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1,139 results on '"Hosseini, Mahmoud"'

41. Cardioprotective effect of cedrol in an inflammation systemic model induced by lipopolysaccharide: Biochemical and histological verification.

Author

Rastegar-Moghaddam, Seyed Hamidreza, Amirahmadi, Sabiheh, Akbarian, Mahsan, Sharizina, Matin, Beheshti, Farimah, Rajabian, Arezoo, Eshaghi Ghalibaf, Mohammad Hosein, Azimi, Mohaddeseh, Mahmoudabady, Maryam, and Hosseini, Mahmoud

Subjects
INFLAMMATION prevention, ANTI-inflammatory agents, SUPEROXIDE dismutase, RESEARCH funding, INTRAPERITONEAL injections, CARDIOMYOPATHIES, TERPENES, CARDIOTONIC agents, HEART, OXIDATIVE stress, CATALASE, BIOCHEMISTRY, FIBROSIS, RATS, LIPID peroxidation (Biology), ANTIOXIDANTS, ANIMAL experimentation, HISTOLOGICAL techniques, STAINS & staining (Microscopy), MALONDIALDEHYDE, INTERLEUKINS, BIOMARKERS, PHARMACODYNAMICS
Abstract

Introduction: Evidence declared lipopolysaccharide (LPS) initiates inflammatory responses by stimulating the abandon of cytokines, which may perturb organ function. On the other side, it has been suggested Cedrol has potential properties, including anti-inflammatory and anti-oxidative activities. Herein, this study was done to assess the protective effect of Cedrol against LPS-associated heart damage. Methods: Thirty-five rats (200-250 g) were sorted into five groups, including control, LPS, LPS-Cedrol 7.5 mg/kg, LPS-Cedrol 15 mg/kg, and LPS-Cedrol 30 mg/kg groups. Cedrol was administrated through injected intra-peritoneally for two weeks. The heart tissues were removed and malondialdehyde (MDA) as a lipid peroxidation marker, superoxide dismutase (SOD), and catalase (CAT) as antioxidant markers were assessed. Furthermore, the interleukin (IL)-6 level in cardiac tissue was measured and Masson's trichrome methods were employed to appraise cardiac inflammation and fibrosis, respectively. Results: Inflammation induced by LPS was significantly accompanied by myocardial fibrosis which was shown by Masson's trichrome staining (P < 0.001). In addition, LPS administration enhanced the MDA level while it diminished the activity of anti-oxidant markers such as CAT and SOD (P < 0.001 for all cases). In the histological results, Cedrol improved LPS-induced inflammation and cardiac fibrosis (P < 0.01 to P< 0.001). Cedrol also enhanced CAT and SOD activities, whereas declined MDA level in the cardiac tissue (P < 0.01 to P< 0.001). Conclusion: The current findings proposed that the administration of Cedrol exerted a protective role in LPS-associated heart damage by reducing inflammation, cardiac fibrosis, and oxidative stress. [ABSTRACT FROM AUTHOR]

Published
2024
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42. Clemastine as a Main Sedative Drug in Colonoscopy.

Author

Eshagh Hosseini, Mohammad Mehdi, Oghalaie, Akbar, Oghalaie, Milad, Kazemi-Lomedasht, Fatemeh, and Hosseini, Mahmoud Eshagh

Subjects
HETEROCYCLIC compounds, COMBINATION drug therapy, PAIN measurement, OXYGEN saturation, RESEARCH funding, STATISTICAL sampling, MIDAZOLAM, DESCRIPTIVE statistics, HEMODYNAMICS, RANDOMIZED controlled trials, ANALGESIA, PRE-tests & post-tests, DRUG efficacy, DIASTOLIC blood pressure, SYSTOLIC blood pressure, PULSE (Heart beat), COMPARATIVE studies, COLONOSCOPY, FENTANYL
Abstract

Background: Colonoscopy is the endoscopic examination of the large bowel and the distal part of the small bowel with a CCD camera or a fiber-optic camera on a flexible tube passed through the anus. It can provide a visual diagnosis. Methods: In this study, clemastine plus fentanyl was compared with fentanyl plus midazolam in analgesia during colonoscopy. Patients were monitored for pain and hemodynamic changes. The mean age in the group treated with clemastine was 52 years and in the group treated with midazolam was 54 years. There were 56 males and 35 females in the study. There was no significant difference in gender in the two groups. Systolic blood pressure was 109.9 mmHg before and 109.35 mmHg after clemastine administration, which showed no significant difference. Results: Diastolic blood pressure was 72.2 mmHg before and 73.7 mmHg after clemastine administration, which showed no significant difference. No change in mean pulse rate (PR) was seen (84/min before and after clemastine administration). In the group receiving midazolam, systolic and diastolic blood pressure changes were not significant, but changes in PR and arterial oxygen saturation were significantly different. Meanwhile, the two groups had a significant lower pain level after colonoscopy in the group receiving clemastine compared to midazolam. Conclusion: Based on the results of the present study, clemastine can be used as a main drug for sedation during colonoscopy. [ABSTRACT FROM AUTHOR]

Published
2024
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