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24 results on '"Hou, YangFeng"'

2. Distinct interferon signatures and cytokine patterns define additional systemic autoinflammatory diseases

Author

de Jesus, Adriana A, Hou, Yangfeng, Brooks, Stephen, Malle, Louise, Biancotto, Angelique, Huang, Yan, Calvo, Katherine R, Marrero, Bernadette, Moir, Susan, Oler, Andrew J, Deng, Zuoming, Montealegre Sanchez, Gina A, Ahmed, Amina, Allenspach, Eric, Arabshahi, Bita, Behrens, Edward, Benseler, Susanne, Bezrodnik, Liliana, Bout-Tabaku, Sharon, Brescia, AnneMarie C, Brown, Diane, Burnham, Jon M, Caldirola, Maria Soledad, Carrasco, Ruy, Chan, Alice Y, Cimaz, Rolando, Dancey, Paul, Dare, Jason, DeGuzman, Marietta, Dimitriades, Victoria, Ferguson, Ian, Ferguson, Polly, Finn, Laura, Gattorno, Marco, Grom, Alexei A, Hanson, Eric P, Hashkes, Philip J, Hedrich, Christian M, Herzog, Ronit, Horneff, Gerd, Jerath, Rita, Kessler, Elizabeth, Kim, Hanna, Kingsbury, Daniel J, Laxer, Ronald M, Lee, Pui Y, Lee-Kirsch, Min Ae, Lewandowski, Laura, Li, Suzanne, Lilleby, Vibke, Mammadova, Vafa, Moorthy, Lakshmi N, Nasrullayeva, Gulnara, O'Neil, Kathleen M, Onel, Karen, Ozen, Seza, Pan, Nancy, Pillet, Pascal, Piotto, Daniela Gp, Punaro, Marilynn G, Reiff, Andreas, Reinhardt, Adam, Rider, Lisa G, Rivas-Chacon, Rafael, Ronis, Tova, Rösen-Wolff, Angela, Roth, Johannes, Ruth, Natasha Mckerran, Rygg, Marite, Schmeling, Heinrike, Schulert, Grant, Scott, Christiaan, Seminario, Gisella, Shulman, Andrew, Sivaraman, Vidya, Son, Mary Beth, Stepanovskiy, Yuriy, Stringer, Elizabeth, Taber, Sara, Terreri, Maria Teresa, Tifft, Cynthia, Torgerson, Troy, Tosi, Laura, Van Royen-Kerkhof, Annet, Wampler Muskardin, Theresa, Canna, Scott W, and Goldbach-Mansky, Raphaela

Subjects
Genetics, Clinical Research, Rare Diseases, 2.1 Biological and endogenous factors, Aetiology, Autoimmune Diseases, Female, Humans, Interferon Type I, Interleukin-18, Macrophage Activation Syndrome, Male, Mutation, Panniculitis, Pulmonary Alveolar Proteinosis, Genetic diseases, Immunology, Inflammation, Innate immunity, Monogenic diseases, Medical and Health Sciences
Abstract

BACKGROUNDUndifferentiated systemic autoinflammatory diseases (USAIDs) present diagnostic and therapeutic challenges. Chronic interferon (IFN) signaling and cytokine dysregulation may identify diseases with available targeted treatments.METHODSSixty-six consecutively referred USAID patients underwent underwent screening for the presence of an interferon signature using a standardized type-I IFN-response-gene score (IRG-S), cytokine profiling, and genetic evaluation by next-generation sequencing.RESULTSThirty-six USAID patients (55%) had elevated IRG-S. Neutrophilic panniculitis (40% vs. 0%), basal ganglia calcifications (46% vs. 0%), interstitial lung disease (47% vs. 5%), and myositis (60% vs. 10%) were more prevalent in patients with elevated IRG-S. Moderate IRG-S elevation and highly elevated serum IL-18 distinguished 8 patients with pulmonary alveolar proteinosis (PAP) and recurrent macrophage activation syndrome (MAS). Among patients with panniculitis and progressive cytopenias, 2 patients were compound heterozygous for potentially novel LRBA mutations, 4 patients harbored potentially novel splice variants in IKBKG (which encodes NF-κB essential modulator [NEMO]), and 6 patients had de novo frameshift mutations in SAMD9L. Of additional 12 patients with elevated IRG-S and CANDLE-, SAVI- or Aicardi-Goutières syndrome-like (AGS-like) phenotypes, 5 patients carried mutations in either SAMHD1, TREX1, PSMB8, or PSMG2. Two patients had anti-MDA5 autoantibody-positive juvenile dermatomyositis, and 7 could not be classified. Patients with LRBA, IKBKG, and SAMD9L mutations showed a pattern of IRG elevation that suggests prominent NF-κB activation different from the canonical interferonopathies CANDLE, SAVI, and AGS.CONCLUSIONSIn patients with elevated IRG-S, we identified characteristic clinical features and 3 additional autoinflammatory diseases: IL-18-mediated PAP and recurrent MAS (IL-18PAP-MAS), NEMO deleted exon 5-autoinflammatory syndrome (NEMO-NDAS), and SAMD9L-associated autoinflammatory disease (SAMD9L-SAAD). The IRG-S expands the diagnostic armamentarium in evaluating USAIDs and points to different pathways regulating IRG expression.TRIAL REGISTRATIONClinicalTrials.gov NCT02974595.FUNDINGThe Intramural Research Program of the NIH, NIAID, NIAMS, and the Clinical Center.

Published
2020

8. Adenovirus-mediated Overexpression of FcγRIIB Attenuates Pulmonary Inflammation and Fibrosis

Author

Zhang, Zhe, primary, Cao, Zhujie, additional, Hou, Lin, additional, Song, Meiyue, additional, Zhou, Yitian, additional, Chen, Yiling, additional, Hu, Huiyuan, additional, Hou, Yangfeng, additional, Liu, Ying, additional, Li, Bolun, additional, Song, Xiaomin, additional, Ge, Weipeng, additional, Li, Baicun, additional, Jiang, Xuehan, additional, Yang, Jie, additional, Song, Dingyun, additional, Zhang, Xinri, additional, Pang, Junling, additional, Zhang, Tiantian, additional, Zhang, Hong, additional, Yang, Peiran, additional, Wang, Jing, additional, and Wang, Chen, additional

Published
2023
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10. Single-Cell Transcriptome Profiles Reveal Fibrocytes as Potential Targets of Cell Therapies for Abdominal Aortic Aneurysm

Author

Li, Bolun, primary, Song, Xiaomin, additional, Guo, Wenjun, additional, Hou, Yangfeng, additional, Hu, Huiyuan, additional, Ge, Weipeng, additional, Fan, Tianfei, additional, Han, Zhifa, additional, Li, Zhiwei, additional, Yang, Peiran, additional, Gao, Ran, additional, Zhao, Hongmei, additional, and Wang, Jing, additional

Published
2021
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17. Fructus Ligustri Lucidi (FLL) ethanol extract increases bone mineral density and improves bone properties in growing female rats

Author

Hao Xu, Ying Lyu, Yajun Xu, Liya Denney, Yuehui Fang, Zhenghao Wu, Xin Feng, Pengling Zhao, Haotian Feng, and Hou Yangfeng

Subjects
Peak bone mass, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Ligustrum, Osteoporosis, Rats, Sprague-Dawley, chemistry.chemical_compound, Endocrinology, Calcitriol, Bone Density, In vivo, Internal medicine, medicine, Animals, Orthopedics and Sports Medicine, Bone Resorption, Bone mineral, Ethanol, Dose-Response Relationship, Drug, biology, Plant Extracts, RANK Ligand, Osteoprotegerin, General Medicine, medicine.disease, Rats, Dose–response relationship, chemistry, RANKL, biology.protein, Calcium, Female, Ligustri lucidi
Abstract

Osteoporosis is a chronic disease affecting millions of people worldwide. It is generally accepted that acquisition of a high peak bone mass (PBM) early in life can reduce the risk of osteoporosis later in life. The aims of this study were to investigate the effects of Fructus Ligustri Lucidi (FLL) ethanol extract on bone mineral density and its mechanical properties in growing female rats and to explore the underlying mechanisms. The rats were given different doses of FLL extract mixed with AIN-93G formula (0.40, 0.65 and 0.90 %), and a group given AIN-93G diet treatment only was used as control. The intervention lasted for 16 weeks until the animals were about 5 months old, the time when the animals almost reach their PBM. Our results showed that FLL treatment increased bone mineral density and improved bone mechanical properties in the growing female rats in a dose-dependent manner. In addition, FLL treatment significantly decreased the serum bone-resorbing marker, CTX-I, while significantly increasing serum 25(OH)D3 and thereby increasing Ca absorption and Ca retention. Intriguingly, both in vivo and in vitro results demonstrated that FLL treatment could reduce the RANKL/OPG ratio. In conclusion, FLL ethanol extract exerted beneficial effects on peak bone mass acquisition and the improvement of bone mechanical properties by favoring Ca metabolism and decreasing the RANKL/OPG ratio.

Published
2013

21. Maternal Docosahexaenoic Acid Feeding Protects Against Impairment of Learning and Memory and Oxidative Stress in Prenatally Stressed Rats: Possible Role of Neuronal Mitochondria Metabolism

Author

Feng, Zhihui, primary, Zou, Xuan, additional, Jia, Haiqun, additional, Li, Xuesen, additional, Zhu, Zhongliang, additional, Liu, Xuebo, additional, Bucheli, Peter, additional, Ballevre, Olivier, additional, Hou, Yangfeng, additional, Zhang, Weiguo, additional, Wang, Junkaun, additional, Chen, Yan, additional, and Liu, Jiankang, additional

Published
2012
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24. Painting with Needle, Silk, and Human Hair.

Author

Hou Yangfeng and Zhu Wezhi

Abstract

This article offers information regarding the art work entitled "Seven Scholars." Some experts in China said that art work, embroidered with silk and human hair at the Jinan General Embroidery Factory in China, produces a subtle harmony in fineness and textures. The embroidery is such meticulous quality of an ornamental needle work showing seven men of letters in the Three Kingdoms period and the Western Jin Dynasty. It is hand-embroidered with silk threads and colored human hair in 27 varieties of stitches.

Published
1990

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