Kaori, additional, Yoshimura, Sohei, additional, Kamiyama, Kenji, additional, Yagita, Yoshiki, additional, Nagakane, Yoshinari, additional, Hoshino, Haruhiko, additional, Terasaki, Tadashi, additional, Okada, Yasushi, additional, Yakushiji, Yusuke, additional, Takahashi, Shinichi, additional, Ueda, Toshihiro, additional, Hasegawa, Yasuhiro, additional, Shiozawa, Masayuki, additional, Sasaki, Makoto, additional, Kudo, Kohsuke, additional, Tanaka, Jun, additional, Nishihara, Masashi, additional, Yamaguchi, Yoshitaka, additional, Fujita, Kyohei, additional, Honda, Yuko, additional, Kawano, Hiroyuki, additional, Ide, Toshihiro, additional, Yoshimoto, Takeshi, additional, Ihara, Masafumi, additional, Koga, Masatoshi, additional, Hirano, Teruyuki, additional, and Toyoda, Kazunori, additional

Published
2023
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24. Dual antiplatelet therapy with cilostazol in stroke patients with extracranial arterial stenosis or without arterial stenosis: A subgroup analysis of the CSPS.com trial.

Author

Uchiyama, Shinichiro, Toyoda, Kazunori, Okamura, Satomi, Omae, Katsuhiro, Hoshino, Haruhiko, Kimura, Kazumi, Kitagawa, Kazuo, Minematsu, Kazuo, and Yamaguchi, Takenori

Subjects
ARTERIAL stenosis, PLATELET aggregation inhibitors, STROKE patients, SUBGROUP analysis (Experimental design), ISCHEMIC stroke
Abstract

Background: We previously reported that dual antiplatelet therapy (DAPT) with cilostazol was superior to aspirin or clopidogrel for the prevention of recurrent stroke and vascular events in a subgroup analysis of intracranial arterial stenosis in the Cilostazol Stroke Prevention Study for Antiplatelet Combination (CSPS.com), a randomized controlled trial. Aims: We conducted another subgroup analysis to investigate the benefit of DAPT with cilostazol in patients with extracranial arterial stenosis (ECAS) and those without arterial stenosis. Methods: We compared the risk of recurrent ischemic stroke, vascular events, and major bleeding between DAPT with cilostazol plus aspirin or clopidogrel and aspirin or clopidogrel alone in patients with ischemic stroke between 8 and 180 days before starting trial treatment and ECAS or without arterial stenosis. Results: The median follow-up period was 1.4 years. The risk of recurrent ischemic stroke (hazard ratio (HR): 1.04, 95% confidence interval (CI): 0.42–2.57) and vascular events (HR: 0.97, 95% CI: 0.42–2.24) did not differ between the two groups for the 253 patients with ECAS, whereas they were lower (HR: 0.36, 95% CI: 0.18–0.74 and HR: 0.47, 95% CI: 0.26–0.85, respectively) in the DAPT group for the 944 patients without arterial stenosis. The risk of major bleeding did not differ between the groups in patients with ECAS (HR: 0.58, 95% CI: 0.05–6.39) or without arterial stenosis (HR: 0.79, 95% CI: 0.27–2.26). Conclusion: DAPT with cilostazol might be beneficial for prevention of recurrent stroke and vascular events in patients without arterial stenosis but not in those with ECAS. Data access statement: We will make the deidentified participant data from this research available to the scientific community with as few restrictions as feasible, while retaining exclusive use until the publication of major output. [ABSTRACT FROM AUTHOR]

Published
2023
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25. Effect of Simultaneous Dual-Task Training on Regional Cerebral Blood Flow in Older Adults with Amnestic Mild Cognitive Impairment

Author

Kunieda, Yota, primary, Arakawa, Chiaki, additional, Yamada, Takumi, additional, Koyama, Shingo, additional, Suzuki, Mizue, additional, Ishiyama, Daisuke, additional, Yamada, Minoru, additional, Hirokawa, Ryuto, additional, Matsuda, Tadamitsu, additional, Nio, Shintaro, additional, Adachi, Tomohide, additional, Hoshino, Haruhiko, additional, and Fujiwara, Toshiyuki, additional

Published
2022
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26. Association of Timing for Starting Dual Antiplatelet Treatment With Cilostazol and Recurrent Stroke

Author

Toyoda, Kazunori, primary, Omae, Katsuhiro, additional, Hoshino, Haruhiko, additional, Uchiyama, Shinichiro, additional, Kimura, Kazumi, additional, Miwa, Kaori, additional, Minematsu, Kazuo, additional, Yamaguchi, Keiji, additional, Suda, Yoshitaka, additional, Toru, Shuta, additional, Kitagawa, Kazuo, additional, Ihara, Masafumi, additional, Koga, Masatoshi, additional, and Yamaguchi, Takenori, additional

Published
2022
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29. sj-docx-1-wso-10.1177_17474930221112343 – Supplemental material for Dual antiplatelet therapy with cilostazol in stroke patients with extracranial arterial stenosis or without arterial stenosis: A subgroup analysis of the CSPS.com trial

Author

Uchiyama, Shinichiro, Toyoda, Kazunori, Okamura, Satomi, Omae, Katsuhiro, Hoshino, Haruhiko, Kimura, Kazumi, Kitagawa, Kazuo, Minematsu, Kazuo, and Yamaguchi, Takenori

Subjects
FOS: Clinical medicine, Cardiology, Medicine, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-docx-1-wso-10.1177_17474930221112343 for Dual antiplatelet therapy with cilostazol in stroke patients with extracranial arterial stenosis or without arterial stenosis: A subgroup analysis of the CSPS.com trial by Shinichiro Uchiyama, Kazunori Toyoda, Satomi Okamura, Katsuhiro Omae, Haruhiko Hoshino, Kazumi Kimura, Kazuo Kitagawa, Kazuo Minematsu and Takenori Yamaguchi in International Journal of Stroke

Published
2022
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34. COVID-19 vaccine induced interstitial lung disease

Author

Yoshifuji, Ayumi, primary, Ishioka, Kota, additional, Masuzawa, Yuya, additional, Suda, Shuntaro, additional, Murata, Saori, additional, Uwamino, Yoshifumi, additional, Fujino, Motoko, additional, Miyahara, Hiromi, additional, Hasegawa, Naoki, additional, Ryuzaki, Munekazu, additional, Hoshino, Haruhiko, additional, and Sekine, Kazuhiko, additional

Published
2022
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35. Effect of Standard vs Intensive Blood Pressure Control on the Risk of Recurrent Stroke A Randomized Clinical Trial and Meta-analysis

Author

Kitagawa Kazuo, Yamamoto Yasumasa, Arima Hisatomi, Maeda Toshiki, Sunami Norio, Kanzawa Takao, Eguchi Kazuo, Kamiyama Kenji, Minematsu Kazuo, Ueda Shinichiro, Rakugi Hiromi, Ohya Yusuke, Kohro Takahide, Yonemoto Koji, Okada Yasushi, Higaki Jitsuo, Tanahashi Norio, Kimura Genjiro, Umemura Satoshi, Matsumoto Masayasu, Shimamoto Kazuaki, Ito Sadayoshi, Saruta Takao, Shimada Kazuyuki, Kario Kazuomi, Saito Yoshihiko, Terayama Yasuo, Toyoda Kazunori, Okura Takafumi, Hoshino Haruhiko, Makino Hirofumi, Uchida Haruhito, Uchiyama Shinichiro, Etani Hideki, Kohriyama Tatsuo, Tomimoto Hidekazu, Yoshio Taku, Kobayashi , Shotai, Usami Hiroko, Iihoshi Satoshi, Mikami Takeshi, Mikuni Nobuhiro, Miyata Kei, Murakami Tomohiro, Endo Hideki, Fukui Takahito, Fumoto Kentaro, Hara Keiji, Honjo Kaori, Kinoshita Yusuke, Maeda Masana, Mikamoto Masaaki, Mori Daisuke, Murahashi Takeo, Nomura Ryota, Noro Shusaku, Ogino Tatsuya, Okuma Masahiro, Otake Yasuhumi, Shindo Koichiro, Sugio Hironori, Takada Hidekazu, Takahira Kazuki, Takeuchi Akiko, Watanabe Toshiichi, Yamaguchi Yohei, Abumiya Takeo, Houkin Kiyohiro, Matsumura Shigeki, Shinohe Rikiya, Kuroshima Kiyomi, Takizawa Katsumi, Yoshida Kazuto, Morimoto Hideo, Hasebe Naoyuki, Koyama Satoshi, Maruyama Junichi, Irie Shinsuke, Nakano Takahiro, Ogasawara Yukari, Ohkuma Hiroki, Shibanai Kazuo, Hikichi Kentaro, Kobayashi Shinya, Moroi Junta, Nakase Taizen, Okada Takeshi, Takano Daiki, Takenaka Shunsuke, Yoshioka Shotaro, Yanagisawa Toshiharu, Hirata Yutaka, Konno Shu, Sato Tomohiko, Ito Miiko, Kondo Rei, Mori Wataru, Saito Shinjiro, Kokubo Yasuaki, Kato Hideaki, Oyama Hideki, Matsuo Kaneyuki, Matsumoto Masahiro, Nakamura Mari, Koizumi Takayuki, Sato Hiroyuki, Shibata Yasushi, Hashimoto Masaaki, Kurita Hideharu, Matsumoto Eiji, Ishiguro Koji, Asakura Ken, Fujimaki Hiroya, Wakabayashi Kazuki, Akaji Kazunori, Horikoshi Tomo, Kano Tadashige, Katano Takehiro, Kimura Hiroaki, Mihara Ban, Suzuki Kentaro, Takayama Yohei, Ishii Akira, Momomura Sin-ichi, Sugawara Hitoshi, Yamashita Takeshi, Kaneko Uichi, Takahashi Toshie, Arai Toshinari, Tanaka Yoshihiro, Inokuma Shigehisa, Kato Yuji, Ishige Naoki, Muramatsu Kazuhiro, Nogawa Shigeru, Yoshizaki Takahito, Ohashi Takashi, Suda Sumio, Iguchi Yasuyuki, Mitsumura Hidetaka, Adachi Tomohide, Konoeda Fumie, Oki Koichi, Tanaka Ryota, Urabe Takao, Yamashiro Kazuo, Ito Akihiro, Nakatomi Hirofumi, Shojima Masaaki, Otsuka Kuniaki, Shibata Koichi, Abe Takato, Itoh Yoshiaki, Suzuki Norihiro, Toi Sono, Teramoto Tamio, Fukunaga Atsushi, Kujuro Yuki, Ohta Kouichi, Osada Takashi, Shimizu Katuyoshi, Kitagawa Yasuhisa, Tokuoka Kentaro, Omura Masao, Kikyo Hideyuki, Kamide Tomoya, Kitamura Yoshihisa, Miyashita Katsuyoshi, Mori Kentaro, Shima Hiroshi, Tamase Akira, Akutsu Tsugio, Nishiyama Kazutoshi, Takizawa Shunya, Uesugi Tsuyoshi, Ikeda Uichi, Koshikawa Megumi, Yamasaki Saeko, Inoue Atsushi, Matsumoto Yasuko, Yamaguchi Kazuyoshi, Hirose Genjirou, Kontani Satoshi, Takasawa Kazuya, Hirahara Katsumi, Kodama Makoto, Yagihara Nobue, Hata Takashi, Hori Makoto, Oda Rokuhei, Kubo Ayuka, Okuda Satoshi, Yamada Kentaro, Takeuchi Hiroki, Araki Yoshio, Ito Mizuki, Senda Joe, Wakabayashi Toshihiko, Ito Shinji, Mutoh Tatsuro, Kawase Yukinori, Ando Fumio, Okamoto Shinya, Shimada Takuya, Shindo Akihiro, Nishikawa Masakatsu, Niwa Atsushi, Sasaki Ryogen, Murata Hiroto, Yata Kenichiro, Matsuo Koushun, Yagi Hideo, Shiogai Toshiyuki, Nagakane Yoshinari, Fujinami Jun, Nakagawa Masanori, Ohara Ryo, Tomii Yasuhiro, Arakawa Yoshiki, Funaki Takeshi, Ihara Masafumi, Kitamura Akihiro, Maki Takakuni, Miyamoto Susumu, Nakaya Yoshifumi, Takahashi Ryosuke, Takenobu Yohei, Yoshida Kazumichi, Ino Tadashi, Murase Nagako, Ohotani Ryo, Kawashima Atsushi, Watanabe Akiko, Hayashi Yuko, Ohmichi Takuma, Yasuda Rei, Yoshioka Akira, Yuki Natsuko, Makino Masahiro, Yamaguchi Tatsuyuki, Matsuzaki Jyo, Niki Hitoshi, Shiraishi Shoichi, Yanagihara Takehiko, Yamada Keiichi, Hatate Jun, Miwa Kaori, Okazaki Shuhei, Arihiro Shoji, Doijiri Ryosuke, Higashida Kyoko, Kajimoto Katsufumi, Miyashita Kotaro, Nagatsuka Kazuyuki, Saito Kozue, Sugiura Yuri, Takizawa Hotake, Torii Takako, Yokota Chiaki, Kajimoto Yoshinaga, Kuroiwa Toshihiko, Fukunaga Ryuzo, Takahashi Tsutomu, Nakao Kazutami, Kajiyama Yuta, Kimura Yasuyoshi, Naka Takashi, Otomune Hironori, Tanahashi Takao, Uehara Takuya, Hashimoto Hiroyuki, Uematsu Toshihiko, Kataoka Kazuo, Okayama Satoshi, Somekawa Satoshi, Yamada Shuichi, Sasaki Rie, Yamano Shigeru, Nakao Naoyuki, Obayashi Shinji, Hamaguchi Hirotoshi, Toda Tatsushi, Washida Kazuo, Hoshi Taku, Kono Tomoyuki, Sekiya Hiroaki, Sugo Norifumi, Todo Kenichi, Togo Masaya, Yamagami Hiroshi, Yamamoto Shiro, Shiro Yoshihiko, Takaoka Toshio, Abe Satoshi, Hamada Chizuko, Ishihara Masaki, Kadota Katuhiko, Nakagawa Tomonori, Oguro Hiroaki, Takayoshi Hiroyuki, Yamaguchi Takuya, Yamaguchi , Shuuhei, Mizuhara Ryo, Okada Kazunori, Yamagata Shingo, Sasaki Akira, Abe Koji, Deguchi Kentaro, Deguchi Shoko, Nakano Yumiko, Hirai Satoshi, Uno Masaaki, Yokosuka Kimihiko, Manabe Yasuhiro, Ito Hijiri, Aoki Shiro, Hosomi Naohisa, Kihara Yasuki, Kisaka Tomohiko, Maruyama Hirofumi, Araki Hayato, Ogami Ryo, Torii Tsuyoshi, Yokoyama Noboru, Yokoyama Takakazu, Kataoka Satoshi, Kitamura Takeshi, Kanda Takashi, Maeda Toshihiko, Shimizu Fumitaka, Seki Kozaburo, Bando Yuko, Ohara Masaki, Yamasaki Masahiro, Masahira Noritaka, Ueba Tetsuya, Ueba Yusuke, Fujimoto Yuichi, Haro Keiko, Ogata Hidenori, Shida Norihiko, Matsumoto Takeshi, Okamoto Kensho, Kawamoto Ryuichi, Arakawa Shuji, Shii Hirofumi, Kanai Hidetoshi, Fujimoto Shigeru, Jinnouchi Juro, Matsuki Takayuki, Osaki Masato, Arakawa Kimika, Ibaraki Ai, Kiyohara Kanako, Ohta Yuko, Oniki Hideyuki, Sakaki Minako, Tominaga Mitsuhiro, Tsuchihashi Takuya, Higashi Saho, Ishikawa Hiromi, Ishitsuka Koji, Kitayama Jiro, Nakane Hiroshi, Yoshimura Takeo, Kakino Shunsuke, Kaneko Yoshirou, Inoue Junnosuke, Maruyama Yoshikazu, Isa Katsunori, Sakima Hirokuni, and Nakada Seigo

Subjects
medicine.medical_specialty, education.field_of_study, business.industry, Standard treatment, Population, medicine.disease, law.invention, 03 medical and health sciences, 0302 clinical medicine, Blood pressure, Randomized controlled trial, law, Relative risk, Internal medicine, Multicenter trial, Number needed to treat, Medicine, 030212 general & internal medicine, Neurology (clinical), business, education, Stroke, 030217 neurology & neurosurgery, Original Investigation
Abstract

Importance The Systolic Blood Pressure Intervention Trial (SPRINT) demonstrated that a systolic blood pressure (BP) target less than 120 mm Hg was superior to less than 140 mm Hg for preventing vascular events. This trial excluded patients with prior stroke; therefore, the ideal BP target for secondary stroke prevention remains unknown. Objective To assess whether intensive BP control would achieve fewer recurrent strokes vs standard BP control. Design, Setting, and Participants Randomized clinical trial (RCT) of standard vs intensive BP control in an intent-to-treat population of patients who had a history of stroke. Patients were enrolled between October 20, 2010, and December 7, 2016. For an updated meta-analysis, PubMed and the Cochrane Central Library database were searched through September 30, 2018, using the Medical Subject Headings and relevant search terms forcerebrovascular diseaseand forintensive BP lowering. This was a multicenter trial that included 140 hospitals in Japan; 1514 patients who had a history of stroke within the previous 3 years were approached, but 234 refused to give informed consent. Interventions In total, 1280 patients were randomized 1:1 to BP control to less than 140/90 mm Hg (standard treatment) (n = 640) or to less than 120/80 mm Hg (intensive treatment) (n = 640). However, 17 patients never received intervention; therefore, 1263 patients assigned to standard treatment (n = 630) or intensive treatment (n = 633) were analyzed. Main Outcomes and Measures The primary outcome was stroke recurrence. Results The trial was stopped early. Among 1263 analyzed patients (mean [SD] age, 67.2 [8.8] years; 69.4% male), 1257 of 1263 (99.5%) completed a mean (SD) of 3.9 (1.5) years of follow-up. The mean BP at baseline was 145.4/83.6 mm Hg. Throughout the overall follow-up period, the mean BP was 133.2/77.7 (95% CI, 132.5-133.8/77.1-78.4) mm Hg in the standard group and 126.7/77.4 (95% CI, 125.9-127.2/73.8-75.0) mm Hg in the intensive group. Ninety-one first recurrent strokes occurred. Nonsignificant rate reductions were seen for recurrent stroke in the intensive group compared with the standard group (hazard ratio [HR], 0.73; 95% CI, 0.49-1.11;P = .15). When this finding was pooled in 3 previous relevant RCTs in a meta-analysis, the risk ratio favored intensive BP control (relative risk, 0.78; 95% CI, 0.64-0.96;P = .02; absolute risk difference, −1.5%; 95% CI, −2.6% to −0.4%; number needed to treat, 67; 95% CI, 39-250). Conclusions and Relevance Intensive BP lowering tended to reduce stroke recurrence. The updated meta-analysis supports a target BP less than 130/80 mm Hg in secondary stroke prevention. Trial Registration ClinicalTrials.gov identifier:NCT01198496

Published
2019

36. Dual Antiplatelet Therapy Using Cilostazol in Patients With Stroke and Intracranial Arterial Stenosis

Author

Uchiyama, Shinichiro, primary, Toyoda, Kazunori, additional, Omae, Katsuhiro, additional, Saita, Ryotaro, additional, Kimura, Kazumi, additional, Hoshino, Haruhiko, additional, Sakai, Nobuyuki, additional, Okada, Yasushi, additional, Tanaka, Kortaro, additional, Origasa, Hideki, additional, Naritomi, Hiroaki, additional, Houkin, Kiyohiro, additional, Yamaguchi, Keiji, additional, Isobe, Masanori, additional, Minematsu, Kazuo, additional, Matsumoto, Masayasu, additional, Tominaga, Teiji, additional, Tomimoto, Hidekazu, additional, Terayama, Yasuo, additional, Yasuda, Satoshi, additional, and Yamaguchi, Takenori, additional

Published
2021
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41. Effect of Simultaneous Dual-Task Training on Regional Cerebral Blood Flow in Older Adults with Amnestic Mild Cognitive Impairment

Author

Kunieda, Yota, Arakawa, Chiaki, Yamada, Takumi, Koyama, Shingo, Suzuki, Mizue, Ishiyama, Daisuke, Yamada, Minoru, Hirokawa, Ryuto, Matsuda, Tadamitsu, Nio, Shintaro, Adachi, Tomohide, Hoshino, Haruhiko, and Fujiwara, Toshiyuki

Abstract

Background: No previous study has examined the effect of dual-task training using changes in regional cerebral blood flow (rCBF) using single-photon emission computed tomography (SPECT) as an outcome. Objective: This study aimed to examine the effects of simultaneous dual-task training of exercise and cognitive tasks on rCBF using SPECT in older adults with amnestic mild cognitive impairment (aMCI). Methods: In this non-randomized control trial, 40 older adults with aMCI participated from May 2016 to April 2018. Outpatients in the intervention group (n = 22) underwent 24 sessions (12 months) of dualtask training twice a month for 60 mins per session. Participants in the control group (n = 18) continued to have regular outpatient visits. The primary outcome was rCBF at baseline and after 12 months, which was compared in each group using the two-sample t-test. The secondary outcomes were the rate of reversion and conversion from aMCI after 12 months. Results: Of the 22 participants in the intervention group, six dropped out; therefore, 16 were included in the analysis. The intervention group showed more significant increases in rCBF in multiple regions, including the bilateral frontal lobes, compared with the control group. However, the rates of reversion or conversion from mild cognitive impairment (MCI) were not significantly different. Conclusion: Dual-task training for older adults with aMCI increased rCBF in the frontal gyrus but did not promote reversion from MCI to normal cognition. Future intervention studies, such as follow-up examinations after the intervention, are warranted to consider long-term prognosis.

Published
2023
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44. Characteristics of Regional Cerebral Blood Flow in Alzheimer Disease and Amnestic Mild Cognitive Impairment by Single-Photon Emission Computerized Tomography: A Cross-Sectional Study

Author

Kunieda, Yota, primary, Arakawa, Chiaki, additional, Yamada, Takumi, additional, Suzuki, Mizue, additional, Koyama, Shingo, additional, Kimura, Yosuke, additional, Ichikawa, Takeo, additional, Shino, Shuhei, additional, Yamada, Minoru, additional, Hirokawa, Ryuto, additional, Matsuda, Tadamitsu, additional, Takakura, Tomokazu, additional, Adachi, Tomohide, additional, and Hoshino, Haruhiko, additional

Published
2021
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49. sj-pdf-1-eso-10.1177_2396987320960618 - Supplemental material for The bleeding with antithrombotic therapy study 2: Rationale, design, and baseline characteristics of the participants

Author

Takagi, Masahito, Tanaka, Kanta, Miwa, Kaori, Sasaki, Makoto, Koga, Masatoshi, Teruyuki Hirano, Kamiyama, Kenji, Yagita, Yoshiki, Nagakane, Yoshinari, Hoshino, Haruhiko, Terasaki, Tadashi, Yakushiji, Yusuke, Kudo, Kohsuke, Ihara, Masafumi, Yoshimura, Sohei, Yamaguchi, Yoshitaka, Shiozawa, Masayuki, and Toyoda, Kazunori

Subjects
FOS: Clinical medicine, Cardiology, Medicine, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-pdf-1-eso-10.1177_2396987320960618 for The bleeding with antithrombotic therapy study 2: Rationale, design, and baseline characteristics of the participants by Masahito Takagi, Kanta Tanaka, Kaori Miwa, Makoto Sasaki, Masatoshi Koga, Teruyuki Hirano, Kenji Kamiyama, Yoshiki Yagita, Yoshinari Nagakane, Haruhiko Hoshino, Tadashi Terasaki, Yusuke Yakushiji, Kohsuke Kudo, Masafumi Ihara, Sohei Yoshimura, Yoshitaka Yamaguchi, Masayuki Shiozawa, Kazunori Toyoda and for BAT2 Investigators in European Stroke Journal

Published
2020
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50. Regional differences in the response to acute blood pressure lowering after cerebral hemorrhage

Author

Toyoda, Kazunori, primary, Palesch, Yuko Y, additional, Koga, Masatoshi, additional, Foster, Lydia, additional, Yamamoto, Haruko, additional, Yoshimura, Sohei, additional, Ihara, Masafumi, additional, Fukuda-Doi, Mayumi, additional, Okazaki, Shuhei, additional, Tanaka, Kanta, additional, Miwa, Kaori, additional, Hasegawa, Yasuhiro, additional, Shiokawa, Yoshiaki, additional, Iwama, Toru, additional, Kamiyama, Kenji, additional, Hoshino, Haruhiko, additional, Steiner, Thorsten, additional, Yoon, Byung-Woo, additional, Wang, Yongjun, additional, Hsu, Chung Y, additional, and Qureshi, Adnan I, additional

Published
2020
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