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The objective of this study was to investigate the association between depression and anxiety and adolescents' smoking status, and to determine whether depression or anxiety mediate the association between Attention Deficit Hyperactivity Disorder (ADHD) and smoking. A cross-sectional survey of tobacco use was conducted in regional school districts located outside the Greater Vancouver area of British Columbia, Canada. The sample included 6,943 students. Having taken medications for depression, anxiety, or ADHD; ethnicity/race; and parental, peer, and sibling smoking status were significantly associated with smoking status. ADHD was significantly associated with depression and anxiety. In multivariate analysis, although depression/anxiety and ADHD were found to be significant correlates of regular smoking when each variable was independently included in a multinomial logistic regression model, ADHD did not remain significant when it was included with depression/anxiety. Depression and anxiety may mediate the relationship between ADHD and smoking.

Presence of detection limit (DL) in covariates causes inflated bias and inaccurate mean squared error to the estimators of the regression parameters. This paper suggests a response-driven multiple imputation method to correct the deleterious impact introduced by the covariate DL in the estimators of the parameters of simple logistic regression model. The performance of the method has been thoroughly investigated, and found to outperform the existing competing methods. The proposed method is computationally simple and easily implementable by using three existing R libraries. The method is robust to the violation of distributional assumption for the covariate of interest. [ABSTRACT FROM AUTHOR]

This article investigates the performance of the shrinkage estimator (SE) of the parameters of a simple linear regression model under the LINEX loss criterion. The risk function of the estimator under the asymmetric LINEX loss is derived and analyzed. The moment-generating functions and the first two moments of the estimators are also obtained. The risks of the SE have been compared numerically with that of pre-test and least-square estimators (LSEs) under the LINEX loss criterion. The numerical comparison reveals that under certain conditions the LSE is inadmissible, and the SE is the best among the three estimators. [ABSTRACT FROM AUTHOR]

In this article, we propose a flexible parametric (FP) approach for adjusting for covariate measurement errors in regression that can accommodate replicated measurements on the surrogate (mismeasured) version of the unobserved true covariate on all the study subjects or on a sub-sample of the study subjects as error assessment data. We utilize the general framework of the FP approach proposed by Hossain and Gustafson in 2009 for adjusting for covariate measurement errors in regression. The FP approach is then compared with the existing non-parametric approaches when error assessment data are available on the entire sample of the study subjects (complete error assessment data) considering covariate measurement error in a multiple logistic regression model. We also developed the FP approach when error assessment data are available on a sub-sample of the study subjects (partial error assessment data) and investigated its performance using both simulated and real life data. Simulation results reveal that, in comparable situations, the FP approach performs as good as or better than the competing non-parametric approaches in eliminating the bias that arises in the estimated regression parameters due to covariate measurement errors. Also, it results in better efficiency of the estimated parameters. Finally, the FP approach is found to perform adequately well in terms of bias correction, confidence coverage, and in achieving appropriate statistical power under partial error assessment data. [ABSTRACT FROM PUBLISHER]