Search

Your search keyword '"Hossain, Mahboob"' showing total 22 results
Start Over Author "Hossain, Mahboob"
22 results on '"Hossain, Mahboob"'

2. In-silico formulation of a next-generation polyvalent vaccine against multiple strains of monkeypox virus and other related poxviruses.

Author

Moin, Abu Tayab, Rani, Nurul Amin, Patil, Rajesh B., Robin, Tanjin Barketullah, Ullah, Md. Asad, Rahim, Zahidur, Rahman, Md. Foyzur, Zubair, Talha, Hossain, Mohabbat, Mollah, A. K. M. Moniruzzaman, Absar, Nurul, Hossain, Mahboob, Manchur, Mohammed Abul, and Islam, Nazneen Naher

Subjects
MONKEYPOX, T cells, SMALLPOX, VIRAL vaccines, VACCINES, B cells, POXVIRUSES
Abstract

Mpox (formerly known as monkeypox) virus and some related poxviruses including smallpox virus pose a significant threat to public health, and effective prevention and treatment strategies are needed. This study utilized a reverse vaccinology approach to retrieve conserved epitopes for monkeypox virus and construct a vaccine that could provide cross-protection against related viruses with similar antigenic properties. The selected virulent proteins of monkeypox virus, MPXVgp165, and Virion core protein P4a, were subjected to epitope mapping for vaccine construction. Two vaccines were constructed using selected T cell epitopes and B cell epitopes with PADRE and human beta-defensins adjuvants conjugated in the vaccine sequence. Both constructs were found to be highly antigenic, non-allergenic, nontoxic, and soluble, suggesting their potential to generate an adequate immune response and be safe for humans. Vaccine construct 1 was selected for molecular dynamic simulation studies. The simulation studies revealed that the TLR8-vaccine complex was more stable than the TLR3-vaccine complex. The lower RMSD and RMSF values of the TLR8 bound vaccine compared to the TLR3 bound vaccine suggested better stability and consistency of hydrogen bonds. The Rg values of the vaccine chain bound to TLR8 indicated overall stability, whereas the vaccine chain bound to TLR3 showed deviations throughout the simulation. These results suggest that the constructed vaccine could be a potential preventive measure against monkeypox and related viruses however, further experimental validation is required to confirm these findings. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

3. Polyethylene, Low-Densitypolyethylene, and Expanded Polystyrene Bioremediation Using Zophobas Morio Reared in Dhaka, Bangladesh and Whole Genome Analysis of Potential Plastic Degrading Pseudomonas Aeruginosa Isolated from the Larvae Frass

Author

Zaman, Ifthikhar, primary, Turjya, Rafeed Rahman, additional, Shakil, Md Salman, additional, Shahariar, Mahruf Al, additional, Howlader, MD. Rezanur Rahman, additional, Ahmed, Akash, additional, and Hossain, Mahboob, additional

Published
2023
Full Text
View/download PDF

22. A Survey on Antimicrobial Sensitivity Pattern of Different Antibiotics on Clinical Isolates of Escherichia coli Collected from Dhaka City, Bangladesh.

Author

Shahriar, Mohammad, Hossain, Mahboob, and Kabir, Shaila

Abstract

A study of antimicrobial sensitivity of Escherichia coli isolated from clinical sources of Medinova Diagnostic Center and Popular Diagnostic Center, Dhaka, Bangladesh was carried out to facilitate the preference of drug in the management of Escherichia coli induced symptoms. Very low sensitivity of E. coli towards ampicillin (4%), aztreonam (4%), cloxacillin (5%), nalidixic acid (5%), ciprofloxacin (7.5%), ceftriaxone (12.5%), doxycycline (12.5%), ceftazidime (16.25%), co-trimoxazole (20%), chloramphenicol (22.51%), tetracycline (25%), and netilmicin (35%) was observed. Higher sensitivity pattern was observed for gentamicin (56%) and only imipenem (95%) has shown sensitivity pattern possibly susceptible enough to consider for the management of E. coli induced cases in the area under study. The low sensitivity to different antimicrobial could be attributed to their prevailing usage and abuse in the area under study. [ABSTRACT FROM AUTHOR]

Published
2010

Catalog

Books, media, physical & digital resources
See catalog results