479 results on '"Howell, Gareth R."'
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2. Differential splicing of neuronal genes in a Trem2*R47H mouse model mimics alterations associated with Alzheimer’s disease
3. Prophylactic evaluation of verubecestat on disease‐ and symptom‐modifying effects in 5XFAD mice
4. Translational animal models for Alzheimer's disease: An Alzheimer's Association Business Consortium Think Tank
5. Model organism development and evaluation for late-onset Alzheimer's disease: MODEL-AD.
6. Inhibition of monocyte-like cell extravasation protects from neurodegeneration in DBA/2J glaucoma
7. Characterizing molecular and synaptic signatures in mouse models of late‐onset Alzheimer's disease independent of amyloid and tau pathology
8. Assessment of neurovascular uncoupling: APOE status is a key driver of early metabolic and vascular dysfunction
9. In vivo validation of late‐onset Alzheimer's disease genetic risk factors
10. Vascular derived endothelin receptor A controls endothelin-induced retinal ganglion cell death
11. Microglia depletion leads to increased susceptibility to ocular hypertension-dependent glaucoma.
12. Improving mouse models for the study of Alzheimer's disease
13. Sperm DNA methylation defects in a new mouse model of the 5,10-methylenetetrahydrofolate reductase 677C>T variant and correction with moderate dose folic acid supplementation
14. Neuroinflammation in glaucoma: A new opportunity
15. Metabolomics profiling reveals distinct, sex‐specific signatures in serum and brain metabolomes in mouse models of Alzheimer's disease.
16. Sperm DNA methylation defects in a new mouse model of the 5,10-methylenetetrahydrofolate reductase 677C>T variant and correction with moderate dose folic acid supplementation.
17. Transcriptional control of retinal ganglion cell death after axonal injury
18. Metabolomics profiling reveals distinct, sex-specific signatures in the serum and brain metabolomes in the mouse models of Alzheimer’s disease
19. Genetic context drives age‐related disparities in synaptic maintenance and structure across cortical and hippocampal neuronal circuits
20. Assessment of Neurovascular Uncoupling: APOE Status is a Key Driver of Early Metabolic and Vascular Dysfunction
21. An Integrative Multi‐Omics Approach Reveals Molecular Signatures Associated with Age and High‐Fat Diet in Mouse Models of Alzheimer’s Disease
22. Genetic diversity differentially regulates molecular mechanisms of brain aging under normal and pathological conditions
23. Genetic context controls microglia‐induced neuronal damage in Alzheimer’s disease
24. Investigating enhancement of TIE2 activation as a means of preserving blood‐brain barrier integrity and preventing cerebral amyloid angiopathy in Alzheimer’s Disease
25. Identifying human‐relevant genetic interactors of APOE using genetically diverse mouse strains
26. Assessing the Role of PLCG2*M28L Risk In A Novel Mouse Model Late‐Onset Alzheimer’s Disease
27. Metabolic syndrome in New Zealand Obese mice promotes microglial-vascular interactions and reduces microglial plasticity
28. Using genetic mouse models to gain insight into glaucoma: Past results and future possibilities
29. What are the earlier life contributions to reserve and resilience?
30. A common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome
31. Exercise prevents obesity-induced cognitive decline and white matter damage in mice
32. Folate Deficiency and/or the Genetic Variant Mthfr677C >T Can Drive Hepatic Fibrosis or Steatosis in Mice, in a Sex‐Specific Manner.
33. Genetic context drives age‐related disparities in synaptic maintenance and structure across cortical and hippocampal neuronal circuits.
34. Control of hippocampal synaptic plasticity by microglia–dendrite interactions depends on genetic context in mouse models of Alzheimer's disease.
35. New directions for Alzheimer's disease research from the Jackson Laboratory Center for Alzheimer's and Dementia Research 2022 workshop.
36. Control of hippocampal synaptic plasticity by microglia–dendrite interactions depends on genetic context in mouse models of Alzheimer's disease
37. Early immune responses are independent of RGC dysfunction in glaucoma with complement component C3 being protective
38. Genetic context controls early microglia-synaptic interactions in mouse models of Alzheimers disease
39. Endothelin 1-induced retinal ganglion cell death is largely mediated by JUN activation
40. A novel mouse model expressing human forms for complement receptors CR1 and CR2
41. Genetic perturbations of disease risk genes in mice capture transcriptomic signatures of late-onset Alzheimer’s disease
42. Transcriptional profiling predicts running promotes cerebrovascular remodeling in young but not midlife mice
43. Increased interactions and engulfment of dendrites by microglia precede Purkinje cell degeneration in a mouse model of Niemann Pick Type-C
44. Meox2 haploinsufficiency increases neuronal cell loss in a mouse model of Alzheimer's disease
45. Additional file 2 of Differential splicing of neuronal genes in a Trem2*R47H mouse model mimics alterations associated with Alzheimer’s disease
46. Transcriptome profiling of brain myeloid cells revealed activation of Itgal, Trem1, and Spp1 in western diet-induced obesity
47. Pharmacodynamics Assessment of Aducanumab in 5XFAD mice: A MODEL‐AD PTC Study
48. Genetically diverse mouse models of Alzheimer’s Disease reveal an association between amyloid deposition and glycan metabolism in the brain
49. Cerebral perfusion and glucose metabolism profiling reveal special phenotypes in the hAPOE3, hAPOE4, Trem2 risk, and doubled risks mice
50. A more natural context: Variation in mouse background improves models of vascular contributions to Alzheimer’s disease
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