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19 results on '"Houston, Michelle L"'

2. Sex‐specific associations of cerebrospinal fluid YKL‐40 with white matter hyperintensities over a 7‐year follow‐up period

Author

Peterson, Amalia Jo, primary, Zhang, Panpan, additional, Moore, Elizabeth E., additional, Eaton, James, additional, Pechman, Kimberly R., additional, Liu, Dandan, additional, Houston, Michelle L, additional, Davis, L. Taylor, additional, Gifford, Katherine A., additional, Landman, Bennett A., additional, Blennow, Kaj, additional, Zetterberg, Henrik, additional, Hohman, Timothy J., additional, and Jefferson, Angela L., additional

Published
2023
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3. Area Deprivation Index is associated with biomarkers of inflammation cross‐sectionally and longitudinally over a 9‐year follow‐up period

Author

Gogniat, Marissa A., primary, Khan, Omair A., additional, Bolton, Corey J, additional, Ratangee, Brina A., additional, Liu, Dandan, additional, Pechman, Kimberly R., additional, Yates, Alexis, additional, Eaton, James, additional, Houston, Michelle L, additional, Gifford, Katherine A., additional, Hohman, Timothy J., additional, Blennow, Kaj, additional, Zetterberg, Henrik, additional, and Jefferson, Angela L., additional

Published
2023
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4. Cognitive status modifies the association between elevated cerebrospinal fluid phosphorylated tau and longitudinal cerebral blood flow changes over a 7‐year follow‐up period

Author

Robb, W Hudson, primary, Gogniat, Marissa A., additional, Zhang, Panpan, additional, Shah, Krish U, additional, Houston, Michelle L, additional, Pechman, Kimberly R., additional, Liu, Dandan, additional, Landman, Bennett A., additional, Blennow, Kaj, additional, Zetterberg, Henrik, additional, Hohman, Timothy J., additional, and Jefferson, Angela L., additional

Published
2023
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5. Discovery‐based proteomics identifies plasma proteins that predict longitudinal cognitive decline in older adults over a 7‐year follow‐up period

Author

Kresge, Hailey A., primary, Patterson, Khiry L, additional, Libby, Julia B., additional, Robb, W Hudson, additional, Arul, Albert B, additional, Choi, Min Ji, additional, Oliver, Nekesa, additional, Whitaker, Marsalas D, additional, Moore, Elizabeth E., additional, Houston, Michelle L, additional, Pechman, Kimberly R., additional, Dumitrescu, Logan C, additional, Gifford, Katherine A., additional, Hohman, Timothy J., additional, Robinson, Renã AS, additional, and Jefferson, Angela L., additional

Published
2023
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7. CSF‐plasma albumin ratio differs by sex in community dwelling older adults

Author

Yates, Alexis, primary, Zhang, Panpan, additional, Liu, Dandan, additional, Pechman, Kimberly R., additional, Houston, Michelle L, additional, Davis, L. Taylor, additional, Landman, Bennett A., additional, Gifford, Katherine A., additional, Blennow, Kaj, additional, Zetterberg, Henrik, additional, Hohman, Timothy J., additional, and Jefferson, Angela L., additional

Published
2023
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9. Higher baseline cerebrospinal fluid platelet‐derived growth factor receptor‐β levels are associated with slower reductions in longitudinal cerebral blood flow among cognitively unimpaired individuals

Author

Moore, Elizabeth E., primary, Zhang, Panpan, additional, Pechman, Kimberly R., additional, Liu, Dandan, additional, Houston, Michelle L, additional, Shashikumar, Niranjana, additional, Davis, L. Taylor, additional, Archer, Derek B., additional, Gifford, Katherine A., additional, Landman, Bennett A., additional, Blennow, Kaj, additional, Zetterberg, Henrik, additional, Hohman, Timothy J., additional, and Jefferson, Angela L., additional

Published
2023
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10. Baseline plasma levels of ADAMTS13 predict cognitive decline and neurodegeneration among APOE‐ε4 carriers over a 7 year follow‐up period

Author

Kresge, Hailey A., primary, Khan, Omair A., additional, Liu, Dandan, additional, Libby, Julia B., additional, Robb, W Hudson, additional, Patterson, Khiry L, additional, Arul, Albert B, additional, Choi, Min Ji, additional, Oliver, Nekesa, additional, Whitaker, Marsalas D, additional, Houston, Michelle L, additional, Pechman, Kimberly R., additional, Landman, Bennett A., additional, Gifford, Katherine A., additional, Robinson, Renã AS, additional, Hohman, Timothy J., additional, and Jefferson, Angela L., additional

Published
2023
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11. Combining plasma p‐tau231 and glial fibrillary acidic protein produces higher discriminative accuracy for amyloid positivity than other blood‐based biomarker combinations

Author

Bolton, Corey J, primary, Khan, Omair A., additional, Liu, Dandan, additional, Houston, Michelle L, additional, Pechman, Kimberly R., additional, Gifford, Katherine A., additional, Hohman, Timothy J., additional, Blennow, Kaj, additional, Zetterberg, Henrik, additional, and Jefferson, Angela L., additional

Published
2023
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13. Adult Age Differences in Self-Reported Pain and Anterior CSF Space in Chiari Malformation

Author

García, Maitane, primary, Eppelheimer, Maggie S., additional, Houston, James R., additional, Houston, Michelle L., additional, Nwotchouang, Blaise Simplice Talla, additional, Kaut, Kevin P., additional, Labuda, Richard, additional, Bapuraj, J. Rajiv, additional, Maleki, Jahangir, additional, Klinge, Petra M., additional, Vorster, Sarel, additional, Luciano, Mark G., additional, Loth, Francis, additional, and Allen, Philip A., additional

Published
2021
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17. An Electrophysiological Study of Aging and Perceptual Letter-Matching.

Author

Mallik, Peter R., Allen, Philip A., Lien, Mei-Ching, Jardin, Elliott, Houston, Michelle L., Houston, James R., and Jurosic, Brianna K.

Subjects
AGE distribution, AGING, ELECTROENCEPHALOGRAPHY, NOISE, VISUAL perception, PHONOLOGICAL awareness, PATIENTS' attitudes
Abstract

Background: Previous studies on perceptual letter-matching have found that younger and older adults showed "fast-same" effects for response time and "false-different" effects for errors but the effects were more pronounced for older adults. According to the Noisy Operator Theory, internal noise in visual processing distorts "same" trials into appearing different whereas distortion for "different" trials does not affect performance. Older adults have a "noisier" representation of items within perceptual processing which can impact perceptual matching. However, EEG measures may provide a more direct measure of letter-matching decisions. Methods: We measured the P300 event-related potential (ERP) amplitude, an index of familiarity in stimulus categorization, and behavioral measures (response time and accuracy) to assess letter-matching performance. Results: Individuals responded faster to "same" trials than to "different" trials but were less accurate. Older adults showed similar P300 amplitudes across trial type whereas younger adults produced a larger amplitude for "same" than "different" trials, suggesting that older adults showed less familiarity for "same" trials than did younger adults – a prediction of the Noisy Operator Theory. Conclusions: These ERP results are consistent with the Noisy Operator Theory – suggesting that an age-related increase in internal noise affected letter-matching performance. [ABSTRACT FROM AUTHOR]

Published
2021
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18. Reduced temporal lobe cerebral blood flow is associated with regional white matter damage among apolipoprotein E ε4 carriers.

Author

Moore, Elizabeth E., Khan, Omair A., Shashikumar, Niranjana, Pechman, Kimberly R., Liu, Dandan, Houston, Michelle L, Archer, Derek B, Gifford, Katherine A., Landman, Bennett A., Hohman, Timothy J., and Jefferson, Angela L.

Abstract

Background: Reduced cerebral blood flow (CBF) is a risk factor for white matter damage. Apolipoprotein E (APOE) e4, a genetic risk factor for Alzheimer's disease and vascular health modifier, is associated with lower CBF. However, it remains unknown if lower CBF is associated with more severe white matter damage among APOE‐e4 carriers. We examine whether associations among regional CBF, cerebrovascular reactivity (CVR), and white matter integrity are modified by APOE‐e4 status in older adults. Method: Vanderbilt Memory and Aging Project participants (n = 313, 73±7 years) underwent 3T brain MRI. Resting grey matter CBF and CVR (CBF response to hypercapnic stimulus, ΔCBF/100*ΔCO2) were quantified in regions of interest from pseudo‐continuous arterial spin labeling (ASL). Fractional anisotropy (FA) was quantified from diffusion tensor imaging in tracts of interest derived from tractography templates. Linear regressions related regional CBF and CVR to tract‐specific FA, adjusting for demographic and vascular variables, regional tissue volume, cognitive status, and APOE‐e4 status. Follow‐up models tested an APOE‐ε4 status x ASL variable interaction term. Result: In main models, lower temporal lobe CBF was associated with lower FA in the occipital lobe, suggesting compromised white matter integrity (p = 0.02). Lower CBF and higher CVR in the occipital lobe were associated with compromised lower FA in all lobes (all p‐values<0.04). Temporal lobe CBF and CVR interacted with APOE‐e4 status, such that lower temporal lobe CBF related to lower FA in the frontal lobe (p = 0.01) and higher temporal lobe CVR related to lower FA in the frontal (p = 0.001) and temporal (p = 0.007) lobes among APOE‐e4 carriers only. Frontal lobe CVR interacted with APOE‐e4 status, such that higher CVR related to lower FA in the frontal (p<0.001) and temporal lobes (p = 0.008) in APOE‐e4 carriers only. Conclusion: Among older adults, APOE‐e4 modifies associations between cerebral hemodynamics and white matter integrity, such that reduced CBF and greater CVR in the temporal lobe are associated with greater white matter damage in APOE‐e4 carriers. APOE‐e4 carriers may be more susceptible to changes in temporal lobe hemodynamics, and vascular changes in the temporal lobe may have a stronger impact on brain health outcomes for carriers compared to non‐carriers. [ABSTRACT FROM AUTHOR]

Published
2023
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19. Real zeros of polynomials whose coefficients are independent random variables, each of which is either +1 or ~1, with equal probability, 1996

Author

Houston, Michelle L. (Author), Wilkins, J. Ernest (Degree supervisor), Houston, Michelle L. (Author), and Wilkins, J. Ernest (Degree supervisor)

Abstract

Suppose that the coefficients ak(k=0, 1,, n) in the polynomial of degree n,(1) f(x) = anxn + an-ix-1 + + aix + a0, are independent random variables, each of which is either +1 or -1 with equal probability. Then the number, N = N (f) , of real zeros of f(x) is a random variable. We will determine the mean, vn, and the variance, an2, of N when n = 1(1)6.

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