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Yanjiao Shen,1,&ast; Yuting Wang,2,&ast; Qingyang Shi,1 Lisha Hou,3 Xiaoyan Chen,4 Birong Dong,3 Qiukui Hao3,5 1Department of Guideline and Rapid Recommendation, Cochrane China Centre, MAGIC China Centre, Chinese Evidence-Based Medicine Centre, West China Hospital, Sichuan University, Chengdu, Sichuan, People’s Republic of China; 2Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Canada; 3The Center of Gerontology and Geriatrics/National Clinical Research Center of Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan, People’s Republic of China; 4Zigong Mental Health Center, Zigong, Sichuan, People’s Republic of China; 5School of Rehabilitation Science, McMaster University, Hamilton, Ontario, Canada&ast;These authors contributed equally to this workCorrespondence: Qiukui HaoThe Center of Gerontology and Geriatrics/National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, #37 Guoxue Lane, Chengdu, 610041, People’s Republic of ChinaTel/Fax +86-28-85422321Email haoqiukui@gmail.comIntroduction: To assess whether the electronic frailty index (eFI) is independently associated with all-cause mortality and chemotherapy adverse reactions among older Chinese patients with lung cancer.Methods: This is a retrospective, single-institution, chart review, and not a prospective cohort study. All patients ≥ 60 years with primary lung cancer in the West China Hospital from 2010 to 2017 were included in this cohort. The eFI was established using 35 frailty-related variables in the electronic medical record (EMR) system and was cut by a value of 0.2 to classify the patients into frail (eFI ≥ 0.2) and robust/non-frail groups (eFI< 0.2). The long-term outcome was all-cause mortality identified by government databases and telephone interviews. Short-term outcomes were any infection, bone suppression, chemotherapy discontinuation, impaired liver function, any gastrointestin

Yanli Zhao, 1 Taiping Lin, 1 Lisha Hou, 1 Meng Zhang, 1 Xuchao Peng, 1 Dongmei Xie, 1 Langli Gao, 1 Xiaoyu Shu, 1 Jirong Yue, 1 Chenkai Wu 2 1Department of Geriatrics and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, People’s Republic of China; 2Global Health Research Center, Duke Kunshan University, Kunshan, 215300, Jiangsu, People’s Republic of ChinaCorrespondence: Jirong YueDepartment of Geriatrics and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan Province, 610041, People’s Republic of ChinaTel +86 18980601143Email yuejirong11@hotmail.comObjective: Previous studies have explored the association between malnutrition and frailty, but no study has investigated whether the Geriatric Nutritional Risk Index (GNRI), a simple and objective nutritional risk screening tool, is associated with the frailty of older adults. The study aimed to examine the relationship between nutrition-related risk, as assessed by the GNRI, and frailty among older hospitalized patients.Methods: A cross-sectional study was conducted in the West China Hospital of Sichuan University with 740 patients aged ≥ 70 years between March 2016 and Jan 2017. Nutritional and frailty status was evaluated with the GNRI and FRAIL scale, respectively. The adjusted and unadjusted ordinal logistic regression analyses were used to examine the relationship between nutritional risk and frailty. The ability of GNRI in detecting frailty was assessed by receiver operating characteristic (ROC) curve analysis.Results: The prevalence of low, moderate, and severe nutritional risk among frail patients were 30.1%, 27.6%, and 12.5%, respectively. Ordinal logistic regression analysis showed that malnutrition assessed by the GNRI had a significant association with frailty after adjustment of age, sex, polypharmacy, comorbidity, vision impairment, hearing impair