Search

Your search keyword '"Hsu, Chih-Chao"' showing total 209 results
Start Over Author "Hsu, Chih-Chao"
209 results on '"Hsu, Chih-Chao"'

1. Transcriptomic classification of diffuse large B-cell lymphoma identifies a high-risk activated B-cell-like subpopulation with targetable MYC dysregulation

Author

Stokes, Matthew E., Wenzl, Kerstin, Huang, C. Chris, Ortiz, María, Hsu, Chih-Chao, Maurer, Matthew J., Stong, Nicholas, Nakayama, Yumi, Wu, Lei, Chiu, Hsiling, Polonskaia, Ann, Danziger, Samuel A., Towfic, Fadi, Parker, Joel, King, Rebecca L., Link, Brian K., Slager, Susan L., Sarangi, Vivekananda, Asmann, Yan W., Novak, Joseph P., Sudhindra, Akshay, Ansell, Stephen M., Habermann, Thomas M., Hagner, Patrick R., Nowakowski, Grzegorz S., Cerhan, James R., Novak, Anne J., and Gandhi, Anita K.

Published
2024
Full Text
View/download PDF

3. A Surge of DNA Damage Links Transcriptional Reprogramming and Hematopoietic Deficit in Fanconi Anemia

Author

Shen, Xi, Wang, Rui, Kim, Moon Jong, Hu, Qianghua, Hsu, Chih-Chao, Yao, Jun, Klages-Mundt, Naeh, Tian, Yanyan, Lynn, Erica, Brewer, Thomas F, Zhang, Yilei, Arun, Banu, Gan, Boyi, Andreeff, Michael, Takeda, Shunichi, Chen, Junjie, Park, Jae-Il, Shi, Xiaobing, Chang, Christopher J, Jung, Sung Yun, Qin, Jun, and Li, Lei

Subjects
Biological Sciences, Genetics, Stem Cell Research - Nonembryonic - Non-Human, Hematology, Rare Diseases, Stem Cell Research, Aetiology, 2.1 Biological and endogenous factors, Cell Differentiation, Cellular Reprogramming, DNA Damage, DNA Repair, Fanconi Anemia, Formaldehyde, Gene Expression Regulation, Developmental, Genomic Instability, Hematopoietic Stem Cell Transplantation, Hematopoietic Stem Cells, Humans, K562 Cells, Transcription, Genetic, DNA damage, Fanconi anemia, bone marrow failure, differentiation, formaldehyde, hematopoiesis, transcription reprogramming, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

Impaired DNA crosslink repair leads to Fanconi anemia (FA), characterized by a unique manifestation of bone marrow failure and pancytopenia among diseases caused by DNA damage response defects. As a germline disorder, why the hematopoietic hierarchy is specifically affected is not fully understood. We find that reprogramming transcription during hematopoietic differentiation results in an overload of genotoxic stress, which causes aborted differentiation and depletion of FA mutant progenitor cells. DNA damage onset most likely arises from formaldehyde, an obligate by-product of oxidative protein demethylation during transcription regulation. Our results demonstrate that rapid and extensive transcription reprogramming associated with hematopoietic differentiation poses a major threat to genome stability and cell viability in the absence of the FA pathway. The connection between differentiation and DNA damage accumulation reveals a novel mechanism of genome scarring and is critical to exploring therapies to counteract the aplastic anemia for the treatment of FA patients.

Published
2020

10. Supplementary Data from Myeloma Genome Project Panel is a Comprehensive Targeted Genomics Panel for Molecular Profiling of Patients with Multiple Myeloma

Author

Sudha, Parvathi, primary, Ahsan, Aarif, primary, Ashby, Cody, primary, Kausar, Tasneem, primary, Khera, Akhil, primary, Kazeroun, Mohammad H., primary, Hsu, Chih-Chao, primary, Wang, Lin, primary, Fitzsimons, Evelyn, primary, Salminen, Outi, primary, Blaney, Patrick, primary, Czader, Magdalena, primary, Williams, Jonathan, primary, Abu Zaid, Mohammad I., primary, Ansari-Pour, Naser, primary, Yong, Kwee L., primary, van Rhee, Frits, primary, Pierceall, William E., primary, Morgan, Gareth J., primary, Flynt, Erin, primary, Gooding, Sarah, primary, Abonour, Rafat, primary, Ramasamy, Karthik, primary, Thakurta, Anjan, primary, and Walker, Brian A., primary

Published
2023
Full Text
View/download PDF

11. Supplementary Table from Myeloma Genome Project Panel is a Comprehensive Targeted Genomics Panel for Molecular Profiling of Patients with Multiple Myeloma

Author

Sudha, Parvathi, primary, Ahsan, Aarif, primary, Ashby, Cody, primary, Kausar, Tasneem, primary, Khera, Akhil, primary, Kazeroun, Mohammad H., primary, Hsu, Chih-Chao, primary, Wang, Lin, primary, Fitzsimons, Evelyn, primary, Salminen, Outi, primary, Blaney, Patrick, primary, Czader, Magdalena, primary, Williams, Jonathan, primary, Abu Zaid, Mohammad I., primary, Ansari-Pour, Naser, primary, Yong, Kwee L., primary, van Rhee, Frits, primary, Pierceall, William E., primary, Morgan, Gareth J., primary, Flynt, Erin, primary, Gooding, Sarah, primary, Abonour, Rafat, primary, Ramasamy, Karthik, primary, Thakurta, Anjan, primary, and Walker, Brian A., primary

Published
2023
Full Text
View/download PDF

12. Supplementary Figure from Myeloma Genome Project Panel is a Comprehensive Targeted Genomics Panel for Molecular Profiling of Patients with Multiple Myeloma

Author

Sudha, Parvathi, primary, Ahsan, Aarif, primary, Ashby, Cody, primary, Kausar, Tasneem, primary, Khera, Akhil, primary, Kazeroun, Mohammad H., primary, Hsu, Chih-Chao, primary, Wang, Lin, primary, Fitzsimons, Evelyn, primary, Salminen, Outi, primary, Blaney, Patrick, primary, Czader, Magdalena, primary, Williams, Jonathan, primary, Abu Zaid, Mohammad I., primary, Ansari-Pour, Naser, primary, Yong, Kwee L., primary, van Rhee, Frits, primary, Pierceall, William E., primary, Morgan, Gareth J., primary, Flynt, Erin, primary, Gooding, Sarah, primary, Abonour, Rafat, primary, Ramasamy, Karthik, primary, Thakurta, Anjan, primary, and Walker, Brian A., primary

Published
2023
Full Text
View/download PDF

13. The Influence of Playing for or against a Controversial Position on Elementary Students' Ability to Construct Cogent Arguments

Author

Lin, Chun-Hsu, Chiu, Chiung-Hui, Hsu, Chih-Chao, and Wang, Tzone-I

Abstract

This study investigated the influence of requiring elementary students to participate in a detective role-playing game, within which students had to be for or against a controversial issue. Three intact sixth grade classes (N = 94) participated in this study. One class of students was asked to search for supporting evidence for one side of an online ethics dilemma and to create convincing arguments (pro), while another searched for opposing evidence (con). The third other class searched for both supporting and opposing evidence (balanced). A one-way multivariate analysis of covariance shows that the balanced role-play strategy had a notable positive impact on the students' ability to construct cogent arguments.

Published
2015
Full Text
View/download PDF

16. Biological Features of a High-Risk Transcriptional Molecular Subtype in Diffuse Large B-Cell Lymphoma

Author

Stokes, Matthew E, primary, Wenzl, Kerstin, additional, Huang, C. Chris, additional, Ortiz Estevez, Maria, additional, Maurer, Matthew J., additional, Stong, Nicholas, additional, Hagner, Patrick, additional, Nakayama, Yumi, additional, Hsu, Chih-Chao, additional, Danziger, Samuel A, additional, Towfic, Fadi, additional, King, Rebecca L., additional, Parker, Joel S., additional, Link, Brian K., additional, Slager, Susan L., additional, Sarangi, Vivekananda, additional, Asmann, Yan, additional, Novak, Joseph P., additional, Sudhindra, Akshay, additional, Ansell, Stephen M., additional, Habermann, Thomas M., additional, Nowakowski, Grzegorz S., additional, Cerhan, James R., additional, Novak, Anne J., additional, and Gandhi, Anita K., additional

Published
2022
Full Text
View/download PDF

18. Enhancing Concept Comprehension in a Web-Based Course Using a Framework Integrating the Learning Cycle with Variation Theory

Author

Hsu, Chih-Chao and Wang, Tzone-I

Abstract

Concept comprehension is an important foundation for more complex thoughts. To enhance concept comprehension, teachers of traditional classrooms have been using instructional strategies and specific course designs, which have been proven effective. It initiates a hypothesis that integrating instructional strategies in the course designs of an e-learning system would improve the effectiveness of concept comprehension. The purpose of this study is to propose a framework that integrates the learning cycle with variation theory in the course design of a web-based e-learning system to prove the hypothesis. A pretest and posttest quasi-experimental design is employed to test whether the framework is feasible. Two types of web-based courses are designed for the experiments: a course designed according to a science textbook and another course designed using the framework. The participants in this study were 120 fifth-grade students in Taiwan. The results of the experiments show that the average scores of the experimental group, using the course designed with the framework, are significantly higher than that of the control group, using the course designed without any instructional strategy, on comprehension of course concepts. This confirms that the coherent, explicit and systematic framework is feasible for designing web-based e-learning courses for effectively enhancing concept comprehension as well as the evidence to prove the hypothesis.

Published
2014
Full Text
View/download PDF

25. Myeloma Genome Project Panel is a Comprehensive Targeted Genomics Panel for Molecular Profiling of Patients with Multiple Myeloma

Author

Sudha, Parvathi, primary, Ahsan, Aarif, additional, Ashby, Cody, additional, Kausar, Tasneem, additional, Khera, Akhil, additional, Kazeroun, Mohammad H., additional, Hsu, Chih-Chao, additional, Wang, Lin, additional, Fitzsimons, Evelyn, additional, Salminen, Outi, additional, Blaney, Patrick, additional, Czader, Magdalena, additional, Williams, Jonathan, additional, Abu Zaid, Mohammad I., additional, Ansari-Pour, Naser, additional, Yong, Kwee L., additional, van Rhee, Frits, additional, Pierceall, William E., additional, Morgan, Gareth J., additional, Flynt, Erin, additional, Gooding, Sarah, additional, Abonour, Rafat, additional, Ramasamy, Karthik, additional, Thakurta, Anjan, additional, and Walker, Brian A., additional

Published
2022
Full Text
View/download PDF

30. Super-Enhancer Driven Regulation of CKS1B in Multiple Myeloma: Implications in Mediating Response to BET Inhibitor and Celmod Agent Combination

Author

Ahsan, Aarif, primary, Polonskaia, Ann, additional, Hsu, Chih-Chao, additional, Bjorklund, Chad C, additional, Ortiz Estevez, Maria, additional, Towfic, Fadi, additional, Bahlis, Nizar J., additional, Pourdehnad, Michael, additional, Flynt, Erin, additional, Ahsan, Aarif, additional, and Thakurta, Anjan, additional

Published
2021
Full Text
View/download PDF

41. Large deletions (>10.9 MB) in 17p and bi-allelic TP53 inactivation events in newly-diagnosed multiple myeloma are associated with higher clonal cell fraction and poor prognosis

Author

Towfic, Fadi, primary, Thakurta, Anjan, additional, Flynt, Erin, additional, Walker, Brian, additional, Morgan, Gareth, additional, Bisht, Kamlesh, additional, Jeyaraju, Danny, additional, Ortiz, Maria, additional, Mavrommatis, Konstantinos, additional, Hsu, Chih-Chao, additional, and Gooding, Sarah, additional

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results