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14 results on '"Hou, Ruxia"'

4. Application of chronic disease management model in early childhood caries

Author

ZHANG Ning, WANG Xiangyu, HOU Ruxia, LIU Junyu, and LIU Jiajia

Subjects
children, deciduous teeth, caries, early childhood caries, prevention, chronic disease management, risk assessment, oral health management, behavioral management, Medicine
Abstract

Early childhood caries (ECC) is not only harmful to children's oral cavity and even the whole body, the government and relevant health departments pay more and more attention to the prevention and treatment of early childhood caries. However, at present, the primary treatment for ECC is the traditional filling therapy. The chronic disease management model can conduct regular testing of chronic non-communicable diseases and their risk factors, and provide long-term and effective professional management to patients by supervision and advice by doctors, nurses and pharmacists. This model has a good effect on slowing down the development of the disease, improving the quality of life of patients and saving public health resources. As a common chronic non-communicable disease, ECC is very suitable for prevention and treatment through chronic disease management. In recent years, chronic disease management models have also been increasingly used in the management of caries. The current common chronic disease management models include the chronic care model, innovative care for chronic condition, and British chronic disease management system models. And above models have certain applications in the management of ECC. How to establish the caries risk assessment system suitable for the diagnosis and treatment model of our country, and how to screen the children with high risk of caries by step-by-step prevention and control network for personalized prevention needed to be further studied in the future.

Published
2022
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7. Preparation and characterization of a biocompatible glucose-sensitive electrospun nanofibers scaffolds containing dexamethasone with enhanced osteogenic properties in vitro high glucose environment

Author

Jia, Yongliang, primary, Liu, Junyu, additional, Tan, Ziwei, additional, Liu, Jiajia, additional, Meng, Xiangjie, additional, Luo, Dongmei, additional, Fu, Xinyu, additional, Hou, Ruxia, additional, Li, Peiwen, additional, Chen, Yurou, additional, and Wang, Xiangyu, additional

Published
2023
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9. Glucose-sensitive delivery of tannic acid by a photo-crosslinked chitosan hydrogel film for antibacterial and anti-inflammatory therapy

Author

Liu, Junyu, Liu, Haifeng, Jia, Yongliang, Tan, Ziwei, Hou, Ruxia, Lu, Jie, Luo, Dongmei, Fu, Xinyu, Wang, Lu, and Wang, Xiangyu

Subjects
Biomaterials, Chitosan, Glucose, Anti-Inflammatory Agents, Biomedical Engineering, Biophysics, Hydrogels, Bioengineering, macromolecular substances, Methylgalactosides, Tannins, Anti-Bacterial Agents
Abstract

A glucose-sensitive antibacterial and anti-inflammatory hydrogel film with controlled release of tannic acid (TA) was synthesized using chitosan (CS). Specifically, the photo-crosslinked CS hydrogel was first obtained and then immersed in TA solution to generate composite hydrogel film with enhanced mechanical properties. Subsequently, N-hydroxysuccinimide/1-ethyl-3-(3-dimethylaminopropyl) carbodiimide based coupling chemistry was used to covalently crosslink glucose oxidase (GOx) to CS to obtain glucose sensitivity. The physicochemical properties, including chemical composition, enzyme-related characteristics, glucose responsiveness, and mechanical strength, were thoroughly investigated, followed by the cytotoxicity, antibacterial and anti-inflammatory tests. The results showed that the GOx immobilized on the film surface by covalent bonding gave better stability than those that were physically adsorbed. In addition, it could quickly and correspondingly modify its inner pore structure in response to the glucose stimulus and then control the loaded TA release. Meanwhile, the TA addition could enhance the film's mechanical properties. The composite hydrogel film demonstrated adequate biocompatibility and can inhibit NO, IL-6, and TNF-α production in stimulated macrophages, as well as Porphyromonas gingivalis growth, demonstrating effective antibacterial and anti-inflammatory activity.

Published
2022
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