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317 results on '"Hotter G"'

9. Production of avirulent mutants of Mycobacterium bovis with vaccine properties by the use of illegitimate recombination and screening of stationary-phase cultures

Author

Collins, D. M., Wilson, T., Campbell, S., Buddle, B. M., Wards, B. J., Hotter, G., and De Lisle, G. W.

Subjects
Microbiological research -- Analysis, Mycobacterium bovis -- Genetic aspects, Mycobacterium bovis -- Physiological aspects, Gene mutations -- Physiological aspects, Virulence (Microbiology) -- Research, Virulence (Microbiology) -- Genetic aspects, Vaccines -- Physiological aspects, Tuberculosis -- Causes of, Biological sciences
Abstract

Research has been conducted on Mycobacterium bovis illegitimate mutants. The screening of these mutants has been carried out via the use of the fragment made from another M. bovis gene and the results are reported.

Published
2002

20. Hepatic involvement in pancreatitis-induced lung damage

Author

Closa, D., Bardaji, M., Hotter, G., Prats, N., Gelpi, E., Fernandez-Cruz, L., and Rosello-Catafau, J.

Subjects
Lungs -- Inflammation, Liver -- Physiological aspects, Pancreatitis -- Physiological aspects, Biological sciences
Abstract

The liver participates in acute pancreatitis-induced inflammatory changes in lung arachidonic acid metabolism and oxidative stress. Histopathological analysis indicates that liver activation enhances plasma phospholipase A2 activity. Lung prostacyclin and thromboxane B2 synthesis increase, whereas lung superoxide dismutase activity reduces, 12 hrs after the initiation of pancreatitis. The portocaval shunt inhibits metabolic alterations and improves inflammatory activities in lungs.

Published
1996

26. Urinary neuropilin-1 : A predictive biomarker for renal outcome in lupus nephritis

Author

Torres-Salido, Maria Teresa, Sanchis, M., Solé, Cristina, Moliné, Teresa, Vidal, Marta, Vidal Guitart, Xavier., Solà, Anna, Hotter, G., Ordi-Ros, Josep, Cortés-Hernández, Josep, Universitat Autònoma de Barcelona, Instituto de Salud Carlos III, Fundación Bosch i Gimpera, Fundació Catalana de Lupus, [Torres-Salido MT] Internal Medicine Department, Hospital Quironsalud del Vallés, Sabadell, Spain. [Sanchis M, Solé C, Ordi-Ros J, Cortés-Hernández J] Unitat del Lupus, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Grup de Recerca en Reumatologia, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Moliné T, Vidal M] Servei de Patologia Renal, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Vidal X] Servei Farmacologia Clínica, Fundació Institut Català de Farmacologia, Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain., and Vall d'Hebron Barcelona Hospital Campus

Subjects
0301 basic medicine, Male, aminoácidos, péptidos y proteínas::proteínas::proteínas de membranas::receptores de superficie celular::neuropilinas::neuropilina-1 [COMPUESTOS QUÍMICOS Y DROGAS], Biopsy, T-Lymphocytes, Lupus nephritis, Gene Expression, clinical responder, lcsh:Chemistry, chemistry.chemical_compound, 0302 clinical medicine, Cell Movement, Medicine, urinary biomarker, lcsh:QH301-705.5, Spectroscopy, Immune System Diseases::Autoimmune Diseases::Lupus Erythematosus, Systemic::Lupus Nephritis [DISEASES], Kidney, Proteinuria, medicine.diagnostic_test, General Medicine, Middle Aged, Prognosis, Immunohistochemistry, Computer Science Applications, medicine.anatomical_structure, 030220 oncology & carcinogenesis, enfermedades del sistema inmune::enfermedades autoinmunes::lupus eritematoso sistémico::nefritis lúpica [ENFERMEDADES], Marcadors bioquímics, Biomarker (medicine), Female, Renal biopsy, medicine.symptom, Adult, medicine.medical_specialty, Prognosi, Urinary system, Urology, Catalysis, Article, Inorganic Chemistry, 03 medical and health sciences, renal biopsy, Lupus eritematós sistèmic, Humans, RNA, Messenger, Physical and Theoretical Chemistry, Diagnosis::Prognosis [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], Molecular Biology, Cell Proliferation, lupus nephritis, Creatinine, business.industry, Organic Chemistry, Glomerulosclerosis, Clinical responder, medicine.disease, Neuropilin-1, Patient Outcome Assessment, 030104 developmental biology, neuropilin-1, chemistry, lcsh:Biology (General), lcsh:QD1-999, ROC Curve, Urinary biomarker, business, Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Neuropilins::Neuropilin-1 [CHEMICALS AND DRUGS], Biomarkers, Diagnóstico::Pronóstico [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS]
Abstract

At present, Lupus Nephritis (LN) is still awaiting a biomarker to better monitor disease activity, guide clinical treatment, and predict a patient’s long-term outcome. In the last decade, novel biomarkers have been identified to monitor the disease, but none have been incorporated into clinical practice. The transmembrane receptor neuropilin-1 (NRP-1) is highly expressed by mesangial cells and its genetic deletion results in proteinuric disease and glomerulosclerosis. NRP-1 is increased in kidney biopsies of LN. In this work we were interested in determining whether urinary NRP-1 levels could be a biomarker of clinical response in LN. Our results show that patients with active LN have increased levels of urinary NRP-1. When patients were divided according to clinical response, responders displayed higher urinary and tissue NRP-1 levels at the time of renal biopsy. Areas under the receiver operating characteristic curve, comparing baseline creatinine, proteinuria, urinary NRP-1, and VEGFA protein levels, showed NRP-1 to be an independent predictor for clinical response. In addition, in vitro studies suggest that NRP-1could promote renal recovery through endothelial proliferation and migration, mesangial migration and local T cell cytotoxicity. Based on these results, NRP-1 may be used as an early prognostic biomarker in LN., This work was supported by grants from the Spain Government (Instituto de Salud Carlos III). This research also received donations from Catalan Lupus Foundation and A.Bosch Foundation.

Published
2019

33. Campylobacter jejuni colonization and population structure in urban populations of ducks and starlings in New Zealand

Author

Mohan, V, Stevenson, M, Marshall, J, Fearnhead, P, Holland, BR, Hotter, G, French, NP, Mohan, V, Stevenson, M, Marshall, J, Fearnhead, P, Holland, BR, Hotter, G, and French, NP

Abstract

A repeated cross-sectional study was conducted to determine the prevalence of Campylobacter spp. and the population structure of C. jejuni in European starlings and ducks cohabiting multiple public access sites in an urban area of New Zealand. The country's geographical isolation and relatively recent history of introduction of wild bird species, including the European starling and mallard duck, create an ideal setting to explore the impact of geographical separation on the population biology of C. jejuni, as well as potential public health implications. A total of 716 starling and 720 duck fecal samples were collected and screened for C. jejuni over a 12 month period. This study combined molecular genotyping, population genetics and epidemiological modeling and revealed: (i) higher Campylobacter spp. isolation in starlings (46%) compared with ducks (30%), but similar isolation of C. jejuni in ducks (23%) and starlings (21%), (ii) significant associations between the isolation of Campylobacter spp. and host species, sampling location and time of year using logistic regression, (iii) evidence of population differentiation, as indicated by FST , and host-genotype association with clonal complexes CC ST-177 and CC ST-682 associated with starlings, and clonal complexes CC ST-1034, CC ST-692, and CC ST-1332 associated with ducks, and (iv) greater genetic diversity and genotype richness in ducks compared with starlings. These findings provide evidence that host-associated genotypes, such as the starling-associated ST-177 and ST-682, represent lineages that were introduced with the host species in the 19th century. The isolation of sequence types associated with human disease in New Zealand indicate that wild ducks and starlings need to be considered as a potential public health risk, particularly in urban areas.

Published
2013

35. AKI - experimental models

Author

Lai, C.-F., primary, Lin, S.-L., additional, Chiang, W.-C., additional, Chen, Y.-M., additional, Kuo, M.-L., additional, Tsai, T.-J., additional, Hwang, H. S., additional, Choi, Y. A., additional, Park, K. C., additional, Yang, K. J., additional, Choi, H. S., additional, Kim, S. H., additional, Lee, S. J., additional, Chang, Y. K., additional, Kim, S. Y., additional, Yang, C. W., additional, Xiujuan, Z., additional, Yoshimura, R., additional, Matsuyama, M., additional, Chargui, J., additional, Touraine, J.-L., additional, Yoshimura, N., additional, Zulkarnaev, A. B., additional, Vasilenko, I. A., additional, Artemov, D. V., additional, Vatazin, A. V., additional, Park, S. K., additional, Kang, K. P., additional, Lee, S., additional, Kim, W., additional, Schneider, R., additional, Betz, B., additional, Moller-Ehrlich, K., additional, Wanner, C., additional, Sauvant, C., additional, Park, C. W., additional, Sohotnik, R., additional, Nativ, O., additional, Abbasi, A., additional, Awad, H., additional, Frajewicki, V., additional, Armaly, Z., additional, Heyman, S. N., additional, Abassi, Z., additional, Chen, P. Y., additional, Chen, B. L., additional, Yang, C. C., additional, Chiang, C. K., additional, Liu, S. H., additional, Abozahra, A. E., additional, Abd-Elkhabir, A. A., additional, Shokeir, A., additional, Hussein, A., additional, Awadalla, A., additional, Barakat, N., additional, Abdelaziz, A., additional, Yamaguchi, J., additional, Tanaka, T., additional, Eto, N., additional, Nangaku, M., additional, Quiros, Y., additional, Lopez-Hernandez, F. J., additional, Perez de Obanos, M. P., additional, Ruiz, J., additional, Lopez-Novoa, J. M., additional, Shin, H.-S., additional, Kim, M.-J., additional, Choi, Y.-J., additional, Ryu, E.-S., additional, Choi, H.-S., additional, Kang, D.-H., additional, Jankauskas, S. S., additional, Pevzner, I. B., additional, Zorova, L. D., additional, Babenko, V. A., additional, Morosanova, M. A., additional, Plotnikov, E. Y., additional, Zorov, D. B., additional, Huang, C.-Y., additional, Huang, T.-M., additional, Wu, V.-C., additional, Young, G.-H., additional, Chupyrkina, A. A., additional, Zorov, S. D., additional, Grande, J. P., additional, Hartono, S. P., additional, Knudsen, B. E., additional, Mederle, K., additional, Castrop, H., additional, Hocherl, K., additional, Iwakura, T., additional, Fujikura, T., additional, Ohashi, N., additional, Yasuda, H., additional, Fujigaki, Y., additional, Matsui, I., additional, Hamano, T., additional, Inoue, K., additional, Obi, Y., additional, Nakano, C., additional, Kusunoki, Y., additional, Tsubakihara, Y., additional, Rakugi, H., additional, Isaka, Y., additional, Shimomura, A., additional, Wallentin Guron, C., additional, Nguy, L., additional, Lundgren, J., additional, Grimberg, E., additional, Kashioulis, P., additional, Guron, G., additional, DiBona, G. F., additional, Nedergaard Mikkelsen, M., additional, Marcussen, N., additional, Saeed, A., additional, Edvardsson, K., additional, Lindberg, K., additional, Larsson, T., additional, Ito, K., additional, Nakashima, H., additional, Watanabe, M., additional, Abe, Y., additional, Ogahara, S., additional, Saito, T., additional, Albertoni, G., additional, Borges, F., additional, Schor, N., additional, Beresneva, O. N., additional, Parastayeva, M. M., additional, Kucher, A. G., additional, Ivanova, G. T., additional, Shved, N., additional, Rybakova, M. G., additional, Kayukov, I. G., additional, Smirnov, A. V., additional, Chen, J.-F., additional, Ni, H.-F., additional, Pan, M.-M., additional, Liu, H., additional, Xu, M., additional, Zhang, M.-H., additional, Liu, B.-C., additional, Kim, Y., additional, Choi, B. S., additional, Kim, Y. S., additional, Han, J. S., additional, Reis, L. A., additional, Christo, J. S., additional, Simoes, M. d. J., additional, Mulay, S. R., additional, Santhosh Kumar, V. R., additional, Kulkarni, O. P., additional, Darisipudi, M., additional, Lech, M., additional, Anders, H.-J., additional, Silachev, D. N., additional, Sola, A., additional, Jung, M., additional, Ventayol, M., additional, Mastora, C., additional, Buenestado, S., additional, Hotter, G., additional, Rong, S., additional, Shushakova, N., additional, Wensvoort, G., additional, Haller, H., additional, Gueler, F., additional, Morais, C., additional, Vesey, D. A., additional, Johnson, D. W., additional, Gobe, G. C., additional, Godo, M., additional, Kaucsar, T., additional, Revesz, C., additional, Hamar, P., additional, Cheng, Q., additional, Wen, J., additional, Ma, Q., additional, Zhao, J., additional, Castellano, G., additional, Stasi, A., additional, Di Palma, A. M., additional, Gigante, M., additional, Netti, G. S., additional, Curci, C., additional, Intini, A., additional, Divella, C., additional, Prattichizzo, C., additional, Fiaccadori, E., additional, Pertosa, G., additional, Grandaliano, G., additional, Gesualdo, L., additional, Wei, Q. W., additional, Jing, Q. Q., additional, Ying, N. J., additional, Dong, Q. Z., additional, Yong, G., additional, Pulkova, N. V., additional, Sukhikh, G. T., additional, Kim, S., additional, Lee, J., additional, Nam, N. J., additional, Na, K. Y., additional, Ma, S. K., additional, Joo, S. Y., additional, Kim, C. S., additional, Choi, J. S., additional, Bae, E. H., additional, Kim, S. W., additional, Cernaro, V., additional, Medici, M. A., additional, Donato, V., additional, Trimboli, D., additional, Lorenzano, G., additional, Santoro, D., additional, Montalto, G., additional, Buemi, M., additional, Longo, V., additional, Segreto, H. R. C., additional, Almeida, W., additional, Ramos, M. F., additional, Gomes, L., additional, Razvickas, C., additional, Gutberlet, M., additional, Meier, M., additional, Mengel, M., additional, Wacker, D., additional, Hueper, K., additional, Uzum, A., additional, Ersoy, R., additional, Cakalagaoglu, F., additional, Karaman, M., additional, Kolatan, E., additional, Sahin, O., additional, Yilmaz, O., additional, Cirit, M., additional, Inal, S., additional, Koc, E., additional, Okyay, G. U., additional, Pasaoglu, O., additional, Gonul, I., additional, Oyar, E., additional, Pasaoglu, H., additional, Guz, G., additional, Sabbatini, M., additional, Rossano, R., additional, Andreucci, M., additional, Pisani, A., additional, Riccio, E., additional, Choi, D. E., additional, Jeong, J. Y., additional, Kim, S. S., additional, Na, K.-R., additional, Lee, K. W., additional, Shin, Y. T., additional, Silva, A. F., additional, Teixeira, V. C., additional, Meszaros, K., additional, Koleganova-Gut, N., additional, Schaefer, F., additional, Ritz, E., additional, Walacides, D., additional, Ruskamp, N., additional, Schiffer, M., additional, Marom, O., additional, Haick, H., additional, Nakhoul, F., additional, Lv, L.-L., additional, Tang, R.-N., additional, Zhang, J.-D., additional, Ma, K.-L., additional, Chen, P.-S., additional, Ko, W.-J., additional, Misiara, G. P., additional, Coimbra, T. M., additional, Silva, G. E. B., additional, Costa, R. S., additional, Francescato, H. D. C., additional, Neto, M. M., additional, Dantas, M., additional, Olauson, H., additional, Amin, R., additional, Ponnusamy, A., additional, Goetz, R., additional, Mohammadi, M., additional, Canfield, A., additional, Kublickiene, K., additional, Rodriguez, J., additional, Reyes, E. P., additional, Cortes, P. P., additional, Fernandez, R., additional, Yoon, H. E., additional, Koh, E. S., additional, Chung, S., additional, Shin, S. J., additional, Pazzano, D., additional, Lupica, R., additional, Torre, F., additional, Costantino, G., additional, Prieto, M., additional, Gonzalez-Buitrago, J. M., additional, Lopez-Hernandez, F., additional, Morales, A. I., additional, Vicente-Vicente, L., additional, Ferreira, L., additional, Simoes, M. J., additional, Passos, C. d., additional, Schor, N. S., additional, Shimizu, M. H. M., additional, Canale, D., additional, de Braganca, A. C., additional, Andrade, L., additional, Luchi, W. M., additional, Seguro, A. C., additional, Goncalves, J., additional, Volpini, R. A., additional, Garrido, P., additional, Fernandes, J., additional, Ribeiro, S., additional, Vala, H., additional, Parada, B., additional, Alves, R., additional, Belo, L., additional, Costa, E., additional, Santos-Silva, A., additional, and Reis, F., additional

Published
2013
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36. Benefits and risks when pushing renal regeneration

Author

Hotter, G., primary, Vinas, J. L., additional, Ventayol, M., additional, Mastora, C., additional, Rosello-Catafau, J., additional, Sola, A., additional, Tetta, C., additional, Herrera, M. B., additional, Bruno, S., additional, and Camussi, G., additional

Published
2013
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44. Markers of early renal changes induced by industrial pollutants: III Application to workers exposed to cadmium

Author

Roels, Harry, Bernard, Alfred, Cárdenas, A., Buchet, Jean-Pierre, Lauwerys, Robert, Hotter, G., Ramis, I., Mutti, A., Franchini, I., Bundschuh, I., Stolte, H., De Broe, M. E., Nuyts, G. D., Taylor, S. A., Price, R. G., UCL - MD/ESP - Ecole de santé publique, UCL - (SLuc) Service d'anatomie pathologique, and UCL - (SLuc) Centre de toxicologie clinique

Subjects
Adult, Occupational Diseases, Cadmium Poisoning, Occupational Exposure, Public Health, Environmental and Occupational Health, Humans, Biological Markers, Kidney Diseases, Kidney, Biomarkers, Research Article
Abstract

Cadmium (Cd) was the third heavy metal investigated in the European collaborative research project on the development and validation of new markers of nephrotoxicity. Fifty workers exposed to Cd and 50 control workers were examined. After application of selection criteria 37 workers (mean age 43) exposed to Cd for an average of 11.3 years; and 43 age matched referents were retained for final analysis. The average concentrations of Cd in blood (Cd-B) and urine (Cd-U) of exposed workers were 5.5 micrograms Cd/l and 5.4 micrograms Cd/g creatinine respectively. By contrast with lead and mercury, Cd had a broad spectrum of effects on the kidney, producing significant alterations in amounts of almost all potential indicators of nephrotoxicity that were measured in urine--namely, low and high molecular weight proteins, kidney derived antigens or enzymes, prostanoids, and various other biochemical indices such as glycosaminoglycans and sialic acid. An increase in beta 2-microglobulin and a decrease of sialic acid concentration were found in serum. Dose-effect/response relations could be established between most of these markers and Cd-U or Cd-B. The thresholds of Cd-U associated with a significantly higher probability of change in these indicators were estimated by logistic regression analysis. Three main groups of thresholds could be identified: one around 2 micrograms Cd/g creatinine mainly associated with biochemical alterations, a second around 4 micrograms Cd/g creatinine for high molecular weight proteins and some tubular antigens or enzymes, and a third one around 10 micrograms Cd/g creatinine for low molecular weight proteins and other indicators. The recent recommendation by the American Conference of Governmental Industrial Hygienists (ACGIH) of 5 micrograms Cd/g creatinine in urine as the biological exposure limit for occupational exposure to Cd appears thus justified, although for most of the effects occurring around this threshold the link with the subsequent development of overt Cd nephropathy is not established. In that respect, the very early interference with production of some prostanoids (threshold 2 micrograms Cd/g creatinine) deserves further investigation; although this effect might contribute to protect the filtration capacity of the kidneys, it might also play a part in the toxicity of Cd on bone.

Published
1993

47. Beneficial effect of superoxide dismutase (SOD) on erythrocyte trapping and 6-keto-PGF1 alpha TxB2 ratio after ischemia-reperfusion in kidney transplantation

Author

Vicens A, Ma, López-Boado, Alcaraz A, Saenz A, Piera C, Hotter G, Ramos E, Klaustermeier J, Eduardo m Targarona, and Fernandez-Cruz L

Subjects
Male, Kidney Medulla, Erythrocytes, Kidney Cortex, Superoxide Dismutase, Hypertonic Solutions, 6-Ketoprostaglandin F1 alpha, Organ Preservation, Kidney Transplantation, Dinoprostone, Rats, Cold Temperature, Thromboxane B2, Transplantation, Isogeneic, Ischemia, Rats, Inbred Lew, Reperfusion, Animals
Published
1990

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