Search

Your search keyword '"Howland, Shanshan Wu"' showing total 25 results
Start Over Author "Howland, Shanshan Wu"
25 results on '"Howland, Shanshan Wu"'

3. Robust Virus-Specific Adaptive Immunity in COVID-19 Patients with SARS-CoV-2 Δ382 Variant Infection

Author

Fong, Siew-Wai, Yeo, Nicholas Kim-Wah, Chan, Yi-Hao, Goh, Yun Shan, Amrun, Siti Naqiah, Ang, Nicholas, Rajapakse, Menaka Priyadharsani, Lum, Josephine, Foo, Shihui, Lee, Cheryl Yi-Pin, Carissimo, Guillaume, Chee, Rhonda Sin-Ling, Torres-Ruesta, Anthony, Tay, Matthew Zirui, Chang, Zi Wei, Poh, Chek Meng, Young, Barnaby Edward, Tambyah, Paul A., Kalimuddin, Shirin, Leo, Yee-Sin, Lye, David C., Lee, Bernett, Biswas, Subhra, Howland, Shanshan Wu, Renia, Laurent, and Ng, Lisa F. P.

Published
2022
Full Text
View/download PDF

4. Plasmodium vivax binds host CD98hc (SLC3A2) to enter immature red blood cells

Author

Malleret, Benoît, El Sahili, Abbas, Tay, Matthew Zirui, Carissimo, Guillaume, Ong, Alice Soh Meoy, Novera, Wisna, Lin, Jianqing, Suwanarusk, Rossarin, Kosaisavee, Varakorn, Chu, Trang T. T., Sinha, Ameya, Howland, Shanshan Wu, Fan, Yiping, Gruszczyk, Jakub, Tham, Wai-Hong, Colin, Yves, Maurer-Stroh, Sebastian, Snounou, Georges, Ng, Lisa F. P., Chan, Jerry Kok Yen, Chacko, Ann-Marie, Lescar, Julien, Chandramohanadas, Rajesh, Nosten, François, Russell, Bruce, and Rénia, Laurent

Published
2021
Full Text
View/download PDF

6. Single-Cell Analysis of Human Mononuclear Phagocytes Reveals Subset-Defining Markers and Identifies Circulating Inflammatory Dendritic Cells

Author

Dutertre, Charles-Antoine, Becht, Etienne, Irac, Sergio Erdal, Khalilnezhad, Ahad, Narang, Vipin, Khalilnezhad, Shabnam, Ng, Pei Y., van den Hoogen, Lucas L., Leong, Jing Yao, Lee, Bernett, Chevrier, Marion, Zhang, Xiao Meng, Yong, Pearly Jean Ai, Koh, Geraldine, Lum, Josephine, Howland, Shanshan Wu, Mok, Esther, Chen, Jinmiao, Larbi, Anis, Tan, Henry Kun Kiaang, Lim, Tony Kiat Hon, Karagianni, Panagiota, Tzioufas, Athanasios G., Malleret, Benoit, Brody, Joshua, Albani, Salvatore, van Roon, Joel, Radstake, Timothy, Newell, Evan W., and Ginhoux, Florent

Published
2019
Full Text
View/download PDF

7. Correction to: Robust Virus‐Specific Adaptive Immunity in COVID‐19 Patients with SARS‐CoV‐2 Δ382 Variant Infection

Author

Fong, Siew‐Wai, Yeo, Nicholas Kim‐Wah, Chan, Yi‐Hao, Goh, Yun Shan, Amrun, Siti Naqiah, Ang, Nicholas, Rajapakse, Menaka Priyadharsani, Lum, Josephine, Foo, Shihui, Lee, Cheryl Yi‐Pin, Carissimo, Guillaume, Chee, Rhonda Sin‐Ling, Torres‐Ruesta, Anthony, Tay, Matthew Zirui, Chang, Zi Wei, Poh, Chek Meng, Young, Barnaby Edward, Tambyah, Paul A., Kalimuddin, Shirin, Leo, Yee‐Sin, Lye, David C., Lee, Bernett, Biswas, Subhra, Howland, Shanshan Wu, Renia, Laurent, and Ng, Lisa F. P.

Published
2022
Full Text
View/download PDF

10. Notch-dependent cooperativity between myeloid lineages promotes Langerhans cell histiocytosis pathology

Author

Kvedaraite, Egle, primary, Milne, Paul, additional, Khalilnezhad, Ahad, additional, Chevrier, Marion, additional, Sethi, Raman, additional, Lee, Hong Kai, additional, Hagey, Daniel W., additional, von Bahr Greenwood, Tatiana, additional, Mouratidou, Natalia, additional, Jädersten, Martin, additional, Lee, Nicole Yee Shin, additional, Minnerup, Lara, additional, Tan, Yingrou, additional, Dutertre, Charles-Antoine, additional, Benac, Nathan, additional, Hwang, You Yi, additional, Lum, Josephine, additional, Loh, Amos Hong Pheng, additional, Jansson, Jessica, additional, Teng, Karen Wei Weng, additional, Khalilnezhad, Shabnam, additional, Xu, Weili, additional, Resteu, Anastasia, additional, Tey, Hong Liang, additional, Guan, Ng Lai, additional, Larbi, Anis, additional, Howland, Shanshan Wu, additional, Arnell, Henrik, additional, Andaloussi, Samir E. L., additional, Braier, Jorge, additional, Rassidakis, Georgios, additional, Galluzzo, Laura, additional, Dzionek, Andrzej, additional, Henter, Jan-Inge, additional, Chen, Jinmiao, additional, Collin, Matthew, additional, and Ginhoux, Florent, additional

Published
2022
Full Text
View/download PDF

11. CD8+ T Cells Trigger Auricular Dermatitis and Blepharitis in Mice after Zika Virus Infection in the Absence of CD4+ T Cells

Author

Lee, Cheryl Yi-Pin, primary, Carissimo, Guillaume, additional, Teo, Teck-Hui, additional, Tong, Samuel Jia Ming, additional, Chang, Zi Wei, additional, Rajarethinam, Ravisankar, additional, Chua, Tze Kwang, additional, Chen, Zheyuan, additional, Chee, Rhonda Sin-Ling, additional, Tay, Alicia, additional, Howland, Shanshan Wu, additional, Ang, Kok Siong, additional, Chen, Jinmiao, additional, Renia, Laurent, additional, and Ng, Lisa F.P., additional

Published
2022
Full Text
View/download PDF

13. Correction to: Robust Virus‐Specific Adaptive Immunity in COVID‐19 Patients with SARS‐CoV‐2 Δ382 Variant Infection

Author

Fong, Siew‐Wai, primary, Yeo, Nicholas Kim‐Wah, additional, Chan, Yi‐Hao, additional, Goh, Yun Shan, additional, Amrun, Siti Naqiah, additional, Ang, Nicholas, additional, Rajapakse, Menaka Priyadharsani, additional, Lum, Josephine, additional, Foo, Shihui, additional, Lee, Cheryl Yi‐Pin, additional, Carissimo, Guillaume, additional, Chee, Rhonda Sin‐Ling, additional, Torres‐Ruesta, Anthony, additional, Tay, Matthew Zirui, additional, Chang, Zi Wei, additional, Poh, Chek Meng, additional, Young, Barnaby Edward, additional, Tambyah, Paul A., additional, Kalimuddin, Shirin, additional, Leo, Yee‐Sin, additional, Lye, David C., additional, Lee, Bernett, additional, Biswas, Subhra, additional, Howland, Shanshan Wu, additional, Renia, Laurent, additional, and Ng, Lisa F. P., additional

Published
2021
Full Text
View/download PDF

14. Robust Virus-Specific Adaptive Immunity in COVID-19 Patients with SARS-CoV-2 Δ382 Variant Infection

Author

Fong, Siew-Wai, primary, Yeo, Nicholas Kim-Wah, additional, Chan, Yi-Hao, additional, Goh, Yun Shan, additional, Amrun, Siti Naqiah, additional, Ang, Nicholas, additional, Rajapakse, Menaka Priyadharsani, additional, Lum, Josephine, additional, Foo, Shihui, additional, Lee, Cheryl Yi-Pin, additional, Carissimo, Guillaume, additional, Chee, Rhonda Sin-Ling, additional, Torres-Ruesta, Anthony, additional, Tay, Matthew Zirui, additional, Chang, Zi Wei, additional, Poh, Chek Meng, additional, Young, Barnaby Edward, additional, Tambyah, Paul A., additional, Kalimuddin, Shirin, additional, Leo, Yee-Sin, additional, Lye, David C., additional, Lee, Bernett, additional, Biswas, Subhra, additional, Howland, Shanshan Wu, additional, Renia, Laurent, additional, and Ng, Lisa F. P., additional

Published
2021
Full Text
View/download PDF

16. Single-Cell Analysis of Human Mononuclear Phagocytes Reveals Subset-Defining Markers and Identifies Circulating Inflammatory Dendritic Cells

Author

Dutertre, Charles Antoine, Becht, Etienne, Irac, Sergio Erdal, Khalilnezhad, Ahad, Narang, Vipin, Khalilnezhad, Shabnam, Ng, Pei Y., van den Hoogen, Lucas L., Leong, Jing Yao, Lee, Bernett, Chevrier, Marion, Zhang, Xiao Meng, Yong, Pearly Jean Ai, Koh, Geraldine, Lum, Josephine, Howland, Shanshan Wu, Mok, Esther, Chen, Jinmiao, Larbi, Anis, Tan, Henry Kun Kiaang, Lim, Tony Kiat Hon, Karagianni, Panagiota, Tzioufas, Athanasios G., Malleret, Benoit, Brody, Joshua, Albani, Salvatore, van Roon, Joel, Radstake, Timothy, Newell, Evan W., Ginhoux, Florent, Dutertre, Charles Antoine, Becht, Etienne, Irac, Sergio Erdal, Khalilnezhad, Ahad, Narang, Vipin, Khalilnezhad, Shabnam, Ng, Pei Y., van den Hoogen, Lucas L., Leong, Jing Yao, Lee, Bernett, Chevrier, Marion, Zhang, Xiao Meng, Yong, Pearly Jean Ai, Koh, Geraldine, Lum, Josephine, Howland, Shanshan Wu, Mok, Esther, Chen, Jinmiao, Larbi, Anis, Tan, Henry Kun Kiaang, Lim, Tony Kiat Hon, Karagianni, Panagiota, Tzioufas, Athanasios G., Malleret, Benoit, Brody, Joshua, Albani, Salvatore, van Roon, Joel, Radstake, Timothy, Newell, Evan W., and Ginhoux, Florent

Published
2019

17. Single-Cell Analysis of Human Mononuclear Phagocytes Reveals Subset-Defining Markers and Identifies Circulating Inflammatory Dendritic Cells

Author

UMC Utrecht, Translationele immunologie, Infection & Immunity, CTI Radstake, Dutertre, Charles Antoine, Becht, Etienne, Irac, Sergio Erdal, Khalilnezhad, Ahad, Narang, Vipin, Khalilnezhad, Shabnam, Ng, Pei Y., van den Hoogen, Lucas L., Leong, Jing Yao, Lee, Bernett, Chevrier, Marion, Zhang, Xiao Meng, Yong, Pearly Jean Ai, Koh, Geraldine, Lum, Josephine, Howland, Shanshan Wu, Mok, Esther, Chen, Jinmiao, Larbi, Anis, Tan, Henry Kun Kiaang, Lim, Tony Kiat Hon, Karagianni, Panagiota, Tzioufas, Athanasios G., Malleret, Benoit, Brody, Joshua, Albani, Salvatore, van Roon, Joel, Radstake, Timothy, Newell, Evan W., Ginhoux, Florent, UMC Utrecht, Translationele immunologie, Infection & Immunity, CTI Radstake, Dutertre, Charles Antoine, Becht, Etienne, Irac, Sergio Erdal, Khalilnezhad, Ahad, Narang, Vipin, Khalilnezhad, Shabnam, Ng, Pei Y., van den Hoogen, Lucas L., Leong, Jing Yao, Lee, Bernett, Chevrier, Marion, Zhang, Xiao Meng, Yong, Pearly Jean Ai, Koh, Geraldine, Lum, Josephine, Howland, Shanshan Wu, Mok, Esther, Chen, Jinmiao, Larbi, Anis, Tan, Henry Kun Kiaang, Lim, Tony Kiat Hon, Karagianni, Panagiota, Tzioufas, Athanasios G., Malleret, Benoit, Brody, Joshua, Albani, Salvatore, van Roon, Joel, Radstake, Timothy, Newell, Evan W., and Ginhoux, Florent

Published
2019

18. Cerebral malaria

Author

Rénia, Laurent, primary, Howland, Shanshan Wu, additional, Claser, Carla, additional, Gruner, Anne Charlotte, additional, Suwanarusk, Rossarin, additional, Teo, Teck-Hui, additional, Russell, Bruce, additional, and Ng, Lisa F.P., additional

Published
2012
Full Text
View/download PDF

21. CD8+ T Cells Trigger Auricular Dermatitis and Blepharitis in Mice after Zika Virus Infection in the Absence of CD4+ T Cells

Author

Yi-Pin Lee, Cheryl, Carissimo, Guillaume, Teo, Teck-Hui, Ming Tong, Samuel Jia, Chang, Zi Wei, Rajarethinam, Ravisankar, Chua, Tze Kwang, Chen, Zheyuan, Sin-Ling, Rhonda Chee, Tay, Alicia, Howland, Shanshan Wu, Ang, Kok Siong, Chen, Jinmiao, Renia, Laurent, and Ng, Lisa F.P.

Abstract

Zika virus (ZIKV) became a public health concern when it re-emerged in 2015 owing to its ability to cause congenital deformities in the fetus and neurological complications in adults. Despite extensive data on protection, the interplay of protective and pathogenic adaptive immune responses toward ZIKV infection remains poorly understood. In this study, using a T-cell‒deficient mouse model that retains persistent ZIKV viral titers in the blood and organs, we show that the adoptive transfer of CD8+ T cells led to a significant reduction in viral load. This mouse model reveals that ZIKV can induce grossly visible auricular dermatitis and blepharitis, mediated by ZIKV-specific CD8+ T cells. Single-cell RNA sequencing of these causative CD8+ T cells from the ears shows an overactivated and elevated cytotoxic signature in mice with severe symptoms. Our results strongly suggest a role for CD8+ T-cell‒associated pathologies after ZIKV infection in CD4+ T-cell‒immunodeficient patients.

Published
2023
Full Text
View/download PDF

22. CD8+ T Cells and IFN-γ Mediate the Time-Dependent Accumulation of Infected Red Blood Cells in Deep Organs during Experimental Cerebral Malaria.

Author

Claser, Carla, Malleret, Benoît, Yee Gun, Sin, Yoke Wei^Wong, Alicia, Zi Wei Chang, Teo, Pearline, Chi, Peter, Ee See, Howland, Shanshan Wu, Ginhoux, Florent, and Rénia, Laurent

Subjects
PLASMODIUM, CEREBRAL malaria, LABORATORY mice, T cells, CYTOKINES, ERYTHROCYTE disorders, CELLULAR immunity, TRANSGENIC organisms, LUCIFERASES
Abstract

Background: Infection with Plasmodium berghei ANKA (PbA) in susceptible mice induces a syndrome called experimental cerebral malaria (ECM) with severe pathologies occurring in various mouse organs. Immune mediators such as T cells or cytokines have been implicated in the pathogenesis of ECM. Red blood cells infected with PbA parasites have been shown to accumulate in the brain and other tissues during infection. This accumulation is thought to be involved in PbA-induced pathologies, which mechanisms are poorly understood. Methods and Findings: Using transgenic PbA parasites expressing the luciferase protein, we have assessed by real-time in vivo imaging the dynamic and temporal contribution of different immune factors in infected red blood cell (IRBC) accumulation and distribution in different organs during PbA infection. Using deficient mice or depleting antibodies, we observed that CD8+ T cells and IFN-c drive the rapid increase in total parasite biomass and accumulation of IRBC in the brain and in different organs 6-12 days post-infection, at a time when mice develop ECM. Other cells types like CD4+ T cells, monocytes or neutrophils or cytokines such as IL-12 and TNF-α did not influence the early increase of total parasite biomass and IRBC accumulation in different organs. Conclusions: CD8+ T cells and IFN-γ are the major immune mediators controlling the time-dependent accumulation of P. berghei-infected red blood cells in tissues. [ABSTRACT FROM AUTHOR]

Published
2011
Full Text
View/download PDF

23. Author Correction: Lung endothelial cell antigen cross-presentation to CD8+T cells drives malaria-associated lung injury.

Author

Claser, Carla, Nguee, Samantha Yee Teng, Balachander, Akhila, Howland, Shanshan Wu, Becht, Etienne, Gunasegaran, Bavani, Hartimath, Siddesh V., Lee, Audrey W. Q., Ho, Jacqueline Theng Theng, Ong, Chee Bing, Newell, Evan W., Goggi, Julian, Ng, Lai Guan, and Renia, Laurent

Subjects
ENDOTHELIAL cells, LUNG injuries
Abstract

An amendment to this paper has been published and can be accessed via a link at the top of the paper. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
View/download PDF

24. A practical approach to immunotherapy of hepatocellular carcinoma using T cells redirected against hepatitis B virus.

Author

Koh S, Shimasaki N, Suwanarusk R, Ho ZZ, Chia A, Banu N, Howland SW, Ong AS, Gehring AJ, Stauss H, Renia L, Sällberg M, Campana D, and Bertoletti A

Abstract

Hepatocellular carcinoma (HCC) cells often have hepatitis B virus (HBV)-DNA integration and can be targeted by HBV-specific T cells. The use of viral vectors to introduce exogenous HBV-specific T-cell receptors (TCR) on T cells to redirect their specificity is complex and expensive to implement in clinical trials. Moreover, it raises safety concerns related to insertional mutagenesis and potential toxicity of long-lived HBV-specific T cells in patients with persistent infection. To develop a more practical and safer approach to cell therapy of HCC, we used electroporation of mRNA encoding anti-HBV TCR. Approximately 80% of CD8(+) T cells expressed functional HBV TCR 24 hours postelectroporation, an expression efficiency much higher than that obtained by retroviral transduction (~18%). Antigen-specific cytokine production of electroporated T cells was efficient within 72-hour period, after which the redirected T cells lost their HBV-specific function. Despite this transient functionality, the TCR-electroporated T cells efficiently prevented tumor seeding and suppressed the growth of established tumors in a xenograft model of HCC. Finally, we established a method for large-scale TCR mRNA electroporation that yielded large numbers of highly functional clinical-grade anti-HBV T cells. This method represents a practical approach to cell therapy of HCC and its inherently self-limiting toxicity suggests potential for application in other HBV-related pathologies.Molecular Therapy-Nucleic Acids (2013) 2, e114; doi:10.1038/mtna.2013.43; published online 13 August 2013.

Published
2013
Full Text
View/download PDF

25. Cerebral malaria: mysteries at the blood-brain barrier.

Author

Rénia L, Howland SW, Claser C, Charlotte Gruner A, Suwanarusk R, Hui Teo T, Russell B, and Ng LF

Subjects
Animals, Disease Models, Animal, Humans, Mice, Blood-Brain Barrier immunology, Blood-Brain Barrier parasitology, Host-Pathogen Interactions, Malaria, Cerebral parasitology, Malaria, Cerebral pathology, Plasmodium falciparum immunology, Plasmodium falciparum pathogenicity
Abstract

Cerebral malaria is the most severe pathology caused by the malaria parasite, Plasmodium falciparum. The pathogenic mechanisms leading to cerebral malaria are still poorly defined as studies have been hampered by limited accessibility to human tissues. Nevertheless, histopathology of post-mortem human tissues and mouse models of cerebral malaria have indicated involvement of the blood-brain barrier in cerebral malaria. In contrast to viruses and bacteria, malaria parasites do not infiltrate and infect the brain parenchyma. Instead, rupture of the blood-brain barrier occurs and may lead to hemorrhages resulting in neurological alterations. Here, we review the most recent findings from human studies and mouse models on the interactions of malaria parasites and the blood-brain barrier, shedding light on the pathogenesis of cerebral malaria, which may provide directions for possible interventions.

Published
2012
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results