1. Profile of exposures and lung function in adults with asthma: An exposome approach in the EGEA study
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Christophe Pison, Raphaëlle Varraso, Judith Garcia-Aymerich, Jean-Louis Pépin, Valérie Siroux, Bruno Degano, Isabelle Pin, Emie Seyve, Orianne Dumas, Nicole Le Moual, Alicia Guillien, Johanna Lepeule, Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Université Grenoble Alpes (UGA), Vieillissement et Maladies chroniques : approches épidémiologique et de santé publique (VIMA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil (UVSQ Santé), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Hypoxie : Physiopathologie Respiratoire et Cardiovasculaire (HP2), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), Instituto de Salud Global - Institute For Global Health [Barcelona] (ISGlobal), CIBER de Epidemiología y Salud Pública (CIBERESP), Laboratory of Fundamental and Applied Bioenergetics = Laboratoire de bioénergétique fondamentale et appliquée (LBFA), ANR Investissements d'avenir (ANR-15-IDEX-02), This work was supported in part by the Hospital Program of Clinical Research (PHRC)–Paris, PHRC-Grenoble, National PHRC 2012, the scientific committee 'AGIR pour les Maladies Chroniques' Merck Sharp & Dohme (MSD), the GA2LEN project (Global Allergy and Asthma European Network) and ANR 'Investissements d'avenir' (ANR-15-IDEX-02). ISGlobal is a member of CERCA Programme/Generalitat de Catalunya. Funding sources had no involvement in study design, the collection, analysis and interpretation of data, in the writing of the report, and the decision to submit the article for publication., BARBAGALLO, Maïlys, and Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)
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[SDE] Environmental Sciences ,Adult ,Male ,medicine.medical_specialty ,Exposome ,010501 environmental sciences ,01 natural sciences ,Biochemistry ,[SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract ,Atopy ,03 medical and health sciences ,0302 clinical medicine ,Environmental health ,Forced Expiratory Volume ,Epidemiology ,medicine ,Humans ,030212 general & internal medicine ,Lung ,Lung function ,0105 earth and related environmental sciences ,General Environmental Science ,Asthma ,Bayesian profile regression ,Heavy smoking ,business.industry ,Bayes Theorem ,Environmental Exposure ,medicine.disease ,Uncorrelated ,3. Good health ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,Bronchial hyperresponsiveness ,[SDE]Environmental Sciences ,[SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract ,Female ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,business - Abstract
International audience; Background: Environmental research on multifactorial health outcomes calls for exposome approaches able to assess the joint effect of multiple exposures.Objective: Our aim was to identify profiles of exposure to lifestyle/environmental factors associated with lung function in adults with asthma using a cluster-based approach.Methods: We used data from 599 adults of the Epidemiological study on the Genetics and Environment of Asthma, bronchial hyperresponsiveness and atopy (EGEA) (mean age 39.0 years, 52% men) who ever had asthma. Exposures to 53 lifestyle/environmental factors were assessed by questionnaires or geographic information systems-based models. A two-step approach was developed: 1) exposome dimension reduction by selecting factors showing association with forced expiratory volume in 1 s (FEV1) (p < 0.20) in an exposome-wide association study (ExWAS), 2) clustering analysis using the supervised Bayesian Profile Regression (sBPR) to group individuals according to FEV1 level and to their profile of exposure to a reduced set of uncorrelated exposures (each paired correlation
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- 2020