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139 results on '"Hou, Chien-Wen"'

25. Deep ocean mineral water accelerates recovery from physical fatigue

Author

Hou Chien-Wen, Tsai Yung-Shen, Jean Wei-Horng, Chen Chung-Yu, Ivy John L, Huang Chih-Yang, and Kuo Chia-Hua

Subjects
Deep seawater, Origin of life, Trace elements, Hydrothermal vent hypothesis, Nutrition. Foods and food supply, TX341-641, Sports medicine, RC1200-1245
Abstract

Abstract Background Deep oceans have been suggested as a possible site where the origin of life occurred. Along with this theoretical lineage, experiments using components from deep ocean water to recreate life is underway. Here, we propose that if terrestrial organisms indeed evolved from deep oceans, supply of deep ocean mineral water (DOM) to humans, as a land creature, may replenish loss of molecular complexity associated with evolutionary sea-to-land migration. Methods We conducted a randomized, double-blind, placebo-controlled crossover human study to evaluate the effect of DOM, taken from a depth of 662 meters off the coast of Hualien, Taiwan, on time of recovery from a fatiguing exercise conducted at 30°C. Results The fatiguing exercise protocol caused a protracted reduction in aerobic power (reduced VO2max) for 48 h. However, DOM supplementation resulted in complete recovery of aerobic power within 4 h (P Conclusion Our results provide compelling evidence that DOM contains soluble elements, which can increase human recovery following an exhaustive physical challenge.

Published
2013
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26. Oral Rg1 supplementation strengthens antioxidant defense system against exercise-induced oxidative stress in rat skeletal muscles

Author

Yu Szu-Hsien, Huang Hui-Yu, Korivi Mallikarjuna, Hsu Ming-Fen, Huang Chih-Yang, Hou Chien-Wen, Chen Chung-Yu, Kao Chung-Lan, Lee Ru-Ping, Lee Shin-Da, and Kuo Chia-Hua

Subjects
Ginseng, Ginsenoside, Antioxidant status, Lipid peroxidation, Swimming, MDA, Protein carbonyl, Oxidative damage, Free radical attack, Sports nutrition, Sarcolemma, Nutrition. Foods and food supply, TX341-641, Sports medicine, RC1200-1245
Abstract

Abstract Background Previous studies reported divergent results on nutraceutical actions and free radical scavenging capability of ginseng extracts. Variations in ginsenoside profile of ginseng due to different soil and cultivating season may contribute to the inconsistency. To circumvent this drawback, we assessed the effect of major ginsenoside-Rg1 (Rg1) on skeletal muscle antioxidant defense system against exhaustive exercise-induced oxidative stress. Methods Forty weight-matched rats were evenly divided into control (N = 20) and Rg1 (N = 20) groups. Rg1 was orally administered at the dose of 0.1 mg/kg bodyweight per day for 10-week. After this long-term Rg1 administration, ten rats from each group performed an exhaustive swimming, and remaining rats considered as non-exercise control. Tibialis anterior (TA) muscles were surgically collected immediately after exercise along with non-exercise rats. Results Exhaustive exercise significantly (p Conclusions This study provide compelling evidences that Rg1 supplementation can strengthen antioxidant defense system in skeletal muscle and completely attenuate the membrane lipid peroxidation induced by exhaustive exercise. Our findings suggest that Rg1 can use as a nutraceutical supplement to buffer the exhaustive exercise-induced oxidative stress.

Published
2012
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42. Protective effect of Co-enzyme Q10 On doxorubicin-induced cardiomyopathy of rat hearts.

Author

Chen, Pei‐Yu, Hou, Chien‐Wen, Shibu, Marthandam Asokan, Day, Cecilia Hsuan, Pai, Peiying, Liu, Zhao‐Rong, Lin, Tze‐Yi, Viswanadha, Vijaya Padma, Kuo, Chia‐Hua, and Huang, Chih‐Yang

Subjects
APOPTOSIS, COENZYMES, MICE anatomy, DOXORUBICIN, CARDIOMYOPATHIES, PREVENTION, MAMMALS
Abstract

ABSTRACT Q10 is a powerful antioxidant often used in medical nutritional supplements for cancer treatment. This study determined whether Q10 could effectively prevent cardio-toxicity caused by doxorubicin treatment. Four week old SD rats were segregated into groups namely control, doxorubicin group (challenged with doxorubicin), Dox + Q10 group (with doxorubicin challenge and oral Q10 treatment), and Q10 group (with oral Q10 treatment). Doxorubicin groups received IP doxorubicin (2.5 mg/kg) every 3 days and Q10 groups received Q10 (10 mg/kg) every day. Three weeks of doxorubicin challenge caused significant reduction in heart weight, disarray in cardiomyocyte arrangement, elevation of collagen accumulation, enhancement of fibrosis and cell death associated proteins, and inhibition of survival proteins. However, Q10 effectively protected cardiomyocytes and ameliorated fibrosis and cell death induced by doxorubicin. Q10 is, therefore, evidently a potential drug to prevent heart damage caused by doxorubicin. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 679-689, 2017. [ABSTRACT FROM AUTHOR]

Published
2017
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43. The role of dehydroepiandrosterone levels on physiologic acclimatization to chronic mountaineering activity.

Author

Lee, Wen-Chih, Chen, Shu-Man, Wu, Min-Chieh, Hou, Chien-Wen, Lai, Yu-Chiang, Laio, Yi-Hung, Lin, Chin-Hung, Kuo, Chia-Hua, Lee, Wen-Chih, Chen, Shu-Man, Wu, Min-Chieh, Hou, Chien-Wen, Lai, Yu-Chiang, Laio, Yi-Hung, Lin, Chin-Hung, and Kuo, Chia-Hua

Abstract

Previous studies have reported that glucose tolerance can be improved by short-term altitude living and activity. However, not all literature agrees that insulin sensitivity is increased at altitude. The present study investigated the effect of a 25-day mountaineering activity on glucose tolerance and its relation to serum levels of dehydroepiandrosterone-sulfate (DHEA-S) and tumor necrosis factor-alpha (TNF-alpha) in 12 male subjects. On day 3 at altitude, we found that serum DHEAS was reduced in the subjects with initially greater DHEA-S value, whereas the subjects with initially lower DHEA-S remained unchanged. To further elucidate the role of DHEA-S in acclimatization to mountaineering activity, all subjects were then divided into lower and upper halves according to their sea-level DHEA-S concentrations: low DHEA-S (n = 6) and high DHEA-S groups (n = 6). Glucose tolerance, insulin level, and the normal physiologic responses to altitude exposure, including hematocrit, hemoglobin, erythropoietin (EPO), and cortisol were measured. We found that glucose and insulin concentrations on an oral glucose tolerance test were significantly lowered by the mountaineering activity only in the high DHEA-S group. Similarly, hematocrit and hemoglobin concentration in altitude were increased only in the high DHEA-S group. In contrast, the low DHEA-S subjects exhibited an EPO value at sea level and altitude greater than the high DHEA-S group, suggesting an EPO resistance. The findings of the study imply that DHEA-S is essential for physiologic acclimatization to mountaineering challenge.

Published
2006

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