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1. Factors Associated with Asthma Severity in Children: Data from the French COBRAPed Cohort

Author

Abou-Taam, Rola, Le Bourgeois, Muriel, Hadchouel-Duvergé, Alice, Drummond, David, Delacourt, Christophe, Alyanakian, Marie-Alexandra, Chatennoud, Lucienne, Thumerelle, Caroline, Mordacq, Clémence, Badiu-Decleyre, Irina, Bonnel, Cécile, Delbecque, Laure, Beghin, Laurent, Mingardi, Graziella, Tournegros, Caroline, Roditis, Léa, Wanin, Stéphanie, Lebras, Marie Noelle, Debelleix, Stéphane, Siao, Valérie, Servat, Marine, Simon, Guillaume, El Boustany, Patricia, Bosdure, Emmanuelle, Mazenq, Julie, Cabon, Isabelle, Ohlmann, Camille, Vrielynck, Stéphanie, Jubin, Virginie, André Gomez, Sylvie-Anne, Werck Gallois, Marie-Christine, Lezmi, Guillaume, Lejeune, Stéphanie, Pin, Isabelle, Blanchon, Sylvain, Bouazza, Naïm, Jolaine, Valérie, Marguet, Christophe, Houdoin, Véronique, Berger, Patrick, Fayon, Michael, Dubus, Jean-Christophe, Reix, Philippe, Pellan, Mathieu, Brouard, Jacques, Chiron, Raphael, Giovannini-Chami, Lisa, Deschildre, Antoine, and de Blic, Jacques

Published
2021
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2. Factors Associated with Asthma Severity in Children: Data from the French COBRAPed Cohort

Author

Lezmi, Guillaume, primary, Lejeune, Stéphanie, additional, Pin, Isabelle, additional, Blanchon, Sylvain, additional, Bouazza, Naïm, additional, Jolaine, Valérie, additional, Marguet, Christophe, additional, Houdoin, Véronique, additional, Berger, Patrick, additional, Fayon, Michael, additional, Dubus, Jean-Christophe, additional, Reix, Philippe, additional, Pellan, Mathieu, additional, Brouard, Jacques, additional, Chiron, Raphael, additional, Giovannini-Chami, Lisa, additional, Deschildre, Antoine, additional, de Blic, Jacques, additional, Abou-Taam, Rola, additional, Le Bourgeois, Muriel, additional, Hadchouel-Duvergé, Alice, additional, Drummond, David, additional, Delacourt, Christophe, additional, Alyanakian, Marie-Alexandra, additional, Chatennoud, Lucienne, additional, Thumerelle, Caroline, additional, Mordacq, Clémence, additional, Badiu-Decleyre, Irina, additional, Bonnel, Cécile, additional, Delbecque, Laure, additional, Beghin, Laurent, additional, Mingardi, Graziella, additional, Tournegros, Caroline, additional, Roditis, Léa, additional, Wanin, Stéphanie, additional, Lebras, Marie Noelle, additional, Debelleix, Stéphane, additional, Siao, Valérie, additional, Servat, Marine, additional, Simon, Guillaume, additional, El Boustany, Patricia, additional, Bosdure, Emmanuelle, additional, Mazenq, Julie, additional, Cabon, Isabelle, additional, Ohlmann, Camille, additional, Vrielynck, Stéphanie, additional, Jubin, Virginie, additional, André Gomez, Sylvie-Anne, additional, and Werck Gallois, Marie-Christine, additional

Published
2021
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3. Retrospective French nationwide survey of childhood aggressive vascular anomalies of bone, 1988-2009

Author

Forin Véronique, Houdoin Véronique, Revillon Yann, Wendling Daniel, Pin Isabelle, de Blic Jacques, Mary Pierre, Boccon-Gibod Liliane, Ouache Marie, Léonard Jean-Claude, Bost-Bru Cécile, Chastagner Pascal, Carrie Christian, Bertrand Yves, Ziade Makram, de Courtivron Benoit, Gillibert-Yvert Marion, Bigorre Michèle, Jaubert Francis, Le Merrer Martine, Héritier Sébastien, Lepointe Hubert, Languepin Jane, Wagnon Jeanne, Epaud Ralph, Fauroux Brigitte, and Donadieu Jean

Subjects
Medicine
Abstract

Abstract Objective To document the epidemiological, clinical, histological and radiological characteristics of aggressive vascular abnormalities of bone in children. Study design Correspondents of the French Society of Childhood Malignancies were asked to notify all cases of aggressive vascular abnormalities of bone diagnosed between January 1988 and September 2009. Results 21 cases were identified; 62% of the patients were boys. No familial cases were observed, and the disease appeared to be sporadic. Mean age at diagnosis was 8.0 years [0.8-16.9 years]. Median follow-up was 3 years [0.3-17 years]. The main presenting signs were bone fracture (n = 4) and respiratory distress (n = 7), but more indolent onset was observed in 8 cases. Lung involvement, with lymphangiectasies and pleural effusion, was the most frequent form of extraosseous involvement (10/21). Bisphosphonates, alpha interferon and radiotherapy were used as potentially curative treatments. High-dose radiotherapy appeared to be effective on pleural effusion but caused major late sequelae, whereas antiangiogenic drugs like alpha interferon and zoledrenate have had a limited impact on the course of pulmonary complications. The impact of bisphosphonates and alpha interferon on bone lesions was also difficult to assess, owing to insufficient follow-up in most cases, but it was occasionally positive. Six deaths were observed and the overall 10-year mortality rate was about 30%. The prognosis depended mainly on pulmonary and spinal complications. Conclusion Aggressive vascular abnormalities of bone are extremely rare in childhood but are lifethreatening. The impact of anti-angiogenic drugs on pulmonary complications seems to be limited, but they may improve bone lesions.

Published
2010
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4. Retrospective French nationwide survey of childhood aggressive vascular anomalies of bone, 1988-2009

Author

Héritier, Sébastien, primary, Le Merrer, Martine, additional, Jaubert, Francis, additional, Bigorre, Michèle, additional, Gillibert-Yvert, Marion, additional, de Courtivron, Benoit, additional, Ziade, Makram, additional, Bertrand, Yves, additional, Carrie, Christian, additional, Chastagner, Pascal, additional, Bost-Bru, Cécile, additional, Léonard, Jean-Claude, additional, Ouache, Marie, additional, Boccon-Gibod, Liliane, additional, Mary, Pierre, additional, de Blic, Jacques, additional, Pin, Isabelle, additional, Wendling, Daniel, additional, Revillon, Yann, additional, Houdoin, Véronique, additional, Forin, Véronique, additional, Lepointe, Hubert Ducou, additional, Languepin, Jane, additional, Wagnon, Jeanne, additional, Epaud, Ralph, additional, Fauroux, Brigitte, additional, and Donadieu, Jean, additional

Published
2010
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