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192 results on '"Hoshino, Yumi"'

2. Immune‐mediated necrotizing myopathy with concomitant development of Kikuchi–Fujimoto disease.

Author

Ichikawa, Takanori, Furukawa, Ryo, Shimojima, Yasuhiro, Hoshino, Yumi, Kishida, Dai, and Sekijima, Yoshiki

Subjects
MUSCLE diseases, RHEUMATOID arthritis, ORAL drug administration, PREDNISOLONE, MYOSITIS, DERMATOMYOSITIS, TACROLIMUS
Abstract

Immune‐mediated necrotizing myopathy (IMNM) is a distinct type of idiopathic inflammatory myositis, pathologically characterized by myofiber necrosis and degeneration in the absence of lymphocyte infiltration. Herein, we present a case of IMNM with concomitant development of Kikuchi–Fujimoto disease (KFD), characterized by histiocytic necrotizing lymphadenitis, in a 36‐year‐old woman who had a treatment history for rheumatoid arthritis (RA). Treatment with oral prednisolone and tacrolimus as immunosuppressants resulted in the remission of the skeletomuscular involvement and lymphadenopathy. To the best of our knowledge, this is the first report of IMNM and KFD developing concomitantly during the clinical course of RA. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Frontal Encephalocele Plus Epilepsy: A Case Report and Review of the Literature

Author

Yamazaki, Ken, primary, Kanaya, Kohei, additional, Uda, Takehiro, additional, Fukuyama, Tetsuhiro, additional, Nishioka, Makoto, additional, Hoshino, Yumi, additional, Kaneko, Tomoki, additional, Hardian, Ridzky Firmansyah, additional, Yamazaki, Daisuke, additional, Kuwabara, Haruki, additional, Funato, Kohei, additional, and Horiuchi, Tetsuyoshi, additional

Published
2023
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15. Protein kinase B (PKB/Akt) is required for the completion of meiosis in mouse oocytes

Author

Hoshino, Yumi and Sato, Eimei

Subjects
Protein kinases, Biological sciences
Abstract

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ydbio.2007.12.005 Byline: Yumi Hoshino, Eimei Sato Keywords: Akt/protein kinase B; Mouse oocyte; Meiotic maturation; Fertilization; Spindle; Polar body emission; SH-6/Akt inhibitor III; Peptide; Microinjection Abstract: Akt, also known as protein kinase B, is implicated in many cellular processes. Akt is phosphorylated at two residues, Thr308 and Ser473. Thr308-phosphorylated Akt is present in pericentriolar materials, while localization of Ser473-phosphorylated Akt was similar to that of microtubules in metaphase oocytes. Spindles were shorter and aberrant in oocytes injected with Thr308- or Ser473-phosphorylated Akt antibodies. Specifically, Thr308- and Ser473-phosphorylated Akts function individually and are both necessary to assemble the metaphase II (MII) spindle. Moreover, the functions of Thr308- and Ser473-phosphorylated Akts differ in MII oocytes. Although oocytes exhibited second polar body (PB2) emission after the injection of a peptide for Thr308, the chromosomal alignment and microtubular organization were aberrant. In contrast, the injection of a peptide for Ser473 caused a failure of PB2 emission. These results suggest that Thr308- and Ser473-phosphorylated Akts are individually involved in fertilization to complete meiosis, including different roles (i.e., Ser473-phosphorylated Akts are involved in PB2 emission, whereas Thr308-phosphorylated Akts regulate the organization of microtubules). Author Affiliation: Laboratory of Animal Reproduction, Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555, Japan Article History: Received 10 July 2007; Revised 22 November 2007; Accepted 4 December 2007

Published
2008

24. Proliferation and Differentiation of Mouse Spermatogonial Stem Cells on a Three-Dimensional Surface Composed of PCL/Gel Nanofibers

Author

Talebi, Ali, Sadighi-Gilani, Mohammad Ali, Koruji, Morteza, Ai, Jafar, Navid, Shadan, Rezaie, Mohammad Jafar, Jabari, Ayob, Ashouri-Movassagh, Sepideh, Khadivi, Farnaz, Salehi, Majid, Hoshino, Yumi, and Abbasi, Mehdi

Subjects
Polycaprolactone, Male infertility, nanofibras, Adult germline stem cell, Cell differentiation, Nanofibers, Policaprolactona, Célula madre adulta de la línea germinal, Infertilidad masculina, Diferenciación celular
Abstract

SUMMARY: Spermatogonial stem cells (SSCs) have self-renewal and differentiation capacity essential for sperm production throughout the male reproductive life. The electrospun polycaprolactone/gelatin (PCL/Gel) nanofibrous scaffold mimics important features of the extracellular matrix (ECM), which can provide a promising technique for the proliferation and differentiation of SSCs in vitro. The goal of the present study was to investigate the effects of PCL/Gel nanofibrous scaffold on the propagation and differentiation of neonate mouse SSCs (mSSCs). mSSCs were enzymatically isolated, and the cells were purified by differential plating method and seeded on scaffold. After 2 weeks, viability, colony number and diameter, and expression of specific spermatogonial cell genes were investigated. After mSSCs propagation, the cells were cultivated in a differentiation medium on the scaffold for another 2 weeks, and differentiating cells were analyzed by real-time PCR. The number of mSSC colony (P

Published
2019

27. Requirement for nuclear autoantigenic sperm protein mRNA expression in bovine preimplantation development

Author

Nagatomo, Hiroaki, Kohri, Nanami, Akizawa, Hiroki, Hoshino, Yumi, Yamauchi, Nobuhiko, Kono, Tomohiro, Takahashi, Masashi, and Kawahara, Manabu

Subjects
knockdown, bovine embryo, NASP
Abstract

Nuclear autoantigenic sperm protein (NASP) is associated with DNA replication, cell proliferation, and cell cycle progression through its specific binding to histones. The aim of this study was to examine the roles of NASP in bovine preimplantation embryonic development. Using NASP gene knockdown (KD), we confirmed the reduction of NASP messenger RNA (mRNA) expression during preimplantation development. NASP KD did not affect cleavage but significantly decreased development of embryos into the blastocyst stage. Furthermore, blastocyst hatching was significantly decreased in NASP KD embryos. Cell numbers in the inner cell mass of NASP KD blastocysts were also decreased compared to those of controls. These results suggest that NASP mRNA expression is required for preimplantation development into the blastocyst stage in cattle.

Published
2016

28. Updating the markers for oocyte quality evaluation: intracellular temperature as a new index

Author

Hoshino, Yumi

Subjects
0301 basic medicine, lcsh:RC648-665, lcsh:QH471-489, Oocyte selection, temperature, Embryo, Review Article, Cell Biology, Biology, Oocyte, lcsh:Diseases of the endocrine glands. Clinical endocrinology, Cell biology, 03 medical and health sciences, Polar body, 030104 developmental biology, medicine.anatomical_structure, Reproductive Medicine, medicine, meiosis, lcsh:Reproduction, assisted reproductive techniques, oocyte, Review Articles, Intracellular
Abstract

Background The developmental competence of an embryo is principally dictated by the oocyte. Usually, oocyte selection is based on morphological properties; however, all morphological criteria that are currently used for the grading and screening of oocytes are not able to eliminate the subjectivity. Despite recent studies of the molecular factors related to oocyte quality, it is technically difficult to develop an index based on these factors, and new indices that reflect intracellular conditions are necessary. Methods Morphological and molecular factors influencing developmental competence were comprehensively reviewed, and intracellular temperature was evaluated as a new marker of oocyte quality. Main findings The intracellular temperature of mature oocytes was high in fresh oocytes and decreased with time after polar body release. Under the same conditions, the intracellular temperature and its distribution differed among oocytes, suggesting that temperature represents the state of each oocyte. Conclusion Intracellular temperature is advantageous as an objective and quantitative indicator of oocyte quality. Further studies should evaluate the link between temperature and cellular phenomena to establish its use as an indicator of quality.

Published
2018

29. Proliferation and Differentiation of Mouse Spermatogonial Stem Cells on a Three-Dimensional Surface Composed of PCL/Gel Nanofibers

Author

Talebi, Ali, primary, Sadighi-Gilani, Mohammad Ali, additional, Koruji, Morteza, additional, Ai, Jafar, additional, Navid, Shadan, additional, Rezaie, Mohammad Jafar, additional, Jabari, Ayob, additional, Ashouri-Movassagh, Sepideh, additional, Khadivi, Farnaz, additional, Salehi, Majid, additional, Hoshino, Yumi, additional, and Abbasi, Mehdi, additional

Published
2019
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33. Selection of In Vitro-Matured Porcine Oocytes Based on Localization Patterns of Lipid Droplets to Evaluate Developmental Competence

Author

HIRAGA, Kou, HOSHINO, Yumi, TANEMURA, Kentaro, and SATO, Eimei

Subjects
Microscopy, Confocal, Swine, Porcine oocyte, Oocytes, Animals, Embryonic Development, Lipid droplet, Female, Fertilization in Vitro, Technology Report, Lipid Metabolism, Novel marker, In Vitro Oocyte Maturation Techniques
Abstract

Localization patterns of lipid droplets in the cytoplasm of porcine oocytes were evaluated as a novel marker for in vitro maturation (IVM) of oocytes with high developmental competence. Porcine oocytes were cultured in TCM-199, which is a complete synthetic medium, for 44 h at 38.5 C. Localization patterns were divided into 2 classes: lipid droplets localized uniformly in the whole cytoplasm (class I) and those that were centrally located (class II). After IVM in TCM-199, 60% of matured oocytes exhibited the class II pattern. To investigate the relation between the distribution of lipid droplets and the developmental rate of the oocyte, the developmental rates of class I and class II oocytes were compared after in vitro fertilization (IVF). Class II oocytes showed a significantly higher rate of blastocyst development than class I oocytes. These results suggest that porcine oocytes with high developmental competence can be selected based on the localization patterns of lipid droplets.

Published
2013

35. Cover Image, Volume 118, Number 3, March 2017

Author

Fukuda, Tomokazu, primary, Tani, Tetsuya, additional, Haraguchi, Seiki, additional, Donai, Kenichiro, additional, Nakajima, Nobuyoshi, additional, Uenishi, Hirohide, additional, Eitsuka, Takahiro, additional, Miyagawa, Makoto, additional, Song, Sanghoun, additional, Onuma, Manabu, additional, Hoshino, Yumi, additional, Sato, Eimei, additional, and Honda, Arata, additional

Published
2017
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37. Expression of Six Proteins Causes Reprogramming of Porcine Fibroblasts Into Induced Pluripotent Stem Cells With Both Active X Chromosomes

Author

Fukuda, Tomokazu, primary, Tani, Tetsuya, additional, Haraguchi, Seiki, additional, Donai, Kenichiro, additional, Nakajima, Nobuyoshi, additional, Uenishi, Hirohide, additional, Eitsuka, Takahiro, additional, Miyagawa, Makoto, additional, Song, Sanghoun, additional, Onuma, Manabu, additional, Hoshino, Yumi, additional, Sato, Eimei, additional, and Honda, Arata, additional

Published
2016
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49. Distribution of tubulointerstitial nephritis antigen-like 1 and structural matrix proteins in mouse embryos during preimplantation developmentin vivoandin vitro

Author

Sakurai, Masahiro, primary, Sato, Yusuke, additional, Mukai, Kuniaki, additional, Suematsu, Makoto, additional, Fukui, Emiko, additional, Yoshizawa, Midori, additional, Tanemura, Kentaro, additional, Hoshino, Yumi, additional, Matsumoto, Hiromichi, additional, and Sato, Eimei, additional

Published
2012
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