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198 results on '"Hsiao, Fu‐Jung"'

7. Magnetoencephalography

Author

Hsiao, Fu-Jung, Xiang, Jing, Chen, Wei-Ta, Martelletti, Paolo, Series Editor, Coppola, Gianluca, editor, and Chen, Wei-Ta, editor

Published
2021
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10. Abnormal heart rate variability and its application in predicting treatment efficacy in patients with chronic migraine: An exploratory study

Author

Chuang, Chun-Hsiang, primary, Li, Jhe-Yu, additional, King, Jung-Tai, additional, Chen, Wei-Ta, additional, Chen, Shih-Pin, additional, Wang, Yen-Feng, additional, Liu, Hung-Yu, additional, Hsiao, Fu-Jung, additional, Pan, Li-Ling Hope, additional, Wang, Shuu-Jiun, additional, and Lai, Kuan-Lin, additional

Published
2023
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33. Pilot study of focused ultrasound for drug‐resistant epilepsy.

Author

Lee, Cheng‐Chia, Chou, Chien‐Chen, Hsiao, Fu‐Jung, Chen, Yi‐Hsiu, Lin, Chun‐Fu, Chen, Ching‐Jen, Peng, Syu‐Jyun, Liu, Hao‐Li, and Yu, Hsiang‐Yu

Subjects
EPILEPSY, EPILEPSY in animals, MAGNETIC resonance imaging, EPILEPTIFORM discharges, CEREBRAL edema
Abstract

Objective: The neuromodulatory effects of focused ultrasound (FUS) have been demonstrated in animal epilepsy models; however, the safety and efficacy of FUS in humans with epilepsy have not been well established. Patients with drug‐resistant epilepsy (DRE) undergoing stereo‐electroencephalography (SEEG) provide an opportunity to investigate the neuromodulatory effects of FUS in humans. Methods: Patients with DRE undergoing SEEG for localization of the seizure onset zone (SOZ) were prospectively enrolled. FUS was delivered to the SOZ using a neuronavigation‐guided FUS system (ceiling spatial‐peak temporal‐average intensity level = 2.8 W/cm2, duty cycle = 30%, modulating duration = 10 min). Simultaneous SEEG recordings were obtained during sonication and for 3 days after treatment. Seizures, interictal epileptiform discharges, and adverse events after FUS were monitored. Results: Six patients met the eligibility criteria and completed FUS treatment. A decrease in seizure frequency was observed in two patients within the 3‐day follow‐up; however, one patient presented an increase in the frequency of subclinical seizures. Posttreatment magnetic resonance imaging revealed neither lesion nor brain edema. Significant changes in spectral power of SEEG were noted at the targeted electrodes during FUS treatment. One patient reported subjective scalp heating during FUS, and one patient developed transient naming and memory impairment that resolved within 3 weeks after FUS. Significance: FUS can be safely delivered to the SOZ of patients with DRE, resulting in significant changes in spectral power of SEEG. A larger sample cohort and pursuing optimal sonication parameters will be required to elucidate the neuromodulatory effects of FUS when used for seizure control. [ABSTRACT FROM AUTHOR]

Published
2022
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43. Aberrant Sensory Gating of the Primary Somatosensory Cortex Contributes to the Motor Circuit Dysfunction in Paroxysmal Kinesigenic Dyskinesia

Author

Liu, Yo-Tsen, primary, Chen, Yi-Chieh, additional, Kwan, Shang-Yeong, additional, Chou, Chien-Chen, additional, Yu, Hsiang-Yu, additional, Yen, Der-Jen, additional, Liao, Kwong-Kum, additional, Chen, Wei-Ta, additional, Lin, Yung-Yang, additional, Chen, Rou-Shayn, additional, Jih, Kang-Yang, additional, Lu, Shu-Fen, additional, Wu, Yu-Te, additional, Wang, Po-Shan, additional, and Hsiao, Fu-Jung, additional

Published
2018
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50. Somatosensory gating is altered and associated with migraine chronification: A magnetoencephalographic study.

Author

Hsiao, Fu-Jung, Wang, Shuu-Jiun, Lin, Yung-Yang, Fuh, Jong-Ling, Ko, Yu-Chieh, Wang, Pei-Ning, and Chen, Wei-Ta

Subjects
*MIGRAINE, *SOMATOSENSORY cortex, *MAGNETOENCEPHALOGRAPHY, *HABITUATION (Neuropsychology), *HEADACHE
Abstract

Background Brain excitability is changed in migraine but not fully characterized yet. This study explored if somatosensory gating is altered in migraine and linked to migraine chronification. Methods Paired electrical stimuli were delivered to the left index fingers of 21 patients with migraine without aura (MO), 22 patients with chronic migraine (CM), and 36 controls. The first and second responses to the paired stimuli were obtained from the contralateral primary (cSI), contralateral secondary (cSII) and ipsilateral secondary (iSII) somatosensory cortices to compute the gating ratios (second vs. first response strengths). Results The first and second cSI responses and gating ratios differed in all groups ( p < 0.05); the responses were typically smaller in the MO and CM groups. The cSI gating ratio increased as a continuum across controls (0.73 ± 0.04, p < 0.001), MO (0.83 ± 0.04) to CM (0.97 ± 0.06) and was higher in CM vs. controls ( p < 0.001). When MO and CM were combined, cSI gating ratio was associated with headache frequency (r = 0.418, p = 0.005). Paired responses and gating ratios of cSII and iSII did not differ among the groups. Conclusions Somatosensory gating is altered in migraine and associated with headache chronification. Further studies must clarify if this abnormal sensory modulation is a true gating deficit independent of low preexcitation level. [ABSTRACT FROM AUTHOR]

Published
2018
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