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1,297 results on '"Hou, Hua"'

3. Research progress in experimental and integrated calculations of high modulus magnesium based materials

Author

LI Zhiqiang, SHUAI Chuan, LIU Wei, HOU Hua, ZHANG Gaolong, and ZHAO Yuhong

Subjects
magnesium alloy, magnesium matrix composites, high modulus performance, integrated computational material engineering, Motor vehicles. Aeronautics. Astronautics, TL1-4050
Abstract

Magnesium alloy is widely used in the aerospace field due to its low density，high specific strength，high damping and good thermal conductivity. However，its low elastic modulus limits its reliable application in large thin-walled components. Aiming at the problem to improve the modulus properties of magnesium-based materials，this paper briefly introduces the main factors affecting the modulus of the alloy，compares the advantages，disadvantages and application scope of relevant calculation models such as equal stress-strain model，rule of mixture，Halpin-Tsai model and two-phase composite model，summarizes the current situation and progress of the research on the modulus properties of magnesium-based materials，and reviews the two major ways of modulus improvement of magnesium-based materials and the mechanism of performance improvement. Based on the integrated computational material engineering，the integrated development strategy of high-strength and high-modulus magnesium-based materials for atomic-lattice scale analogy high-modulus aluminum alloy development and machine learning assisted optimization experimental design is proposed.

Published
2024
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15. Exosomal PGAM1 promotes prostate cancer angiogenesis and metastasis by interacting with ACTG1

Author

Jun-qi Luo, Tao-wei Yang, Jun Wu, Hou-hua Lai, Li-bin Zou, Wen-bin Chen, Xu-min Zhou, Dao-jun Lv, Sheng-ren Cen, Zi-ning Long, Yi-you Mao, Peng-xiang Zheng, Xiao-hong Su, Zhi-yong Xian, Fang-peng Shu, and Xiang-ming Mao

Subjects
Cytology, QH573-671
Abstract

Abstract Tumor-derived exosomes and their contents promote cancer metastasis. Phosphoglycerate mutase 1 (PGAM1) is involved in various cancer-related processes. Nevertheless, the underlying mechanism of exosomal PGAM1 in prostate cancer (PCa) metastasis remains unclear. In this study, we performed in vitro and in vivo to determine the functions of exosomal PGAM1 in the angiogenesis of patients with metastatic PCa. We performed Glutathione-S-transferase pulldown, co-immunoprecipitation, western blotting and gelatin degradation assays to determine the pathway mediating the effect of exosomal PGAM1 in PCa. Our results revealed a significant increase in exosomal PGAM1 levels in the plasma of patients with metastatic PCa compared to patients with non-metastatic PCa. Furthermore, PGAM1 was a key factor initiating PCa cell metastasis by promoting invadopodia formation and could be conveyed by exosomes from PCa cells to human umbilical vein endothelial cells (HUVECs). In addition, exosomal PGAM1 could bind to γ-actin (ACTG1), which promotes podosome formation and neovascular sprouting in HUVECs. In vivo results revealed exosomal PGAM1 enhanced lung metastasis in nude mice injected with PCa cells via the tail vein. In summary, exosomal PGAM1 promotes angiogenesis and could be used as a liquid biopsy marker for PCa metastasis.

Published
2023
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34. Comparative Analysis of Six Complete Plastomes of Tripterospermum spp.

Author

Xiong-De Tu, Wen-Jun Lin, Hou-Hua Fu, Yi-Zhe Lin, Jun Shen, Shuai Chen, Zhong-Jian Liu, Ming-He Li, and Shi-Pin Chen

Subjects
comparative analysis, Gentianinae, plastid genome, phylogenetic analysis, Tripterospermum, Biology (General), QH301-705.5, Chemistry, QD1-999
Abstract

The Tripterospermum, comprising 34 species, is a genus of Gentianaceae. Members of Tripterospermum are mostly perennial, entwined herbs with high medicinal value and rich in iridoids, xanthones, flavonoids, and triterpenes. However, our inadequate understanding of the differences in the plastid genome sequences of Tripterospermum species has severely hindered the study of their evolution and phylogeny. Therefore, we first analyzed the 86 Gentianae plastid genomes to explore the phylogenetic relationships within the Gentianae subfamily where Tripterospermum is located. Then, we analyzed six plastid genomes of Tripterospermum, including two newly sequenced plastid genomes and four previously published plastid genomes, to explore the plastid genomes’ evolution and phylogenetic relationships in the genus Tripterospermum. The Tripterospermum plastomes have a quadripartite structure and are between 150,929 and 151,350 bp in size. The plastomes of Tripterospermum encoding 134 genes were detected, including 86 protein-coding genes (CDS), 37 transfer RNA (tRNA) genes, eight ribosomal RNA (rRNA) genes, and three pseudogenes (infA, rps19, and ycf1). The result of the comparison shows that the Tripterospermum plastomes are very conserved, with the total plastome GC content ranging from 37.70% to 37.79%. In repeat sequence analysis, the number of single nucleotide repeats (A/T) varies among the six Tripterospermum species, and the identified main long repeat types are forward and palindromic repeats. The degree of conservation is higher at the SC/IR boundary. The regions with the highest divergence in the CDS and the intergenic region (IGS) are psaI and rrn4.5-rrn5, respectively. The average pi of the CDS and the IGS are only 0.071% and 0.232%, respectively, indicating that the Tripterospermum plastomes are highly conserved. Phylogenetic analysis indicated that Gentianinae is divided into two clades, with Tripterospermum as a sister to Sinogeniana. Phylogenetic trees based on CDS and CDS + IGS combined matrices have strong support in Tripterospermum. These findings contribute to the elucidation of the plastid genome evolution of Tripterospermum and provide a foundation for further exploration and resource utilization within this genus.

Published
2024
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