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Your search keyword '"Hou, Yaming"' showing total 5 results
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5. Incorporation of Tellurocysteine into Glutathione Transferase Generates High Glutathione Peroxidase EfficiencyWe acknowledge financial support from the Natural Science Foundation of China No. 20534030, 20874036, the NSFC for Outstanding Younger Scientists No. 20725415, the National Basic Research Program 2007CB808006, and the 111 Project B06009. We thank Prof. August Böck for providing the cysteineauxotrophic expression system and Prof. Nediljko Budisa for critical reading of the manuscript.

Author

Liu, Xiaoman, Silks, LouisA., Liu, Cuiping, OllivaultShiflett, Morgane, Huang, Xin, Li, Jing, Luo, Guimin, Hou, YaMing, Liu, Junqiu, and Shen, Jiacong

Abstract

A rival to native peroxidase!An existing binding site for glutathione was combined with the catalytic residue tellurocysteine by using an auxotrophic expression system to create an engineered enzyme that functions as a glutathione peroxidase from the scaffold of a glutathione transferase see picture. The catalytic activity of the telluroenzyme in the reduction of hydroperoxides by glutathione is comparable to that of native glutathione peroxidase.

Published
2009
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