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126 results on '"Hoyer, Denton"'

1. A γ-lactam siderophore antibiotic effective against multidrug-resistant Pseudomonas aeruginosa, Klebsiella pneumoniae, and Acinetobacter spp.

Author

Goldberg, Joel A., Kumar, Vijay, Spencer, Elizabeth J., Hoyer, Denton, Marshall, Steven H., Hujer, Andrea M., Hujer, Kristine M., Bethel, Christopher R., Papp-Wallace, Krisztina M., Perez, Federico, Jacobs, Michael R., van Duin, David, Kreiswirth, Barry N., van den Akker, Focco, Plummer, Mark S., and Bonomo, Robert A.

Published
2021
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7. Macrolides selectively inhibit mutant KCNJ5 potassium channels that cause aldosterone-producing adenoma

Author

Scholl, Ute I., Abriola, Laura, Zhang, Chengbiao, Reimer, Esther N., Plummer, Mark, Kazmierczak, Barbara I., Zhang, Junhui, Hoyer, Denton, Merkel, Jane S., Wang, Wenhui, and Lifton, Richard P.

Subjects
Hypertension -- Care and treatment -- Risk factors, Gene mutation -- Research, Adenoma -- Diagnosis -- Genetic aspects, Health care industry
Abstract

Aldosterone-producing adenomas (APAs) are benign tumors of the adrenal gland that constitutively produce the saltretaining steroid hormone aldosterone and cause millions of cases of severe hypertension worldwide. Either of 2 somatic mutations in the potassium channel KCNJ5 (G151R and L168R, hereafter referred to as [KCNJ5.sup.MUT]) in adrenocortical cellsaccount for half of APAs worldwide. These mutations alter channel selectivity to allow abnormal [Na.sup.+] conductance, resulting in membrane depolarization, calcium influx, aldosterone production, and cell proliferation. Because APA diagnosis requires a difficult invasive procedure, patients often remain undiagnosed and inadequately treated. Inhibitors of [KCNJ5.sup.MUT] could allow noninvasive diagnosis and therapy of APAs carrying KCNJ5 mutations. Here, we developed a high-throughput screen for rescue of [KCNJ5.sup.MUT]-induced lethality and identified a series of macrolide antibiotics, including roxithromycin, that potently inhibit [KCNJ5.sup.MUT], but not [KCNJ5.sup.WT]. Electrophysiology demonstrated direct [KCNJ5.sup.MUT] inhibition. In human aldosteroneproducing adrenocortical cancer cell lines, roxithromycin inhibited [KCNJ5.sup.MUT]-induced induction of CYP11B2 (encoding aldosterone synthase) expression and aldosterone production. Further exploration of macrolides showed that [KCNJ5.sup.MUT] was similarly selectively inhibited by idremcinal, a macrolide motilin receptor agonist, and by synthesized macrolide derivatives lacking antibiotic or motilide activity. Macrolide-derived selective [KCNJ5.sup.MUT] inhibitors thus have the potential to advance the diagnosis and treatment of APAs harboring [KCNJ5.sup.MUT]., Introduction Hypertension affects more than 1.1 billion people (1) and is a major risk factor for heart attack, stroke, and congestive heart failure, contributing to more than nine million deaths [...]

Published
2017
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10. Experiences in Academic and Industry Partnerships – Forging a Path to Translational Drug Discovery

Author

Hoyer Denton W, Anna‐Lena Gustavsson, Vadim J. Gurvich, Al Edwards, Paul D. Andrews, Daniel Ebner, Stephen Frye, Denise Barrault, Erik Chorell, Peter I. Dosa, Neil O. Carragher, Michael R. Myers, Gunda I. Georg, Hirotatsu Kojima, Andrew M. Hopkins, Richard E. Taylor, Michael A. Walters, Roland E. Dolle, and Jon E. Hawkinson

Subjects
Public–private partnership, Knowledge management, business.industry, Crowd sourcing, Path (graph theory), Business, Forging, Open innovation
Published
2021

11. Phosphorylated WNK kinase networks in recoded bacteria recapitulate physiological function

Author

Schiapparelli, Paula, primary, Pirman, Natasha L., additional, Mohler, Kyle, additional, Miranda-Herrera, Pierre A., additional, Zarco, Natanael, additional, Kilic, Onur, additional, Miller, Chad, additional, Shah, Sagar R., additional, Rogulina, Svetlana, additional, Hungerford, William, additional, Abriola, Laura, additional, Hoyer, Denton, additional, Turk, Benjamin E., additional, Guerrero-Cázares, Hugo, additional, Isaacs, Farren J., additional, Quiñones-Hinojosa, Alfredo, additional, Levchenko, Andre, additional, and Rinehart, Jesse, additional

Published
2021
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12. Experiences in Academic and Industry Partnerships – Forging a Path to Translational Drug Discovery

Author

Dolle, Roland E., primary, Barrault, Denise, additional, Carragher, Neil, additional, Andrews, Paul, additional, Ebner, Daniel, additional, Hopkins, Andrew, additional, Kojima, Hirotatsu, additional, Frye, Stephen, additional, Edwards, Al, additional, Dosa, Peter I., additional, Georg, Gunda I., additional, Gurvich, Vadim J., additional, Hawkinson, Jon E., additional, Walters, Michael A., additional, Gustavsson, Anna‐Lena, additional, Chorell, Erik, additional, Taylor, Richard E., additional, Hoyer, Denton, additional, and Myers, Michael R., additional

Published
2021
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14. A γ-Lactam Siderophore Antibiotic Effective against Multidrug-Resistant Gram-Negative Bacilli

Author

Goldberg, Joel A., primary, Nguyen, Ha, additional, Kumar, Vijay, additional, Spencer, Elizabeth J., additional, Hoyer, Denton, additional, Marshall, Emma K., additional, Cmolik, Anna, additional, O’Shea, Margaret, additional, Marshall, Steven H., additional, Hujer, Andrea M., additional, Hujer, Kristine M., additional, Rudin, Susan D., additional, Domitrovic, T. Nicholas, additional, Bethel, Christopher R., additional, Papp-Wallace, Krisztina M., additional, Logan, Latania K., additional, Perez, Federico, additional, Jacobs, Michael R., additional, van Duin, David, additional, Kreiswirth, Barry M., additional, Bonomo, Robert A., additional, Plummer, Mark S., additional, and van den Akker, Focco, additional

Published
2020
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16. 698. In vitro Activity of a New Generation Oxopyrazole Antibiotic Against Multidrug-Resistant Gram-Negative Bacilli

Author

Goldberg, Joel, primary, Bethel, Christopher, additional, Hujer, Andrea M, additional, Hujer, Kristine, additional, Marshall, Steven, additional, Papp-Wallace, Krisztina M, additional, Perez, Federico, additional, Spencer, Elizabeth, additional, Hoyer, Denton, additional, Plummer, Mark, additional, and Bonomo, Robert A, additional

Published
2019
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18. Palladium-catalyzed cross-coupling in the synthesis of pyridinyl boxazomycin C analogues

Author

Richardson, Chris, Rewcastle, Gordon W., Hoyer, Denton, and Denny, William A.

Subjects
Pyridine -- Chemical properties, Chemical synthesis -- Research, Ethers -- Chemical properties, Biological sciences, Chemistry
Abstract

Palladium-catalyzed cross-coupling chemistry is successfully applied in the model synthesis of a precursor to pyridinyl boxazomycin C analogues. It is also an example where thioether compounds provide an attractive alternative when other coupling partners cannot be used.

Published
2005

19. Pyrrolocin A, a 3-Decalinoyltetramic Acid with Selective Biological Activity, Isolated from Amazonian Cultures of the Novel Endophyte Diaporthales sp. E6927E

Author

Patridge, Eric V., Darnell, Alicia, Kucera, Kaury, Phillips, Gillian M., Bokesch, Heidi R., Gustafson, Kirk R., Dan Spakowicz, Zhou, Linda, Hungerford, William M., Plummer, Mark, Hoyer, Denton, Narvaez-Trujillo, Alexandra, Phillips, Andrew J., and Strobel, Scott A.

Subjects
Ascomycota, Bacteria, Molecular Structure, Endophytes, Genomics, Microbial Sensitivity Tests, DNA, Fungal, Ficus, Article, Phylogeny, Pyrrolidinones, Anti-Bacterial Agents
Abstract

Natural products remain an important source of new therapeutics for emerging drug-resistant pathogens like Candida albicans, which particularly affects immunocompromised patients. A bioactive 3-decalinoyltetramic acid, pyrrolocin A, was isolated from extracts of a novel Amazonian fungal endophyte, E6927E, of the Diaporthales family. The structure of the natural product was solved using NMR and CD spectroscopy and it is structurally related to the fungal setins, equisetin and phomasetin, which are well-characterized tetramic acid antibiotics specific for Gram-positive organisms. We show that the compound inhibits growth of Staphylococcus aureus and Enterococcus faecalis. It shows selective and potent bioactivity against fungal strains, with an MIC of 4 μg/mL for C. albicans, 100 μg/mL for Aspergillus sp. and greater than 100 μg/mL for Saccharomyces cerevisiae. Further, the compound is less toxic to mammalian cells (IC(50) = 150 μg/mL), with an inhibitory concentration greater than forty times that for C. albicans. Pyrrolocin A retained potent activity against eight out of seventeen strains of clinical Candida sp. isolates tested.

Published
2015

20. Effects of the ECE/NEP inhibitor CGS 34225 on the big ET-1-induced pressor response and plasma atrial natriuretic peptide concentration in conscious rats

Author

Paula Savage, Hoyer Denton W, Arco Y. Jeng, Cynthia A. Fink, Charles W. Bruseo, Angelo J. Trapani, and Michael E. Beil

Subjects
Male, medicine.hormone, medicine.medical_specialty, Endothelin converting enzyme 1, Phenylalanine, Blood Pressure, Endothelin-Converting Enzymes, Pharmacology, Rats, Sprague-Dawley, Endothelins, Inhibitory Concentration 50, Atrial natriuretic peptide, Internal medicine, medicine, Animals, Aspartic Acid Endopeptidases, Sulfhydryl Compounds, Enzyme Inhibitors, Protein Precursors, education, education.field_of_study, Dose-Response Relationship, Drug, Endothelin-1, Chemistry, Area under the curve, Metalloendopeptidases, General Medicine, Endothelin 1, Peptide Fragments, Rats, Dose–response relationship, Endocrinology, Area Under Curve, Neprilysin, Omapatrilat, Endothelin receptor, Atrial Natriuretic Factor, medicine.drug
Abstract

CGS 34226 is a thiol-containing, potent dual inhibitor of endothelin converting enzyme-1 (ECE-1) and neutral endopeptidase 24.11 (NEP) with IC50 values of 11 and 5nM respectively. The purpose of the present study was to characterize the inhibitory effects of CGS 34225, an orally active prodrug of CGS 34226, on ECE-1 and NEP in vivo. The effects on ECE-1 and NEP were assessed by determining the inhibition of big endothelin-1 (big ET-1)-induced increases in mean arterial pressure (MAP) and increases in plasma atrial natriuretic peptide (ANP) concentrations respectively, in conscious rats. Thirty and 120min after the administration of vehicle, big ET-1 (0.3nmol/kg, intravenously; i.v.) produced pressor responses of approximately 800mmHg·min (area under the curve for change in MAP×time). Treatment with CGS 34225 at 1mgEq/kg, per os (p.o.), decreased the pressor effect of big ET-1 by 39 and 53% at 30 and 120min respectively (P

Published
2002

24. Potent non-peptidic dual inhibitors of endothelin-converting enzyme and neutral endopeptidase 24.11

Author

Michael A. Moskal, Dongchu Wei, Lisa B. Stamford, Jenny Tan, Clive Gideon Diefenbacher, Eli M. Wallace, L. Blanchard, Paula Savage, Stéphane De Lombaert, Hoyer Denton W, and Arco Y. Jeng

Subjects
chemistry.chemical_classification, education.field_of_study, biology, Endothelin converting enzyme 1, Stereochemistry, fungi, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, law.invention, Enzyme, chemistry, law, Enzyme inhibitor, Drug Discovery, Recombinant DNA, biology.protein, Molecular Medicine, Moiety, education, Endothelin receptor, Molecular Biology, Neprilysin, IC50
Abstract

Structural modifications of CGS 26303, a non-peptidic α-aminophosphonate dual ECE/NEP inhibitor lead, were performed to maximize inhibition of recombinant human ECE-1, while maintaining strong NEP inhibition. Specifically, substitution of the α-aminophosphonate moiety with aryl ethyl side-chains led to the discovery of a new class of potent, non-peptidic, dual inhibitors, such as CGS 31447, which blocked ECE-1 and NEP activities with IC50's of 17 and 5 nM, respectively.

Published
1997

25. 3-chloro-4-carboxamido-6-arylpyridazines as a non-peptide class of interleukin-1β converting enzyme inhibitor

Author

Carla T. Helaszek, Schmidt Stanley J, Hoyer Denton W, Rinker James M, Tina Morgan Ross, Roland E. Dolle, and Mark A. Ator

Subjects
chemistry.chemical_classification, biology, medicine.drug_class, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Nitro compound, Pharmaceutical Science, Carboxamide, Biochemistry, Chemical synthesis, In vitro, Pyridazine, chemistry.chemical_compound, Enzyme, chemistry, Mechanism of action, Enzyme inhibitor, Drug Discovery, medicine, biology.protein, Molecular Medicine, medicine.symptom, Molecular Biology
Abstract

The 3-chloro-4-carboxamido-6-arylpyridazines are a novel class of interleukin-1β converting enzyme (ICE) inhibitor. These agents are irreversible inhibitors with pyridazine 23 possessing a k obs [I] = 355 M−1s−1. A structure-activity relationship for this non-peptide class of compounds and the putative mechanism for irreversible inactivation are described.

Published
1997

26. α-((Tetronoyl)oxy)- and α-((tetramoyl)oxy)methyl ketone inhibitors of the interleukin-1β converting enzyme (ICE)

Author

Prouty Catherine P, Roland E. Dolle, Joost Strastes, Mark A. Ator, Speier Gary J, Carla T. Helaszek, Hoyer Denton W, Todd L. Graybill, and Joanne Uhl

Subjects
chemistry.chemical_classification, Dipeptide, Ketone, biology, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Tripeptide, Biochemistry, Chemical synthesis, Cysteine protease, chemistry.chemical_compound, chemistry, Enzyme inhibitor, Drug Discovery, biology.protein, Lactam, Molecular Medicine, Molecular Biology, Lactone
Abstract

Aryl-substituted tetronic acids, tetramic acids, and cyclic β-dicarbonyl moieties were evaluated as leaving groups in the peptidyl-COCH2-X type inhibitor iii. Tripeptidyl aspartyl α-((tetronoyl)oxy)- and α-((tetramoyl)oxy)methyl ketone derivatives demonstrate potent time-dependent inhibition ( k obs [I] 100,000–250,000 M−1s−1) of the cysteine protease ICE.

Published
1997

27. Ace inhibitors as a template for the design of bradykinin B2 receptor antagonists

Author

Awad Mohamed M A, Wayne T. Houck, Hoyer Denton W, Peter R. Seoane, Roland E. Dolle, David G. Sawutz, and Salvino Joseph M

Subjects
biology, Bradykinin B2 Receptor Antagonists, Chemistry, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Bradykinin, Angiotensin-converting enzyme, Pharmacology, Biochemistry, Angiotensin II, chemistry.chemical_compound, Quinapril, Drug Discovery, ACE inhibitor, medicine, biology.protein, Molecular Medicine, Bradykinin receptor, Molecular Biology, Bradykinin receptor activity, medicine.drug
Abstract

Angiotensin converting enzyme (ACE) degrades both angiotensin II and bradykinin. Accordingly, we hypothesize that ACE inhibitors can serve as models to design antagonists for the bradykinin receptor. The potent ACE inhibitor Quinapril was modified to serve as a spacer separating two lipophilic positive charges required for bradykinin binding. The synthesis and bradykinin receptor activity of a series of antagonists 2–10 based on this hypothesis is described in this report.

Published
1995

28. Structural and stereochemical requirements of time-dependent inactivators of the interleukin-1β converting enzyme

Author

Hoyer Denton W, Schmidt Stanley J, Roland E. Dolle, C. V. C. Prasad, I. Kelly Osifo, Mark A. Ator, Carla T. Helaszek, Prouty Catherine P, Mohamad M. A. Awad, Tina Morgan Ross, Robert E. Miller, Salvino Joseph M, and Todd L. Graybill

Subjects
chemistry.chemical_classification, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Substrate (chemistry), Biochemistry, Amino acid, Enzyme, chemistry, mental disorders, Drug Discovery, Molecular Medicine, Interleukin 1β converting enzyme, Molecular Biology
Abstract

Structural and stereochemical requirements of substrate based time-dependent inactivators of interleukin-1β converting enzyme were investigated. Hydrophobic amino acids with L-stereochemistry are preferred at the P 2 and P 3 positions. It appears that both D-and L-Asp are accepted by the enzyme at the P I position.

Published
1995

29. Pyrrolocin A, a 3-Decalinoyltetramic Acid with Selective Biological Activity, Isolated from Amazonian Cultures of the Novel Endophyte Diaporthales sp. E6927E

Author

Patridge, Eric V., primary, Darnell, Alicia, additional, Kucera, Kaury, additional, Phillips, Gillian M., additional, Bokesch, Heidi R., additional, Gustafson, Kirk R., additional, Spakowicz, Daniel J., additional, Zhou, Linda, additional, Hungerford, William M., additional, Plummer, Mark, additional, Hoyer, Denton, additional, Narvaez-Trujillo, Alexandra, additional, Phillips, Andrew J., additional, and Strobel, Scott A., additional

Published
2015
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30. YU238259 Is a Novel Inhibitor of Homology-Dependent DNA Repair That Exhibits Synthetic Lethality and Radiosensitization in Repair-Deficient Tumors

Author

Stachelek, Gregory C., primary, Peterson-Roth, Elizabeth, additional, Liu, Yanfeng, additional, Fernandez, Rafael J., additional, Pike, Luke R.G., additional, Qian, Jack M., additional, Abriola, Laura, additional, Hoyer, Denton, additional, Hungerford, William, additional, Merkel, Janie, additional, and Glazer, Peter M., additional

Published
2015
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31. Design and synthesis of potent thiol-based inhibitors of endothelin converting enzyme-1

Author

Arco Y. Jeng, Ying Qiao, Paula Savage, Michael A. Moskal, Michael E. Beil, Angelo J. Trapani, Fariborz Firooznia, Hoyer Denton W, Cynthia A. Fink, Dongchu Wei, and David Symonsbergen

Subjects
Endothelin converting enzyme 1, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Endothelin-Converting Enzymes, Thioester, Biochemistry, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Animals, Aspartic Acid Endopeptidases, Humans, Structure–activity relationship, Protease Inhibitors, Sulfhydryl Compounds, education, Molecular Biology, chemistry.chemical_classification, education.field_of_study, biology, Organic Chemistry, Metalloendopeptidases, Rats, Enzyme, chemistry, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine, Endothelin receptor, Derivative (chemistry)
Abstract

Through directed screening of compounds prepared as metalloprotease inhibitors a compound, CGS 30084 , that had potent endothelin converting enzyme-1 (ECE-1) in vitro inhibitory activity (IC 50 =77 nM) was identified. Herein we report the synthesis and optimization of ECE-1 inhibitory activity of additional analogues from this lead. Compound 3c , the thioacetate methyl ester derivative of compound 4c , was found to be a long acting inhibitor of ECE-1 activity in rats after oral administration.

Published
2000

32. Molecular Basis of Purinergic Signal Metabolism by Ectonucleotide Pyrophosphatase/Phosphodiesterases 4 and 1 and Implications in Stroke*

Author

Albright, Ronald A., primary, Ornstein, Deborah L., additional, Cao, Wenxiang, additional, Chang, William C., additional, Robert, Donna, additional, Tehan, Martin, additional, Hoyer, Denton, additional, Liu, Lynn, additional, Stabach, Paul, additional, Yang, Guangxiao, additional, De La Cruz, Enrique M., additional, and Braddock, Demetrios T., additional

Published
2014
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33. CGS 34226, a thiol-based dual inhibitor of endothelin converting enzyme-1 and neutral endopeptidase 24.11

Author

Michael E. Beil, Y. Arco Jeng, Cynthia A. Fink, Angelo J. Trapani, Charles W. Bruseo, Hoyer Denton W, and Paula Savage

Subjects
medicine.hormone, Male, medicine.medical_specialty, Endothelin converting enzyme 1, medicine.medical_treatment, Phenylalanine, Pharmacology, Endothelin-Converting Enzymes, Kidney, Endothelins, Rats, Sprague-Dawley, Inhibitory Concentration 50, Atrial natriuretic peptide, In vivo, Internal medicine, medicine, Animals, Aspartic Acid Endopeptidases, Sulfhydryl Compounds, Enzyme Inhibitors, Protein Precursors, education, Neprilysin, chemistry.chemical_classification, education.field_of_study, Dose-Response Relationship, Drug, Endothelin-1, Cell Membrane, Metalloendopeptidases, General Medicine, In vitro, Peptide Fragments, Rats, Enzyme, Endocrinology, chemistry, COS Cells, Diuretic, Atrial Natriuretic Factor
Abstract

Endothelins (ETs) are potent vasoconstrictors and have been implicated in the pathogenesis of various cardiovascular and renal diseases. In contrast, atrial natriuretic peptide (ANP) is a potent vasorelaxant and diuretic agent, which is mainly degraded by neutral endopeptidase 24.11 (NEP) in vivo. Thus, compounds that can suppress the biosynthesis of ETs by inhibiting endothelin converting enzymes (ECEs), which catalyse the final step of post-translational processing of the vasoconstrictors, while simultaneously potentiating the levels of ANP by inhibiting NEP may have novel therapeutic utility. Through targeted screening of our compound library and subsequent optimization, CGS 34226 was identified as a potent, dual inhibitor of ECE-1 and NEP, inhibiting the enzymes with respective IC50 values of 11 and 4.6nM. In vivo, CGS 34226 suppressed the big endothelin-1 (big ET-1)-induced pressor response dose-dependently. At 15 and 90min after an intravenous dose of 30mg/kg in anaesthetized rats, this compound inhibited the big ET-1-induced effect by 79% and 65% respectively. In addition, CGS 34226 increased plasma ANP immunoreactivity by 120% up to 4h after an intravenous dose of 10mg/kg in conscious rats infused with ANP at a rate of 450ng/kg per min, intravenously. These results show that CGS 34226 is a potent dual inhibitor of ECE-1 and NEP in vitro and in vivo and that the compound may represent a novel agent for the treatment of cardiovascular and renal dysfunction.

Published
2002

35. Pyridazinodiazepines as a high-affinity, P2-P3 peptidomimetic class of interleukin-1 beta-converting enzyme inhibitor

Author

Roland E. Dolle, Mark A. Ator, Bruce Miller, Todd L. Graybill, Carla T. Helaszek, Tina Morgan Ross, Speier Gary J, Salvino Joseph M, Schmidt Stanley J, Joanne Uhl, Awad Mohamed M A, Prouty Catherine P, Hoyer Denton W, and C. V. C. Prasad

Subjects
medicine.drug_class, Cysteine Endopeptidases, Peptidomimetic, Stereochemistry, Metabolic Clearance Rate, Carboxamide, Viral Proteins, Dogs, Drug Discovery, medicine, Animals, Interleukin 1β converting enzyme, Enzyme Inhibitors, Serpins, chemistry.chemical_classification, biology, Bicyclic molecule, Chemistry, Azepines, In vitro, Pyridazines, Enzyme, Biochemistry, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine
Published
1997

39. Potent and Selective Non-Peptidic Inhibitors of Endothelin-Converting Enzyme-1 with Sustained Duration of Action

Author

De Lombaert, Stéphane, primary, Blanchard, Louis, additional, Stamford, Lisa B., additional, Tan, Jenny, additional, Wallace, Eli M., additional, Satoh, Yoshitaka, additional, Fitt, John, additional, Hoyer, Denton, additional, Simonsbergen, David, additional, Moliterni, John, additional, Marcopoulos, Nicholas, additional, Savage, Paula, additional, Chou, Mary, additional, Trapani, Angelo J., additional, and Jeng, Arco Y., additional

Published
2000
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44. Structural and stereochemical requirements of time-dependent inactivators of the interleukin-1β converting enzyme

Author

Prasad, C.V.C., primary, Prouty, Catherine P., additional, Hoyer, Denton, additional, Ross, Tina M., additional, Salvino, Joseph M., additional, Awad, Mohamad, additional, Graybill, Todd L., additional, Schmidt, Stanley J., additional, Kelly Osifo, I., additional, Dolle, Roland E., additional, Helaszek, Carla T., additional, Miller, Robert E., additional, and Ator, Mark A., additional

Published
1995
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46. Aspartyl .alpha.-((1-Phenyl-3-(trifluoromethyl)- pyrazol-5-yl)oxy)methyl Ketones as Interleukin-1.beta. Converting Enzyme Inhibitors. Significance of the P1 and P3 Amido Nitrogens for Enzyme-Peptide Inhibitor Binding

Author

Dolle, Roland E., primary, Singh, Jasbir, additional, Rinker, James, additional, Hoyer, Denton, additional, Prasad, C. V. C., additional, Graybill, Todd L., additional, Salvino, Joseph M., additional, Helaszek, Carla T., additional, Miller, Robert E., additional, and Ator, Mark A., additional

Published
1994
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