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3. Incorporating progesterone receptor expression into the PREDICT breast prognostic model

Author

Grootes, Isabelle, Keeman, Renske, Blows, Fiona M, Milne, Roger L, Giles, Graham G, Swerdlow, Anthony J, Fasching, Peter A, Abubakar, Mustapha, Andrulis, Irene L, Anton-Culver, Hoda, Beckmann, Matthias W, Blomqvist, Carl, Bojesen, Stig E, Bolla, Manjeet K, Bonanni, Bernardo, Briceno, Ignacio, Burwinkel, Barbara, Camp, Nicola J, Castelao, Jose E, Choi, Ji-Yeob, Clarke, Christine L, Couch, Fergus J, Cox, Angela, Cross, Simon S, Czene, Kamila, Devilee, Peter, Dörk, Thilo, Dunning, Alison M, Dwek, Miriam, Easton, Douglas F, Eccles, Diana M, Eriksson, Mikael, Ernst, Kristina, Evans, D Gareth, Figueroa, Jonine D, Fink, Visnja, Floris, Giuseppe, Fox, Stephen, Gabrielson, Marike, Gago-Dominguez, Manuela, García-Sáenz, José A, González-Neira, Anna, Haeberle, Lothar, Haiman, Christopher A, Hall, Per, Hamann, Ute, Harkness, Elaine F, Hartman, Mikael, Hein, Alexander, Hooning, Maartje J, Hou, Ming-Feng, Howell, Sacha J, Investigators, ABCTB, Investigators, kConFab, Ito, Hidemi, Jakubowska, Anna, Janni, Wolfgang, John, Esther M, Jung, Audrey, Kang, Daehee, Kristensen, Vessela N, Kwong, Ava, Lambrechts, Diether, Li, Jingmei, Lubiński, Jan, Manoochehri, Mehdi, Margolin, Sara, Matsuo, Keitaro, Taib, Nur Aishah Mohd, Mulligan, Anna Marie, Nevanlinna, Heli, Newman, William G, Offit, Kenneth, Osorio, Ana, Park, Sue K, Park-Simon, Tjoung-Won, Patel, Alpa V, Presneau, Nadege, Pylkäs, Katri, Rack, Brigitte, Radice, Paolo, Rennert, Gad, Romero, Atocha, Saloustros, Emmanouil, Sawyer, Elinor J, Schneeweiss, Andreas, Schochter, Fabienne, Schoemaker, Minouk J, Shen, Chen-Yang, Shibli, Rana, Sinn, Peter, Tapper, William J, Tawfiq, Essa, Teo, Soo Hwang, Teras, Lauren R, Torres, Diana, Vachon, Celine M, van Deurzen, Carolien HM, Wendt, Camilla, and Williams, Justin A

Subjects
Cancer, Breast Cancer, Breast Neoplasms, Female, Humans, Progesterone, Prognosis, Receptor, ErbB-2, Receptors, Progesterone, PREDICT Breast, breast cancer, Progesterone receptor, ABCTB Investigators, kConFab Investigators, Receptor, erbB-2, Oncology and Carcinogenesis, Public Health and Health Services, Oncology & Carcinogenesis
Abstract

BackgroundPredict Breast (www.predict.nhs.uk) is an online prognostication and treatment benefit tool for early invasive breast cancer. The aim of this study was to incorporate the prognostic effect of progesterone receptor (PR) status into a new version of PREDICT and to compare its performance to the current version (2.2).MethodThe prognostic effect of PR status was based on the analysis of data from 45,088 European patients with breast cancer from 49 studies in the Breast Cancer Association Consortium. Cox proportional hazard models were used to estimate the hazard ratio for PR status. Data from a New Zealand study of 11,365 patients with early invasive breast cancer were used for external validation. Model calibration and discrimination were used to test the model performance.ResultsHaving a PR-positive tumour was associated with a 23% and 28% lower risk of dying from breast cancer for women with oestrogen receptor (ER)-negative and ER-positive breast cancer, respectively. The area under the ROC curve increased with the addition of PR status from 0.807 to 0.809 for patients with ER-negative tumours (p = 0.023) and from 0.898 to 0.902 for patients with ER-positive tumours (p = 2.3 × 10-6) in the New Zealand cohort. Model calibration was modest with 940 observed deaths compared to 1151 predicted.ConclusionThe inclusion of the prognostic effect of PR status to PREDICT Breast has led to an improvement of model performance and more accurate absolute treatment benefit predictions for individual patients. Further studies should determine whether the baseline hazard function requires recalibration.

Published
2022

8. Functional annotation of the 2q35 breast cancer risk locus implicates a structural variant in influencing activity of a long-range enhancer element

Author

Baxter, Joseph S, Johnson, Nichola, Tomczyk, Katarzyna, Gillespie, Andrea, Maguire, Sarah, Brough, Rachel, Fachal, Laura, Michailidou, Kyriaki, Bolla, Manjeet K, Wang, Qin, Dennis, Joe, Ahearn, Thomas U, Andrulis, Irene L, Anton-Culver, Hoda, Antonenkova, Natalia N, Arndt, Volker, Aronson, Kristan J, Augustinsson, Annelie, Becher, Heiko, Beckmann, Matthias W, Behrens, Sabine, Benitez, Javier, Bermisheva, Marina, Bogdanova, Natalia V, Bojesen, Stig E, Brenner, Hermann, Brucker, Sara Y, Cai, Qiuyin, Campa, Daniele, Canzian, Federico, Castelao, Jose E, Chan, Tsun L, Chang-Claude, Jenny, Chanock, Stephen J, Chenevix-Trench, Georgia, Choi, Ji-Yeob, Clarke, Christine L, Collaborators, NBCS, Colonna, Sarah, Conroy, Don M, Couch, Fergus J, Cox, Angela, Cross, Simon S, Czene, Kamila, Daly, Mary B, Devilee, Peter, Dörk, Thilo, Dossus, Laure, Dwek, Miriam, Eccles, Diana M, Ekici, Arif B, Eliassen, A Heather, Engel, Christoph, Fasching, Peter A, Figueroa, Jonine, Flyger, Henrik, Gago-Dominguez, Manuela, Gao, Chi, García-Closas, Montserrat, García-Sáenz, José A, Ghoussaini, Maya, Giles, Graham G, Goldberg, Mark S, González-Neira, Anna, Guénel, Pascal, Gündert, Melanie, Haeberle, Lothar, Hahnen, Eric, Haiman, Christopher A, Hall, Per, Hamann, Ute, Hartman, Mikael, Hatse, Sigrid, Hauke, Jan, Hollestelle, Antoinette, Hoppe, Reiner, Hopper, John L, Hou, Ming-Feng, Investigators, kConFab, Investigators, ABCTB, Ito, Hidemi, Iwasaki, Motoki, Jager, Agnes, Jakubowska, Anna, Janni, Wolfgang, John, Esther M, Joseph, Vijai, Jung, Audrey, Kaaks, Rudolf, Kang, Daehee, Keeman, Renske, Khusnutdinova, Elza, Kim, Sung-Won, Kosma, Veli-Matti, Kraft, Peter, Kristensen, Vessela N, Kubelka-Sabit, Katerina, Kurian, Allison W, Kwong, Ava, and Lacey, James V

Subjects
Human Genome, Genetics, Cancer, Estrogen, Prevention, Breast Cancer, 2.1 Biological and endogenous factors, Aetiology, Breast Neoplasms, CRISPR-Cas Systems, Cell Line, Chromosome Mapping, Chromosomes, Human, Pair 2, Female, Genetic Association Studies, Genetic Variation, Humans, Insulin-Like Growth Factor Binding Protein 5, Molecular Sequence Annotation, Promoter Regions, Genetic, Risk Factors, Sequence Deletion, NBCS Collaborators, kConFab Investigators, ABCTB Investigators, breast cancer risk, functional annotation, risk locus, Biological Sciences, Medical and Health Sciences, Genetics & Heredity
Abstract

A combination of genetic and functional approaches has identified three independent breast cancer risk loci at 2q35. A recent fine-scale mapping analysis to refine these associations resulted in 1 (signal 1), 5 (signal 2), and 42 (signal 3) credible causal variants at these loci. We used publicly available in silico DNase I and ChIP-seq data with in vitro reporter gene and CRISPR assays to annotate signals 2 and 3. We identified putative regulatory elements that enhanced cell-type-specific transcription from the IGFBP5 promoter at both signals (30- to 40-fold increased expression by the putative regulatory element at signal 2, 2- to 3-fold by the putative regulatory element at signal 3). We further identified one of the five credible causal variants at signal 2, a 1.4 kb deletion (esv3594306), as the likely causal variant; the deletion allele of this variant was associated with an average additional increase in IGFBP5 expression of 1.3-fold (MCF-7) and 2.2-fold (T-47D). We propose a model in which the deletion allele of esv3594306 juxtaposes two transcription factor binding regions (annotated by estrogen receptor alpha ChIP-seq peaks) to generate a single extended regulatory element. This regulatory element increases cell-type-specific expression of the tumor suppressor gene IGFBP5 and, thereby, reduces risk of estrogen receptor-positive breast cancer (odds ratio = 0.77, 95% CI 0.74-0.81, p = 3.1 × 10-31).

Published
2021

11. Erdafitinib in patients with advanced solid tumours with FGFR alterations (RAGNAR): an international, single-arm, phase 2 study

Author

Carranza, Omar, Greco, Martin Alberto, Coward, Jim, Joshua, Anthony, Karapetis, Christos, Hart, Christopher, Zhang, Alison, Prenen, Hans, Goeminne, Jean-Charles, Machiels, Jean-Pascal, Rottey, Sylvie, Corassa, Marcelo, Molin, Graziela Zibetti Dal, Tiscoski, Katsuki, Jardim, Denis Leonardo Fontes, Mak, Milena, Fu, Wei, Yao, Herui, Huang, Jing, Jiang, Haiping, Qin, Shukui, Chen, Baoshi, Yan, Dong, Yang, Yu, Loriot, Yohann, Le Tourneau, Christophe, Penel, Nicolas, Salas, Sébastien, Blay, Jean-Yves, Brachet, Pierre-Emmanuel, Durando, Xavier, Emambux, Sheik, Ravaud, Alain, Folprecht, Gunnar, Arnold, Dirk, Schuler, Martin, Ahrens, Marit, Golf, Alexander, Haag, Georg Martin, Lordick, Florian, Desuki, Alexander, Cazzaniga, Marina, Ciardiello, Fortunato, Milella, Michele, Koyama, Takafumi, Hirooka, Yoshiki, Okamoto, Wataru, Aogi, Kenjiro, Kuboki, Yasutoshi, Lee, Jungyun, Kim, Sung-Bae, Ahn, Myung-Ju, Chang, Jong Hee, Kim, Yong-Man, Nam, Do-Hyun, Park, Jae-Sung, Lugowska, Iwona, Paz-Ares, Luis, Moreno, Victor, Cervantes, Andres, Calvo, Mariona, Falcon, Alejandro, Gonzalez, Antonio, Tabernero, Josep, Martinez Bueno, Alejandro, García-Corbacho, Javier, Longo, Federico, Yen, Chia-Jui, Chen, Jen-Shi, Hou, Ming-Feng, Chao, Yee, Rau, Kun-Ming, Chiu, Tai-Jan, Feng, Yin-Hsun, Hsu, Chih-Hung, Huang, Wen-Tsung, Lai, Kuan-Ming, Yeh, Su-peng, Palmer, Daniel, Minchom, Anna, Winter, Helen, Welsh, Liam, Plummer, Ruth, Iyer, Gopakumar, Gutierrez, Martin, Bilen, Mehmet, Arrowsmith, Edward, Pant, Shubham, Spigel, David Robert, Zandberg, Dan Paul, Doroshow, Deborah, Lu-Emerson, Christine, Moezi, Mehdi, Paulson, Scott, Reardon, David, Ward, Patrick, Chaves, Jorge, Grigg, Claud, Hussein, Atif, Manda, Sudhir, Monticelli, Michael, Qamar, Rubina, Richey, Stephen L, Tamura, David, Wilks, Sharon, Iyer, Gopa, Witt, Olaf, Doi, Toshihiko, Reardon, David A, Massard, Christophe, Stuyckens, Kim, Crow, Lauren, Najmi, Saltanat, Hammond, Constance, Thomas, Shibu, Santiago-Walker, Ademi, Triantos, Spyros, and Sweiti, Hussein

Published
2023
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12. Breast Cancer Polygenic Risk Score and Contralateral Breast Cancer Risk

Author

Kramer, Iris, Hooning, Maartje J, Mavaddat, Nasim, Hauptmann, Michael, Keeman, Renske, Steyerberg, Ewout W, Giardiello, Daniele, Antoniou, Antonis C, Pharoah, Paul DP, Canisius, Sander, Abu-Ful, Zumuruda, Andrulis, Irene L, Anton-Culver, Hoda, Aronson, Kristan J, Augustinsson, Annelie, Becher, Heiko, Beckmann, Matthias W, Behrens, Sabine, Benitez, Javier, Bermisheva, Marina, Bogdanova, Natalia V, Bojesen, Stig E, Bolla, Manjeet K, Bonanni, Bernardo, Brauch, Hiltrud, Bremer, Michael, Brucker, Sara Y, Burwinkel, Barbara, Castelao, Jose E, Chan, Tsun L, Chang-Claude, Jenny, Chanock, Stephen J, Chenevix-Trench, Georgia, Choi, Ji-Yeob, Clarke, Christine L, Collée, J Margriet, Couch, Fergus J, Cox, Angela, Cross, Simon S, Czene, Kamila, Daly, Mary B, Devilee, Peter, Dörk, Thilo, dos-Santos-Silva, Isabel, Dunning, Alison M, Dwek, Miriam, Eccles, Diana M, Evans, D Gareth, Fasching, Peter A, Flyger, Henrik, Gago-Dominguez, Manuela, García-Closas, Montserrat, García-Sáenz, José A, Giles, Graham G, Goldgar, David E, González-Neira, Anna, Haiman, Christopher A, Håkansson, Niclas, Hamann, Ute, Hartman, Mikael, Heemskerk-Gerritsen, Bernadette AM, Hollestelle, Antoinette, Hopper, John L, Hou, Ming-Feng, Howell, Anthony, Ito, Hidemi, Jakimovska, Milena, Jakubowska, Anna, Janni, Wolfgang, John, Esther M, Jung, Audrey, Kang, Daehee, Kets, C Marleen, Khusnutdinova, Elza, Ko, Yon-Dschun, Kristensen, Vessela N, Kurian, Allison W, Kwong, Ava, Lambrechts, Diether, Le Marchand, Loic, Li, Jingmei, Lindblom, Annika, Lubiński, Jan, Mannermaa, Arto, Manoochehri, Mehdi, Margolin, Sara, Matsuo, Keitaro, Mavroudis, Dimitrios, Meindl, Alfons, Milne, Roger, Mulligan, Anna Marie, Muranen, Taru A, Neuhausen, Susan L, Nevanlinna, Heli, Newman, William G, Olshan, Andrew F, Olson, Janet E, Olsson, Håkan, Park-Simon, Tjoung-Won, and Peto, Julian

Subjects
Breast Cancer, Prevention, Cancer, Adult, Aged, Asian People, Breast Neoplasms, Cohort Studies, Estrogen Receptor alpha, Female, Gene Expression, Genetic Predisposition to Disease, Genome, Human, Genome-Wide Association Study, Humans, Middle Aged, Multifactorial Inheritance, Neoadjuvant Therapy, Neoplasms, Second Primary, Prognosis, Proportional Hazards Models, Receptor, ErbB-2, Receptors, Progesterone, Risk Assessment, White People, NBCS Collaborators, ABCTB Investigators, kConFab Investigators, Receptor, erbB-2, contralateral breast cancer, epidemiology, genetic, polygenic risk score, Biological Sciences, Medical and Health Sciences, Genetics & Heredity
Abstract

Previous research has shown that polygenic risk scores (PRSs) can be used to stratify women according to their risk of developing primary invasive breast cancer. This study aimed to evaluate the association between a recently validated PRS of 313 germline variants (PRS313) and contralateral breast cancer (CBC) risk. We included 56,068 women of European ancestry diagnosed with first invasive breast cancer from 1990 onward with follow-up from the Breast Cancer Association Consortium. Metachronous CBC risk (N = 1,027) according to the distribution of PRS313 was quantified using Cox regression analyses. We assessed PRS313 interaction with age at first diagnosis, family history, morphology, ER status, PR status, and HER2 status, and (neo)adjuvant therapy. In studies of Asian women, with limited follow-up, CBC risk associated with PRS313 was assessed using logistic regression for 340 women with CBC compared with 12,133 women with unilateral breast cancer. Higher PRS313 was associated with increased CBC risk: hazard ratio per standard deviation (SD) = 1.25 (95%CI = 1.18-1.33) for Europeans, and an OR per SD = 1.15 (95%CI = 1.02-1.29) for Asians. The absolute lifetime risks of CBC, accounting for death as competing risk, were 12.4% for European women at the 10th percentile and 20.5% at the 90th percentile of PRS313. We found no evidence of confounding by or interaction with individual characteristics, characteristics of the primary tumor, or treatment. The C-index for the PRS313 alone was 0.563 (95%CI = 0.547-0.586). In conclusion, PRS313 is an independent factor associated with CBC risk and can be incorporated into CBC risk prediction models to help improve stratification and optimize surveillance and treatment strategies.

Published
2020

14. Neratinib Plus Capecitabine Versus Lapatinib Plus Capecitabine in HER2-Positive Metastatic Breast Cancer Previously Treated With ≥ 2 HER2-Directed Regimens: Phase III NALA Trial

Author

Saura, Cristina, Oliveira, Mafalda, Feng, Yin-Hsun, Dai, Ming-Shen, Chen, Shang-Wen, Hurvitz, Sara A, Kim, Sung-Bae, Moy, Beverly, Delaloge, Suzette, Gradishar, William, Masuda, Norikazu, Palacova, Marketa, Trudeau, Maureen E, Mattson, Johanna, Yap, Yoon Sim, Hou, Ming-Feng, De Laurentiis, Michelino, Yeh, Yu-Min, Chang, Hong-Tai, Yau, Thomas, Wildiers, Hans, Haley, Barbara, Fagnani, Daniele, Lu, Yen-Shen, Crown, John, Lin, Johnson, Takahashi, Masato, Takano, Toshimi, Yamaguchi, Miki, Fujii, Takaaki, Yao, Bin, Bebchuk, Judith, Keyvanjah, Kiana, Bryce, Richard, and Brufsky, Adam

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Breast Cancer, Prevention, Clinical Research, Cancer, Clinical Trials and Supportive Activities, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Aged, Antineoplastic Combined Chemotherapy Protocols, Brain Neoplasms, Breast Neoplasms, Breast Neoplasms, Male, Capecitabine, Diarrhea, Female, Humans, Kaplan-Meier Estimate, Lapatinib, Male, Middle Aged, Nausea, Progression-Free Survival, Quality of Life, Quinolines, Receptor, ErbB-2, Retreatment, Survival Rate, NALA Investigators, Receptor, erbB-2, Clinical Sciences, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

PurposeNALA (ClinicalTrials.gov identifier: NCT01808573) is a randomized, active-controlled, phase III trial comparing neratinib, an irreversible pan-HER tyrosine kinase inhibitor (TKI), plus capecitabine (N+C) against lapatinib, a reversible dual TKI, plus capecitabine (L+C) in patients with centrally confirmed HER2-positive, metastatic breast cancer (MBC) with ≥ 2 previous HER2-directed MBC regimens.MethodsPatients, including those with stable, asymptomatic CNS disease, were randomly assigned 1:1 to neratinib (240 mg once every day) plus capecitabine (750 mg/m2 twice a day 14 d/21 d) with loperamide prophylaxis, or to lapatinib (1,250 mg once every day) plus capecitabine (1,000 mg/m2 twice a day 14 d/21 d). Coprimary end points were centrally confirmed progression-free survival (PFS) and overall survival (OS). NALA was considered positive if either primary end point was met (α split between end points). Secondary end points were time to CNS disease intervention, investigator-assessed PFS, objective response rate (ORR), duration of response (DoR), clinical benefit rate, safety, and health-related quality of life (HRQoL).ResultsA total of 621 patients from 28 countries were randomly assigned (N+C, n = 307; L+C, n = 314). Centrally reviewed PFS was improved with N+C (hazard ratio [HR], 0.76; 95% CI, 0.63 to 0.93; stratified log-rank P = .0059). The OS HR was 0.88 (95% CI, 0.72 to 1.07; P = .2098). Fewer interventions for CNS disease occurred with N+C versus L+C (cumulative incidence, 22.8% v 29.2%; P = .043). ORRs were N+C 32.8% (95% CI, 27.1 to 38.9) and L+C 26.7% (95% CI, 21.5 to 32.4; P = .1201); median DoR was 8.5 versus 5.6 months, respectively (HR, 0.50; 95% CI, 0.33 to 0.74; P = .0004). The most common all-grade adverse events were diarrhea (N+C 83% v L+C 66%) and nausea (53% v 42%). Discontinuation rates and HRQoL were similar between groups.ConclusionN+C significantly improved PFS and time to intervention for CNS disease versus L+C. No new N+C safety signals were observed.

Published
2020

15. Globo H-KLH vaccine adagloxad simolenin (OBI-822)/OBI-821 in patients with metastatic breast cancer: phase II randomized, placebo-controlled study.

Author

Huang, Chiun-Sheng, Yu, Alice L, Tseng, Ling-Ming, Chow, Louis WC, Hou, Ming-Feng, Hurvitz, Sara A, Schwab, Richard B, L Murray, James, Chang, Hsien-Kun, Chang, Hong-Tai, Chen, Shin-Cheh, Kim, Sung-Bae, Hung, Jung-Tung, Ueng, Shir-Hwa, Lee, Su-Hua, Chen, Chwen-Cheng, and Rugo, Hope S

Subjects
Humans, Breast Neoplasms, Neoplasm Metastasis, Cancer Vaccines, Vaccines, Conjugate, Treatment Outcome, Survival Analysis, Double-Blind Method, Adult, Aged, Aged, 80 and over, Middle Aged, Female, immunology, oncology, randomized trials, Clinical Research, Cancer, Clinical Trials and Supportive Activities, Breast Cancer, Vaccine Related, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals
Abstract

This randomized, double-blind, placebo-controlled, parallel-group, phase II trial assessed the efficacy and safety of adagloxad simolenin (OBI-822; a Globo H epitope covalently linked to keyhole limpet hemocyanin (KLH)) with adjuvant OBI-821 in metastatic breast cancer (MBC). At 40 sites in Taiwan, USA, Korea, India, and Hong Kong, patients with MBC of any molecular subtype and ≤2 prior progressive disease events with stable/responding disease after the last anticancer regimen were randomized (2:1) to adagloxad simolenin (AS/OBI-821) or placebo, subcutaneously for nine doses with low-dose cyclophosphamide. The primary endpoint was progression-free survival (PFS). Secondary endpoints included overall survival, correlation of clinical outcome with humoral immune response and Globo H expression, and safety. Of 349 patients randomized, 348 received study drug. Patients with the following breast cancer subtypes were included: hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-) (70.4%), triple negative (12.9%), and HER2+ (16.7%), similarly distributed between treatment arms. Median PFS was 7.6 months (95% CI: 6.5-10.9) with AS/OBI-821 (n=224) and 9.2 months (95% CI: 7.3-11.3) with placebo (n=124) (HR=0.96; 95% CI: 0.74-1.25; p=0.77), with no difference by breast cancer subtype. AS/OBI-821 recipients with anti-Globo H IgG titer ≥1:160 had significantly longer median PFS (11.1 months (95% CI: 9.3-17.6)) versus those with titers

Published
2020

16. Germline HOXB13 mutations p.G84E and p.R217C do not confer an increased breast cancer risk.

Author

Liu, Jingjing, Prager-van der Smissen, Wendy JC, Collée, J Margriet, Bolla, Manjeet K, Wang, Qin, Michailidou, Kyriaki, Dennis, Joe, Ahearn, Thomas U, Aittomäki, Kristiina, Ambrosone, Christine B, Andrulis, Irene L, Anton-Culver, Hoda, Antonenkova, Natalia N, Arndt, Volker, Arnold, Norbert, Aronson, Kristan J, Augustinsson, Annelie, Auvinen, Päivi, Becher, Heiko, Beckmann, Matthias W, Behrens, Sabine, Bermisheva, Marina, Bernstein, Leslie, Bogdanova, Natalia V, Bogdanova-Markov, Nadja, Bojesen, Stig E, Brauch, Hiltrud, Brenner, Hermann, Briceno, Ignacio, Brucker, Sara Y, Brüning, Thomas, Burwinkel, Barbara, Cai, Qiuyin, Cai, Hui, Campa, Daniele, Canzian, Federico, Castelao, Jose E, Chang-Claude, Jenny, Chanock, Stephen J, Choi, Ji-Yeob, Christiaens, Melissa, Clarke, Christine L, NBCS Collaborators, Couch, Fergus J, Czene, Kamila, Daly, Mary B, Devilee, Peter, Dos-Santos-Silva, Isabel, Dwek, Miriam, Eccles, Diana M, Eliassen, A Heather, Fasching, Peter A, Figueroa, Jonine, Flyger, Henrik, Fritschi, Lin, Gago-Dominguez, Manuela, Gapstur, Susan M, García-Closas, Montserrat, García-Sáenz, José A, Gaudet, Mia M, Giles, Graham G, Goldberg, Mark S, Goldgar, David E, Guénel, Pascal, Haiman, Christopher A, Håkansson, Niclas, Hall, Per, Harrington, Patricia A, Hart, Steven N, Hartman, Mikael, Hillemanns, Peter, Hopper, John L, Hou, Ming-Feng, Hunter, David J, Huo, Dezheng, ABCTB Investigators, Ito, Hidemi, Iwasaki, Motoki, Jakimovska, Milena, Jakubowska, Anna, John, Esther M, Kaaks, Rudolf, Kang, Daehee, Keeman, Renske, Khusnutdinova, Elza, Kim, Sung-Won, Kraft, Peter, Kristensen, Vessela N, Kurian, Allison W, Le Marchand, Loic, Li, Jingmei, Lindblom, Annika, Lophatananon, Artitaya, Luben, Robert N, Lubiński, Jan, Mannermaa, Arto, Manoochehri, Mehdi, Manoukian, Siranoush, Margolin, Sara, and Mariapun, Shivaani

Subjects
NBCS Collaborators, ABCTB Investigators
Abstract

In breast cancer, high levels of homeobox protein Hox-B13 (HOXB13) have been associated with disease progression of ER-positive breast cancer patients and resistance to tamoxifen treatment. Since HOXB13 p.G84E is a prostate cancer risk allele, we evaluated the association between HOXB13 germline mutations and breast cancer risk in a previous study consisting of 3,270 familial non-BRCA1/2 breast cancer cases and 2,327 controls from the Netherlands. Although both recurrent HOXB13 mutations p.G84E and p.R217C were not associated with breast cancer risk, the risk estimation for p.R217C was not very precise. To provide more conclusive evidence regarding the role of HOXB13 in breast cancer susceptibility, we here evaluated the association between HOXB13 mutations and increased breast cancer risk within 81 studies of the international Breast Cancer Association Consortium containing 68,521 invasive breast cancer patients and 54,865 controls. Both HOXB13 p.G84E and p.R217C did not associate with the development of breast cancer in European women, neither in the overall analysis (OR = 1.035, 95% CI = 0.859-1.246, P = 0.718 and OR = 0.798, 95% CI = 0.482-1.322, P = 0.381 respectively), nor in specific high-risk subgroups or breast cancer subtypes. Thus, although involved in breast cancer progression, HOXB13 is not a material breast cancer susceptibility gene.

Published
2020

18. Relevance of the MHC region for breast cancer susceptibility in Asians

Author

Ho, Peh Joo, Khng, Alexis Jiaying, Tan, Benita Kiat-Tee, Tan, Ern Yu, Tan, Su-Ming, Tan, Veronique Kiak Mien, Lim, Geok Hoon, Aronson, Kristan J., Chan, Tsun L., Choi, Ji-Yeob, Dennis, Joe, Ho, Weang-Kee, Hou, Ming-Feng, Ito, Hidemi, Iwasaki, Motoki, John, Esther M., Kang, Daehee, Kim, Sung-Won, Kurian, Allison W., Kwong, Ava, Lophatananon, Artitaya, Matsuo, Keitaro, Mohd-Taib, Nur Aishah, Muir, Kenneth, Murphy, Rachel A., Park, Sue K., Shen, Chen-Yang, Shu, Xiao-Ou, Teo, Soo Hwang, Wang, Qin, Yamaji, Taiki, Zheng, Wei, Bolla, Manjeet K., Dunning, Alison M., Easton, Douglas F., Pharoah, Paul D. P., Hartman, Mikael, and Li, Jingmei

Published
2022
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19. Efficacy of the minimal-invasive vacuum-assisted biopsy under direct visualization with ultrasound for impalpable breast lesions in Taiwanese female: A retrospective case-control study

Author

Chen, Sherry Ying-Hsuan, primary, Moi, Sin-Hua, additional, Pan, Mei-Ren, additional, Chiang, Chih-Po, additional, Luo, Chi-Wen, additional, Lin, Huei-Shan, additional, Kao, Chieh-Ni, additional, Wu, Cheng-Che, additional, Li, Chung-Liang, additional, Shiau, Jun-Ping, additional, Yang, Ping-Fu, additional, Kan, Jung-Yu, additional, Chuang, Chieh-Han, additional, Shih, Shen-Liang, additional, Chen, Fang-Ming, additional, and Hou, Ming-Feng, additional

Published
2024
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25. Analysis of the pan-Asian subgroup of patients in the NALA Trial: a randomized phase III NALA Trial comparing neratinib+capecitabine (N+C) vs lapatinib+capecitabine (L+C) in patients with HER2+metastatic breast cancer (mBC) previously treated with two or more HER2-directed regimens

Author

Dai, Ming Shen, Feng, Yin Hsun, Chen, Shang Wen, Masuda, Norikazu, Yau, Thomas, Chen, Shou Tung, Lu, Yen Shen, Yap, Yoon Sim, Ang, Peter C. S., Chu, Sung Chao, Kwong, Ava, Lee, Keun Seok, Ow, Samuel, Kim, Sung Bae, Lin, Johnson, Chung, Hyun Cheol, Ngan, Roger, Kok, Victor C., Rau, Kun Ming, Sangai, Takafumi, Ng, Ting Ying, Tseng, Ling Ming, Bryce, Richard, Bebchuk, Judith, Chen, Mei Chieh, and Hou, Ming Feng

Published
2021
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29. Fine‐scale mapping of 8q24 locus identifies multiple independent risk variants for breast cancer

Author

Shi, Jiajun, Zhang, Yanfeng, Zheng, Wei, Michailidou, Kyriaki, Ghoussaini, Maya, Bolla, Manjeet K, Wang, Qin, Dennis, Joe, Lush, Michael, Milne, Roger L, Shu, Xiao‐Ou, Beesley, Jonathan, Kar, Siddhartha, Andrulis, Irene L, Anton‐Culver, Hoda, Arndt, Volker, Beckmann, Matthias W, Zhao, Zhiguo, Guo, Xingyi, Benitez, Javier, Beeghly‐Fadiel, Alicia, Blot, William, Bogdanova, Natalia V, Bojesen, Stig E, Brauch, Hiltrud, Brenner, Hermann, Brinton, Louise, Broeks, Annegien, Brüning, Thomas, Burwinkel, Barbara, Cai, Hui, Canisius, Sander, Chang‐Claude, Jenny, Choi, Ji‐Yeob, Couch, Fergus J, Cox, Angela, Cross, Simon S, Czene, Kamila, Darabi, Hatef, Devilee, Peter, Droit, Arnaud, Dork, Thilo, Fasching, Peter A, Fletcher, Olivia, Flyger, Henrik, Fostira, Florentia, Gaborieau, Valerie, García‐Closas, Montserrat, Giles, Graham G, Grip, Mervi, Guenel, Pascal, Haiman, Christopher A, Hamann, Ute, Hartman, Mikael, Miao, Hui, Hollestelle, Antoinette, Hopper, John L, Hsiung, Chia‐Ni, Investigators, kConFab, Ito, Hidemi, Jakubowska, Anna, Johnson, Nichola, Torres, Diana, Kabisch, Maria, Kang, Daehee, Khan, Sofia, Knight, Julia A, Kosma, Veli‐Matti, Lambrechts, Diether, Li, Jingmei, Lindblom, Annika, Lophatananon, Artitaya, Lubinski, Jan, Mannermaa, Arto, Manoukian, Siranoush, Le Marchand, Loic, Margolin, Sara, Marme, Frederik, Matsuo, Keitaro, McLean, Catriona, Meindl, Alfons, Muir, Kenneth, Neuhausen, Susan L, Nevanlinna, Heli, Nord, Silje, Børresen‐Dale, Anne‐Lise, Olson, Janet E, Orr, Nick, van den Ouweland, Ans MW, Peterlongo, Paolo, Putti, Thomas Choudary, Rudolph, Anja, Sangrajrang, Suleeporn, Sawyer, Elinor J, Schmidt, Marjanka K, Schmutzler, Rita K, Shen, Chen‐Yang, Hou, Ming‐Feng, Shrubsole, Matha J, and Southey, Melissa C

Subjects
Genetics, Cancer, Breast Cancer, Human Genome, Aetiology, 2.1 Biological and endogenous factors, Alleles, Breast Neoplasms, Case-Control Studies, Chromosome Mapping, Chromosomes, Human, Pair 8, Female, Genetic Variation, Genome-Wide Association Study, Genotype, Haplotypes, Humans, Linkage Disequilibrium, Odds Ratio, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Risk, White People, breast cancer, genetic susceptibility, 8q24, fine-mapping, single nucleotide polymorphism, Mervi Grip, kConFab Investigators, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

Previous genome-wide association studies among women of European ancestry identified two independent breast cancer susceptibility loci represented by single nucleotide polymorphisms (SNPs) rs13281615 and rs11780156 at 8q24. A fine-mapping study across 2.06 Mb (chr8:127,561,724-129,624,067, hg19) in 55,540 breast cancer cases and 51,168 controls within the Breast Cancer Association Consortium was conducted. Three additional independent association signals in women of European ancestry, represented by rs35961416 (OR = 0.95, 95% CI = 0.93-0.97, conditional p = 5.8 × 10(-6) ), rs7815245 (OR = 0.94, 95% CI = 0.91-0.96, conditional p = 1.1 × 10(-6) ) and rs2033101 (OR = 1.05, 95% CI = 1.02-1.07, conditional p = 1.1 × 10(-4) ) were found. Integrative analysis using functional genomic data from the Roadmap Epigenomics, the Encyclopedia of DNA Elements project, the Cancer Genome Atlas and other public resources implied that SNPs rs7815245 in Signal 3, and rs1121948 in Signal 5 (in linkage disequilibrium with rs11780156, r(2)  = 0.77), were putatively functional variants for two of the five independent association signals. The results highlighted multiple 8q24 variants associated with breast cancer susceptibility in women of European ancestry.

Published
2016

33. Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation

Author

Lee, Heng-Huan, Wang, Ying-Nai, Yang, Wen-Hao, Xia, Weiya, Wei, Yongkun, Chan, Li-Chuan, Wang, Yu-Han, Jiang, Zhou, Xu, Shouping, Yao, Jun, Qiu, Yufan, Hsu, Yi-Hsin, Hwang, Wei-Lun, Yan, Meisi, Cha, Jong-Ho, Hsu, Jennifer L., Shen, Jia, Ye, Yuanqing, Wu, Xifeng, Hou, Ming-Feng, Tseng, Lin-Ming, Wang, Shao-Chun, Pan, Mei-Ren, Yang, Chin-Hua, Wang, Yuan-Liang, Yamaguchi, Hirohito, Pang, Da, Hortobagyi, Gabriel N., Yu, Dihua, and Hung, Mien-Chie

Published
2021
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36. Erdafitinib in patients with advanced solid tumours with FGFR alterations (RAGNAR): an international, single-arm, phase 2 study

Author

Pant, Shubham, primary, Schuler, Martin, additional, Iyer, Gopa, additional, Witt, Olaf, additional, Doi, Toshihiko, additional, Qin, Shukui, additional, Tabernero, Josep, additional, Reardon, David A, additional, Massard, Christophe, additional, Minchom, Anna, additional, Lugowska, Iwona, additional, Carranza, Omar, additional, Arnold, Dirk, additional, Gutierrez, Martin, additional, Winter, Helen, additional, Stuyckens, Kim, additional, Crow, Lauren, additional, Najmi, Saltanat, additional, Hammond, Constance, additional, Thomas, Shibu, additional, Santiago-Walker, Ademi, additional, Triantos, Spyros, additional, Sweiti, Hussein, additional, Loriot, Yohann, additional, Greco, Martin Alberto, additional, Coward, Jim, additional, Joshua, Anthony, additional, Karapetis, Christos, additional, Hart, Christopher, additional, Zhang, Alison, additional, Prenen, Hans, additional, Goeminne, Jean-Charles, additional, Machiels, Jean-Pascal, additional, Rottey, Sylvie, additional, Corassa, Marcelo, additional, Molin, Graziela Zibetti Dal, additional, Tiscoski, Katsuki, additional, Jardim, Denis Leonardo Fontes, additional, Mak, Milena, additional, Fu, Wei, additional, Yao, Herui, additional, Huang, Jing, additional, Jiang, Haiping, additional, Chen, Baoshi, additional, Yan, Dong, additional, Yang, Yu, additional, Le Tourneau, Christophe, additional, Penel, Nicolas, additional, Salas, Sébastien, additional, Blay, Jean-Yves, additional, Brachet, Pierre-Emmanuel, additional, Durando, Xavier, additional, Emambux, Sheik, additional, Ravaud, Alain, additional, Folprecht, Gunnar, additional, Ahrens, Marit, additional, Golf, Alexander, additional, Haag, Georg Martin, additional, Lordick, Florian, additional, Desuki, Alexander, additional, Cazzaniga, Marina, additional, Ciardiello, Fortunato, additional, Milella, Michele, additional, Koyama, Takafumi, additional, Hirooka, Yoshiki, additional, Okamoto, Wataru, additional, Aogi, Kenjiro, additional, Kuboki, Yasutoshi, additional, Lee, Jungyun, additional, Kim, Sung-Bae, additional, Ahn, Myung-Ju, additional, Chang, Jong Hee, additional, Kim, Yong-Man, additional, Nam, Do-Hyun, additional, Park, Jae-Sung, additional, Paz-Ares, Luis, additional, Moreno, Victor, additional, Cervantes, Andres, additional, Calvo, Mariona, additional, Falcon, Alejandro, additional, Gonzalez, Antonio, additional, Martinez Bueno, Alejandro, additional, García-Corbacho, Javier, additional, Longo, Federico, additional, Yen, Chia-Jui, additional, Chen, Jen-Shi, additional, Hou, Ming-Feng, additional, Chao, Yee, additional, Rau, Kun-Ming, additional, Chiu, Tai-Jan, additional, Feng, Yin-Hsun, additional, Hsu, Chih-Hung, additional, Huang, Wen-Tsung, additional, Lai, Kuan-Ming, additional, Yeh, Su-peng, additional, Palmer, Daniel, additional, Welsh, Liam, additional, Plummer, Ruth, additional, Iyer, Gopakumar, additional, Bilen, Mehmet, additional, Arrowsmith, Edward, additional, Pant, Shubham, additional, Spigel, David Robert, additional, Zandberg, Dan Paul, additional, Doroshow, Deborah, additional, Lu-Emerson, Christine, additional, Moezi, Mehdi, additional, Paulson, Scott, additional, Reardon, David, additional, Ward, Patrick, additional, Chaves, Jorge, additional, Grigg, Claud, additional, Hussein, Atif, additional, Manda, Sudhir, additional, Monticelli, Michael, additional, Qamar, Rubina, additional, Richey, Stephen L, additional, Tamura, David, additional, and Wilks, Sharon, additional

Published
2023
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46. Diterpenes from Grangea maderaspatana

Author

Chang, Fang-Rong, Huang, Shih-Ting, Liaw, Chih-Chuang, Yen, Ming-Hong, Hwang, Tsong-Long, Chen, Ching-Yeu, Hou, Ming-Feng, Yuan, Shyng-Shiou, Cheng, Yuan-Bin, and Wu, Yang-Chang

Published
2016
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47. Wild-type p53 upregulates an early onset breast cancer-associated gene GAS7 to suppress metastasis via GAS7–CYFIP1-mediated signaling pathway

Author

Chang, Jer-Wei, Kuo, Wen-Hung, Lin, Chiao-Mei, Chen, Wen-Ling, Chan, Shih-Hsuan, Chiu, Meng-Fan, Chang, I-Shou, Jiang, Shih-Sheng, Tsai, Fang-Yu, Chen, Chung-Hsing, Huang, Pei-Hsin, Chang, King-Jen, Lin, Kai-Ti, Lin, Sheng-Chieh, Wang, Ming-Yang, Uen, Yih-Huei, Tu, Chi-Wen, Hou, Ming-Feng, Tsai, Shih-Feng, Shen, Chen-Yang, Tung, Shiao-Lin, and Wang, Lu-Hai

Published
2018
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49. Supplementary Methods, Figures S1 - S3 from Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types

Author

Kar, Siddhartha P., primary, Beesley, Jonathan, primary, Amin Al Olama, Ali, primary, Michailidou, Kyriaki, primary, Tyrer, Jonathan, primary, Kote-Jarai, ZSofia, primary, Lawrenson, Kate, primary, Lindstrom, Sara, primary, Ramus, Susan J., primary, Thompson, Deborah J., primary, Kibel, Adam S., primary, Dansonka-Mieszkowska, Agnieszka, primary, Michael, Agnieszka, primary, Dieffenbach, Aida K., primary, Gentry-Maharaj, Aleksandra, primary, Whittemore, Alice S., primary, Wolk, Alicja, primary, Monteiro, Alvaro, primary, Peixoto, Ana, primary, Kierzek, Andrzej, primary, Cox, Angela, primary, Rudolph, Anja, primary, Gonzalez-Neira, Anna, primary, Wu, Anna H., primary, Lindblom, Annika, primary, Swerdlow, Anthony, primary, Ziogas, Argyrios, primary, Ekici, Arif B., primary, Burwinkel, Barbara, primary, Karlan, Beth Y., primary, Nordestgaard, Børge G., primary, Blomqvist, Carl, primary, Phelan, Catherine, primary, McLean, Catriona, primary, Pearce, Celeste Leigh, primary, Vachon, Celine, primary, Cybulski, Cezary, primary, Slavov, Chavdar, primary, Stegmaier, Christa, primary, Maier, Christiane, primary, Ambrosone, Christine B., primary, Høgdall, Claus K., primary, Teerlink, Craig C., primary, Kang, Daehee, primary, Tessier, Daniel C., primary, Schaid, Daniel J., primary, Stram, Daniel O., primary, Cramer, Daniel W., primary, Neal, David E., primary, Eccles, Diana, primary, Flesch-Janys, Dieter, primary, Edwards, Digna R. Velez, primary, Wokozorczyk, Dominika, primary, Levine, Douglas A., primary, Yannoukakos, Drakoulis, primary, Sawyer, Elinor J., primary, Bandera, Elisa V., primary, Poole, Elizabeth M., primary, Goode, Ellen L., primary, Khusnutdinova, Elza, primary, Høgdall, Estrid, primary, Song, Fengju, primary, Bruinsma, Fiona, primary, Heitz, Florian, primary, Modugno, Francesmary, primary, Hamdy, Freddie C., primary, Wiklund, Fredrik, primary, Giles, Graham G., primary, Olsson, Håkan, primary, Wildiers, Hans, primary, Ulmer, Hans-Ulrich, primary, Pandha, Hardev, primary, Risch, Harvey A., primary, Darabi, Hatef, primary, Salvesen, Helga B., primary, Nevanlinna, Heli, primary, Gronberg, Henrik, primary, Brenner, Hermann, primary, Brauch, Hiltrud, primary, Anton-Culver, Hoda, primary, Song, Honglin, primary, Lim, Hui-Yi, primary, McNeish, Iain, primary, Campbell, Ian, primary, Vergote, Ignace, primary, Gronwald, Jacek, primary, Lubiński, Jan, primary, Stanford, Janet L., primary, Benítez, Javier, primary, Doherty, Jennifer A., primary, Permuth, Jennifer B., primary, Chang-Claude, Jenny, primary, Donovan, Jenny L., primary, Dennis, Joe, primary, Schildkraut, Joellen M., primary, Schleutker, Johanna, primary, Hopper, John L., primary, Kupryjanczyk, Jolanta, primary, Park, Jong Y., primary, Figueroa, Jonine, primary, Clements, Judith A., primary, Knight, Julia A., primary, Peto, Julian, primary, Cunningham, Julie M., primary, Pow-Sang, Julio, primary, Batra, Jyotsna, primary, Czene, Kamila, primary, Lu, Karen H., primary, Herkommer, Kathleen, primary, Khaw, Kay-Tee, primary, Matsuo, Keitaro, primary, Muir, Kenneth, primary, Offitt, Kenneth, primary, Chen, Kexin, primary, Moysich, Kirsten B., primary, Aittomäki, Kristiina, primary, Odunsi, Kunle, primary, Kiemeney, Lambertus A., primary, Massuger, Leon F.A.G., primary, Fitzgerald, Liesel M., primary, Cook, Linda S., primary, Cannon-Albright, Lisa, primary, Hooning, Maartje J., primary, Pike, Malcolm C., primary, Bolla, Manjeet K., primary, Luedeke, Manuel, primary, Teixeira, Manuel R., primary, Goodman, Marc T., primary, Schmidt, Marjanka K., primary, Riggan, Marjorie, primary, Aly, Markus, primary, Rossing, Mary Anne, primary, Beckmann, Matthias W., primary, Moisse, Matthieu, primary, Sanderson, Maureen, primary, Southey, Melissa C., primary, Jones, Michael, primary, Lush, Michael, primary, Hildebrandt, Michelle A.T., primary, Hou, Ming-Feng, primary, Schoemaker, Minouk J., primary, Garcia-Closas, Montserrat, primary, Bogdanova, Natalia, primary, Rahman, Nazneen, primary, Le, Nhu D., primary, Orr, Nick, primary, Wentzensen, Nicolas, primary, Pashayan, Nora, primary, Peterlongo, Paolo, primary, Guénel, Pascal, primary, Brennan, Paul, primary, Paulo, Paula, primary, Webb, Penelope M., primary, Broberg, Per, primary, Fasching, Peter A., primary, Devilee, Peter, primary, Wang, Qin, primary, Cai, Qiuyin, primary, Li, Qiyuan, primary, Kaneva, Radka, primary, Butzow, Ralf, primary, Kopperud, Reidun Kristin, primary, Schmutzler, Rita K., primary, Stephenson, Robert A., primary, MacInnis, Robert J., primary, Hoover, Robert N., primary, Winqvist, Robert, primary, Ness, Roberta, primary, Milne, Roger L., primary, Travis, Ruth C., primary, Benlloch, Sara, primary, Olson, Sara H., primary, McDonnell, Shannon K., primary, Tworoger, Shelley S., primary, Maia, Sofia, primary, Berndt, Sonja, primary, Lee, Soo Chin, primary, Teo, Soo-Hwang, primary, Thibodeau, Stephen N., primary, Bojesen, Stig E., primary, Gapstur, Susan M., primary, Kjær, Susanne Krüger, primary, Pejovic, Tanja, primary, Tammela, Teuvo L.J., primary, Dörk, Thilo, primary, Brüning, Thomas, primary, Wahlfors, Tiina, primary, Key, Tim J., primary, Edwards, Todd L., primary, Menon, Usha, primary, Hamann, Ute, primary, Mitev, Vanio, primary, Kosma, Veli-Matti, primary, Setiawan, Veronica Wendy, primary, Kristensen, Vessela, primary, Arndt, Volker, primary, Vogel, Walther, primary, Zheng, Wei, primary, Sieh, Weiva, primary, Blot, William J., primary, Kluzniak, Wojciech, primary, Shu, Xiao-Ou, primary, Gao, Yu-Tang, primary, Schumacher, Fredrick, primary, Freedman, Matthew L., primary, Berchuck, Andrew, primary, Dunning, Alison M., primary, Simard, Jacques, primary, Haiman, Christopher A., primary, Spurdle, Amanda, primary, Sellers, Thomas A., primary, Hunter, David J., primary, Henderson, Brian E., primary, Kraft, Peter, primary, Chanock, Stephen J., primary, Couch, Fergus J., primary, Hall, Per, primary, Gayther, Simon A., primary, Easton, Douglas F., primary, Chenevix-Trench, Georgia, primary, Eeles, Rosalind, primary, Pharoah, Paul D.P., primary, and Lambrechts, Diether, primary

Published
2023
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50. Supplementary Tables S1 - S10 from Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types

Author

Kar, Siddhartha P., primary, Beesley, Jonathan, primary, Amin Al Olama, Ali, primary, Michailidou, Kyriaki, primary, Tyrer, Jonathan, primary, Kote-Jarai, ZSofia, primary, Lawrenson, Kate, primary, Lindstrom, Sara, primary, Ramus, Susan J., primary, Thompson, Deborah J., primary, Kibel, Adam S., primary, Dansonka-Mieszkowska, Agnieszka, primary, Michael, Agnieszka, primary, Dieffenbach, Aida K., primary, Gentry-Maharaj, Aleksandra, primary, Whittemore, Alice S., primary, Wolk, Alicja, primary, Monteiro, Alvaro, primary, Peixoto, Ana, primary, Kierzek, Andrzej, primary, Cox, Angela, primary, Rudolph, Anja, primary, Gonzalez-Neira, Anna, primary, Wu, Anna H., primary, Lindblom, Annika, primary, Swerdlow, Anthony, primary, Ziogas, Argyrios, primary, Ekici, Arif B., primary, Burwinkel, Barbara, primary, Karlan, Beth Y., primary, Nordestgaard, Børge G., primary, Blomqvist, Carl, primary, Phelan, Catherine, primary, McLean, Catriona, primary, Pearce, Celeste Leigh, primary, Vachon, Celine, primary, Cybulski, Cezary, primary, Slavov, Chavdar, primary, Stegmaier, Christa, primary, Maier, Christiane, primary, Ambrosone, Christine B., primary, Høgdall, Claus K., primary, Teerlink, Craig C., primary, Kang, Daehee, primary, Tessier, Daniel C., primary, Schaid, Daniel J., primary, Stram, Daniel O., primary, Cramer, Daniel W., primary, Neal, David E., primary, Eccles, Diana, primary, Flesch-Janys, Dieter, primary, Edwards, Digna R. Velez, primary, Wokozorczyk, Dominika, primary, Levine, Douglas A., primary, Yannoukakos, Drakoulis, primary, Sawyer, Elinor J., primary, Bandera, Elisa V., primary, Poole, Elizabeth M., primary, Goode, Ellen L., primary, Khusnutdinova, Elza, primary, Høgdall, Estrid, primary, Song, Fengju, primary, Bruinsma, Fiona, primary, Heitz, Florian, primary, Modugno, Francesmary, primary, Hamdy, Freddie C., primary, Wiklund, Fredrik, primary, Giles, Graham G., primary, Olsson, Håkan, primary, Wildiers, Hans, primary, Ulmer, Hans-Ulrich, primary, Pandha, Hardev, primary, Risch, Harvey A., primary, Darabi, Hatef, primary, Salvesen, Helga B., primary, Nevanlinna, Heli, primary, Gronberg, Henrik, primary, Brenner, Hermann, primary, Brauch, Hiltrud, primary, Anton-Culver, Hoda, primary, Song, Honglin, primary, Lim, Hui-Yi, primary, McNeish, Iain, primary, Campbell, Ian, primary, Vergote, Ignace, primary, Gronwald, Jacek, primary, Lubiński, Jan, primary, Stanford, Janet L., primary, Benítez, Javier, primary, Doherty, Jennifer A., primary, Permuth, Jennifer B., primary, Chang-Claude, Jenny, primary, Donovan, Jenny L., primary, Dennis, Joe, primary, Schildkraut, Joellen M., primary, Schleutker, Johanna, primary, Hopper, John L., primary, Kupryjanczyk, Jolanta, primary, Park, Jong Y., primary, Figueroa, Jonine, primary, Clements, Judith A., primary, Knight, Julia A., primary, Peto, Julian, primary, Cunningham, Julie M., primary, Pow-Sang, Julio, primary, Batra, Jyotsna, primary, Czene, Kamila, primary, Lu, Karen H., primary, Herkommer, Kathleen, primary, Khaw, Kay-Tee, primary, Matsuo, Keitaro, primary, Muir, Kenneth, primary, Offitt, Kenneth, primary, Chen, Kexin, primary, Moysich, Kirsten B., primary, Aittomäki, Kristiina, primary, Odunsi, Kunle, primary, Kiemeney, Lambertus A., primary, Massuger, Leon F.A.G., primary, Fitzgerald, Liesel M., primary, Cook, Linda S., primary, Cannon-Albright, Lisa, primary, Hooning, Maartje J., primary, Pike, Malcolm C., primary, Bolla, Manjeet K., primary, Luedeke, Manuel, primary, Teixeira, Manuel R., primary, Goodman, Marc T., primary, Schmidt, Marjanka K., primary, Riggan, Marjorie, primary, Aly, Markus, primary, Rossing, Mary Anne, primary, Beckmann, Matthias W., primary, Moisse, Matthieu, primary, Sanderson, Maureen, primary, Southey, Melissa C., primary, Jones, Michael, primary, Lush, Michael, primary, Hildebrandt, Michelle A.T., primary, Hou, Ming-Feng, primary, Schoemaker, Minouk J., primary, Garcia-Closas, Montserrat, primary, Bogdanova, Natalia, primary, Rahman, Nazneen, primary, Le, Nhu D., primary, Orr, Nick, primary, Wentzensen, Nicolas, primary, Pashayan, Nora, primary, Peterlongo, Paolo, primary, Guénel, Pascal, primary, Brennan, Paul, primary, Paulo, Paula, primary, Webb, Penelope M., primary, Broberg, Per, primary, Fasching, Peter A., primary, Devilee, Peter, primary, Wang, Qin, primary, Cai, Qiuyin, primary, Li, Qiyuan, primary, Kaneva, Radka, primary, Butzow, Ralf, primary, Kopperud, Reidun Kristin, primary, Schmutzler, Rita K., primary, Stephenson, Robert A., primary, MacInnis, Robert J., primary, Hoover, Robert N., primary, Winqvist, Robert, primary, Ness, Roberta, primary, Milne, Roger L., primary, Travis, Ruth C., primary, Benlloch, Sara, primary, Olson, Sara H., primary, McDonnell, Shannon K., primary, Tworoger, Shelley S., primary, Maia, Sofia, primary, Berndt, Sonja, primary, Lee, Soo Chin, primary, Teo, Soo-Hwang, primary, Thibodeau, Stephen N., primary, Bojesen, Stig E., primary, Gapstur, Susan M., primary, Kjær, Susanne Krüger, primary, Pejovic, Tanja, primary, Tammela, Teuvo L.J., primary, Dörk, Thilo, primary, Brüning, Thomas, primary, Wahlfors, Tiina, primary, Key, Tim J., primary, Edwards, Todd L., primary, Menon, Usha, primary, Hamann, Ute, primary, Mitev, Vanio, primary, Kosma, Veli-Matti, primary, Setiawan, Veronica Wendy, primary, Kristensen, Vessela, primary, Arndt, Volker, primary, Vogel, Walther, primary, Zheng, Wei, primary, Sieh, Weiva, primary, Blot, William J., primary, Kluzniak, Wojciech, primary, Shu, Xiao-Ou, primary, Gao, Yu-Tang, primary, Schumacher, Fredrick, primary, Freedman, Matthew L., primary, Berchuck, Andrew, primary, Dunning, Alison M., primary, Simard, Jacques, primary, Haiman, Christopher A., primary, Spurdle, Amanda, primary, Sellers, Thomas A., primary, Hunter, David J., primary, Henderson, Brian E., primary, Kraft, Peter, primary, Chanock, Stephen J., primary, Couch, Fergus J., primary, Hall, Per, primary, Gayther, Simon A., primary, Easton, Douglas F., primary, Chenevix-Trench, Georgia, primary, Eeles, Rosalind, primary, Pharoah, Paul D.P., primary, and Lambrechts, Diether, primary

Published
2023
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